公开(公告)号：US20210171666A1

公开(公告)日：2021-06-10

申请号：US16071152

申请日：2017-01-20

Applicant: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Inventor： Theodoor Maximiliaan SLAGHEK ,  Johannes Wilhelmus TIMMERMANS ,  Ingrid Karin HAAKSMAN ,  Johannes Cornelis Petrus HOPMAN

IPC: C08B31/14 ,  C08B31/10

Abstract: A method for the etherification of a carbohydrate is provided, by subjecting the carbohydrate to superheated steam under alkaline conditions in the presence of an etherification agent to obtain a carbohydrate ether.

公开(公告)号：US10195312B2

公开(公告)日：2019-02-05

申请号：US15427801

申请日：2017-02-08

Applicant: Xin Ji

Inventor： Xin Ji ,  Cheng Xing ,  Xueshen Shi

IPC: A61K31/718 ,  A61L31/04 ,  C08B31/08 ,  C08B31/02 ,  C08B33/04 ,  C08B31/10 ,  C08B31/16 ,  C08B35/02 ,  C08B33/06 ,  C08B35/06 ,  C08B35/04 ,  C08B33/02 ,  C08B31/12 ,  C08B31/04 ,  C08B30/20 ,  C08B31/00 ,  C08B31/18 ,  C08B30/00 ,  A61K31/738 ,  A61L24/08 ,  A61L26/00 ,  A61K45/06 ,  A61K9/14 ,  C08L3/04 ,  C08L3/18 ,  C08L89/06 ,  A61K9/00 ,  A61K9/19 ,  A61L24/00 ,  A61L24/10 ,  A61L31/12

Abstract: A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.

公开(公告)号：US10076590B2

公开(公告)日：2018-09-18

申请号：US15359255

申请日：2016-11-22

Applicant: Xin Ji

Inventor： Xin Ji ,  Cheng Xing ,  Xueshen Shi

IPC: A61K31/718 ,  A61L31/04 ,  C08B31/08 ,  C08B31/02 ,  C08B33/04 ,  C08B31/10 ,  C08B31/16 ,  C08B35/02 ,  C08B33/06 ,  C08B35/06 ,  C08B35/04 ,  C08B33/02 ,  C08B31/12 ,  C08B31/04 ,  C08B30/20 ,  C08B31/00 ,  C08B30/00 ,  A61K31/738 ,  A61L24/08 ,  A61L26/00 ,  A61K45/06 ,  A61K9/14 ,  C08L3/04 ,  C08L3/18 ,  C08L89/06 ,  A61K9/00 ,  A61K9/19 ,  A61L24/00 ,  A61L24/10 ,  A61L31/12

CPC classification number: A61L31/042 ,  A61K9/0014 ,  A61K9/14 ,  A61K9/19 ,  A61K31/718 ,  A61K31/738 ,  A61K45/06 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/0073 ,  A61L24/08 ,  A61L24/104 ,  A61L26/0023 ,  A61L26/0085 ,  A61L31/045 ,  A61L31/125 ,  A61L2300/406 ,  A61L2400/04 ,  A61L2430/34 ,  C08B30/00 ,  C08B30/20 ,  C08B31/00 ,  C08B31/003 ,  C08B31/02 ,  C08B31/04 ,  C08B31/08 ,  C08B31/10 ,  C08B31/12 ,  C08B31/16 ,  C08B31/18 ,  C08B33/02 ,  C08B33/04 ,  C08B33/06 ,  C08B35/02 ,  C08B35/04 ,  C08B35/06 ,  C08L3/04 ,  C08L3/18 ,  C08L89/06 ,  Y10T428/2982

Abstract: A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.

公开(公告)号：US5977348A

公开(公告)日：1999-11-02

申请号：US900753

申请日：1997-07-25

Applicant: Rosemarie Harris ,  Sharon H. Jureller ,  Judith L. Kerschner ,  Peter T. Trzasko ,  Robert W. R. Humphreys

Inventor： Rosemarie Harris ,  Sharon H. Jureller ,  Judith L. Kerschner ,  Peter T. Trzasko ,  Robert W. R. Humphreys

IPC: C08B3/00 ,  C08B31/00 ,  C08B37/00 ,  C08B31/04 ,  C08B31/10

CPC classification number: C08B37/0096 ,  C08B31/00 ,  Y02P20/544

Abstract: This invention relates to a process for chemically modifying polysaccharides in a densified fluid. In particular, the modification includes esterification and/or etherification of a starch in supercritical carbon dioxide. The process is advantageous in that it allows for a high degree of substitution without the use of organic solvents or repeated reactions.

Abstract translation: 本发明涉及在致密化流体中化学改性多糖的方法。 特别地，改性包括在超临界二氧化碳中淀粉的酯化和/或醚化。 该方法的优点在于，其允许高度取代而不使用有机溶剂或重复反应。

公开(公告)号：US5138046A

公开(公告)日：1992-08-11

申请号：US656041

申请日：1991-05-13

Applicant: Willi Wuest ,  Rainer Eskuchen ,  Josef Wollman ,  Karlheinz Hill ,  Manfred Biermann

Inventor： Willi Wuest ,  Rainer Eskuchen ,  Josef Wollman ,  Karlheinz Hill ,  Manfred Biermann

IPC: B01F17/56 ,  C07H15/04 ,  C08B31/10 ,  C11D1/68

CPC classification number: C07H15/04 ,  Y02P20/582

Abstract: Surface active alkylglucosides are prepared in a 2-step process from starch or starch degradation products such as polyglucose or glucose syrup, the first step consisting of reaction with a short chained alcohol, particularly butanol, while the second step comprises transacetalization with the longer chained C.sub.8-22, more particularly C.sub.12-18, alcohol, with fatty alcohols of natural origin preferably being used.

Abstract translation: PCT No.PCT / EP89 / 00923。 371日期1991年5月13日 102（e）日期1991年5月13日PCT PCT 1989年8月4日PCT公布。 出版物WO90 / 01489 1990年2月22日。表面活性烷基葡糖苷以淀粉或淀粉降解产物如葡萄糖或葡萄糖浆为原料，以两步法制备，第一步是与短链醇（特别是丁醇）反应，其中第二步 包括使用较长链C8-22，更特别是C12-18醇，与优选使用天然来源的脂肪醇进行缩醛化。

公开(公告)号：US4758279A

公开(公告)日：1988-07-19

申请号：US909976

申请日：1986-09-22

Applicant: Michael J. Hasuly ,  Peter T. Trzasko

Inventor： Michael J. Hasuly ,  Peter T. Trzasko

IPC: D06M13/00 ,  C08B31/04 ,  C08B31/10 ,  C08L3/00 ,  D06M13/02 ,  D06M13/144 ,  D06M13/224 ,  D06M15/11

CPC classification number: D06M15/11 ,  D06M13/02 ,  D06M13/2243 ,  D06M7/00 ,  D06M2200/40

Abstract: Textile warp sizing compositions and hydrophobic starch derivatives useful therefor are provided. The compositions strengthen and protect warp yarns as well as render textile lubricants uniformly dispersible thereon. The compositions additionally facilitate efficient lubricant removal during desizing. The hydrophobic starch derivatives contain an ether, simple ester or half-acid ester substituent with a saturated or unsaturated hydrocarbon chain of at least 5 carbon atoms.

Abstract translation: 提供了纺织品经纱施胶组合物和用于其的疏水性淀粉衍生物。 组合物增强和保护经纱以及使织物润滑剂在其上均匀分散。 该组合物另外促进了在退浆期间有效的润滑剂去除。 疏水性淀粉衍生物含有具有至少5个碳原子的饱和或不饱和烃链的醚，简单酯或半酸酯取代基。

公开(公告)号：US09687501B2

公开(公告)日：2017-06-27

申请号：US13894396

申请日：2013-05-14

Applicant: Xin Ji ,  Cheng Xing ,  Xueshen Shi ,  Jianping Chen

Inventor： Xin Ji ,  Cheng Xing ,  Xueshen Shi ,  Jianping Chen

IPC: A61K31/718 ,  A61L24/00 ,  A61L26/00 ,  A61K9/14 ,  C08L3/18 ,  C08L3/04 ,  C08L89/06 ,  C08B31/12 ,  C08B31/08 ,  C08B31/02 ,  C08B33/04 ,  C08B31/10 ,  C08B31/16 ,  C08B35/02 ,  C08B33/06 ,  C08B35/06 ,  C08B35/04 ,  C08B33/02 ,  C08B31/04 ,  C08B30/20 ,  C08B31/00 ,  C08B30/00 ,  A61K31/738 ,  A61L24/08 ,  A61K45/06 ,  A61K9/19 ,  C08B31/06 ,  A61K9/00

CPC classification number: A61L31/042 ,  A61K9/0014 ,  A61K9/14 ,  A61K9/19 ,  A61K31/718 ,  A61K31/738 ,  A61K45/06 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/0073 ,  A61L24/08 ,  A61L24/104 ,  A61L26/0023 ,  A61L26/0085 ,  A61L31/045 ,  A61L31/125 ,  A61L2300/406 ,  A61L2400/04 ,  A61L2430/34 ,  C08B30/00 ,  C08B30/20 ,  C08B31/00 ,  C08B31/003 ,  C08B31/02 ,  C08B31/04 ,  C08B31/08 ,  C08B31/10 ,  C08B31/12 ,  C08B31/16 ,  C08B33/02 ,  C08B33/04 ,  C08B33/06 ,  C08B35/02 ,  C08B35/04 ,  C08B35/06 ,  C08L3/04 ,  C08L3/18 ,  C08L89/06 ,  Y10T428/2982

Abstract: A modified starch material is arranged for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.

公开(公告)号：US20150297738A1

公开(公告)日：2015-10-22

申请号：US14753783

申请日：2015-06-29

Applicant: Fresenius Kabi Deutschland GmbH

Inventor： Helmut Knoller ,  Dominik Heckmann ,  Frank Hacket ,  Norbert Zander ,  Frank Nocken ,  Saswata Lahiri ,  Nitin Gupta ,  Sunil Sanghani ,  Azim Abul ,  Hemant Kumar Singh ,  Sandeep Grewal ,  Sandeep Kaur

IPC: A61K47/48 ,  C08B31/10

CPC classification number: A61K47/36 ,  A61K47/61 ,  C08B31/10

Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

Abstract translation: 本发明涉及羟烷基淀粉缀合物及其制备方法，所述羟烷基淀粉缀合物包含羟烷基淀粉衍生物和细胞毒性剂，所述细胞毒性剂包含至少一个仲羟基，其中所述羟烷基淀粉通过所述 仲羟基对细胞毒性剂。 根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，和 n大于或等于1，并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量（MW）。

公开(公告)号：US20130184455A1

公开(公告)日：2013-07-18

申请号：US13809081

申请日：2011-07-11

Applicant: Helmut Knoller ,  Dominik Heckmann ,  Frank Hacket ,  Norbert Zander ,  Frank Nocken ,  Saswata Lahiri ,  Nitin Gupta ,  Sunil Sanghani ,  Azim Abul ,  Hemant Kumar Singh ,  Sandeep Grewal ,  Sandeep Kaur

Inventor： Helmut Knoller ,  Dominik Heckmann ,  Frank Hacket ,  Norbert Zander ,  Frank Nocken ,  Saswata Lahiri ,  Nitin Gupta ,  Sunil Sanghani ,  Azim Abul ,  Hemant Kumar Singh ,  Sandeep Grewal ,  Sandeep Kaur

IPC: C08B31/10

CPC classification number: A61K47/36 ,  A61K47/61 ,  C08B31/10

Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

Abstract translation: 本发明涉及羟烷基淀粉缀合物及其制备方法，所述羟烷基淀粉缀合物包含羟烷基淀粉衍生物和细胞毒性剂，所述细胞毒性剂包含至少一个仲羟基，其中所述羟烷基淀粉通过所述 仲羟基对细胞毒性剂。 根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，和 n大于或等于1，并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量（MW）。

公开(公告)号：US5883242A

公开(公告)日：1999-03-16

申请号：US845408

申请日：1997-04-25

Applicant: Satoshi Kubota ,  Akitomo Terada ,  Yoshiteru Yamamoto

Inventor： Satoshi Kubota ,  Akitomo Terada ,  Yoshiteru Yamamoto

IPC: C08B31/00 ,  C08B31/12 ,  C08F251/00 ,  C08L3/00 ,  D21H11/14 ,  D21H17/28 ,  D21H17/29 ,  D21H21/18 ,  C08B31/10 ,  D21F11/00

CPC classification number: D21H17/29 ,  C08B31/125 ,  C08L3/00 ,  D21H11/14 ,  D21H21/18

Abstract: The present invention provides a cationic starch prepared by roasting starch under the presence of a cationic polymer, a method for preparing the cationic starch, and a method for making paper board with the cationic starch. The method for making paper board of the present invention provides high retention of starch in paper board, enhances paper board strength in a high level and reduces a load of treating waste water from a paper machine, in comparison with the starch which has conventionally been employed for paper making.

Abstract translation: 本发明提供通过在阳离子聚合物的存在下焙烧淀粉而制备的阳离子淀粉，阳离子淀粉的制备方法以及用阳离子淀粉制造纸板的方法。 本发明的纸板的制造方法相对于常规使用的淀粉，在纸板中提供高保留性的纸板，提高了纸板强度，降低了造纸机处理废水的负担 用于造纸。