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    RF BIOSENSING SYSTEM USING AN RF SENSOR WITH MICRONEEDLE
    1.
    发明公开
    RF BIOSENSING SYSTEM USING AN RF SENSOR WITH MICRONEEDLE 审中-公开

    公开(公告)号：US20240324960A1

    公开(公告)日：2024-10-03

    申请号：US18617785

    申请日：2024-03-27

    申请人： KIMS BIO LAB CO., LTD.

    发明人： Nam Young KIM ,  EunSeong KIM ,  Wei YUE

    IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61L31/04 ,  A61L31/14

    CPC分类号： A61B5/685 ,  A61B5/14532 ,  A61B5/14865 ,  A61L31/045 ,  A61L31/145

    摘要： An RF biosensing system using an RF biosensor with glucose-responsive hydrogel-based microneedles can minimally invasively contact the epidermis/dermis/hypodermis of the skin or the skin surface/fat/muscle in vivo by using glucose-responsive hydrogel-based microneedles provided on the bottom of a flexible substrate of an RF biosensor using resonant frequencies within 400˜3,000 MHZ, detect and transmit the sensing signal to a reader antenna and a reader antenna sensing circuit through a readout coil by RF biosensing and wireless transmission through EM coupling of RF biosensors, and measure the sensing signals by a vector network analyzer (VNA), thereby providing biosensing of proteins, glucose, and fats within the skin in accordance with changes in capacitances of the sensing antenna circuit (LC resonator) of the RF biosensor, resonant frequency shift of the LC resonator, and changes in S-parameters.

    Anti-adhesion membrane
    4.
    发明授权
    Anti-adhesion membrane 有权
    防粘膜

    公开(公告)号：US08741969B2

    公开(公告)日：2014-06-03

    申请号：US11989701

    申请日：2006-08-02

    申请人： Hitoshi Otani ,  Shojiro Matsuda ,  Tsuguyoshi Taira ,  Noriyuki Morikawa

    发明人： Hitoshi Otani ,  Shojiro Matsuda ,  Tsuguyoshi Taira ,  Noriyuki Morikawa

    IPC分类号： A61K47/42 ,  C07K1/00 ,  C07K14/78 ,  A61P19/04

    CPC分类号： A61K47/42 ,  A61L31/045 ,  C07K1/00 ,  C07K14/78

    摘要： An object of the present invention is to provide an anti-adhesion membrane that has no toxicity to a living body, has flexibility allowing itself to fit an affected part as a hydrated gel, is uniformly crosslinked, and is immediately absorbed in a living body after maintaining its shape in the living body for a certain period of time.The present invention provides anti-adhesion material, which comprises a thermally crosslinked gelatin film, and has a water content of 60 to 85% calculated by the following formula (1): water content (%)=[(Ws−Wd)/Ws]×100(%)  (1), in the formula (1), Ws representing a weight (wet weight) of the anti-adhesion material immersed in a phosphate buffered saline solution at a temperature of 25° C. for one hour, and Wd representing a weight (dry weight) of the anti-adhesion material dried completely using a vacuum drying apparatus.

    摘要翻译： 本发明的目的是提供一种对生物体无毒性的抗粘附膜，具有使其自身适合作为水合凝胶的患部的柔软性，均匀交联，并且立即被吸收在生物体内 保持其在生命体中的形状一段时间。 本发明提供一种抗粘连材料，其包含热交联明胶膜，并且通过下式（1）计算的水含量为60-85％：水含量（％）= [（Ws-Wd）/ Ws ]×100（％）（1）在式（1）中，Ws表示浸渍在磷酸盐缓冲盐水溶液中的温度为25℃的抗粘附材料的重量（湿重）1小时， Wd表示使用真空干燥装置完全干燥的防粘附材料的重量（干重）。

    ELONGATED EXPANDABLE MEMBER FOR OCCLUDING VARICOSE VEINS
    6.
    发明申请
    ELONGATED EXPANDABLE MEMBER FOR OCCLUDING VARICOSE VEINS 有权
    延长会员可以免费使用VARICOSE VEINS

    公开(公告)号：US20130144323A1

    公开(公告)日：2013-06-06

    申请号：US13310503

    申请日：2011-12-02

    申请人： Howard Root ,  James Murto ,  Stephen Penegor ,  Gregg Sutton

    发明人： Howard Root ,  James Murto ,  Stephen Penegor ,  Gregg Sutton

    IPC分类号： A61M29/04

    CPC分类号： A61B17/12109 ,  A61B17/12031 ,  A61B17/1219 ,  A61B2017/00429 ,  A61B2017/00526 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61B2017/00942 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61L31/044 ,  A61L31/045 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/404 ,  A61L2430/36 ,  F04C2270/041

    摘要： Assemblies, kits, and methods for occluding a vascular vessel, such as a varicose vein, are disclosed. An assembly can include a removable inner member, a removable outer member, and an elongated expandable member positioned in a compressed form between portions of the inner and outer members. To facilitate their removal, one or both of the inner and outer members can include a handle coupled to a proximal end. The elongated expandable member can include a gelatin material or a collagen material that is configured, when wetted, to expand from a compressed first diametrical size to a second larger diametrical size within a time period of 5 minutes or less. At the second larger diametrical size, the gelatin or collagen material can occlude a vascular vessel for a period of at least 20 days without degrading.

    摘要翻译： 公开了用于闭塞血管的静脉曲张，套件和方法，例如静脉曲张。 组件可以包括可拆卸的内部构件，可移除的外部构件和在内部构件和外部构件的部分之间以压缩形式定位的细长可扩展构件。 为了便于其移除，内部和外部构件中的一个或两个可以包括联接到近端的手柄。 细长可扩张构件可以包括明胶材料或胶原材料，其在被润湿时被构造成在5分钟或更短的时间段内从压缩的第一直径尺寸膨胀到第二较大直径尺寸。 在第二个更大的直径尺寸下，明胶或胶原材料可以将血管容器封闭至少20天的时间，而不会降解。

    STERILIZATION OF POLYMERIC MATERIALS
    7.
    发明申请
    STERILIZATION OF POLYMERIC MATERIALS 有权
    聚合材料的灭菌

    公开(公告)号：US20130084381A1

    公开(公告)日：2013-04-04

    申请号：US13685367

    申请日：2012-11-26

    申请人： ETHICON, INC.

    发明人： James COMOLLI ,  Stephen C. YEADON

    IPC分类号： A61L2/08

    CPC分类号： A61L2/081 ,  A61L2/0035 ,  A61L2/082 ,  A61L2/087 ,  A61L27/222 ,  A61L27/50 ,  A61L27/54 ,  A61L29/046 ,  A61L29/14 ,  A61L29/16 ,  A61L31/045 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00

    摘要： A method of sterilizing a polymeric material that is sensitive to radiation. The method includes the steps of applying at least one radiosensitizer to the polymeric material and irradiating the polymeric material with a suitable radiation at an effective dose and time to sterilize the polymeric material. Also disclosed is a method of enhancing the ability of a medical device to withstand sterilization by radiation and a bioabsorbable polymeric medical device.

    摘要翻译： 对辐射敏感的聚合材料进行灭菌的方法。 该方法包括以下步骤：将至少一种放射增敏剂施加到聚合物材料上，并以合适的辐射以有效剂量和时间照射聚合物材料以对聚合物材料进行灭菌。 还公开了一种增强医疗装置耐受辐射灭菌和生物可吸收的聚合物医疗装置的能力的方法。

    Medical film
    8.
    发明授权
    Medical film 有权
    医疗电影

    公开(公告)号：US07718556B2

    公开(公告)日：2010-05-18

    申请号：US10536590

    申请日：2003-12-08

    申请人： Shojiro Matsuda ,  Hitoshi Ohtani ,  Yoshimi Tanaka ,  Hideki Tadokoro

    发明人： Shojiro Matsuda ,  Hitoshi Ohtani ,  Yoshimi Tanaka ,  Hideki Tadokoro

    IPC分类号： A61F2/02 ,  A61F2/06 ,  B32B5/04 ,  B32B27/04 ,  B32B27/12

    CPC分类号： A61L31/148 ,  A61L31/045 ,  A61L31/129 ,  Y10T442/2484 ,  Y10T442/2525 ,  Y10T442/2861 ,  Y10T442/3854 ,  Y10T442/45 ,  Y10T442/674

    摘要： A medical film that is excellent in biocompatibility and bioabsorbability and has an excellent strength in suturing and bonding is provided. A reinforcing material 12 made of a biodegradable polymer is placed in a gelatin solution so as to allow the solution to infiltrate in the reinforcing material 12 and then the gelatin is dried. This allows the gelatin that has infiltrated entirely in an internal part of the reinforcing material 12 to gel, thereby forming a gelatin film 11. Thus, a medical film 1 in which the reinforcing material 12 and the gelatin film 11 are integrated is obtained. The gelatin film 11 preferably is a cross-linked gelatin film.

    摘要翻译： 提供生物相容性和生物吸收性优异，缝合接合强度优异的医用膜。 将由可生物降解的聚合物制成的增强材料12放置在明胶溶液中，以使溶液渗透到增强材料12中，然后将明胶干燥。 由此，能够将完全渗透到增强材料12的内部的凝胶凝胶化，从而形成明胶膜11.因此，得到了增强材料12和明胶膜11一体化的医疗用膜1。 明胶膜11优选为交联明胶膜。

    Gelatin derivatives and high-molecular micelle comprising the derivatives
    9.
    发明授权
    Gelatin derivatives and high-molecular micelle comprising the derivatives 有权
    明胶衍生物和包含该衍生物的高分子胶束

    公开(公告)号：US07605231B2

    公开(公告)日：2009-10-20

    申请号：US10973846

    申请日：2004-10-25

    申请人： Yasuhiko Tabata ,  Koji Sakaguchi ,  Shinji Tanaka

    发明人： Yasuhiko Tabata ,  Koji Sakaguchi ,  Shinji Tanaka

    IPC分类号： A61K38/00

    CPC分类号： A61K9/1075 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6907 ,  A61L31/045 ,  C07K14/78 ,  Y10S977/773

    摘要： The present invention relates to a gelatin derivative having an organic compound as a graft chain and a high-molecular weight micelle containing the gelatin derivative. As the organic compound, a low molecular weight compound such as succinic acid, ethylenediamine, etc., or a high-molecular weight compound such as polyethylene glycol, polylactic acid, etc. can be used. The high-molecular weight micelle can be used as a pharmaceutical composition excellent in control of sustained release or targeting property by carrying it on a drug, etc. Also, the gelatin derivative can be an excellent adhesion preventing membrane by crosslinking it.

    摘要翻译： 本发明涉及具有有机化合物作为接枝链的明胶衍生物和含有明胶衍生物的高分子量胶束。 作为有机化合物，可以使用琥珀酸，乙二胺等低分子化合物或聚乙二醇，聚乳酸等高分子化合物。 高分子量胶束可以作为通过将药物等携带在持续释放或靶向特性上而优异的药物组合物使用。此外，明胶衍生物可以通过交联而成为优异的防粘膜。

    Anti-adhesion membrane
    10.
    发明申请
    Anti-adhesion membrane 有权
    防粘膜

    公开(公告)号：US20090099268A1

    公开(公告)日：2009-04-16

    申请号：US11989701

    申请日：2006-08-02

    申请人： Hitoshi Otani ,  Shojiro Matsuda ,  Tsuguyoshi Taira ,  Noriyuki Morikawa

    发明人： Hitoshi Otani ,  Shojiro Matsuda ,  Tsuguyoshi Taira ,  Noriyuki Morikawa

    IPC分类号： A61K47/42 ,  C07K14/78 ,  C07K1/00 ,  A61P19/04

    CPC分类号： A61K47/42 ,  A61L31/045 ,  C07K1/00 ,  C07K14/78

    摘要： An object of the present invention is to provide an anti-adhesion membrane that has no toxicity to a living body, has flexibility allowing itself to fit an affected part as a hydrated gel, is uniformly crosslinked, and is immediately absorbed in a living body after maintaining its shape in the living body for a certain period of time.The present invention provides anti-adhesion material, which comprises a thermally crosslinked gelatin film, and has a water content of 60 to 85% calculated by the following formula (1): water content (%)=[(Ws−Wd)/Ws]×100(%)  (1), in the formula (1), Ws representing a weight (wet weight) of the anti-adhesion material immersed in a phosphate buffered saline solution at a temperature of 25° C. for one hour, and Wd representing a weight (dry weight) of the anti-adhesion material dried completely using a vacuum drying apparatus.

    摘要翻译： 本发明的目的是提供一种对生物体无毒性的抗粘附膜，具有使其自身适合作为水合凝胶的患部的柔软性，均匀交联，并且立即被吸收在生物体内 保持其在生命体中的形状一段时间。 本发明提供一种抗粘连材料，其包含热交联的明胶膜，并且通过下式（1）计算的水含量为60-85％：<​​？在线配方说明=“在线式 “end =”lead“？>含水量（％）= [（Ws-Wd）/ Ws] x100（％）（1），<？在线公式描述=”在线公式“end =”tail 式（1）中的“○”表示在25℃的温度下浸渍在磷酸盐缓冲盐水溶液中1小时的抗粘附材料的重量（湿重），Wd表示重量 重量）的防粘附材料使用真空干燥装置完全干燥。