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公开(公告)号：US20180093971A1
公开(公告)日：2018-04-05
申请号：US14692597
申请日：2015-04-21
发明人： Duane D. Miller , Jianjun Chen , James T. Dalton , Chien-Ming Li , Sunjoo Ahn , Wei Li
IPC分类号： C07D403/04 , C07D233/02 , A61K31/4178 , A61K45/06 , C07D233/22 , C07D277/56 , C07D277/28 , C07D277/24 , C07D277/04 , C07D263/32 , C07D263/14 , C07D263/06 , C07D417/06 , C07D417/04 , C07D413/06 , C07D413/04 , C07D401/06 , C07D401/04 , C07D233/54
CPC分类号： C07D403/04 , A61K31/4178 , A61K45/06 , C07D233/02 , C07D233/22 , C07D233/54 , C07D263/06 , C07D263/14 , C07D263/32 , C07D277/04 , C07D277/24 , C07D277/28 , C07D277/56 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , A61K2300/00
摘要： The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a method of using thereof in the treatment of various forms of cancer.
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公开(公告)号：US09871216B2
公开(公告)日：2018-01-16
申请号：US14237850
申请日：2012-08-06
申请人： Hiroaki Itoh
发明人： Hiroaki Itoh
IPC分类号： H01L51/42 , C07D311/74 , C07D493/10 , C07D277/04 , C07D295/08 , C07D307/80 , H01L51/00
CPC分类号： H01L51/4253 , C07D277/04 , C07D295/08 , C07D307/80 , C07D311/74 , C07D493/10 , H01L51/0042 , H01L51/0073 , Y02E10/549
摘要： To provide an organic photoelectric conversion element whereby conversion efficiency is increased by morphology improvement in a power generation layer, and whereby short circuit current (Jsc) attenuation when irradiating light is simultaneously suppressed, and an organic solar cell using the same.An organic photoelectric conversion element having: a transparent first electrode; a power generation layer having a p-type organic semiconductor material and an n-type organic semiconductor material; and a second electrode, on a transparent substrate, in which the power generation layer is a bulk heterojunction power generation layer including the p-type organic semiconductor material and the n-type organic semiconductor material, and additionally includes a compound represented by either the following general formula (I) or general formula (II).
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公开(公告)号：US20170226070A1
公开(公告)日：2017-08-10
申请号：US15495496
申请日：2017-04-24
发明人： David RUBIN , Eyal RUBIN
IPC分类号： C07D277/06
CPC分类号： C07D277/06 , C07B2200/13 , C07D277/04
摘要： The present disclosure provides pharmaceutical compositions comprising Gamma-glutamyl cycle inhibitors (GGCI) and certain pharmaceutically acceptable salts thereof, and methods of use.
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公开(公告)号：US09682928B2
公开(公告)日：2017-06-20
申请号：US14472181
申请日：2014-08-28
IPC分类号： C07D295/084 , C07C311/39 , A61K31/4355 , C07D211/44 , C07D231/04 , C07D233/02 , C07D237/02 , C07D239/04 , C07D241/04 , C07D261/02 , C07D263/04 , C07D265/30 , C07D275/02 , C07D277/04 , C07D279/12 , C07D307/52
CPC分类号： A61K31/18 , A61K31/4355 , C07C311/39 , C07D211/44 , C07D231/04 , C07D233/02 , C07D237/02 , C07D239/04 , C07D241/04 , C07D261/02 , C07D263/04 , C07D265/30 , C07D275/02 , C07D277/04 , C07D279/12 , C07D295/084 , C07D307/52
摘要： The present invention provides bumetanide analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide analogs and methods for their use. These analogs are particularly useful for the treatment and/or prophylaxis of conditions that involve the Na+K+Cl− co-transporter or GABAA receptor including but not limited to addictive disorders, Alzheimer's Disease, anxiety disorders, ascites, autism, bipolar disorder, cancer, depression, endothelial corneal dystrophy, edema, epilepsy, glaucoma. Huntington's Disease, insomnia, ischemia, migraine, migraine with aura, neuropathic pain, nociceptive neuralgia, nociceptive pain, ocular diseases, pain, Parkinson's disease, personality disorders, postherpetic neuralgia, psychosis, schizophrenia, seizure disorders, tinnitus, and withdrawal syndromes.
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5.发明申请NOVEL ONIUM SALT COMPOUND, RESIST COMPOSITION, AND PATTERN FORMING PROCESS 有权新型盐酸盐化合物，耐腐蚀组合物和图案形成工艺公开(公告)号：US20160131972A1
公开(公告)日：2016-05-12
申请号：US14930869
申请日：2015-11-03
IPC分类号： G03F7/004 , G03F7/16 , G03F7/20 , C07D295/26 , G03F7/32 , C07D295/155 , C07C321/28 , C07D213/79 , G03F7/038 , G03F7/38
CPC分类号： G03F7/0397 , C07C25/00 , C07C25/02 , C07C69/76 , C07C69/78 , C07C381/12 , C07D203/14 , C07D205/04 , C07D207/04 , C07D211/06 , C07D213/79 , C07D223/04 , C07D225/02 , C07D233/02 , C07D241/04 , C07D263/04 , C07D265/30 , C07D277/04 , C07D279/12 , C07D295/112 , C07D295/155 , C07D295/26 , G03F7/0045 , G03F7/0046 , G03F7/11 , G03F7/168 , G03F7/2037 , G03F7/2041 , G03F7/30 , G03F7/322 , G03F7/325 , G03F7/38
摘要： Sulfonium and iodonium salts of a carboxylate having an aromatic ring to which a nitrogen-containing alkyl or cyclic structure is attached are novel. The onium salt functions as an acid diffusion controlling agent in a resist composition, enabling to form a pattern of good profile with high resolution, improved MEF, LWR and DOF.
摘要翻译： 含有含氮烷基或环状结构的具有芳环的羧酸盐的锍盐和碘鎓盐是新颖的。 鎓盐在抗蚀剂组合物中用作酸扩散控制剂，能够形成具有高分辨率，改进的MEF，LWR和DOF的良好轮廓的图案。
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公开(公告)号：US09029408B2
公开(公告)日：2015-05-12
申请号：US14049950
申请日：2013-10-09
发明人： Duane D. Miller , Wei Li , Jianjun Chen , James T. Dalton , Chien-Ming Li , Sunjoo Ahn
IPC分类号： A61K31/422 , A61K31/427 , A61K31/4178 , C07D403/12 , C07D413/12 , C07D403/04 , C07D233/02 , C07D233/22 , C07D233/54 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D263/06 , C07D263/14 , C07D263/32 , C07D277/04 , C07D277/24 , C07D277/28 , C07D277/56 , A61K45/06
CPC分类号： C07D403/04 , A61K31/4178 , A61K45/06 , C07D233/02 , C07D233/22 , C07D233/54 , C07D263/06 , C07D263/14 , C07D263/32 , C07D277/04 , C07D277/24 , C07D277/28 , C07D277/56 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , A61K2300/00
摘要： The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a method of using thereof in the treatment of various forms of cancer.
摘要翻译： 本发明涉及式XXII化合物和式17ya化合物，其在本说明书中的任何地方定义为包含该化合物的组合物，以及其用于治疗各种形式的癌症的方法。
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公开(公告)号：US20150087823A1
公开(公告)日：2015-03-26
申请号：US14395241
申请日：2013-04-26
IPC分类号： C07D295/185 , C07D277/04 , C07D211/26 , C07D211/74 , C07D211/62 , C07D211/58 , C07D207/16 , C07D211/16
CPC分类号： C07D295/185 , C07D207/08 , C07D207/16 , C07D211/16 , C07D211/18 , C07D211/26 , C07D211/30 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/74 , C07D213/74 , C07D239/42 , C07D243/08 , C07D277/04 , C07D295/18
摘要： The present invention relates to a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical agent containing the compound as an active ingredient. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt, which is the compound of the present invention, is specifically represented by the general formula (I): wherein X is a substituent such as a 1-pyrrolidyl, a 3-thiazolizyl, or a piperidino, and the compound is highly useful as a pharmaceutical agent, such as a prophylactic or therapeutic agent for a peripheral nerve disorder induced by administration of an anticancer agent, a prophylactic or therapeutic agent for neurodegenerative diseases or mental diseases such as dementia, Alzheimer's disease, Parkinson's disease, diabetic neuropathy, depression, glaucoma, or autistic disorder spectrum, a therapeutic or repairing agent for spinal cord injury, analgesics against various pain diseases, or the like.
摘要翻译： 本发明涉及新的反式-2-癸烯酸衍生物或其药学上可接受的盐，以及含有该化合物作为活性成分的药剂。 作为本发明化合物的反式-2-癸烯酸衍生物或药学上可接受的盐，具体地由通式（I）表示：其中X是取代基，例如1-吡咯烷基，3-噻唑基 或哌啶子基，并且该化合物作为药剂非常有用，例如通过施用抗癌剂诱导的周围神经障碍的预防或治疗剂，用于神经变性疾病或精神疾病如痴呆的预防或治疗剂 阿尔茨海默病，帕金森病，糖尿病性神经病，抑郁症，青光眼，自闭症病症谱，脊髓损伤用治疗剂或修复剂，各种疼痛疾病的镇痛剂等。
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8.发明申请公开(公告)号：US20140323440A1
公开(公告)日：2014-10-30
申请号：US14328329
申请日：2014-07-10
发明人： Eric Thomas Miller , Michelle R. Machacek , Benjamin Wesley Trotter , Thomas Allen Miller , Brian Michael Andresen , Neville John Anthony , Brandon M. Taoka , Yuan Liu
IPC分类号： C07F5/02 , C07F9/6558 , C07D417/14
CPC分类号： A61K31/444 , A61K31/496 , A61K31/675 , A61K31/69 , A61K45/06 , C07D277/04 , C07D417/14 , C07F5/025 , C07F9/65583
摘要： The invention provides certain amino-pyridine-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and n are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
摘要翻译： 本发明提供某些含有氨基 - 吡啶的式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如本文所定义。 本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）激酶介导的疾病或病症的方法。
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公开(公告)号：US08796310B2
公开(公告)日：2014-08-05
申请号：US13704484
申请日：2012-04-30
申请人： Eric Thomas Romeo , Michelle R. Machacek , Benjamin Wesley Trotter , Thomas Allen Miller , Brian Michael Andresen , Neville John Anthony , Brandon M. Taoka , Yuan Liu
发明人： Eric Thomas Romeo , Michelle R. Machacek , Benjamin Wesley Trotter , Thomas Allen Miller , Brian Michael Andresen , Neville John Anthony , Brandon M. Taoka , Yuan Liu
IPC分类号： A61K31/444 , C07D277/04
CPC分类号： A61K31/444 , A61K31/496 , A61K31/675 , A61K31/69 , A61K45/06 , C07D277/04 , C07D417/14 , C07F5/025 , C07F9/65583
摘要： The invention provides certain amino-pyridine-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and n are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
摘要翻译： 本发明提供某些含有氨基 - 吡啶的式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如本文所定义。 本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）激酶介导的疾病或病症的方法。
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公开(公告)号：US08686136B2
公开(公告)日：2014-04-01
申请号：US13712715
申请日：2012-12-12
申请人： AbbVie Inc.
发明人： Milan Bruncko , Hong Ding , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Xiaohong Song , Xilu Wang , Michael Wendt
IPC分类号： C07D241/04 , C07D403/02
CPC分类号： C07D295/155 , C07C311/51 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D209/02 , C07D209/52 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/06 , C07D233/22 , C07D233/24 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/20 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/04 , C07D277/36 , C07D277/74 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08 , C07D498/08
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
摘要翻译： 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。
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