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公开(公告)号：US10131657B2
公开(公告)日：2018-11-20
申请号：US14392200
申请日：2014-05-13
申请人： AbbVie Inc.
发明人： Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James Holms , Dachun Liu , William McClellan , Keith McDaniel , Jasmina Marjanovic , George Sheppard , Le Wang
IPC分类号： A61K31/437 , A61K31/454 , A61K31/4545 , C07D471/04 , A61K45/06 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/497 , A61K31/506
摘要： The present invention provides for compounds of formula (I). wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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公开(公告)号：US08686136B2
公开(公告)日：2014-04-01
申请号：US13712715
申请日：2012-12-12
申请人： AbbVie Inc.
发明人： Milan Bruncko , Hong Ding , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Xiaohong Song , Xilu Wang , Michael Wendt
IPC分类号： C07D241/04 , C07D403/02
CPC分类号： C07D295/155 , C07C311/51 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D209/02 , C07D209/52 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/06 , C07D233/22 , C07D233/24 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/20 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/04 , C07D277/36 , C07D277/74 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08 , C07D498/08
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
摘要翻译： 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。
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公开(公告)号：US20170174688A1
公开(公告)日：2017-06-22
申请号：US14972482
申请日：2015-12-17
申请人： AbbVie Inc.
发明人： Yujia Dai , William McClellan , Mike Michaelides , Ramzi Sweis , Noel Wilson , Justin Dietrich
IPC分类号： C07D473/34 , C12Q1/48 , C07D519/00
CPC分类号： C07D473/34 , C07D519/00 , C12Q1/48 , G01N2333/91017 , G01N2500/04
摘要： The invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by SUV420H1. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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公开(公告)号：US20160185769A1
公开(公告)日：2016-06-30
申请号：US14392200
申请日：2014-05-13
申请人： ABBVIE INC.
发明人： Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James Holms , Dachun Liu , William McClellan , Keith McDaniel , Jasmina Marjanovic , George Sheppard , Le Wang
IPC分类号： C07D471/04 , A61K31/541 , A61K31/496 , A61K31/551 , A61K31/437 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06
摘要： The present invention provides for compounds of formula (I). wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
摘要翻译： 本发明提供式（I）化合物。 其中Rx，Ry，Rx1，L1，G1，A1，A2，A3和A4具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症（包括炎症 疾病，癌症和艾滋病。 还提供了由一种或多种式（I）化合物组成的药物组合物。
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公开(公告)号：US20190084981A1
公开(公告)日：2019-03-21
申请号：US16192927
申请日：2018-11-16
申请人： AbbVie Inc.
发明人： Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James Holms , Dachun Liu , William McClellan , Keith McDaniel , Jasmina Marjanovic , George Sheppard , Le Wang
IPC分类号： C07D471/04 , A61K45/06 , A61K31/506 , A61K31/497 , A61K31/437 , A61K31/551 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545
摘要： The present invention provides for compounds of formula (I) wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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公开(公告)号：US09932340B2
公开(公告)日：2018-04-03
申请号：US14972482
申请日：2015-12-17
申请人： AbbVie Inc.
发明人： Yujia Dai , William McClellan , Mike Michaelides , Ramzi Sweis , Noel Wilson , Justin Dietrich
IPC分类号： C07D473/34 , C07D519/00 , C12Q1/48
CPC分类号： C07D473/34 , C07D519/00 , C12Q1/48 , G01N2333/91017 , G01N2500/04
摘要： The invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by SUV420H1. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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公开(公告)号：US20170349589A9
公开(公告)日：2017-12-07
申请号：US14972482
申请日：2015-12-17
申请人： AbbVie Inc.
发明人： Yujia Dai , William McClellan , Mike Michaelides , Ramzi Sweis , Noel Wilson , Justin Dietrich
IPC分类号： C07D473/34 , C07D519/00 , C12Q1/48
CPC分类号： C07D473/34 , C07D519/00 , C12Q1/48 , G01N2333/91017 , G01N2500/04
摘要： The invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by SUV420H1. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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公开(公告)号：US09957263B2
公开(公告)日：2018-05-01
申请号：US14392201
申请日：2014-06-27
申请人： AbbVie Inc.
发明人： Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James Holms , Dachun Liu , William McClellan , Keith McDaniel , Jasmina Marjanovic , George Sheppard , Le Wang
IPC分类号： C07D471/02 , A61K31/44 , A61K31/497 , C07D471/04 , A61K45/06 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/4545 , A61K31/506
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided. The compounds are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Pharmaceutical compositions comprised of one or more compounds of formula (I) are also provided.
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公开(公告)号：US20160272630A1
公开(公告)日：2016-09-22
申请号：US14392201
申请日：2014-06-27
申请人： ABBVIE INC.
发明人： Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James Holms , Dachun Liu , William McClellan , Keith McDaniel , Jasmina Marjanovic , George Sheppard , Le Wang
IPC分类号： C07D471/04 , A61K31/4545 , A61K31/5377 , A61K31/541 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/437 , A61K31/496
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided. The compounds are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Pharmaceutical compositions comprised of one or more compounds of formula (I) are also provided.
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