公开(公告)号：US09957263B2

公开(公告)日：2018-05-01

申请号：US14392201

申请日：2014-06-27

申请人： AbbVie Inc.

发明人： Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James Holms ,  Dachun Liu ,  William McClellan ,  Keith McDaniel ,  Jasmina Marjanovic ,  George Sheppard ,  Le Wang

IPC分类号： C07D471/02 ,  A61K31/44 ,  A61K31/497 ,  C07D471/04 ,  A61K45/06 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K31/4545 ,  A61K31/506

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06

摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided. The compounds are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Pharmaceutical compositions comprised of one or more compounds of formula (I) are also provided.

公开(公告)号：US20180093956A1

公开(公告)日：2018-04-05

申请号：US15549090

申请日：2015-02-06

申请人： AbbVie Inc.

发明人： Yujia Dai ,  Michael Michaelides

IPC分类号： C07D237/34 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D401/14 ,  C07D413/14 ,  C12Q1/48

CPC分类号： C07D237/34 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D409/04 ,  C07D413/14 ,  C12Q1/48

摘要： The invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by SUV420H1. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

公开(公告)号：US20160272630A1

公开(公告)日：2016-09-22

申请号：US14392201

申请日：2014-06-27

申请人： ABBVIE INC.

发明人： Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James Holms ,  Dachun Liu ,  William McClellan ,  Keith McDaniel ,  Jasmina Marjanovic ,  George Sheppard ,  Le Wang

IPC分类号： C07D471/04 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/497 ,  A61K31/506 ,  A61K31/551 ,  A61K31/437 ,  A61K31/496

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06

摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided. The compounds are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Pharmaceutical compositions comprised of one or more compounds of formula (I) are also provided.

公开(公告)号：US20230234971A1

公开(公告)日：2023-07-27

申请号：US18156987

申请日：2023-01-19

申请人： AbbVie Inc.

发明人： George A. Doherty ,  Vikram Bhat ,  Patrick Brady ,  Yujia Dai ,  Jianchun Gong ,  Andrew S. Judd ,  Andrew J. Souers ,  Yiyun Yu

IPC分类号： C07D519/00

CPC分类号： C07D519/00

摘要： The present invention provides for compounds of Formula (I)




wherein A, L, W, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL, SLL, and/or ALL.

公开(公告)号：US20180298003A1

公开(公告)日：2018-10-18

申请号：US16018357

申请日：2018-06-26

申请人： AbbVie Inc.

发明人： Steven D. Fidanze ,  Dachun Liu ,  Robert A. Mantei ,  Keith F. McDaniel ,  John Pratt ,  George S. Sheppard ,  Le Wang ,  Andrew Bogdan ,  James H. Holms ,  Justin D. Dietrich ,  Jasmina Marjanovic ,  Lisa A. Hasvold ,  Yujia Dai

IPC分类号： C07D471/22 ,  C07D471/16

摘要： The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y2, Y3, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

公开(公告)号：US20180296566A1

公开(公告)日：2018-10-18

申请号：US16012379

申请日：2018-06-19

申请人： AbbVie Inc.

发明人： Le Wang ,  John K. Pratt ,  Keith F. McDaniel ,  Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James H. Holms ,  Warren M. Kati ,  Dachun Liu ,  Robert A. Mantei ,  William J. McClellan ,  George S. Sheppard ,  Carol K. Wada

IPC分类号： A61K31/541 ,  A61K45/06 ,  C07D487/04 ,  C07D471/04 ,  A61K31/5025 ,  A61K31/437 ,  A61K31/5377

摘要： The present invention provides for compounds of formula (I) wherein A1, A2, A3, A4, X1, X2, Y1, L1, G1, Rx, and Ry have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

公开(公告)号：US20180193315A1

公开(公告)日：2018-07-12

申请号：US15907597

申请日：2018-02-28

申请人： AbbVie Inc.

发明人： Edward A. Kesicki ,  Arthur F. Kluge ,  Michael A. Patane ,  John H. Van Drie, JR. ,  Ce Wang ,  Maricel Torrent ,  Michael L. Curtin ,  Todd M. Hansen ,  Rick F. Clark ,  Robin R. Frey ,  Zhiqin Ji ,  Yujia Dai ,  William J. McClellan ,  Jane Gong ,  Gui-dong G. Zhu ,  Anthony Mastracchio ,  Michael R. Michaelides ,  Thomas D. Penning ,  Chunqiu C. Lai

IPC分类号： A61K31/4184 ,  C07D403/06 ,  C07D498/10 ,  A61K31/4439 ,  A61K31/423 ,  C07D405/06 ,  C07D409/06 ,  C07D403/12 ,  C07D413/14 ,  C07D235/02 ,  C07D401/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D263/52 ,  C07D491/107 ,  C07D493/10 ,  C07D495/10 ,  C07D401/06

CPC分类号： A61K31/4184 ,  A61K31/423 ,  A61K31/4439 ,  C07D235/02 ,  C07D263/52 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D407/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D491/107 ,  C07D493/10 ,  C07D495/10 ,  C07D498/10

摘要： Compounds having a structure of Formula (IX): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1-Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

公开(公告)号：US09932340B2

公开(公告)日：2018-04-03

申请号：US14972482

申请日：2015-12-17

申请人： AbbVie Inc.

发明人： Yujia Dai ,  William McClellan ,  Mike Michaelides ,  Ramzi Sweis ,  Noel Wilson ,  Justin Dietrich

IPC分类号： C07D473/34 ,  C07D519/00 ,  C12Q1/48

CPC分类号： C07D473/34 ,  C07D519/00 ,  C12Q1/48 ,  G01N2333/91017 ,  G01N2500/04

摘要： The invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by SUV420H1. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

公开(公告)号：US20170349589A9

公开(公告)日：2017-12-07

申请号：US14972482

申请日：2015-12-17

申请人： AbbVie Inc.

发明人： Yujia Dai ,  William McClellan ,  Mike Michaelides ,  Ramzi Sweis ,  Noel Wilson ,  Justin Dietrich

IPC分类号： C07D473/34 ,  C07D519/00 ,  C12Q1/48

CPC分类号： C07D473/34 ,  C07D519/00 ,  C12Q1/48 ,  G01N2333/91017 ,  G01N2500/04

摘要： The invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by SUV420H1. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

公开(公告)号：US20160237084A1

公开(公告)日：2016-08-18

申请号：US15137502

申请日：2016-04-25

申请人： AbbVie Inc.

发明人： Le Wang ,  John Pratt ,  Lisa A. Hasvold ,  Dachun Liu ,  Yujia Dai ,  Steven D. Fidanze ,  James H. Holms ,  Robert A. Mantei ,  Keith F. McDaniel ,  George S. Sheppard ,  William J. McClellan

IPC分类号： C07D471/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D519/00

摘要： The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, and R5 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

摘要翻译： 本发明提供式（I）化合物，其中R 1，R 2，R 3，R 4和R 5具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症的试剂 ，包括炎性疾病，癌症和艾滋病。 还提供了包含一种或多种式（I）化合物的药物组合物。