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公开(公告)号：US09879016B2
公开(公告)日：2018-01-30
申请号：US15130323
申请日：2016-04-15
申请人： AbbVie Inc.
发明人： Eric Breinlinger , Andrew Burchat , Justin Dietrich , Michael Friedman , David Ihle , David Kinsman , Kelly Mullen , Augustine Osuma , Anil Vasudevan , Noel Wilson
IPC分类号： C07D487/04 , C07D498/04 , C07D519/00
CPC分类号： C07D487/04 , C07D498/04 , C07D519/00
摘要： The disclosure provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the disclosure are useful for treating immunological and oncological conditions.
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公开(公告)号：US20160304526A1
公开(公告)日：2016-10-20
申请号：US15130323
申请日：2016-04-15
申请人： AbbVie Inc.
发明人： Eric Breinlinger , Andrew Burchat , Justin Dietrich , Michael Friedman , David Ihle , David Kinsman , Kelly Mullen , Augustine Osuma , Anil Vasudevan , Noel Wilson
IPC分类号： C07D487/04 , C07D498/04 , C07D519/00
CPC分类号： C07D487/04 , C07D498/04 , C07D519/00
摘要： The disclosure provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the disclosure are useful for treating immunological and oncological conditions.
摘要翻译： 药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本公开的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：US20160304517A1
公开(公告)日：2016-10-20
申请号：US15130362
申请日：2016-04-15
申请人： AbbVie Inc.
发明人： Eric C. Breinlinger , Phil B. Cox , Jerome Daanen , Justin Dietrich , Stevan Djuric , Amanda W. Dombrowski , Kristine E. Frank , Michael M. Friedman , Arthur Gomtsyan , Huan-Qui Li , Kenton Longenecker , Augustine Osuma , Ann Marie Rowley , Robert Schmidt , Anil Vasudevan , Noel Wilson
IPC分类号： C07D471/04 , C07D491/147 , C07D491/22 , C07D498/04 , C07D471/18 , C07D471/14 , C07D498/22 , C07D498/14 , C07D498/20 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , C07D471/14 , C07D471/18 , C07D487/04 , C07D491/147 , C07D491/22 , C07D498/04 , C07D498/14 , C07D498/18 , C07D498/20 , C07D498/22 , C07D519/00
摘要： The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.
摘要翻译： 本发明提供三环杂环化合物，药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：US20170174688A1
公开(公告)日：2017-06-22
申请号：US14972482
申请日：2015-12-17
申请人： AbbVie Inc.
发明人： Yujia Dai , William McClellan , Mike Michaelides , Ramzi Sweis , Noel Wilson , Justin Dietrich
IPC分类号： C07D473/34 , C12Q1/48 , C07D519/00
CPC分类号： C07D473/34 , C07D519/00 , C12Q1/48 , G01N2333/91017 , G01N2500/04
摘要： The invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by SUV420H1. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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公开(公告)号：US09932340B2
公开(公告)日：2018-04-03
申请号：US14972482
申请日：2015-12-17
申请人： AbbVie Inc.
发明人： Yujia Dai , William McClellan , Mike Michaelides , Ramzi Sweis , Noel Wilson , Justin Dietrich
IPC分类号： C07D473/34 , C07D519/00 , C12Q1/48
CPC分类号： C07D473/34 , C07D519/00 , C12Q1/48 , G01N2333/91017 , G01N2500/04
摘要： The invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by SUV420H1. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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公开(公告)号：US09856253B2
公开(公告)日：2018-01-02
申请号：US15130362
申请日：2016-04-15
申请人： AbbVie Inc.
发明人： Eric C. Breinlinger , Phil B. Cox , Justin Dietrich , Kristine E. Frank , Michael M. Friedman , Huan-Qui Li , Kenton Longenecker , Augustine Osuma , Ann Marie Rowley , Anil Vasudevan , Noel Wilson
IPC分类号： C07D227/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/18 , C07D498/20 , C07D498/22 , C07D519/00 , C07D471/18 , C07D491/147 , C07D491/22
CPC分类号： C07D471/04 , C07D471/14 , C07D471/18 , C07D487/04 , C07D491/147 , C07D491/22 , C07D498/04 , C07D498/14 , C07D498/18 , C07D498/20 , C07D498/22 , C07D519/00
摘要： The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.
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公开(公告)号：US20170349589A9
公开(公告)日：2017-12-07
申请号：US14972482
申请日：2015-12-17
申请人： AbbVie Inc.
发明人： Yujia Dai , William McClellan , Mike Michaelides , Ramzi Sweis , Noel Wilson , Justin Dietrich
IPC分类号： C07D473/34 , C07D519/00 , C12Q1/48
CPC分类号： C07D473/34 , C07D519/00 , C12Q1/48 , G01N2333/91017 , G01N2500/04
摘要： The invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by SUV420H1. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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