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公开(公告)号：US20190284135A1
公开(公告)日：2019-09-19
申请号：US16421006
申请日：2019-05-23
申请人： AbbVie Inc.
发明人： Dominique Bonafoux , Heather Michele Davis , Kristine E. Frank , Michael M. Friedman , J. Martin Herold , Michael Z. Hoemann , Raymond Huntley , Augustine Osuma , George Sheppard , Gagandeep Kaur Somal , Jennifer Van Camp , Stacy Anne Van Epps , Anil Vasudevan , Grier Allan Wallace , Lu Wang , Lu Wang , Zhi Wang , Noel S. Wilson , Xiangdong Xu
IPC分类号： C07D209/08 , C07D487/04 , C07D405/14 , C07D231/56 , C07D403/14 , C07D401/14 , C07D417/14 , C07D471/04 , C07D417/12 , A61P35/00 , C07D513/04 , C07D209/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D209/10 , C07D209/12 , C07D413/04 , C07D209/18 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D401/12
摘要： The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
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公开(公告)号：US10112911B2
公开(公告)日：2018-10-30
申请号：US14410952
申请日：2013-06-28
申请人： Abbvie Inc
发明人： Artour Gomtsian , Tatyana Dekhtyar , Kristine E. Frank , Michael M. Friedman , Nathan Josephsohn , M-Akhteruzzaman Molla , Anil Vasudevan , Iok Chan Ng , Mikhail Chafeev
IPC分类号： A61K31/495 , A61K31/497 , C07D241/04 , C07D241/26 , A61K31/498 , C07D413/04 , A61K31/496 , A61K31/517 , C07D487/04 , A61K31/519 , C07D405/14 , C07D403/14 , A61K31/499 , A61K31/5377 , A61K31/4985 , C07D401/14 , C07D401/04 , C07D403/04 , C07D405/04 , C07D417/04 , C07D241/44 , C07D471/04 , C07D317/66 , C07D231/40 , C07C335/30
摘要： This disclosure relates to: (a) compounds and salts of formula (I), formula (II), formula (III), and formula (IV), that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
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公开(公告)号：US20150210708A1
公开(公告)日：2015-07-30
申请号：US14610119
申请日：2015-01-30
申请人： AbbVie Inc.
发明人： Neil Wishart , Maria A. Argiriadi , David J. Calderwood , Anna M. Ericsson , Bryan A. Fiamengo , Kristine E. Frank , Michael M. Friedman , Dawn M. George , Eric R. Goedken , Nathan S. Josephsohn , Biqin C. Li , Michael J. Morytko , Kent D. Stewart , Jeffrey W. Voss , Grier A. Wallace , Lu Wang , Kevin R. Woller
IPC分类号： C07D487/14
CPC分类号： C07D487/14 , C07D498/14 , C07D513/14
摘要： The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译： 本发明提供式（I）化合物的药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：US10280184B2
公开(公告)日：2019-05-07
申请号：US15304131
申请日：2015-04-16
申请人： AbbVie Inc.
发明人： Michael M. Friedman , Philip Cox , Kristine E. Frank , Michael Z. Hoemann , Augustine Osuma , Noel S. Wilson , Xiangdong Xu , Kevin Cusack , Raymond Huntley , J. Martin Herold
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , C07D487/04 , C07D498/04
摘要： The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
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公开(公告)号：US09567339B2
公开(公告)日：2017-02-14
申请号：US14315504
申请日：2014-06-26
申请人： AbbVie Inc.
发明人： Dominique Bonafoux , Heather M. Davis , Kristine E. Frank , Michael M. Friedman , J. Martin Herold , Michael Z. Hoemann , Raymond Huntley , Augustine Osuma , George Sheppard , Gagandeep K. Somal , Jennifer Van Camp , Stacy A. Van Epps , Anil Vasudevan , Grier A. Wallace , Lu Wang , Lu Wang , Zhi Wang , Noel S. Wilson , Xiangdong Xu
IPC分类号： C07D487/04 , C07D417/12 , C07D471/04 , C07D209/08 , C07D417/14 , C07D401/14 , C07D403/14 , C07D231/56 , C07D401/12
CPC分类号： C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/18 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译： 本发明提供式（I）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：US20160222020A1
公开(公告)日：2016-08-04
申请号：US15017802
申请日：2016-02-08
申请人： AbbVie Inc.
发明人： Neil Wishart , Maria A. Argiriadi , David J. Calderwood , Anna M. Ericsson , Bryan A. Fiamengo , Kristine E. Frank , Michael M. Friedman , Dawn M. George , Eric R. Goedken , Nathan S. Josephsohn , Biqin C. Li , Michael J. Morytko , Kent D. Stewart , Jeffrey W. Voss , Grier A. Wallace , Lu Wang , Kevin R. Woller
IPC分类号： C07D487/14 , A61K31/437 , C07D471/14 , A61K31/4985 , A61K45/06
CPC分类号： C07D487/14 , A61K31/437 , A61K31/4985 , A61K45/06 , C07D471/14 , C07D498/14 , C07D513/14
摘要： The invention provides compounds of Formula (I) and Formula (II) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
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公开(公告)号：US20210179556A1
公开(公告)日：2021-06-17
申请号：US17173613
申请日：2021-02-11
申请人： AbbVie Inc.
发明人： Dominique Bonafoux , Heather Michele Davis , Kristine E. Frank , Michael M. Friedman , J. Martin Herold , Michael Z. Hoemann , Raymond Huntley , Augustine Osuma , George Sheppard , Gagandeep Kaur Somal , Jennifer Van Camp , Stacy Anne Van Epps , Anil Vasudevan , Grier Allan Wallace , Lu Wang , Lu Wang , Zhi Wang , Noel S. Wilson , Xiangdong Xu
IPC分类号： C07D209/08 , C07D487/04 , C07D417/12 , C07D471/04 , C07D417/14 , C07D401/14 , C07D403/14 , C07D231/56 , C07D401/12 , A61P35/00 , C07D513/04 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/18 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04
摘要： The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
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公开(公告)号：US20180291029A1
公开(公告)日：2018-10-11
申请号：US15806104
申请日：2017-11-07
申请人： AbbVie Inc.
发明人： Neil WISHART , Maria A. Argiriadi , David J. Calderwood , Anna M. Ericsson , Bryan R. Fiamengo , Kristine E. Frank , Michael M. Friedman , Dawn M. George , Eric R. Goedken , Nathan S. Josephsohn , Biqin C. Li , Michael J. Morytko , Kent D. Stewart , Jeffrey W. Voss , Grier A. Wallace , Lu Wang , Kevin R. Woller
IPC分类号： C07D487/14 , C07D513/14 , C07D498/14
摘要： The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
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公开(公告)号：US20160304517A1
公开(公告)日：2016-10-20
申请号：US15130362
申请日：2016-04-15
申请人： AbbVie Inc.
发明人： Eric C. Breinlinger , Phil B. Cox , Jerome Daanen , Justin Dietrich , Stevan Djuric , Amanda W. Dombrowski , Kristine E. Frank , Michael M. Friedman , Arthur Gomtsyan , Huan-Qui Li , Kenton Longenecker , Augustine Osuma , Ann Marie Rowley , Robert Schmidt , Anil Vasudevan , Noel Wilson
IPC分类号： C07D471/04 , C07D491/147 , C07D491/22 , C07D498/04 , C07D471/18 , C07D471/14 , C07D498/22 , C07D498/14 , C07D498/20 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , C07D471/14 , C07D471/18 , C07D487/04 , C07D491/147 , C07D491/22 , C07D498/04 , C07D498/14 , C07D498/18 , C07D498/20 , C07D498/22 , C07D519/00
摘要： The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.
摘要翻译： 本发明提供三环杂环化合物，药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：US20200255423A1
公开(公告)日：2020-08-13
申请号：US16654219
申请日：2019-10-16
申请人： AbbVie Inc.
发明人： Maria A. Argiriadi , Eric C. Breinlinger , Ellen Yulin Tsai Chien , Marlon D. Cowart , Kristine E. Frank , Michael M. Friedman , David J. Hardee , J. Martin Herold , Huaqing Liu , Wei Qiu , Marc J. Scanio , Michael R. Schrimpf , Thomas R. Vargo , Stacy A. Van Epps , Matthew P. Webster , Andrew J. Little , Matthew H. Katcher , Theresa A. Dunstan , David A. Schiedler
IPC分类号： C07D471/04 , C07D487/04
摘要： Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4a, R4b, X1, X2, X3, X4, X5, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.
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