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    NOVEL PHARMACEUTICAL COMPOSITIONS
    3.
    发明公开
    NOVEL PHARMACEUTICAL COMPOSITIONS 审中-公开

    公开(公告)号：US20230293469A1

    公开(公告)日：2023-09-21

    申请号：US18013697

    申请日：2021-07-01

    申请人： NEUROPRO THERAPEUTICS, INC.

    发明人： Daryl W. HOCHMAN

    IPC分类号： A61K31/196 ,  A61K45/06

    CPC分类号： A61K31/196 ,  A61K45/06

    摘要： The present disclosure relates to novel pharmaceutical compositions for active pharmaceutical ingredients subject to first pass metabolism. More particularly, bumetanide analogs, including bumetanide dibenzylamide, bumetanide diethylamide, and bumetanide morpholinoamide, are demonstrated as susceptible to first pass metabolism, thereby prompting effort toward developing an acceptable pharmaceutical formulation to provide adequate bioavailability.

    BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE
    9.
    发明申请
    BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE 有权
    BUMETANIDE ANALOGS，COMPOSITIONS AND METHODS OF USE

    公开(公告)号：US20150080350A1

    公开(公告)日：2015-03-19

    申请号：US14472181

    申请日：2014-08-28

    申请人： NeuroPro Therapeutics, Inc.

    发明人： John J. PARTRIDGE ,  Daryl W. HOCHMAN

    IPC分类号： C07C311/39

    CPC分类号： A61K31/18 ,  A61K31/4355 ,  C07C311/39 ,  C07D211/44 ,  C07D231/04 ,  C07D233/02 ,  C07D237/02 ,  C07D239/04 ,  C07D241/04 ,  C07D261/02 ,  C07D263/04 ,  C07D265/30 ,  C07D275/02 ,  C07D277/04 ,  C07D279/12 ,  C07D295/084 ,  C07D307/52

    摘要： The present invention provides bumetanide, analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide, analogs and methods for their use. These analogs are particularly useful for the treatment and/or prophylaxis of conditions that involve the Na+K+Cl− co-transporter or GABAA receptor including but not limited to addictive disorders, Alzheimer's Disease, anxiety disorders, ascites, autism, bipolar disorder, cancer, depression, endothelial corneal dystrophy, edema, epilepsy, glaucoma. Huntington's Disease, insomnia, ischemia, migraine, migraine with aura, neuropathic pain, nociceptive neuralgia, nociceptive pain, ocular diseases, pain, Parkinson's disease, personality disorders, postherpetic neuralgia, psychosis, schizophrenia, seizure disorders, tinnitus, and withdrawal syndromes.

    摘要翻译： 本发明提供了包含这种类似物的布美他尼，类似物和组合物。 本发明还提供含有这些布美他尼的药物组合物，其用途及其用途。 这些类似物对于治疗和/或预防涉及Na + K + Cl-共转运蛋白或GABA A受体的病症特别有用，包​​括但不限于成瘾性疾病，阿尔茨海默病，焦虑症，腹水，孤独症，双相性精神障碍， 癌症，抑郁症，内皮角膜营养不良，水肿，癫痫，青光眼。 亨廷顿病，失眠，局部缺血，偏头痛，偏头痛，神经性疼痛，伤害性神经痛，伤害性疼痛，眼部疾病，疼痛，帕金森病，人格障碍，带状疱疹后神经痛，精神病，精神分裂症，癫痫发作，耳鸣和戒断综合征。