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公开(公告)号：US09856208B2
公开(公告)日：2018-01-02
申请号：US15255957
申请日：2016-09-02
IPC分类号： C07C249/02 , C07C213/08 , C07C45/29 , C07D265/36 , C07D263/56 , C07C46/08 , C07F7/00 , C07F7/08
CPC分类号： C07C249/02 , C07C46/08 , C07C213/08 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07D263/56 , C07D265/36 , C07F7/00 , C07F7/0812 , C07C50/02 , C07C50/08 , C07C50/28 , C07C50/12 , C07C50/32 , C07C50/24
摘要： A method for producing an arene with an aromatic C—N bond ortho to an aromatic C—O bond from a hydroxy arene comprising said aromatic C—O bond is provided. This method comprising the steps a) ortho-oxygenating the hydroxy arene to produce an ortho-quinone, b) condensating the ortho-quinone with a nitrogen nucleophile to generate a compound of Formula (IVa) or (IVb), and c) allowing 1,5-hydrogen atom shift of the compound of Formula (IVa) or (IVb), thereby producing arenes with a C—N bond ortho to a C—O bond of Formula (Va) and (Vb), respectively:
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2.发明申请EFFICIENT SCALABLE SYNTHESES OF ABSCISIC ACID, 8'-ACETYLENE ABSCISIC ACID AND 8'-CYCLOPROPYL ABSCISIC ACID 有权抗坏血酸，8'-乙酰丙酸和8'-环丙基胆酸的高效可合成的合成公开(公告)号：US20170057899A1
公开(公告)日：2017-03-02
申请号：US15241564
申请日：2016-08-19
CPC分类号： C07C51/09 , C07C46/06 , C07C67/327 , C07C67/40 , C07C403/16 , C07C403/20 , C07C2601/16 , C07C50/02
摘要： Methods are provided for synthesis of abscisic acid and 8′ analogues thereof (including an enantiopure 8′-acetylene analogue) including methods wherein the previously reported first step of oxidation of 2,6-dimethylphenol (VI) to 2,6-dimethylbenzoquinone, mono ketal (VII) is replaced by a novel two step process comprising (i) oxidation of 2,6-dimethylphenol (VI) using potassium peroxymonosulfate with a catalytic amount of iodobenzene to produce 2,6-dimethylbenzoquinone (XVI) and (ii) ketalization of 2,6-dimethylbenzoquinone (XVI) using ethylene glycol, trimethylorthoformate with a catalytic amount of p-toluenesulfonic acid to produce 2,6-dimethylbenzoquinone, mono ketal (VII).
摘要翻译： 提供了用于合成脱落酸及其8'类似物（包括对映体纯的8'-乙炔类似物）的方法，包括先前报导的2,6-二甲基苯酚（Ⅵ）氧化为2,6-二甲基苯醌，单 缩酮（VII）被新的二步法替代，其包括（i）使用过氧化硫酸钾与催化量的碘苯氧化2,6-二甲基苯酚（Ⅵ）以产生2,6-二甲基苯醌（ⅩⅥ）和（ⅱ）缩酮化 的2,6-二甲基苯醌（XVI），使用乙二醇，原甲酸三甲酯与催化量的对甲苯磺酸反应，生成2,6-二甲基苯醌，单缩酮（VII）。
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3.发明授权Treatment of pervasive developmental disorders with redox-active therapeutics 有权用氧化还原活性治疗剂治疗普遍性发育障碍公开(公告)号：US09399612B2
公开(公告)日：2016-07-26
申请号：US14605937
申请日：2015-01-26
发明人： Guy M. Miller
IPC分类号： C07C39/10 , C07C37/00 , C07C50/04 , A61K31/04 , A61K31/122 , C07C50/06 , A61K31/05 , C07C50/02 , C07C39/08
CPC分类号： A61K31/122 , A23L33/10 , A23L33/40 , A23V2002/00 , A61K31/05 , C07C39/08 , C07C50/02 , C07C50/06
摘要： Methods of treating or suppressing pervasive developmental disorders (PDDs) including; autistic disorder, Asperger's syndrome, childhood disintegrative disorder (CDD), Rett's disorder, and PDD-not otherwise specified (PDD-NOS) or attention deficit/hyperactivity disorder (ADHD) comprising administering to a subject in need thereof a therapeutically effective amount of one or more compounds as disclosed herein.
摘要翻译： 治疗或抑制普遍发育障碍（PDD）的方法包括： 自闭症，阿斯伯格综合症，儿童分裂障碍（CDD），雷特氏症（Rett's disorder）和PDD（未另外规定）（PDD-NOS）或注意力缺陷/多动症（ADHD），包括向有需要的受试者施用治疗有效量的一种 或更多的化合物。
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4.发明申请REDOX-ACTIVE THERAPEUTICS FOR TREATMENT OF MITOCHONDRIAL DISEASES AND OTHER CONDITIONS AND MODULATION OF ENERGY BIOMARKERS 审中-公开用于治疗麻醉病毒及其他条件的REDOX活性治疗剂和能量生物标志物的调节公开(公告)号：US20100222436A1
公开(公告)日：2010-09-02
申请号：US12777179
申请日：2010-05-10
申请人： Guy M. Miller , Sidney M. Hecht
发明人： Guy M. Miller , Sidney M. Hecht
IPC分类号： A61K31/122 , A61P3/10 , A61P25/00 , A61P35/00
CPC分类号： C07C37/07 , A61K31/355 , C07C39/08 , C07C39/19 , C07C39/24 , C07C39/245 , C07C46/00 , C07C46/02 , C07C46/08 , C07C50/02 , C07C50/06 , C07C50/28 , C07C50/24 , C07C39/11 , C07C39/04
摘要： Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention, such as alpha-tocopherol quinone. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
摘要翻译： 公开了治疗或抑制线粒体疾病如弗里德里希共济失调（FRDA），莱伯氏遗传性视神经病变（LHON），线粒体肌病，脑病，乳酸脱落症，中风（MELAS）或Kearns-Sayre综合征（KSS）的方法，以及 可用于本发明方法的化合物，例如α-生育酚醌。 还公开了可用于治疗其它疾病的方法和化合物。 还公开了可用于评估受试者的代谢状态和治疗功效的能量生物标志物。 还公开了调节，归一化或增强能量生物标志物的方法以及可用于这些方法的化合物。
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5.发明授权Mixtures of matrix materials and organic semiconductors capable of emission, use of the same and electronic components containing said mixtures 有权能够发射的基体材料和有机半导体的混合物，使用它们和含有所述混合物的电子组件公开(公告)号：US07345301B2
公开(公告)日：2008-03-18
申请号：US10553114
申请日：2004-04-13
CPC分类号： H01L51/0052 , C07C49/223 , C07C49/417 , C07C49/67 , C07C49/675 , C07C49/697 , C07C49/784 , C07C49/792 , C07C49/796 , C07C49/798 , C07C49/813 , C07C49/84 , C07C50/02 , C07C251/24 , C07C325/02 , C07C2603/18 , C07C2603/95 , C07D251/20 , C09B67/0033 , C09B67/0034 , C09K11/06 , C09K2211/1011 , C09K2211/1014 , H01L51/0037 , H01L51/0058 , H01L51/0059 , H01L51/006 , H01L51/0067 , H01L51/0081 , H01L51/0085 , H01L51/5012 , H01L2251/308 , H05B33/14 , Y02E10/549
摘要： The present invention describes new types of material mixtures composed of at least two substances, one serving as a matrix material and the other being an emission material capable of emission, the latter comprising at least one element of atomic number greater than 20, and the use thereof in organic electronic components such as electroluminescent elements and displays.
摘要翻译： 本发明描述了由至少两种物质组成的新型材料混合物，一种用作基质材料，另一种是能够发射的发射材料，后者包括至少一种原子数大于20的元素， 在有机电子部件如电致发光元件和显示器中。
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公开(公告)号：US20050137409A1
公开(公告)日：2005-06-23
申请号：US11008029
申请日：2004-12-09
申请人： Sunil Ashtekar , Pramod Kumbhar , Jan-Pleun Lens , Rathinam Mahalingam , Nadkarni Pradeep , Jegadeesh Thampi
发明人： Sunil Ashtekar , Pramod Kumbhar , Jan-Pleun Lens , Rathinam Mahalingam , Nadkarni Pradeep , Jegadeesh Thampi
摘要： A process for the preparation of benzoquinones and hydroquinones includes oxidizing an aromatic hydroxy compound with oxygen or an oxygen containing gas, a copper containing catalyst, and optionally a promoter to form the benzoquinone. A reduction reaction is employed to form the hydroquinone.
摘要翻译： 制备苯醌和氢醌的方法包括用氧或含氧气体氧化芳族羟基化合物，含铜催化剂和任选的助催化剂以形成苯醌。 采用还原反应形成氢醌。
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公开(公告)号：US20050070744A1
公开(公告)日：2005-03-31
申请号：US10671871
申请日：2003-09-29
CPC分类号： B01J21/063 , B01J37/033 , C07C37/60 , C07C46/06 , C07C50/24 , C07C50/04 , C07C50/02 , C07C39/08
摘要： The present invention relates to a process for the conversion of phenol to hydroquinone and quinones. More particularly this invention relates to a process for the oxidation of phenol to a mixture of 1,4-benzoquinone and hydroquinone using an oxidant in the presence of titanium superoxide as a reusable catalyst in a liquid phase condition.
摘要翻译： 本发明涉及一种将苯酚转化为氢醌和醌的方法。 更具体地说，本发明涉及在液相条件下，在超氧化钛作为可重复使用的催化剂存在下，使用氧化剂将苯酚氧化为1,4-苯醌和氢醌的混合物的方法。
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8.发明申请METHOD FOR PREPARING HYDROQUINONES AND DIHYDROXYBIPHENYL COMPOUNDS FROM MIXTURES OF BROMOPHENOLS AND BENZOQUINONES 有权溴代苯酚和苯并噻唑混合物制备氢醌和二羟基二苯醚化合物的方法公开(公告)号：US20040199027A1
公开(公告)日：2004-10-07
申请号：US10704002
申请日：2003-11-07
IPC分类号： C07C039/24 , C07C050/12
摘要： A method is described for the simultaneous preparation of p-bromophenols and p-benzoquinones, intermediates useful in the preparation of hydroquinones and 4,4null-dihydroxybiphenyls, respectively. Hydroquinones and 4,4null-dihydroxybiphenyls are useful monomers for the preparation of a variety of polymers. The method also comprises reducing the p-benzoquinone to its corresponding hydroquinone in the presence of the p-bromophenol. Limiting the amount of HBr present in the reaction mixture was shown to control the amount of benzoquinone produced. The method also allows for the recycling of many of the reagents used, thereby reducing the cost of producing each monomer.
摘要翻译： 描述了同时制备对溴苯酚和对苯醌的方法，分别用于制备氢醌和4,4'-二羟基联苯的中间体。 氢醌和4,4'-二羟基联苯是用于制备各种聚合物的有用单体。 该方法还包括在对溴苯酚的存在下将对苯醌还原成其对应的氢醌。 显示出限制反应混合物中存在的HBr的量来控制所产生的苯醌的量。 该方法还允许循环使用许多试剂，从而降低生产每种单体的成本。
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9.发明授权Process for preparing para-quinone or ortho-quinone derivatives, possibly alkoxylated or aryloxylated, respectively from the corresonding hydroquinone or pyrocatechic derivatives 失效分别从相应的对苯二酚或邻苯二酚衍生物制备对 - 醌或邻 - 醌衍生物，可能是烷氧基化或芳氧化的方法
公开(公告)号：US4486349A
公开(公告)日：1984-12-04
申请号：US441273
申请日：1982-11-12
IPC分类号： C07C46/06 , C07C46/08 , C07C50/02 , C07C50/04 , C07C50/24 , C07C50/38 , C07C69/95 , C07C205/35 , C07C205/38 , C07F1/08 , C07C50/06
CPC分类号： C07F1/08 , C07C201/12 , C07C46/06 , C07C46/08 , C07C50/02 , C07C50/38 , B01J27/122
摘要： Process for preparing a para-quinone or ortho-quinone derivative, possibly alkoxylated or aryloxylated, which consists in oxidizing respectively the corresponding hydroquinone or pyrocatechic derivative, by means of the complex prepared, in situ or separately, by combining a cuprous salt, a hydrocarbon substituted by a cyano group and molecular oxygen, the oxidation being possibly carried out in the presence of an alkoxylating or aryloxylating agent of the hydroxylated derivative type.
摘要翻译： 用于制备可能是烷氧基化或芳氧基化的对醌或邻醌衍生物的方法，其通过在原位或分开制备的络合物中分别氧化相应的氢醌或焦儿茶酸衍生物，通过将亚铜盐，烃 被氰基和分子氧取代，氧化可能在羟基化衍生物类型的烷氧基化或芳氧化剂的存在下进行。
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公开(公告)号：US4394315A
公开(公告)日：1983-07-19
申请号：US229061
申请日：1981-01-28
申请人： Fumio Ishii , Kenichi Kishi
发明人： Fumio Ishii , Kenichi Kishi
IPC分类号： C07C50/04 , C07C45/00 , C07C46/06 , C07C50/02 , C07C50/06 , C07C50/08 , C07C50/10 , C07C67/00 , C07C50/12 , C07C50/18
摘要： A method for synthesizing p- or o-benzoquinone derivatives represented by formula III or IV ##STR1## by oxidizing, with an aqueous hypohalite solution having a pH of from 8 to 10, a p- or o-hydroquinone derivative represented by formula I or II ##STR2## Oxidation is conducted at a temperature between -20.degree. C. and 35.degree. C., in the presence of a quaternary ammonium salt phase transfer catalyst.
摘要翻译： 用式III或IV表示的对 - 或邻 - 苯醌衍生物的方法通过用pH为8至10的次氢氯酸盐溶液氧化，由式I表示的对 - 或邻 - 氢醌衍生物或 II。在季铵盐相转移催化剂的存在下，在-20℃至35℃的温度下进行氧化。
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