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公开(公告)号:US20240301381A1
公开(公告)日:2024-09-12
申请号:US18261854
申请日:2022-01-25
发明人: Traian SULEA , Yves DUROCHER
CPC分类号: C12N9/485 , A61P31/14 , C12N15/63 , C12Y304/17023
摘要: The present invention relates, in general, to polypeptides capable of neutralizing SARS-CoV-2 and providing ACE2 enzymatic activity, and uses of these polypeptides for treating disorders related coronaviral infections (COVID-19) and the accompanying acute respiratory distress syndrome (ARDS) and major organ injuries, and methods of making such molecules.
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公开(公告)号:US12084510B2
公开(公告)日:2024-09-10
申请号:US16797364
申请日:2020-02-21
发明人: Ilia Alexandre Tikhomirov , Maria L. Jaramillo , Maureen D. O'Connor-McCourt , Traian Sulea , Renald Gilbert , Bruno Gaillet , Jason Baardsnes , Myriam Banville , Suzanne Grothe
CPC分类号: C07K16/30 , C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/567
摘要: Herein described are antibodies to epidermal growth factor receptor (EGER) having an EGER binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.
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公开(公告)号:US12023734B2
公开(公告)日:2024-07-02
申请号:US17121004
申请日:2020-12-14
发明人: Eric Irissou , Jean-Gabriel Legoux , Cristian Victor Cojocaru , Florin Ilinca , Sylvain Bournival
IPC分类号: B05B7/14 , B22F10/364 , B22F10/38 , B22F10/85 , B22F12/13 , B22F12/43 , B22F12/49 , B22F12/53 , B22F12/90 , B33Y10/00 , B33Y30/00 , B33Y40/10 , B33Y40/20 , B33Y50/02 , C23C24/08
CPC分类号: B22F10/85 , B22F10/364 , B22F10/38 , B22F12/13 , B22F12/43 , B22F12/49 , B22F12/53 , B22F12/90 , B33Y10/00 , B33Y30/00 , B33Y40/10 , B33Y40/20 , B33Y50/02 , C23C24/08 , B05B7/1486 , B22F2203/11
摘要: A technique for improving cold spray deposition conditions for cold spray additive manufacture of parts involves providing an in-situ temperature feedback controller with a remote instantaneous temperature sensor supplying surface temperature measurements of the deposition surface, and a (preferably long pulse) laser for heating. Temperature feedback allows for control over deposition conditions yielding predictable deposition properties.
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公开(公告)号:US20240204787A1
公开(公告)日:2024-06-20
申请号:US18431019
申请日:2024-02-02
发明人: Brent CARLSON
CPC分类号: H03L7/0991 , H03L7/141 , H03L7/24
摘要: A method for timing aperture synthesis arrays comprising the steps of: (a) coupling a plurality of independent crystal oscillators, each of the plurality of independent crystal oscillators having a unique output frequency; (b) digitally synchronizing the plurality of independent crystal oscillators in phase; (c) combining the unique output frequencies; and (d) obtaining a stable digital reference signal for timing at least one remote radio device of the aperture synthesis array.
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公开(公告)号:US20240171369A1
公开(公告)日:2024-05-23
申请号:US18550594
申请日:2022-03-10
发明人: Brent Carlson
摘要: The present invention provides a method and system to correctly sample, at a central location, a signal at a second clock frequency from a remote antenna when the signal is at a first clock frequency. The present invention provides an improved method of incoherent clocking to correctly sample a signal from a remote antenna at a clock frequency of a central location, such as a central site of a radio telescope array. The signal contains a “tracer” which is related to the frequency of the remote antenna. The tracer phase is written into a dual-port memory at the first clock frequency and then read from the memory at the second clock frequency. The tracer phase is transferred across digital clock domains using Gray-doe methods so that phase coding errors do not occur.
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公开(公告)号:US11977194B2
公开(公告)日:2024-05-07
申请号:US17288205
申请日:2019-10-25
发明人: Ryan Hunter Griffin , Neil Graddage
CPC分类号: G01T7/06 , H05K1/0283 , H05K1/0393 , H05K1/092 , H05K3/0044 , H05K3/12 , H05K1/0306 , H05K1/032
摘要: An electrostatic concentrator for use in radon detection, comprising of a plastic sheet having conductive electrodes patterned onto the surface. The sheet is patterned and cut in such a way that it can be assembled into a three-dimensional shape (e.g. a cone), such that when a voltage is applied to the electrodes an electrostatic field is created for propelling radon progeny towards a sensor on which it can be detected.
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公开(公告)号:US20240101641A1
公开(公告)日:2024-03-28
申请号:US18457588
申请日:2023-08-29
摘要: The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-β) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.
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公开(公告)号:US11891532B2
公开(公告)日:2024-02-06
申请号:US16954228
申请日:2018-12-20
IPC分类号: C09D11/52 , B41M1/12 , C08K3/28 , C08K5/098 , C08K5/17 , C09D11/037 , C09D11/104 , H05K1/09
CPC分类号: C09D11/52 , B41M1/12 , C08K3/28 , C08K5/098 , C08K5/17 , C09D11/037 , C09D11/104 , H05K1/092 , H05K2203/1131
摘要: A copper-based ink contains copper acetate, 3-dimethylamino-1,2-propanediol and a silver salt. The ink may be coated on a substrate and decomposed on the substrate to form a conductive copper coating on the substrate. The ink provides micron-thick traces and may be screen printed and thermally sintered in the presence of up to about 500 ppm of oxygen or photo-sintered in air to produce highly conductive copper features. Sintered copper traces produced from the ink have improved air stability, and have improved sheet resistivity for 5-20 mil wide screen-printed lines with excellent resolution.
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公开(公告)号:US11873413B2
公开(公告)日:2024-01-16
申请号:US17265572
申请日:2019-08-02
发明人: Xiangyang Liu , Jianfu Ding , Patrick Roland Lucien Malenfant , Chantal Paquet , Bhavana Deore , Arnold J. Kell
IPC分类号: C09D11/52 , C09D11/033 , C09D11/101 , H01B1/22
CPC分类号: C09D11/52 , C09D11/033 , C09D11/101 , H01B1/22
摘要: A printable molecular ink that is can be treated (e.g. dried or curable) and sintered using broad spectrum ultraviolet light is provided to produce electrically conductive traces on a low temperature substrate, for example PET. The ink includes a silver or copper carboxylate, an organic amine compound, and may include a thermal protecting agent.
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公开(公告)号:US20240010686A1
公开(公告)日:2024-01-11
申请号:US18252212
申请日:2021-11-09
IPC分类号: C07K14/005 , C12N9/64 , C12N15/63 , C12N7/04
CPC分类号: C07K14/005 , C12N9/641 , C12N15/63 , C12N7/045 , C12Y304/22028
摘要: Methods and compositions for increasing the production of large amounts of empty capsids of the foot-and-mouth disease virus (FMDV) in a stable manner in mammalian cells by regulating the expression of FMDV 3C protease. The instant methods and compositions are based on the fact that a decreased expression of 3C protease results in a reduced cell toxicity and an increased synthesis of viral capsid proteins, as well as production of recombinant empty capsids. The invention provides recombinant plasmids that direct the expression of P1, 3C, and the use of the plasmids for producing new stable cell lines capable of generating high titers of FMDV empty capsids. The invention provides methods for regulating the expression of the FMDV 3C protease gene at a transcriptional and translational level in order to achieve the required process level of 3C protease for the selection process, as well as the production process.
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