公开(公告)号：US20230227393A1

公开(公告)日：2023-07-20

申请号：US18155431

申请日：2023-01-17

Applicant: Versitech Limited ,  Laboratory for Synthetic Chemistry and Chemical Biology Limited

Inventor： Chi Ming Che ,  Tingting Wang ,  Haixu Wang

IPC: C07C50/04 ,  C07C50/30 ,  C07C50/12 ,  C07C50/36 ,  C07C50/34 ,  B01J31/40

CPC classification number: C07C50/04 ,  C07C50/30 ,  C07C50/12 ,  C07C50/36 ,  C07C50/34 ,  B01J31/4023

Abstract: Methods for asymmetric cis-dihydroxylation (“AD”) of quinones to produce cis-diols of quinones with high yield (i.e. a yield ≥30%) and high enantioselectivity (i.e. an enantiometric excess ≥30%) are disclosed. The method uses an iron-based catalyst, such as one or more Fe(II) complexes, as the catalyst, and can be performed under mild reaction conditions (e.g. a temperature ≤50° C. at 1 atom in open air). The method generally includes: (i) maintaining a reaction mixture at a temperature for a period of time sufficient to form a product, where the reaction mixture contains a quinone, one or more iron-based catalyst(s), and a solvent, and where the product contains a chiral cis-diol. Optionally, the method also includes adding an oxidant into the reaction mixture prior to and/or during step (i), such as a hydrogen peroxide solution.

公开(公告)号：US11667596B2

公开(公告)日：2023-06-06

申请号：US17523880

申请日：2021-11-10

Applicant: PTC THERAPEUTICS, INC.

Inventor： Andrew W. Hinman ,  Charles R. Holst ,  Angela Minnella ,  Paul Mollard ,  Sean Pintchovski ,  Jeffrey K. Trimmer ,  Eric Torrey

IPC: C07C50/04 ,  A61P25/16 ,  C07C46/10

CPC classification number: C07C50/04 ,  A61P25/16 ,  C07C46/10 ,  C07B2200/13

Abstract: Disclosed herein are methods of treating or suppressing a disorder selected from the group consisting of α-synucleinopathies, tauopathies, ALS, traumatic brain injury, and ischemic-reperfusion related injuries.ury, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula: or the hydroquinone form thereof; or a solvate or hydrate thereof.

公开(公告)号：US20230012689A1

公开(公告)日：2023-01-19

申请号：US17851318

申请日：2022-06-28

Applicant: Verdox, Inc

Inventor： Cameron Rogers ,  Sahag Voskian ,  Alexander Reath

IPC: B01D53/32 ,  C07C50/04 ,  C07C50/12 ,  C07C50/18

Abstract: An electroactive species includes a quinone core structure and at least one stabilizing group covalently bound thereto. The stabilizing group includes a cationic group, a hydrogen bond donor, or a combination thereof. The electroactive species has an oxidized state and at least one reduced state capable of bonding with a Lewis acid gas to form an anion adduct. Methods for separating a Lewis acid gas from a fluid mixture, electrochemical cells, and gas separation systems are also provided.

公开(公告)号：US11472786B2

公开(公告)日：2022-10-18

申请号：US17677457

申请日：2022-02-22

Applicant: Canopy Growth Corporation

Inventor： Christopher Adair ,  Mahmood Azizpoor Fard ,  Ben Geiling ,  Mohammadmehdi Haghdoost Manjili

IPC: C07D311/80 ,  C07C50/04 ,  C07C50/24

Abstract: Disclosed herein is a method of converting a THC-rich cannabinoid mixture that comprises at least about 20% THC into a CBN-rich cannabinoid mixture that comprises at least about 2.0% CBN. The method comprises contacting the cannabinoid mixture with a benzoquinone reagent under reaction conditions comprising: (i) a reaction temperature that is within a target reaction-temperature range; and (ii) a reaction time that is within a target reaction-time range, such that at least a portion of the of the THC in the THC-rich cannabinoid mixture is converted into CBN.

公开(公告)号：US20210395906A1

公开(公告)日：2021-12-23

申请号：US17410135

申请日：2021-08-24

Applicant: CustomArray, Inc.

Inventor： Karl Maurer ,  John J. Cooper, JR.

IPC: C25B3/00 ,  C25B3/23 ,  C07D213/16 ,  C07C50/04 ,  B01J19/00 ,  C07B31/00 ,  C07C50/00 ,  C07C309/30 ,  C07H21/02 ,  C07B41/02 ,  C07C39/08 ,  C25B3/25 ,  C07B33/00 ,  C07H21/04 ,  C25B3/29 ,  C07B41/06

Abstract: There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.

公开(公告)号：US10326138B2

公开(公告)日：2019-06-18

申请号：US15065564

申请日：2016-03-09

Applicant: WASEDA UNIVERSITY ,  NISSAN CHEMICAL INDUSTRIES, LTD.

Inventor： Hiroyuki Nishide ,  Kenichi Oyaizu ,  Yuya Kambe ,  Takuji Yoshimoto

IPC: H01B1/00 ,  H01M4/00 ,  H01M12/00 ,  C08G65/00 ,  H01M4/60 ,  C07D471/04 ,  C08G73/06 ,  H01M12/06 ,  H01M10/0525 ,  H01B1/12 ,  C07C50/04 ,  H01M4/02

Abstract: Materials having charge-storing properties and made variously of dipyridine-fused benzoquinones of formula (1) below or derivatives thereof, dipyridine-fused benzoquinones of formula (4) below or derivatives thereof, or dipyridine-fused benzoquinone skeleton-containing polymers are provided. In the formulas, Ar1 and Ar2 are each independently a pyridine ring that forms together with two carbon atoms on a benzoquinone skeleton, or a derivative thereof. When used as electrode active materials, these charge storage materials are capable of providing high-performance batteries possessing a high capacity, high rate characteristics and high cycle characteristics.

公开(公告)号：US09758504B2

公开(公告)日：2017-09-12

申请号：US14902231

申请日：2014-06-25

Applicant: BASF SE

Inventor： Richard Dehn ,  Michael Kraus ,  Martine Dehn ,  Manuel Danz ,  Joaquim Henrique Teles

IPC: C07C45/00 ,  C07D311/72 ,  C07C46/08 ,  C07C50/02 ,  C07C50/04

CPC classification number: C07D311/72 ,  C07C46/08 ,  C07C50/02 ,  C07C50/04

Abstract: The invention relates to a method for producing 2,3,5-trimethyl benzoquinone or a compound containing 2,3,5-trimethyl benzoquinone, the method comprising the following steps: Oxidation of 2,3,6-trimethylphenol with oxygen or an oxygen-containing gas in a two- or multi-phase reaction medium in the presence of a catalyst or catalyst system containing at least one copper (II)-halide to a mixture containing 2,3,5-trimethyl benzoquinone, characterized in that the reaction medium contains water and at least one secondary aliphatic acyclic alcohol having 6 or more, preferably 7 or more, carbon atoms.

公开(公告)号：US20160368887A1

公开(公告)日：2016-12-22

申请号：US14902231

申请日：2014-06-25

Applicant: BASF SE

Inventor： Richard DEHN ,  Michael KRAUS ,  Martine DEHN ,  Manuel DANZ ,  Joaquim Henrique TELES

IPC: C07D311/72 ,  C07C50/04 ,  C07C46/08

CPC classification number: C07D311/72 ,  C07C46/08 ,  C07C50/02 ,  C07C50/04

Abstract: The invention relates to a method for producing 2,3,5-trimethyl benzoquinone or a compound containing 2,3,5-trimethyl benzoquinone, the method comprising the following steps: Oxidation of 2,3,6-trimethylphenol with oxygen or an oxygen-containing gas in a two-or multi-phase reaction medium in the presence of a catalyst or catalyst system containing at least one copper (II)-halide to a mixture containing 2,3,5-trimethyl benzoquinone, characterized in that the reaction medium contains water and at least one secondary aliphatic acyclic alcohol having 6 or more, preferably 7 or more, carbon atoms.

Abstract translation: 本发明涉及一种生产2,3,5-三甲基苯醌或含有2,3,5-三甲基苯醌的化合物的方法，该方法包括以下步骤：用氧或氧气氧化2,3,6-三甲基苯酚 在含有至少一种卤化铜（II）的催化剂或催化剂体系的存在下，在含有2,3,5-三甲基苯醌的混合物存在下，在二相或多相反应介质中存在的气体，其特征在于反应 介质含有水和至少一种具有6个或更多个，优选7个或更多个碳原子的仲脂族无环醇。

公开(公告)号：US08083809B2

公开(公告)日：2011-12-27

申请号：US12808100

申请日：2008-12-09

Applicant: Madeleine Leduc ,  Stéphane Sabelle ,  Eric Metais ,  Christophe Rondot

Inventor： Madeleine Leduc ,  Stéphane Sabelle ,  Eric Metais ,  Christophe Rondot

IPC: A61Q5/10 ,  C07C50/04

CPC classification number: C07C251/22 ,  A61K8/413 ,  A61K8/415 ,  A61K8/4913 ,  A61K8/4946 ,  A61Q5/065 ,  A61Q5/10 ,  C07C215/82 ,  C07C2601/16 ,  C07D207/14 ,  C07D233/58 ,  C07D233/61 ,  C07D403/04 ,  C09B53/00

Abstract: The invention relates to the dyeing of keratinous fibres using azomethine direct dyes of formula (I) or reduced precursors of azomethine direct dyes of formula (II) obtained from 2-chloro-3-amino-6-methylphenol. A subject-matter of the invention is a dyeing composition comprising at least one chlorinated azomethine direct dye or one reduced precursor of a chlorinated azomethine direct dye, a method for dyeing keratinous fibres which employs the said composition and their uses in the dyeing of keratinous fibres. This composition makes it possible to obtain a particularly stable and consistent colouring.

Abstract translation: 本发明涉及使用式（I）的偶氮甲碱直接染料或由2-氯-3-氨基-6-甲基苯酚获得的式（II）的偶氮甲碱直接染料的还原前体染色角质纤维。 本发明的主题是包含至少一种氯化偶氮甲碱直接染料或一种还原的氯化偶氮甲碱直接染料的前体的染色组合物，使用所述组合物染色角质纤维的方法及其在角质纤维染色中的用途 。 这种组合物可以获得特别稳定和一致的着色。

公开(公告)号：US07759504B2

公开(公告)日：2010-07-20

申请号：US12100940

申请日：2008-04-10

Applicant: Tomohito Masaki ,  Keizo Kimura ,  Osamu Uchida

Inventor： Tomohito Masaki ,  Keizo Kimura ,  Osamu Uchida

IPC: C07C50/04 ,  C07C257/00 ,  G03C1/00

CPC classification number: C07C251/22 ,  C07C251/30 ,  C07D207/06 ,  C07D209/08 ,  C07D209/88 ,  C07D215/04 ,  C07D215/10 ,  C07D215/38

Abstract: A triarylamine derivative is represented by the following Formula (I). In Formula (I): R111, R112, R121 and R122 each independently represent a hydrogen atom, an aliphatic group or an aromatic group, R113, R114, R115, R116, R123, R124, R125 and R126 each independently represent a hydrogen atom or a substituent, provided that at least one pair among R111 and R121, R112 and R122, R113 and R123, R114 and R124, R115 and R125 and R116 and R126 includes two different groups; at least one ring may be formed by mutual bonding in at least one pair among R111 and R112, R111 and R114, R113 and R114, R113 and R123, R123 and R124, R121 and R124, R121 and R122, and two R116s which are respectively bound to different phenyl groups; Xm− represents an m-valent anion; m and n represent 1 or 2; and a product of in and n is 2.

Abstract translation: 三芳基胺衍生物由下式（I）表示。 在式（I）中：R 111，R 112，R 121和R 122各自独立地表示氢原子，脂族基或芳基，R 11 3，R 11 4，R 15，R 16，R 123，R 12 4，R 125和R 126各自独立地表示氢原子或 取代基，条件是R111和R121，R112和R122，R113和R123，R114和R124，R115和R125以及R116和R126中至少有一对包括两个不同的基团; 可以通过R111和R112，R111和R114，R113和R114，R113和R123，R123和R124，R121和R124，R121和R122中的至少一对中相互键合形成至少一个环，以及两个R116 结合不同的苯基; Xm-表示m价阴离子; m和n表示1或2; 而n和n的乘积为2。