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公开(公告)号：US10261075B2
公开(公告)日：2019-04-16
申请号：US15990487
申请日：2018-05-25
Applicant: CustomArray, Inc.
Inventor： Karl Maurer , Dominic Suciu , Hetian Gao
IPC: G01N33/543 , B01J19/00 , C40B50/18 , C12Q1/6837
Abstract: There is disclosed a microarray having base cleavable linkers and a process of making the microarray. The microarray has a solid surface with known locations, each having reactive hydroxyl groups. The density of the known locations is greater than approximately 100 locations per square centimeter. Optionally, oligomers are synthesized in situ onto the cleavable linkers and subsequently cleaved using a cleaving base. Optionally, the oligomers are cleaved and recovered as a pool of oligomers.
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公开(公告)号：US20190227060A1
公开(公告)日：2019-07-25
申请号：US16371031
申请日：2019-03-31
Applicant: CustomArray, Inc.
Inventor： Karl Maurer , Dominic Suciu , Hetian Gao
IPC: G01N33/543 , C12Q1/6837 , C40B50/18 , B01J19/00
Abstract: There is disclosed a microarray having base cleavable linkers and a process of making the microarray. The microarray has a solid surface with known locations, each having reactive hydroxyl groups. The density of the known locations is greater than approximately 100 locations per square centimeter. Optionally, oligomers are synthesized in situ onto the cleavable linkers and subsequently cleaved using a cleaving base. Optionally, the oligomers are cleaved and recovered as a pool of oligomers.
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3.发明授权公开(公告)号：US10724143B1
公开(公告)日：2020-07-28
申请号：US16016403
申请日：2018-06-22
Applicant: CustomArray, Inc.
Inventor： Karl Maurer , John J. Cooper
IPC: C25B3/04 , C25B3/02 , C07H21/02 , C07H21/04 , B01J19/00 , C07B31/00 , C07B33/00 , C25B3/00 , C07D213/16 , C07C309/30 , C07C50/00 , C25B3/10 , C07B41/06 , C07B41/02
Abstract: There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.
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公开(公告)号：US10525436B2
公开(公告)日：2020-01-07
申请号：US15208606
申请日：2016-07-13
Applicant: CUSTOMARRAY, INC.
Inventor： Karl Maurer , John J Cooper, Jr. , H Sho Fujii , Joseph Leonetti
Abstract: There is disclosed an electrode array architecture employing continuous and discontinuous circumferential electrodes. There is further disclosed a process for the neutralization of acid generated at anode(s) by base generated at cathode(s) circumferentially located to each other so as to confine a region of pH change. The cathodes can be displayed as concentric rings (continuous) or as counter electrodes in a cross pattern (discontinuous). In this way reagents, such as acid, generated in a center electrode are countered (neutralized) by reagents, such as base, generated at the corners or at the outer ring.
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5.发明授权Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array 有权用于电极阵列上电化学低聚物合成的电化学去块溶液公开(公告)号：US09267213B1
公开(公告)日：2016-02-23
申请号：US14266595
申请日：2014-04-30
Applicant: CustomArray, Inc.
Inventor： Karl Maurer , John J Cooper
CPC classification number: C25B3/00 , B01J19/0046 , B01J2219/00653 , C07B41/02 , C07B41/06 , C07C50/00 , C07C309/30 , C07D213/16 , C07H21/02 , C07H21/04 , C25B3/02 , C25B3/04 , C25B3/10 , Y02P20/55
Abstract: There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.
Abstract translation: 公开了一种用于电极微阵列的电化学去块解决方案。 还公开了使用电化学去块溶液在电极阵列上进行电化学合成的方法。 该解决方案和方法是用于在电极的微阵列上除去用于合成寡核苷酸，肽，小分子或聚合物的酸不稳定保护基团，同时基本上改善了去活化对活性电极的分离。 该方法包括向电极阵列的至少一个电极施加电压或电流。 电极阵列被电化学去块溶液覆盖。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20210395906A1
公开(公告)日：2021-12-23
申请号：US17410135
申请日：2021-08-24
Applicant: CustomArray, Inc.
Inventor： Karl Maurer , John J. Cooper, JR.
IPC: C25B3/00 , C25B3/23 , C07D213/16 , C07C50/04 , B01J19/00 , C07B31/00 , C07C50/00 , C07C309/30 , C07H21/02 , C07B41/02 , C07C39/08 , C25B3/25 , C07B33/00 , C07H21/04 , C25B3/29 , C07B41/06
Abstract: There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.
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公开(公告)号：US11185838B2
公开(公告)日：2021-11-30
申请号：US16699582
申请日：2019-11-30
Applicant: CUSTOMARRAY, INC.
Inventor： Karl Maurer , John J Cooper, Jr. , H Sho Fuji , Joseph Leonetti
Abstract: There is disclosed an electrode array architecture employing continuous and discontinuous circumferential electrodes. There is further disclosed a process for the neutralization of acid generated at anode(s) by base generated at cathode(s) circumferentially located to each other so as to confine a region of pH change. The cathodes can be displayed as concentric rings (continuous) or as counter electrodes in a cross pattern (discontinuous). In this way reagents, such as acid, generated in a center electrode are countered (neutralized) by reagents, such as base, generated at the corners or at the outer ring.
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8.发明申请公开(公告)号：US20200086290A1
公开(公告)日：2020-03-19
申请号：US16699582
申请日：2019-11-30
Applicant: CUSTOMARRAY, INC.
Inventor： Karl Maurer , John J Cooper, JR. , H Sho Fujii , Joseph Leonetti
Abstract: There is disclosed an electrode array architecture employing continuous and discontinuous circumferential electrodes. There is further disclosed a process for the neutralization of acid generated at anode(s) by base generated at cathode(s) circumferentially located to each other so as to confine a region of pH change. The cathodes can be displayed as concentric rings (continuous) or as counter electrodes in a cross pattern (discontinuous). In this way reagents, such as acid, generated in a center electrode are countered (neutralized) by reagents, such as base, generated at the corners or at the outer ring.
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9.发明申请Neutralization and Containment of Redox Species Produced by Circumferential Electrodes 审中-公开由环形电极产生的氧化还原物质的中和遏制公开(公告)号：US20160354751A1
公开(公告)日：2016-12-08
申请号：US15208606
申请日：2016-07-13
Applicant: CUSTOMARRAY, INC.
Inventor： Karl Maurer , John J Cooper, Jr. , H Sho Fujii , Joseph Leonetti
CPC classification number: B01J19/0046 , B01J2219/00527 , B01J2219/00529 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00641 , B01J2219/00653 , B01J2219/00659 , B01J2219/00675 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00736 , B82Y30/00 , C25B3/10 , C25B9/06 , C25B11/02
Abstract: There is disclosed an electrode array architecture employing continuous and discontinuous circumferential electrodes. There is further disclosed a process for the neutralization of acid generated at anode(s) by base generated at cathode(s) circumferentially located to each other so as to confine a region of pH change. The cathodes can be displayed as concentric rings (continuous) or as counter electrodes in a cross pattern (discontinuous). In this way reagents, such as acid, generated in a center electrode are countered (neutralized) by reagents, such as base, generated at the corners or at the outer ring.
Abstract translation: 公开了采用连续和不连续周向电极的电极阵列结构。 进一步公开了一种通过在阳极周围定位的基底产生的阳极中和阳离子的方法，以便限制pH变化的区域。 阴极可以显示为同心环（连续）或以交叉图案（不连续）显示为对电极。 以这种方式，在中心电极中产生的诸如酸的试剂如在拐角处或外环处产生的试剂（例如碱）被抵消（中和）。
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公开(公告)号：US20180267032A1
公开(公告)日：2018-09-20
申请号：US15990487
申请日：2018-05-25
Applicant: CustomArray, Inc.
Inventor： Karl Maurer , Dominic Suciu , Hetian Gao
IPC: C12Q1/6837 , B01J19/00 , G01N33/543 , C40B50/18
CPC classification number: G01N33/54353 , B01J19/0046 , B01J2219/00454 , B01J2219/00608 , B01J2219/00653 , B01J2219/00713 , B01J2219/00722 , C12Q1/6837 , C40B50/18 , C12Q2525/197 , C12Q2527/125
Abstract: There is disclosed a microarray having base cleavable linkers and a process of making the microarray. The microarray has a solid surface with known locations, each having reactive hydroxyl groups. The density of the known locations is greater than approximately 100 locations per square centimeter. Optionally, oligomers are synthesized in situ onto the cleavable linkers and subsequently cleaved using a cleaving base. Optionally, the oligomers are cleaved and recovered as a pool of oligomers.
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