公开(公告)号：US10724143B1

公开(公告)日：2020-07-28

申请号：US16016403

申请日：2018-06-22

Applicant: CustomArray, Inc.

Inventor： Karl Maurer ,  John J. Cooper

IPC: C25B3/04 ,  C25B3/02 ,  C07H21/02 ,  C07H21/04 ,  B01J19/00 ,  C07B31/00 ,  C07B33/00 ,  C25B3/00 ,  C07D213/16 ,  C07C309/30 ,  C07C50/00 ,  C25B3/10 ,  C07B41/06 ,  C07B41/02

Abstract: There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.