发明授权
- 专利标题： Method for producing an arene with an aromatic C—N bond ortho to an aromatic C—O bond
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申请号： US15255957申请日： 2016-09-02
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公开(公告)号： US09856208B2公开(公告)日： 2018-01-02
- 发明人: Jean-Philip Lumb , Kenneth V. N. Esguerra
- 申请人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
- 申请人地址： CA Montreal
- 专利权人： The Royal Institution for the advancement of Learning/McGill University
- 当前专利权人： The Royal Institution for the advancement of Learning/McGill University
- 当前专利权人地址： CA Montreal
- 代理商 Isabelle Pelletier
- 主分类号： C07C249/02
- IPC分类号： C07C249/02 ; C07C213/08 ; C07C45/29 ; C07D265/36 ; C07D263/56 ; C07C46/08 ; C07F7/00 ; C07F7/08
摘要：
A method for producing an arene with an aromatic C—N bond ortho to an aromatic C—O bond from a hydroxy arene comprising said aromatic C—O bond is provided. This method comprising the steps a) ortho-oxygenating the hydroxy arene to produce an ortho-quinone, b) condensating the ortho-quinone with a nitrogen nucleophile to generate a compound of Formula (IVa) or (IVb), and c) allowing 1,5-hydrogen atom shift of the compound of Formula (IVa) or (IVb), thereby producing arenes with a C—N bond ortho to a C—O bond of Formula (Va) and (Vb), respectively:
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