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    METHOD IN BIOPROCESS PURIFICATION SYSTEM
    2.
    发明公开
    METHOD IN BIOPROCESS PURIFICATION SYSTEM 审中-公开

    公开(公告)号：US20240109003A1

    公开(公告)日：2024-04-04

    申请号：US17768671

    申请日：2020-11-19

    申请人： PURIDIFY LTD

    发明人： Lennart Sörby

    IPC分类号： B01D15/24 ,  B01D15/38 ,  B01D15/42 ,  G01N30/82

    CPC分类号： B01D15/247 ,  B01D15/3804 ,  B01D15/424 ,  G01N30/82

    摘要： The present invention relates to a method for controlling fraction collection of a target product 27 in a chromatography system 49 configured for cyclic purification performed on a sample comprising the target product 27. The method comprises determining trigger points for target product 27 collection in relation to presence of target product in the outlet; setting a first time period based on the trigger points within which the elution in the first cycle is captured; evaluating timing of the captured elution to identify the next time period; applying the timing to capture elution during the elution phase in the following cycle; and collecting the captured elution in the following cycle. The last three steps are repeated to capture the elution during the elution phase of the following cycles until no more target product 27 is desired.

    Chromatography System
    7.
    发明申请
    Chromatography System 有权

    公开(公告)号：US20220268745A1

    公开(公告)日：2022-08-25

    申请号：US17737163

    申请日：2022-05-05

    申请人： Puridify Ltd.

    发明人： Michael Williams ,  Iwan Roberts ,  Oliver Hardick ,  Matthew Townsend ,  Christopher Morris ,  Shameer Subratty

    IPC分类号： G01N30/38 ,  G01N30/60 ,  G01N30/84

    摘要： A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.