公开(公告)号：US08273847B2

公开(公告)日：2012-09-25

申请号：US10594627

申请日：2005-03-23

申请人： Tetsuji Yoshimura ,  Tetsuya Yamada ,  Takehisa Matsuda

发明人： Tetsuji Yoshimura ,  Tetsuya Yamada ,  Takehisa Matsuda

IPC分类号： A61L26/00 ,  C08G18/73 ,  C08G18/77 ,  C08K5/13 ,  C09J175/08

CPC分类号： C09J175/04 ,  A61L24/043 ,  C08G18/10 ,  C08G18/773 ,  C08G18/3228

摘要： A medical adhesive comprises a hydrophilic urethane prepolymer (UP) obtained by reacting a fluorine-containing nonaromatic polyisocyanate component (A) and a polyol component (B) having a hydrophilic polyol (B1), and a phenolic radical scavenger (PRS). The content of (PRS) is preferably 0.01 to 3% by weight based on the weight of (UP). The content of oxyethylene groups in (B) is preferably 30 to 100% by weight based on the weight of the oxyalkylene groups in (B). Preferably, (B) is a mixture of a random copolymer obtained by addition of ethylene oxide and propylene oxide to diols and polypropylene glycol. The content of isocyanate groups in the medical adhesive is 1 to 10% by weight based on the weight of (UP). The medical adhesive is suitable for bonding body tissues, such as lung, artery and heart in particular.

摘要翻译： 医用胶粘剂包括通过使含氟非芳族多异氰酸酯组分（A）和具有亲水多元醇（B1）的多元醇组分（B）和酚基清除剂（PRS）反应获得的亲水性氨基甲酸酯预聚物（UP）。 （PRS）的含量以（UP）的重量计优选为0.01〜3重量％。 （B）中的氧化乙烯基的含量相对于（B）中的氧化烯的重量优选为30〜100重量％。 优选地，（B）是通过在二醇和聚丙二醇中加入环氧乙烷和环氧丙烷得到的无规共聚物的混合物。 医用粘合剂中异氰酸酯基的含量为（UP）重量的1〜10重量％。 医用粘合剂特别适用于结合身体组织，如肺，动脉和心脏。

公开(公告)号：US20070282093A1

公开(公告)日：2007-12-06

申请号：US10594627

申请日：2005-03-23

申请人： Tetsuji Yoshimura ,  Tetsuya Yamada ,  Takehisa Matsuda

发明人： Tetsuji Yoshimura ,  Tetsuya Yamada ,  Takehisa Matsuda

IPC分类号： C07C271/06

CPC分类号： C09J175/04 ,  A61L24/043 ,  C08G18/10 ,  C08G18/773 ,  C08G18/3228

摘要： The present invention has its object to provide a medical adhesive excellent in safety, reactivity (curing rate) and duration of adhesive strength. A medical adhesive of the present invention comprises a hydrophilic urethane prepolymer (UP) obtained by reacting a fluorine-containing nonaromatic polyisocyanate component (A) and a polyol component (B) having a hydrophilic polyol (B1) as the essential component, and a phenolic radical scavenger (PRS). The content of (PRS) is preferably 0.01 to 3% by weight based on the weight of (UP). The content of oxyethylene groups in (B) is preferably 30 to 100% by weight based on the weight of the oxyalkylene groups in (B). Preferably, (B) is a mixture of a random copolymer obtained by addition of ethylene oxide and propylene oxide to diols and polypropylene glycol. The content of isocyanate groups in the medical adhesive is 1 to 10% by weight based on the weight of (UP). The medical adhesive of the present invention is suitable for bonding body tissues, such as lung, artery and heart in particular.

摘要翻译： 本发明的目的是提供一种安全性，反应性（固化速度）和粘合强度持续时间优异的医用粘合剂。 本发明的医用粘合剂包含通过使含氟非芳香族多异氰酸酯成分（A）和具有亲水性多元醇（B 1）作为必要成分的多元醇成分（B）反应而得到的亲水性氨基甲酸酯预聚物（UP） 酚类清除剂（PRS）。 （PRS）的含量以（UP）的重量计优选为0.01〜3重量％。 （B）中的氧化乙烯基的含量相对于（B）中的氧化烯的重量优选为30〜100重量％。 优选地，（B）是通过在二醇和聚丙二醇中加入环氧乙烷和环氧丙烷得到的无规共聚物的混合物。 医用粘合剂中异氰酸酯基的含量为（UP）重量的1〜10重量％。 本发明的医用粘合剂特别适用于结合身体组织，如肺，动脉和心脏。

公开(公告)号：US5763504A

公开(公告)日：1998-06-09

申请号：US476236

申请日：1995-06-07

申请人： Takehisa Matsuda ,  Minoo J. Moghaddam ,  Katsukiyo Sakurai

发明人： Takehisa Matsuda ,  Minoo J. Moghaddam ,  Katsukiyo Sakurai

IPC分类号： A61K47/36 ,  A61K31/715 ,  A61K31/726 ,  A61K31/727 ,  A61K31/737 ,  A61K47/48 ,  A61L27/00 ,  A61L27/20 ,  A61L31/04 ,  A61L33/00 ,  A61L33/08 ,  A61L33/10 ,  A61P43/00 ,  C08B37/00 ,  C08B37/08 ,  C08B37/10 ,  C08F251/00 ,  C08L5/00 ,  C08L5/08 ,  C08L5/10 ,  C08L51/02 ,  C08G64/00 ,  A61K9/50 ,  C08G69/08 ,  C08G73/10

CPC分类号： B82Y5/00 ,  A61K47/48961 ,  A61L27/20 ,  A61L31/042 ,  A61L33/08 ,  C08B37/0063

摘要： Photocurable glycosaminoglycan (GAG) derivatives and crosslinked glycosaminoglycans, which are highly safe and biocompatible, a method of preparing such photocurable GAG derivatives readily moldable by casting using a solvent when desired, by which method unreacted substances causative of adverse effects can be readily eliminated, and a method of producing the crosslinked GAGs and medical materials based on the photocurable GAG derivatives or crosslinked GAGs are provided. The photocurable GAG derivatives comprise a glycosaminoglycan and a photoreactive compound bound thereto and can be produced, for example, by subjecting hydroxyl or carboxyl groups of the glycosaminoglycan to esterification reaction or amidation reaction, respectively, with the photoreactive compound. The crosslinked GAGs are derived from the photocurable GAG derivatives by intermolecular crosslinking of the photoreactive compound bound thereto.

摘要翻译： 可光固化的糖胺聚糖（GAG）衍生物和交联的糖胺聚糖，其是高度安全和生物相容的，制备这种可光固化的GAG衍生物的方法，其易于通过在需要时使用溶剂浇铸而成型，由此可以容易地消除引起不利影响的未反应物质，以及 提供了基于可光固化的GAG衍生物或交联的GAG生产交联的GAG和医疗材料的方法。 可光固化的GAG衍生物包含糖胺聚糖和结合到其上的光反应性化合物，并且可以例如通过使糖胺聚糖的羟基或羧基与光反应性化合物分别进行酯化反应或酰胺化反应来制备。 交联的GAG通过与其结合的光反应性化合物的分子间交联衍生自可光固化的GAG衍生物。

公开(公告)号：US5192301A

公开(公告)日：1993-03-09

申请号：US754163

申请日：1991-09-03

申请人： Tetsuro Kamiya ,  Shigeyuki Echigo ,  Takehisa Matsuda ,  Ryuichiro Yoda ,  Nobuko Satoh

发明人： Tetsuro Kamiya ,  Shigeyuki Echigo ,  Takehisa Matsuda ,  Ryuichiro Yoda ,  Nobuko Satoh

IPC分类号： A61B17/00 ,  A61B17/12 ,  A61B19/00 ,  A61F2/00 ,  A61F2/01

CPC分类号： A61B17/0057 ,  A61B2017/00579 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00867 ,  A61B90/39 ,  A61F2002/3008 ,  A61F2250/0098

摘要： The closing plug and the closing plug device are used for closing a body defect percutaneously. During the insertion into the defect, the closing plug can be deformed to a smaller size to facilitate the insertion operation and recovered to its original larger shape after it is fitted to the defect, to thereby close the defect. The closing plug device facilitates the insertion of the closing plug into the defect. The closing plug has a flange or an enlarged portion at least at one end thereof and is made of a shape memory polymer having a shape recovery temperature in the range of 20.degree. C. to 70.degree. C. The closing plug device comprises a closing plug, a catheter and a guide wire or a pushing wire to aid in insertion of the closing plug to a defect.

摘要翻译： 关闭塞子和闭塞装置用于经皮闭合身体缺陷。 在插入缺陷期间，封闭塞可以变形为更小的尺寸以便于插入操作，并且在闭合塞被装配到缺陷之后恢复到其原始较大的形状，从而闭合缺陷。 闭合塞装置便于将闭塞塞插入到缺陷中。 封闭塞至少在其一端具有凸缘或扩大部分，并且由形状恢复温度在20℃至70℃范围内的形状记忆聚合物制成。封闭塞装置包括封闭塞 ，导管和引导线或推动线，以帮助将闭塞塞插入缺陷。

公开(公告)号：US20060228344A1

公开(公告)日：2006-10-12

申请号：US10559835

申请日：2004-01-23

申请人： Takehisa Matsuda

发明人： Takehisa Matsuda

IPC分类号： A61K48/00 ,  C12N15/86

CPC分类号： A61K38/1833 ,  Y02A50/465 ,  A61K2300/00

摘要： The present invention provides a cell-containing preparation comprising cells containing a DNA having a base sequence represented by SEQ ID NO:1 or 2, or a DNA hybridizable with a DNA having a base sequence represented by SEQ ID NO:1 or 2 under stringent conditions, and a fibrous protein. The cell-containing preparation of the present invention makes it possible to more efficiently supply NK4 having an inhibitory action against the growth or metastasis of cancers to cancer cells.

摘要翻译： 本发明提供一种含有细胞的制剂，其含有含有由SEQ ID NO：1或2表示的碱基序列的DNA的细胞，或者与具有由SEQ ID NO：1或2表示的碱基序列的DNA杂交的DNA在严格条件下 条件和纤维蛋白。 本发明的含细胞的制剂使得可以更有效地提供对癌细胞的生长或转移具有抑制作用的NK4。

公开(公告)号：US5718723A

公开(公告)日：1998-02-17

申请号：US305377

申请日：1994-09-13

申请人： Takehisa Matsuda ,  Nobuyuki Nakajima ,  Hiroyuki Kito

发明人： Takehisa Matsuda ,  Nobuyuki Nakajima ,  Hiroyuki Kito

IPC分类号： A61L27/00 ,  A61F2/06 ,  A61L27/34 ,  A61L27/50 ,  A61L33/00 ,  A61L33/08 ,  A61L33/12 ,  A61F2/04

CPC分类号： A61L33/124 ,  A61L27/34 ,  A61L27/507 ,  A61L33/08 ,  A61F2/06 ,  Y10S623/921

摘要： This invention provides a more functionalized artificial blood vessel which can be organized by independently designing its inner and outer surfaces and endowing them with respectively different biocompatibilities, as well as a process for producing the same. The artificial blood vessel comprises a tubular support having a layer of photogelled cinnamic acid-bound chondroitin sulfate coated on the inner surface thereof and a layer of photogelled coumarin-bound gelatin coated on the outer surface thereof. The process for producing the above artificial blood vessel comprises coating a layer of coumarin-bound gelatin on the outer surface of a tubular support and a layer of cinnamic acid-bound chondroitin sulfate on the inner surface of the support and irradiating each of the layers with light.

摘要翻译： 本发明提供了一种更具功能化的人造血管，其可以通过独立地设计其内表面和外表面并赋予它们分别具有不同的生物相容性以及其制造方法来组织。 人造血管包括管状支持体，其具有涂覆在其内表面上的光凝胶状肉桂酸结合的硫酸软骨素层和涂覆在其外表面上的光凝胶化香豆素结合明胶层。 制造上述人造血管的方法包括在支撑体的内表面上在管状载体的外表面上涂布香豆素结合的明胶层，并在载体的内表面上涂布肉桂酸结合的硫酸软骨素层，并用 光。

公开(公告)号：US5348873A

公开(公告)日：1994-09-20

申请号：US963089

申请日：1992-10-19

申请人： Takehisa Matsuda ,  Yasuhide Nakayama ,  Takashi Sugawara

发明人： Takehisa Matsuda ,  Yasuhide Nakayama ,  Takashi Sugawara

IPC分类号： A61L33/00 ,  A61M25/00 ,  C12N11/04 ,  C12N11/08 ,  A61F13/00 ,  C12N11/06

CPC分类号： C12N11/04 ,  A61L33/0029 ,  C12N11/08 ,  Y10S514/822

摘要： An anti-thrombogenic substance is immobilized on a base of a medical device to impart anti-thrombogenic properties to the medical device. The method comprises the steps of applying a photo-reactive azide derivative macromolecular material to a base to form a bonding layer, coating the bonding layer with a macromolecular layer composed of a water-soluble photo-crosslinking macromolecular material containing the anti-thrombogenic substance, and irradiating the base with ultraviolet light with the bonding layer and the macromolecular layer formed thereon to develop inter-molecular covalent bonding in the bonding layer. The macromolecular layer containing the anti-thrombogenic substance is thus fixed onto the base. Concurrently, the anti-thrombogenic substance is immobilized in the macromolecular layer which is crosslinked. The azide derivative can be poly-m-azidostyrene, copolymers, of poly-m-aziodstyrene with styrene and copolymers of poly-m-azidostyrene with methyl methacrylate. The water-soluble photo-crosslinking macromolecular material can be a copolymer of a photo-dimeric monomer with a water-soluble monomer or a copolymer of a photo-reactive azide with a water-soluble monomer.

摘要翻译： 将抗血栓形成物质固定在医疗装置的基底上，以向医疗装置赋予抗血栓形成性质。 该方法包括以下步骤：将光反应性叠氮化物衍生物高分子材料施加到基底上以形成结合层，用包含抗血栓形成物质的水溶性光交联性高分子材料构成的高分子层涂覆粘合层， 并用形成在其上的接合层和高分子层的紫外线照射基底，以在接合层中形成分子间共价键。 因此将含有抗血栓形成物质的大分子层固定在基底上。 同时，抗血栓形成物质固定在交联的高分子层中。 叠氮衍生物可以是聚 - 间 - 叠氮基苯乙烯，聚 - 间 - 偶氮苯乙烯与苯乙烯的共聚物和聚 - 叠氮基苯乙烯与甲基丙烯酸甲酯的共聚物。 水溶性光交联高分子材料可以是光二聚单体与水溶性单体或光反应性叠氮化物与水溶性单体的共聚物的共聚物。

公开(公告)号：US5240747A

公开(公告)日：1993-08-31

申请号：US739353

申请日：1991-08-02

申请人： Takehisa Matsuda ,  Takashi Sugawara ,  Kazuhiko Inoue ,  Nobutaka Tani

发明人： Takehisa Matsuda ,  Takashi Sugawara ,  Kazuhiko Inoue ,  Nobutaka Tani

IPC分类号： A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  A61L33/00 ,  A61L33/06 ,  C03C17/28 ,  C03C17/32 ,  C03C17/34 ,  C04B41/46 ,  C04B41/48 ,  C04B41/52 ,  C04B41/82 ,  C04B41/83 ,  C04B41/89 ,  C07C247/16 ,  C08J7/04 ,  C08J7/12 ,  C12N11/08

CPC分类号： C08J7/047 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L33/0082 ,  A61L33/06 ,  C03C17/28 ,  C03C17/32 ,  C03C17/3405 ,  C04B41/46 ,  C04B41/4857 ,  C04B41/52 ,  C04B41/82 ,  C04B41/83 ,  C04B41/89 ,  C07C247/16 ,  C08J7/12 ,  C12N11/08 ,  C08J2425/00 ,  C08J2433/00

摘要： A process for modifying the surface of a material such as plastics, metals, glasses and ceramics which comprises the steps of (1) coating a compound having at least one azido group on the surface of the material to be modified, (2) making a modifier substance to be fixed for the modification exist on or in the coated surface, and (3) irradiating ultraviolet rays to the coated surface to fix the modifier substance to the coated surface, wherein various compounds can be used as the modifier for converting the characteristics of the material surface to the desired characteristics without previously treating them, and various materials can be easily modified with a firm fixing of the modifier.

摘要翻译： 一种改性材料如塑料，金属，玻璃和陶瓷的表面的方法，其包括以下步骤：（1）在待改性材料的表面上涂覆具有至少一个叠氮基的化合物，（2） 为了改变而要固定的改性剂物质存在于涂布表面上或涂布表面上，（3）向涂布表面照射紫外线以将改性物质固定在涂布表面上，其中可以使用各种化合物作为转化特性的改性剂 的材料表面达到所需的特性，而不预先处理它们，并且可以用改性剂的牢固固定容易地改变各种材料。

公开(公告)号：US5173301A

公开(公告)日：1992-12-22

申请号：US799322

申请日：1991-11-27

申请人： Tetsuo Itoh ,  Takehisa Matsuda

发明人： Tetsuo Itoh ,  Takehisa Matsuda

IPC分类号： A61L24/00 ,  A61L24/04 ,  C08G18/10 ,  C08G18/12 ,  C08G18/40 ,  C08G18/42 ,  C08G18/46 ,  C08G18/77 ,  C09J175/00 ,  C09J175/06 ,  C09J175/08

CPC分类号： C09J175/06 ,  A61L24/046 ,  C08G18/10 ,  C08G18/12 ,  C08G18/4018 ,  C08G18/42 ,  C08G18/425 ,  C08G18/4252 ,  C08G18/4607 ,  C08G18/773 ,  Y10S528/904 ,  Y10S528/905

摘要： Surgical adhesives, comprising an NCO-terminated hydrophilic urethane prepolymer derived from an organic polyisocyanate and a polyol component comprising a polyester polyol derived from an electron-attracting group-containing dicarboxylic acid, such as 2-ketoglutaric acid, are capable of being easily hydrolyzed within a living body after a certain period of time.

公开(公告)号：US4994542A

公开(公告)日：1991-02-19

申请号：US320054

申请日：1989-03-07

申请人： Takehisa Matsuda ,  Teruo Takakura ,  Tetsuo Itoh

发明人： Takehisa Matsuda ,  Teruo Takakura ,  Tetsuo Itoh

IPC分类号： A61B17/00 ,  A61L24/00 ,  C08F283/00 ,  C08G18/10 ,  C08G18/48 ,  C08G18/66 ,  C08G18/77 ,  C09J175/08

CPC分类号： C09J175/08 ,  A61L24/0073 ,  C08F283/00 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/4837 ,  C08G18/6674 ,  C08G18/773 ,  Y10S528/904

摘要： Elastomeric or flexible surgical adhesives, comprising (i) a NCO-terminated hydrophilic urethane prepolymer derived from a fluorine-containing polyisocyanate and a hydrophilic polyether polyol of higher oxyethylene content, or a combinatioin of (i) with (ii) an unsaturated cyano compound containing a cyano group directly bonded to a polymerizable double bond, exhibit low toxicity, may be safely used for bonding of tissues and possess a rapid cure rate and sufficient bonding power.