公开(公告)号：US5718723A

公开(公告)日：1998-02-17

申请号：US305377

申请日：1994-09-13

申请人： Takehisa Matsuda ,  Nobuyuki Nakajima ,  Hiroyuki Kito

发明人： Takehisa Matsuda ,  Nobuyuki Nakajima ,  Hiroyuki Kito

IPC分类号： A61L27/00 ,  A61F2/06 ,  A61L27/34 ,  A61L27/50 ,  A61L33/00 ,  A61L33/08 ,  A61L33/12 ,  A61F2/04

CPC分类号： A61L33/124 ,  A61L27/34 ,  A61L27/507 ,  A61L33/08 ,  A61F2/06 ,  Y10S623/921

摘要： This invention provides a more functionalized artificial blood vessel which can be organized by independently designing its inner and outer surfaces and endowing them with respectively different biocompatibilities, as well as a process for producing the same. The artificial blood vessel comprises a tubular support having a layer of photogelled cinnamic acid-bound chondroitin sulfate coated on the inner surface thereof and a layer of photogelled coumarin-bound gelatin coated on the outer surface thereof. The process for producing the above artificial blood vessel comprises coating a layer of coumarin-bound gelatin on the outer surface of a tubular support and a layer of cinnamic acid-bound chondroitin sulfate on the inner surface of the support and irradiating each of the layers with light.

摘要翻译： 本发明提供了一种更具功能化的人造血管，其可以通过独立地设计其内表面和外表面并赋予它们分别具有不同的生物相容性以及其制造方法来组织。 人造血管包括管状支持体，其具有涂覆在其内表面上的光凝胶状肉桂酸结合的硫酸软骨素层和涂覆在其外表面上的光凝胶化香豆素结合明胶层。 制造上述人造血管的方法包括在支撑体的内表面上在管状载体的外表面上涂布香豆素结合的明胶层，并在载体的内表面上涂布肉桂酸结合的硫酸软骨素层，并用 光。