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公开(公告)号：US20120009188A1
公开(公告)日：2012-01-12
申请号：US13257502
申请日：2010-03-19
Applicant: Christian Behrens , Sylvie Jorieux , Abdelhakim Kharrat , Khalil Bouayadi , Philippe Mondon , Celine Monnet-Mars
Inventor： Christian Behrens , Sylvie Jorieux , Abdelhakim Kharrat , Khalil Bouayadi , Philippe Mondon , Celine Monnet-Mars
IPC: A61K39/395 , C07H21/00 , C12N15/63 , C12P21/00 , C12N1/21 , C12N5/10 , C12N1/19 , A61P37/06 , A61P37/00 , A61P31/00 , A61P29/00 , A61P25/00 , A61P11/00 , A61P7/00 , A61P35/00 , A61P19/04 , A61P35/02 , A61P11/06 , A61P37/08 , A61P1/00 , C07K16/28
CPC classification number: C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/92
Abstract: A variant of a parent polypeptide including an Fc region, which variant exhibits increased binding to FcRn as compared to the parent polypeptide and includes at least one amino acid modification in the Fc region.
Abstract translation: 包含Fc区的亲本多肽的变体，与母体多肽相比，该变体表现出与FcRn的增加的结合，并且包括Fc区中的至少一个氨基酸修饰。
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2.发明申请Method For Expressing Polypeptides In Eukaryotic Cells Using Alternative Splicing 审中-公开使用替代剪接在真核细胞中表达多肽的方法公开(公告)号：US20090305343A1
公开(公告)日：2009-12-10
申请号：US12301192
申请日：2007-05-16
Applicant: Stéphanie Fallot , Abdelhakim Kharrat , Philippe Mondon , Khalil Bouayadi , Patrick Brune , Hervé Prats , Christian Touriol
Inventor： Stéphanie Fallot , Abdelhakim Kharrat , Philippe Mondon , Khalil Bouayadi , Patrick Brune , Hervé Prats , Christian Touriol
CPC classification number: C12N15/10 , C12N15/1027
Abstract: This invention relates to an expression cassette for expressing polypeptides in eukaryotic cells using alternative splicing. The expression cassette comprises in 5′ to 3′ downstream direction: a promoter; a sequence transcribed in a 5′ untranslated region (5′UTR); a donor splice site; an intron; a first acceptor splice site; a first cistron encoding a first polypeptide; a second acceptor splice site; a second cistron encoding a second polypeptide; an internal ribosome entry site (IRES) operably linked to a selection marker; and a sequence transcribed in a 3″ untranslated region (3′UTR) including a polyadenylation signal, wherein the polyadenylation signal is unique.
Abstract translation: 本发明涉及使用选择性剪接在真核细胞中表达多肽的表达盒。 表达盒在下游方向5'到3'包括启动子; 在5'非翻译区（5'UTR）中转录的序列; 供体剪接部位; 内含子 第一受体剪接位点; 编码第一多肽的第一顺反子; 第二受体剪接位点; 编码第二多肽的第二顺反子; 与选择标记可操作地连接的内部核糖体进入位点（IRES）; 和在包含多聚腺苷酸化信号的3''非翻译区（3'UTR）中转录的序列，其中多聚腺苷酸化信号是唯一的。
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公开(公告)号：US09346883B2
公开(公告)日：2016-05-24
申请号：US14116562
申请日：2012-05-11
Applicant: Abdelhakim Kharrat , Olivier Dubreuil , Yassamine Lazrek , Philippe Mondon , Khalil Bouayadi , Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege A. Gaborit
Inventor： Abdelhakim Kharrat , Olivier Dubreuil , Yassamine Lazrek , Philippe Mondon , Khalil Bouayadi , Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege A. Gaborit
CPC classification number: C07K16/2863 , C07K16/32 , C07K2317/21 , C07K2317/34 , C07K2317/76
Abstract: The invention relates to antibodies against HER3 and their use in the treatment of cancer.
Abstract translation: 本发明涉及针对HER3的抗体及其在治疗癌症中的用途。
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公开(公告)号：US20090318308A1
公开(公告)日：2009-12-24
申请号：US12302918
申请日：2006-05-30
Applicant: Philippe Mondon , Khalil Bouayadi , Abdelhakim Kharrat
Inventor： Philippe Mondon , Khalil Bouayadi , Abdelhakim Kharrat
CPC classification number: C07K16/005 , C07K2317/565 , C07K2317/567 , C07K2317/622
Abstract: The present invention provides an in vitro method for obtaining a library of polynucleotides encoding antibodies, derivatives thereof or fragments thereof, comprising the step of performing random mutagenesis of a polynucleotide encoding the variable region of a heavy chain and/or the variable region of a light chain of a light chain, wherein random mutagenesis is performed on a library of polynucleotides comprising a sequence encoding the variable region of a heavy chain and/or the variable region of a light chain; and wherein the random mutagenesis process creates randomly distributed mutations along at least 70% of the sequence encoding the variable region.
Abstract translation: 本发明提供了一种用于获得编码抗体，其衍生物或其片段的多核苷酸文库的体外方法，其包括对编码重链可变区和/或可变区的多核苷酸进行随机诱变的步骤 其中随机诱变对包含编码重链可变区和/或轻链可变区的序列的多核苷酸文库进行; 并且其中随机诱变过程沿编码可变区的序列的至少70％产生随机分布的突变。
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公开(公告)号：US20140141019A1
公开(公告)日：2014-05-22
申请号：US14116562
申请日：2012-05-11
Applicant: Abdelhakim Kharrat , Olivier Dubreuil , Yassamine Lazrek , Philippe Mondon , Khalil Bouayadi , Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege A. Gaborit
Inventor： Abdelhakim Kharrat , Olivier Dubreuil , Yassamine Lazrek , Philippe Mondon , Khalil Bouayadi , Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege A. Gaborit
IPC: C07K16/28
CPC classification number: C07K16/2863 , C07K16/32 , C07K2317/21 , C07K2317/34 , C07K2317/76
Abstract: The invention relates to antibodies against HER3 and their use in the treatment of cancer.
Abstract translation: 本发明涉及针对HER3的抗体及其在治疗癌症中的用途。
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Patent Agency Ranking
公开(公告)号：US20140378663A1
公开(公告)日：2014-12-25
申请号：US14128828
申请日：2012-06-25
Applicant: Alexandre Fontayne , Sylvie Jorieux , Celine Monnet-Mars , Philippe Mondon , Abdelhakim Kharrat , Khalil Bouayadi
Inventor： Alexandre Fontayne , Sylvie Jorieux , Celine Monnet-Mars , Philippe Mondon , Abdelhakim Kharrat , Khalil Bouayadi
CPC classification number: C07K16/28 , C07K16/2887 , C07K16/40 , C07K2317/31 , C07K2317/52 , C07K2317/71 , C07K2317/76
Abstract: A method for producing a variant of a parent polypeptide including a Fc region, which variant exhibits reduced binding to the protein C1q and to at least one receptor Fcgγ R as compared to the parent polypeptide.
Abstract translation: 用于产生包含Fc区的亲本多肽的变体的方法，所述变体与亲本多肽相比显示出降低的与蛋白质C1q的结合和至少一种受体FcγγR的结合。
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公开(公告)号：US08742074B2
公开(公告)日：2014-06-03
申请号：US13257502
申请日：2010-03-19
Applicant: Christian Behrens , Sylvie Jorieux , Abdelhakim Kharrat , Khalil Bouayadi , Philippe Mondon , Celine Monnet-Mars
Inventor： Christian Behrens , Sylvie Jorieux , Abdelhakim Kharrat , Khalil Bouayadi , Philippe Mondon , Celine Monnet-Mars
CPC classification number: C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/92
Abstract: A variant of a parent polypeptide including an Fc region, which variant exhibits increased binding to FcRn as compared to the parent polypeptide and includes at least one amino acid modification in the Fc region.
Abstract translation: 包含Fc区的亲本多肽的变体，与母体多肽相比，该变体表现出与FcRn的增加的结合，并且包括Fc区中的至少一个氨基酸修饰。
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8.发明授权Compounds, in particular peptides, compositions comprising them and cosmetic and dermo-pharmaceutical uses 有权化合物，特别是肽，包含它们的组合物和化妆品和皮肤 - 药物用途公开(公告)号：US08697656B2
公开(公告)日：2014-04-15
申请号：US13144614
申请日：2010-01-15
Applicant: Arnaud Fournial , Philippe Mondon , Olivier Peschard
Inventor： Arnaud Fournial , Philippe Mondon , Olivier Peschard
CPC classification number: A61K38/06 , A61K8/64 , A61Q1/06 , A61Q5/006 , A61Q7/00 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08 , C07K5/0815
Abstract: The present invention concerns a peptide of following formula I: R being a side chain having at least one heteroatom selected from sulfur, nitrogen and oxygen in a carbonyl form (C═O); R1 being either H or a lipophilic chain; R2 being either OH or a lipophilic chain. More particularly the present invention concerns a cosmetic composition comprising a peptide as recited above and a physiologically acceptable medium. Results on the activity of the compounds are obtained and on the general state of the skin and its appendages, in particular via the stimulation of extracellular matrix components.
Abstract translation: 本发明涉及下列式I的肽：R是具有至少一个选自硫，氮和氧的杂原子（C = O）的侧链; R1是H或亲脂链; R2是OH或亲脂链。 更具体地说，本发明涉及包含上述肽和生理上可接受的介质的化妆品组合物。 获得化合物活性的结果，以及皮肤及其附属物的一般状态，特别是通过刺激细胞外基质组分。
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9.发明申请New Use Of An Extract Of Plant Origin Of Globularia And Method For Obtaining Said Extract By In Vitro Plant Culture 有权新鲜使用的球状藻的植物来源和通过体外植物培养获得所述提取物的方法公开(公告)号：US20130309332A1
公开(公告)日：2013-11-21
申请号：US13981837
申请日：2012-01-30
Applicant: Arnaud Fournial , Claire-Marie Grizaud , Philippe Mondon , Caroline Le Moigne
Inventor： Arnaud Fournial , Claire-Marie Grizaud , Philippe Mondon , Caroline Le Moigne
CPC classification number: A61K8/97 , A61K8/99 , A61K36/185 , A61K2800/522 , A61Q5/002 , A61Q7/00 , A61Q19/00 , A61Q19/005 , A61Q19/08
Abstract: According to the present invention the extract of plant origin of the Globularia genus is used for a non-therapeutic cosmetic treatment of the skin and/or appendages. Preferably the species is Globularia cordifolia and the extract is obtained by in vitro plant culture. The extract can be used in particular for preventing and/or treating skin ageing by stimulating the 10 reactions of detoxification and cellular regeneration through a hormetic type response, for improving the transparency and radiance of complexion, for preventing or treating sensitive and reactive skins, for preventing or treating rednesses, for preventing protein glycation, for increasing and/or maintaining the number of dermal stem cells, for increasing and/or maintaining the dermal macromolecules, in particular collagen and elastin, for increasing the volume of the dermis, for 15 preventing and/or treating fines lines and wrinkles, for firming skin, for preventing hair loss and/or stimulating hair regrowth. The invention also proposes an original method of obtaining the extract by in vitro plant culture of undifferenciated cells of Globularia and an extract of plant origin that can be obtained by such method.
Abstract translation: 根据本发明，球状属的植物来源的提取物用于皮肤和/或附属物的非治疗性美容治疗。 优选地，该物种是小球藻，并且通过体外植物培养获得提取物。 提取物特别可用于通过激发类型反应刺激10种解毒和细胞再生反应来预防和/或治疗皮肤老化，以改善肤色的透明度和光泽度，用于预防或治疗敏感和反应性皮肤，用于 预防或治疗发红，防止蛋白质糖基化，增加和/或维持真皮干细胞的数量，以增加和/或维持真皮大分子，特别是胶原蛋白和弹性蛋白，以增加真皮的体积，以防止15种预防 和/或治疗细纹和皱纹，用于紧致皮肤，用于防止脱发和/或刺激头发再生长。 本发明还提出了通过体外植物培养获得提取物的原始方法，该方法可以通过这种方法获得的球状藻的未鉴定细胞和植物来源的提取物。
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10.发明授权Moisturizing cosmetic composition comprising a combination of homarine and erythritol 有权包含均聚物和赤藓糖醇的组合的保湿化妆品组合物公开(公告)号：US08388939B2
公开(公告)日：2013-03-05
申请号：US12735854
申请日：2009-02-13
Applicant: Arnaud Fournial , Claire Mas-Chamberlin , Philippe Mondon , Olivier Peschard
Inventor： Arnaud Fournial , Claire Mas-Chamberlin , Philippe Mondon , Olivier Peschard
CPC classification number: A61K8/345 , A61K8/0212 , A61K8/4926 , A61Q5/00 , A61Q17/04 , A61Q19/002 , A61Q19/004 , A61Q19/007 , A61Q19/08 , A61Q19/10
Abstract: The subject matter of the present invention is a cosmetic or dermopharmaceutic composition comprising a combination of homarine and erythritol as well as a non-therapeutic treatment method of the skin to improve cutaneous hydration, to prevent and/or treat cutaneous dryness signs, to restore and/or protect the cutaneous barrier function, to protect cells of the skin and/or of the scalp from osmotic shocks, for example from UV induced osmotic shocks.
Abstract translation: 本发明的主题是包含均相和赤藓糖醇的组合的化妆品或皮肤药物组合物，以及皮肤的改善皮肤水合的预防和/或治疗皮肤干燥症状的非治疗性治疗方法，以及恢复和 /或保护皮肤屏障功能，以保护皮肤和/或头皮的细胞免受渗透冲击，例如紫外线诱发的渗透性冲击。
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