公开(公告)号：US09050477B2

公开(公告)日：2015-06-09

申请号：US13264547

申请日：2010-04-15

Applicant: Arnaud Fournial ,  Philippe Mondon

Inventor： Arnaud Fournial ,  Philippe Mondon

IPC: A61K31/704 ,  A61K31/352 ,  A61P17/18 ,  A61P17/00 ,  A61Q19/08 ,  A61K8/34 ,  A61K8/49 ,  A61Q19/02

CPC classification number: A61Q19/08 ,  A61K8/347 ,  A61K8/498 ,  A61Q19/02

Abstract: The present invention related to cosmetic compositions comprising oridonin and new cosmetic uses. Oridonin is used for fighting the signs of cutaneous aging and for slimming. A composition comprising a combination of oridonin and darutigenol or a derivative thereof, in particular darutoside, is disclosed together with the cosmetic use of such composition.

Abstract translation: 本发明涉及包含oridonin和新化妆品用途的化妆品组合物。 Oridonin用于抗衰老和减肥的迹象。 本发明公开了组合物，其组合物包含奥曲肽和达鲁必醇或其衍生物，特别是darutoside的组合，以及该组合物的美容用途。

公开(公告)号：US08603498B2

公开(公告)日：2013-12-10

申请号：US13522663

申请日：2011-01-17

Applicant: Arnaud Fournial ,  Philippe Mondon ,  Olivier Peschard

Inventor： Arnaud Fournial ,  Philippe Mondon ,  Olivier Peschard

IPC: A61K9/00 ,  A61K8/02

CPC classification number: A61K8/553 ,  A61Q19/00 ,  A61Q19/08 ,  C07C305/06 ,  C07F9/091

Abstract: The compound according to the invention has the following developed formula IX: wherein: X=PO(OH)2; SO2(OH); PO(OH)(Xaa)m or SO2(Xaa)m; A=H; OH; NH2 or akyl (1-6C); n=1 to 4; Y=—CO—OR2; —CO—NR3R4; —O—CO—R2; —C═CR2; R2=an alkyl, aryl, aralkyl, acyl, sulfonyl, sugar or alkoxy chain of 1 to 24 carbon atoms, linear, branched or cyclic, with or without substitutions, saturated or not, hydroxylated or not, sulfurated or not; R5=OH, O-alk (1-6C), (Xaa)m, NH2 or NH-alkyl(1-6C); Xaa=peptide of m aminoacids Xaa with m from 1 to 10; The compound is preferably phosphated, obtained from malic acid and having the following developed formula: A cosmetic composition comprising the compound of the present invention can improve the general condition of the skin, for example hydration, lightening and mechanical properties.

Abstract translation: 根据本发明的化合物具有以下开发的式IX：其中：X = PO（OH）2; SO2（OH）; PO（OH）（Xaa）m或SO2（Xaa）m; A = H; 哦; NH2或烷基（1-6C）; n = 1〜4; Y = -CO-OR2; -CO-NR3R4; -O-CO-R2; -C = CR2; R 2 =具有1至24个碳原子的烷基，芳基，芳烷基，酰基，磺酰基，糖或烷氧基链，具有或不具有或不具有羟基化或不饱和或不具有取代基，不具有或不具有取代基，不具有或不具有取代基， R5 = OH，O-烷基（1-6C），（Xaa）m，NH2或NH-烷基（1-6C）; Xaa = m为1〜10的m个氨基酸Xaa的肽; 该化合物优选磷酸化，由苹果酸获得并具有以下显影的配方：包含本发明化合物的化妆品组合物可以改善皮肤的一般状况，例如水合，减轻和机械性能。

公开(公告)号：US20130004439A1

公开(公告)日：2013-01-03

申请号：US13522663

申请日：2011-01-17

Applicant: Arnaud Fournial ,  Philippe Mondon ,  Olivier Peschard

Inventor： Arnaud Fournial ,  Philippe Mondon ,  Olivier Peschard

IPC: C07F9/09 ,  A61K8/64 ,  A61Q17/04 ,  A61Q19/08 ,  A61Q19/02 ,  A61K8/55 ,  A61Q19/00

CPC classification number: A61K8/553 ,  A61Q19/00 ,  A61Q19/08 ,  C07C305/06 ,  C07F9/091

Abstract: The compound according to the invention has the following developed formula IX: wherein: X=PO(OH)2; SO2(OH); PO(OH)(Xaa)m or SO2(Xaa)m; A=H; OH; NH2 or akyl (1-6C); n=1 to 4; Y=—CO—OR2; —CO—NR3R4; —O—CO—R2; —C═CR2; R2=an alkyl, aryl, aralkyl, acyl, sulfonyl, sugar or alkoxy chain of 1 to 24 carbon atoms, linear, branched or cyclic, with or without substitutions, saturated or not, hydroxylated or not, sulfurated or not; R5=OH, O-alk (1-6C), (Xaa)m, NH2 or NH-alkyl(1-6C); Xaa=peptide of m aminoacids Xaa with m from 1 to 10; The compound is preferably phosphated, obtained from malic acid and having the following developed formula: A cosmetic composition comprising the compound of the present invention can improve the general condition of the skin, for example hydration, lightening and mechanical properties.

Abstract translation: 根据本发明的化合物具有以下开发的式IX：其中：X = PO（OH）2; SO2（OH）; PO（OH）（Xaa）m或SO2（Xaa）m; A = H; 哦; NH2或烷基（1-6C）; n = 1〜4; Y = -CO-OR2; -CO-NR3R4; -O-CO-R2; -C = CR2; R 2 =具有1至24个碳原子的烷基，芳基，芳烷基，酰基，磺酰基，糖或烷氧基链，具有或不具有或不具有羟基化或不饱和或不具有取代基，不具有或不具有取代基，不具有或不具有取代基， R5 = OH，O-烷基（1-6C），（Xaa）m，NH2或NH-烷基（1-6C）; Xaa = m为1〜10的m个氨基酸Xaa的肽; 该化合物优选磷酸化，由苹果酸获得并具有以下显影的配方：包含本发明化合物的化妆品组合物可以改善皮肤的一般状况，例如水合，减轻和机械性能。

公开(公告)号：US20090305343A1

公开(公告)日：2009-12-10

申请号：US12301192

申请日：2007-05-16

Applicant: Stéphanie Fallot ,  Abdelhakim Kharrat ,  Philippe Mondon ,  Khalil Bouayadi ,  Patrick Brune ,  Hervé Prats ,  Christian Touriol

Inventor： Stéphanie Fallot ,  Abdelhakim Kharrat ,  Philippe Mondon ,  Khalil Bouayadi ,  Patrick Brune ,  Hervé Prats ,  Christian Touriol

IPC: C12P21/00 ,  C12N5/10 ,  C12N1/19 ,  C12N15/63 ,  A61K31/711 ,  C07H21/04

CPC classification number: C12N15/10 ,  C12N15/1027

Abstract: This invention relates to an expression cassette for expressing polypeptides in eukaryotic cells using alternative splicing. The expression cassette comprises in 5′ to 3′ downstream direction: a promoter; a sequence transcribed in a 5′ untranslated region (5′UTR); a donor splice site; an intron; a first acceptor splice site; a first cistron encoding a first polypeptide; a second acceptor splice site; a second cistron encoding a second polypeptide; an internal ribosome entry site (IRES) operably linked to a selection marker; and a sequence transcribed in a 3″ untranslated region (3′UTR) including a polyadenylation signal, wherein the polyadenylation signal is unique.

Abstract translation: 本发明涉及使用选择性剪接在真核细胞中表达多肽的表达盒。 表达盒在下游方向5'到3'包括启动子; 在5'非翻译区（5'UTR）中转录的序列; 供体剪接部位; 内含子 第一受体剪接位点; 编码第一多肽的第一顺反子; 第二受体剪接位点; 编码第二多肽的第二顺反子; 与选择标记可操作地连接的内部核糖体进入位点（IRES）; 和在包含多聚腺苷酸化信号的3''非翻译区（3'UTR）中转录的序列，其中多聚腺苷酸化信号是唯一的。

公开(公告)号：US20090017147A1

公开(公告)日：2009-01-15

申请号：US11795330

申请日：2006-01-13

Applicant: Karl Lintner ,  Claire Mas Chamberlin ,  Louis Francois Lamy ,  Philippe Mondon

Inventor： Karl Lintner ,  Claire Mas Chamberlin ,  Louis Francois Lamy ,  Philippe Mondon

IPC: A61K35/68 ,  A61P17/02

CPC classification number: A61Q19/08 ,  A61K8/9706 ,  A61Q5/00 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/001 ,  A61Q19/007 ,  A61Q19/06

Abstract: The invention provides a cosmetic or dermopharmaceutic composition containing an Euglena extract, its use to activate the cellular metabolism and in particular to protect and/or improve the state of the skin and to reduce the signs of ageing in particular and/or cutaneous fatigue

Abstract translation: 本发明提供一种含有金丝雀素提取物的化妆品或皮肤药物组合物，其用于激活细胞代谢，特别是保护和/或改善皮肤状态并减少特别是老化迹象和/或皮肤疲劳

公开(公告)号：US09925135B2

公开(公告)日：2018-03-27

申请号：US13981837

申请日：2012-01-30

Applicant: Arnaud Fournial ,  Claire-Marie Grizaud ,  Philippe Mondon ,  Caroline Le Moigne

Inventor： Arnaud Fournial ,  Claire-Marie Grizaud ,  Philippe Mondon ,  Caroline Le Moigne

IPC: A61K8/97 ,  A61K8/99 ,  A61K36/185 ,  A61Q19/08 ,  A61Q5/00 ,  A61Q19/00 ,  A61Q7/00

CPC classification number: A61K8/97 ,  A61K8/99 ,  A61K36/185 ,  A61K2800/522 ,  A61Q5/002 ,  A61Q7/00 ,  A61Q19/00 ,  A61Q19/005 ,  A61Q19/08

Abstract: According to the present invention the extract of plant origin of the Globularia genus is used for a non-therapeutic cosmetic treatment of the skin and/or appendages. Preferably the species is Globularia cordifolia and the extract is obtained by in vitro plant culture. The extract can be used in particular for preventing and/or treating skin ageing by stimulating the 10 reactions of detoxification and cellular regeneration through a hormetic type response, for improving the transparency and radiance of complexion, for preventing or treating sensitive and reactive skins, for preventing or treating rednesses, for preventing protein glycation, for increasing and/or maintaining the number of dermal stem cells, for increasing and/or maintaining the dermal macromolecules, in particular collagen and elastin, for increasing the volume of the dermis, for 15 preventing and/or treating fines lines and wrinkles, for firming skin, for preventing hair loss and/or stimulating hair regrowth. The invention also proposes an original method of obtaining the extract by in vitro plant culture of undifferenciated cells of Globularia and an extract of plant origin that can be obtained by such method.

公开(公告)号：US20140378663A1

公开(公告)日：2014-12-25

申请号：US14128828

申请日：2012-06-25

Applicant: Alexandre Fontayne ,  Sylvie Jorieux ,  Celine Monnet-Mars ,  Philippe Mondon ,  Abdelhakim Kharrat ,  Khalil Bouayadi

Inventor： Alexandre Fontayne ,  Sylvie Jorieux ,  Celine Monnet-Mars ,  Philippe Mondon ,  Abdelhakim Kharrat ,  Khalil Bouayadi

IPC: C07K16/28 ,  C07K16/40

CPC classification number: C07K16/28 ,  C07K16/2887 ,  C07K16/40 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/71 ,  C07K2317/76

Abstract: A method for producing a variant of a parent polypeptide including a Fc region, which variant exhibits reduced binding to the protein C1q and to at least one receptor Fcgγ R as compared to the parent polypeptide.

Abstract translation: 用于产生包含Fc区的亲本多肽的变体的方法，所述变体与亲本多肽相比显示出降低的与蛋白质C1q的结合和至少一种受体FcγγR的结合。

公开(公告)号：US08742074B2

公开(公告)日：2014-06-03

申请号：US13257502

申请日：2010-03-19

Applicant: Christian Behrens ,  Sylvie Jorieux ,  Abdelhakim Kharrat ,  Khalil Bouayadi ,  Philippe Mondon ,  Celine Monnet-Mars

Inventor： Christian Behrens ,  Sylvie Jorieux ,  Abdelhakim Kharrat ,  Khalil Bouayadi ,  Philippe Mondon ,  Celine Monnet-Mars

IPC: C07K16/00 ,  C07H21/04 ,  C12N15/00 ,  C12N5/00 ,  C12N1/20 ,  C12P21/04

CPC classification number: C07K16/00 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/92

Abstract: A variant of a parent polypeptide including an Fc region, which variant exhibits increased binding to FcRn as compared to the parent polypeptide and includes at least one amino acid modification in the Fc region.

Abstract translation: 包含Fc区的亲本多肽的变体，与母体多肽相比，该变体表现出与FcRn的增加的结合，并且包括Fc区中的至少一个氨基酸修饰。

公开(公告)号：US08741357B2

公开(公告)日：2014-06-03

申请号：US11795330

申请日：2006-01-13

Applicant: Karl Lintner ,  Claire Mas Chamberlin ,  Louis François Lamy ,  Philippe Mondon

Inventor： Karl Lintner ,  Claire Mas Chamberlin ,  Louis François Lamy ,  Philippe Mondon

IPC: A61K36/00

CPC classification number: A61Q19/08 ,  A61K8/9706 ,  A61Q5/00 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/001 ,  A61Q19/007 ,  A61Q19/06

Abstract: The invention provides a cosmetic or dermopharmaceutic composition containing an Euglena extract, its use to activate the cellular metabolism and in particular to protect and/or improve the state of the skin and to reduce the signs of ageing in particular and/or cutaneous fatigue.

Abstract translation: 本发明提供了含有金丝雀素提取物的化妆品或皮肤制剂组合物，其用于激活细胞代谢，特别是保护和/或改善皮肤状态并减少特别是老化迹象和/或皮肤疲劳的用途。

公开(公告)号：US20130058878A1

公开(公告)日：2013-03-07

申请号：US13639933

申请日：2011-04-07

Applicant: Arnaud Fournial ,  Philippe Mondon ,  Olivier Peschard

Inventor： Arnaud Fournial ,  Philippe Mondon ,  Olivier Peschard

IPC: A61K8/34 ,  A61K8/67 ,  A61K8/40 ,  A61Q9/04 ,  A61Q19/08 ,  A61Q19/02 ,  A61Q17/04 ,  A61K8/64 ,  A61K8/63

CPC classification number: A61Q17/04 ,  A61K8/342 ,  A61Q19/08

Abstract: Geranylgeranyl-2-propanol compound (GGP) having the following formula (I) is proposed for use according to the present invention as a cosmetic active compound for the prevention and treatment of aging of skin and its appendages. The GGP has a protective action against oxidative stress and free radical, on telomeres and on mitochondria and its activity. In particular, GGP can be used for the treatment of wrinkles, fine lines and visible discontinuities of skin, for the treatment pigmentation disorders.

Abstract translation: 提出具有下式（I）的香叶基香叶基-2-丙醇化合物（GGP）用作根据本发明用作预防和治疗皮肤老化及其附属物的化妆品活性化合物。 GGP具有抗氧化应激和自由基，端粒和线粒体及其活性的保护作用。 特别地，GGP可用于治疗皱纹，细纹和可见的皮肤不连续性，用于治疗色素沉着障碍。