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公开(公告)号：US09346883B2
公开(公告)日：2016-05-24
申请号：US14116562
申请日：2012-05-11
Applicant: Abdelhakim Kharrat , Olivier Dubreuil , Yassamine Lazrek , Philippe Mondon , Khalil Bouayadi , Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege A. Gaborit
Inventor： Abdelhakim Kharrat , Olivier Dubreuil , Yassamine Lazrek , Philippe Mondon , Khalil Bouayadi , Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege A. Gaborit
CPC classification number: C07K16/2863 , C07K16/32 , C07K2317/21 , C07K2317/34 , C07K2317/76
Abstract: The invention relates to antibodies against HER3 and their use in the treatment of cancer.
Abstract translation: 本发明涉及针对HER3的抗体及其在治疗癌症中的用途。
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公开(公告)号：US20090318308A1
公开(公告)日：2009-12-24
申请号：US12302918
申请日：2006-05-30
Applicant: Philippe Mondon , Khalil Bouayadi , Abdelhakim Kharrat
Inventor： Philippe Mondon , Khalil Bouayadi , Abdelhakim Kharrat
CPC classification number: C07K16/005 , C07K2317/565 , C07K2317/567 , C07K2317/622
Abstract: The present invention provides an in vitro method for obtaining a library of polynucleotides encoding antibodies, derivatives thereof or fragments thereof, comprising the step of performing random mutagenesis of a polynucleotide encoding the variable region of a heavy chain and/or the variable region of a light chain of a light chain, wherein random mutagenesis is performed on a library of polynucleotides comprising a sequence encoding the variable region of a heavy chain and/or the variable region of a light chain; and wherein the random mutagenesis process creates randomly distributed mutations along at least 70% of the sequence encoding the variable region.
Abstract translation: 本发明提供了一种用于获得编码抗体，其衍生物或其片段的多核苷酸文库的体外方法，其包括对编码重链可变区和/或可变区的多核苷酸进行随机诱变的步骤 其中随机诱变对包含编码重链可变区和/或轻链可变区的序列的多核苷酸文库进行; 并且其中随机诱变过程沿编码可变区的序列的至少70％产生随机分布的突变。
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公开(公告)号：US20120009188A1
公开(公告)日：2012-01-12
申请号：US13257502
申请日：2010-03-19
Applicant: Christian Behrens , Sylvie Jorieux , Abdelhakim Kharrat , Khalil Bouayadi , Philippe Mondon , Celine Monnet-Mars
Inventor： Christian Behrens , Sylvie Jorieux , Abdelhakim Kharrat , Khalil Bouayadi , Philippe Mondon , Celine Monnet-Mars
IPC: A61K39/395 , C07H21/00 , C12N15/63 , C12P21/00 , C12N1/21 , C12N5/10 , C12N1/19 , A61P37/06 , A61P37/00 , A61P31/00 , A61P29/00 , A61P25/00 , A61P11/00 , A61P7/00 , A61P35/00 , A61P19/04 , A61P35/02 , A61P11/06 , A61P37/08 , A61P1/00 , C07K16/28
CPC classification number: C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/92
Abstract: A variant of a parent polypeptide including an Fc region, which variant exhibits increased binding to FcRn as compared to the parent polypeptide and includes at least one amino acid modification in the Fc region.
Abstract translation: 包含Fc区的亲本多肽的变体，与母体多肽相比，该变体表现出与FcRn的增加的结合，并且包括Fc区中的至少一个氨基酸修饰。
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Patent Agency Ranking
公开(公告)号：US20140141019A1
公开(公告)日：2014-05-22
申请号：US14116562
申请日：2012-05-11
Applicant: Abdelhakim Kharrat , Olivier Dubreuil , Yassamine Lazrek , Philippe Mondon , Khalil Bouayadi , Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege A. Gaborit
Inventor： Abdelhakim Kharrat , Olivier Dubreuil , Yassamine Lazrek , Philippe Mondon , Khalil Bouayadi , Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege A. Gaborit
IPC: C07K16/28
CPC classification number: C07K16/2863 , C07K16/32 , C07K2317/21 , C07K2317/34 , C07K2317/76
Abstract: The invention relates to antibodies against HER3 and their use in the treatment of cancer.
Abstract translation: 本发明涉及针对HER3的抗体及其在治疗癌症中的用途。
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5.发明申请Gene expression inducing fusion protein and method for controlling gene expression Induction 审中-公开基因表达诱导融合蛋白和控制基因表达的方法诱导公开(公告)号：US20060134738A1
公开(公告)日：2006-06-22
申请号：US10542471
申请日：2004-01-15
Applicant: Christel Boutonnet , Stephan Vagner , Jean-Charles Faye , Gilles Favre , Abdelhakim Kharrat , Khalil Bouayadi , Laurence Vercaemer
Inventor： Christel Boutonnet , Stephan Vagner , Jean-Charles Faye , Gilles Favre , Abdelhakim Kharrat , Khalil Bouayadi , Laurence Vercaemer
CPC classification number: A61K48/0025 , A61K48/0041 , C07K2319/01 , C07K2319/80 , C12N15/62
Abstract: The invention relates to a gene expression inducing fusion protein comprising a) a ribonucleic acid linking peptide domain and a post-transcriptional gene expression activator domain and b) a domain enabling cytoplasmic membrane delocalization. The invention also relates to a modulatable permanent external method for controlling gene expression induction by modulating the state of post-translational modulation of the gene expression inducing fusion protein for the expression of said gene.
Abstract translation: 本发明涉及诱导基因表达的融合蛋白，其包含a）核糖核酸连接肽结构域和转录后基因表达激活域，以及b）使细胞质膜离域的结构域。 本发明还涉及通过调节用于表达所述基因的基因表达诱导融合蛋白的翻译后调节的状态来控制基因表达诱导的可调节永久外部方法。
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6.发明申请Method For Expressing Polypeptides In Eukaryotic Cells Using Alternative Splicing 审中-公开使用替代剪接在真核细胞中表达多肽的方法公开(公告)号：US20090305343A1
公开(公告)日：2009-12-10
申请号：US12301192
申请日：2007-05-16
Applicant: Stéphanie Fallot , Abdelhakim Kharrat , Philippe Mondon , Khalil Bouayadi , Patrick Brune , Hervé Prats , Christian Touriol
Inventor： Stéphanie Fallot , Abdelhakim Kharrat , Philippe Mondon , Khalil Bouayadi , Patrick Brune , Hervé Prats , Christian Touriol
CPC classification number: C12N15/10 , C12N15/1027
Abstract: This invention relates to an expression cassette for expressing polypeptides in eukaryotic cells using alternative splicing. The expression cassette comprises in 5′ to 3′ downstream direction: a promoter; a sequence transcribed in a 5′ untranslated region (5′UTR); a donor splice site; an intron; a first acceptor splice site; a first cistron encoding a first polypeptide; a second acceptor splice site; a second cistron encoding a second polypeptide; an internal ribosome entry site (IRES) operably linked to a selection marker; and a sequence transcribed in a 3″ untranslated region (3′UTR) including a polyadenylation signal, wherein the polyadenylation signal is unique.
Abstract translation: 本发明涉及使用选择性剪接在真核细胞中表达多肽的表达盒。 表达盒在下游方向5'到3'包括启动子; 在5'非翻译区（5'UTR）中转录的序列; 供体剪接部位; 内含子 第一受体剪接位点; 编码第一多肽的第一顺反子; 第二受体剪接位点; 编码第二多肽的第二顺反子; 与选择标记可操作地连接的内部核糖体进入位点（IRES）; 和在包含多聚腺苷酸化信号的3''非翻译区（3'UTR）中转录的序列，其中多聚腺苷酸化信号是唯一的。
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公开(公告)号：US20140378663A1
公开(公告)日：2014-12-25
申请号：US14128828
申请日：2012-06-25
Applicant: Alexandre Fontayne , Sylvie Jorieux , Celine Monnet-Mars , Philippe Mondon , Abdelhakim Kharrat , Khalil Bouayadi
Inventor： Alexandre Fontayne , Sylvie Jorieux , Celine Monnet-Mars , Philippe Mondon , Abdelhakim Kharrat , Khalil Bouayadi
CPC classification number: C07K16/28 , C07K16/2887 , C07K16/40 , C07K2317/31 , C07K2317/52 , C07K2317/71 , C07K2317/76
Abstract: A method for producing a variant of a parent polypeptide including a Fc region, which variant exhibits reduced binding to the protein C1q and to at least one receptor Fcgγ R as compared to the parent polypeptide.
Abstract translation: 用于产生包含Fc区的亲本多肽的变体的方法，所述变体与亲本多肽相比显示出降低的与蛋白质C1q的结合和至少一种受体FcγγR的结合。
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公开(公告)号：US08742074B2
公开(公告)日：2014-06-03
申请号：US13257502
申请日：2010-03-19
Applicant: Christian Behrens , Sylvie Jorieux , Abdelhakim Kharrat , Khalil Bouayadi , Philippe Mondon , Celine Monnet-Mars
Inventor： Christian Behrens , Sylvie Jorieux , Abdelhakim Kharrat , Khalil Bouayadi , Philippe Mondon , Celine Monnet-Mars
CPC classification number: C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/92
Abstract: A variant of a parent polypeptide including an Fc region, which variant exhibits increased binding to FcRn as compared to the parent polypeptide and includes at least one amino acid modification in the Fc region.
Abstract translation: 包含Fc区的亲本多肽的变体，与母体多肽相比，该变体表现出与FcRn的增加的结合，并且包括Fc区中的至少一个氨基酸修饰。
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