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公开(公告)号：US20140141019A1
公开(公告)日：2014-05-22
申请号：US14116562
申请日：2012-05-11
Applicant: Abdelhakim Kharrat , Olivier Dubreuil , Yassamine Lazrek , Philippe Mondon , Khalil Bouayadi , Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege A. Gaborit
Inventor： Abdelhakim Kharrat , Olivier Dubreuil , Yassamine Lazrek , Philippe Mondon , Khalil Bouayadi , Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege A. Gaborit
IPC: C07K16/28
CPC classification number: C07K16/2863 , C07K16/32 , C07K2317/21 , C07K2317/34 , C07K2317/76
Abstract: The invention relates to antibodies against HER3 and their use in the treatment of cancer.
Abstract translation: 本发明涉及针对HER3的抗体及其在治疗癌症中的用途。
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公开(公告)号：US09346883B2
公开(公告)日：2016-05-24
申请号：US14116562
申请日：2012-05-11
Applicant: Abdelhakim Kharrat , Olivier Dubreuil , Yassamine Lazrek , Philippe Mondon , Khalil Bouayadi , Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege A. Gaborit
Inventor： Abdelhakim Kharrat , Olivier Dubreuil , Yassamine Lazrek , Philippe Mondon , Khalil Bouayadi , Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege A. Gaborit
CPC classification number: C07K16/2863 , C07K16/32 , C07K2317/21 , C07K2317/34 , C07K2317/76
Abstract: The invention relates to antibodies against HER3 and their use in the treatment of cancer.
Abstract translation: 本发明涉及针对HER3的抗体及其在治疗癌症中的用途。
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公开(公告)号：US09127065B2
公开(公告)日：2015-09-08
申请号：US14118747
申请日：2012-05-21
Applicant: Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege Gaborit , Yassamine Lazrek
Inventor： Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege Gaborit , Yassamine Lazrek
IPC: A61K39/395 , C07K16/28 , C07K16/32
CPC classification number: C07K16/2863 , C07K16/32 , C07K2317/34 , C07K2317/76 , C07K2317/77 , C07K2317/92
Abstract: The present invention provides for isolated anti-human-HER3 antibodies or fragments thereof. More particularly the present invention provides an isolated monoclonal antibody that specifically binds to the extracellular domain of HER-3 and competes for binding to the extracellular domain of human HER-3 with the antibody produced obtainable from hybridoma deposited as CNCM-I-4486. The antibodies described in the present invention are useful for the treatment of cancer.
Abstract translation: 本发明提供分离的抗人HER3抗体或其片段。 更具体地说，本发明提供了一种分离的单克隆抗体，其特异性结合HER-3的细胞外结构域，并且与从作为CNCM-I-4486保藏的杂交瘤得到的抗体竞争结合人HER-3的细胞外结构域。 本发明中描述的抗体可用于治疗癌症。
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公开(公告)号：US20140112931A1
公开(公告)日：2014-04-24
申请号：US14118747
申请日：2012-05-21
Applicant: Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege Gaborit , Yassamine Lazrek
Inventor： Thierry Chardes , Andre Pelegrin , Christel Larbouret , Nadege Gaborit , Yassamine Lazrek
IPC: C07K16/28
CPC classification number: C07K16/2863 , C07K16/32 , C07K2317/34 , C07K2317/76 , C07K2317/77 , C07K2317/92
Abstract: The present invention provides for isolated anti-human-HER3 antibodies or fragments thereof. More particularly the present invention provides an isolated monoclonal antibody that specifically binds to the extracellular domain of HER-3 and competes for binding to the extracellular domain of human HER-3 with the antibody produced obtainable from hybridoma deposited as CNCM-I-4486. The antibodies described in the present invention are useful for the treatment of cancer.
Abstract translation: 本发明提供分离的抗人HER3抗体或其片段。 更具体地说，本发明提供了一种分离的单克隆抗体，其特异性结合HER-3的细胞外结构域，并且与从作为CNCM-I-4486保藏的杂交瘤得到的抗体竞争结合人HER-3的细胞外结构域。 本发明中描述的抗体可用于治疗癌症。
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