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    Method for Measuring Bacterial Growth and Antibiotic Resistance using Suspended Microchannel Resonators
    1.
    发明申请
    Method for Measuring Bacterial Growth and Antibiotic Resistance using Suspended Microchannel Resonators 审中-公开
    使用悬浮微通道谐振器测量细菌生长和抗生素抗性的方法

    公开(公告)号：US20120174657A1

    公开(公告)日：2012-07-12

    申请号：US13348809

    申请日：2012-01-12

    申请人： Kenneth Babcock ,  Scott R. Manalis

    发明人： Kenneth Babcock ,  Scott R. Manalis

    IPC分类号： G01N29/00

    CPC分类号： G01N29/036 ,  G01N29/022 ,  G01N2291/0256 ,  G01N2291/0427

    摘要： Methods for improving measurements of bacterial growth, such as mass, in Suspended Microchannel Resonators (SMR's). Methods include techniques to provide for bacterial growth over time in response to changing fluid environment to aid in determining parameters such as drug resistance and drug susceptibility. In particular the methods include trapping multiple bacteria in the SMR for a time period and varying the fluid to include sequences of nutrients and antibiotics, and measuring the rate of mass change of the bacteria in response to the changes in fluid composition.

    摘要翻译： 用于改善悬浮微通道谐振器（SMR）中细菌生长测量的方法，如质量。 方法包括随着时间的推移提供细菌生长以响应于改变的流体环境以帮助确定诸如耐药性和药物敏感性的参数的技术。 特别地，所述方法包括在SMR中捕获多种细菌一段时间并且改变流体以包括营养物和抗生素的序列，以及响应于流体组成的变化来测量细菌的质量变化速率。

    Method for measuring bacterial growth and antibiotic resistance using suspended microchannel resonators
    2.
    发明授权
    Method for measuring bacterial growth and antibiotic resistance using suspended microchannel resonators 有权
    使用悬浮微通道谐振器测量细菌生长和抗生素抗性的方法

    公开(公告)号：US09581569B2

    公开(公告)日：2017-02-28

    申请号：US13348809

    申请日：2012-01-12

    申请人： Kenneth Babcock ,  Scott R. Manalis

    发明人： Kenneth Babcock ,  Scott R. Manalis

    IPC分类号： G01N29/036 ,  G01N29/02

    CPC分类号： G01N29/036 ,  G01N29/022 ,  G01N2291/0256 ,  G01N2291/0427

    摘要： Methods for improving measurements of bacterial growth, such as mass, in Suspended Microchannel Resonators (SMR's). Methods include techniques to provide for bacterial growth over time in response to changing fluid environment to aid in determining parameters such as drug resistance and drug susceptibility. In particular the methods include trapping multiple bacteria in the SMR for a time period and varying the fluid to include sequences of nutrients and antibiotics, and measuring the rate of mass change of the bacteria in response to the changes in fluid composition.

    摘要翻译： 用于改善悬浮微通道谐振器（SMR）中细菌生长测量的方法，如质量。 方法包括随着时间的推移提供细菌生长以响应于改变的流体环境以帮助确定诸如耐药性和药物敏感性的参数的技术。 特别地，所述方法包括在SMR中捕获多种细菌一段时间并且改变流体以包括营养物和抗生素的序列，以及响应于流体组成的变化来测量细菌的质量变化速率。

    Method for making nitride cantilevers devices
    4.
    发明授权
    Method for making nitride cantilevers devices 失效
    制造氮化物悬臂装置的方法

    公开(公告)号：US6156216A

    公开(公告)日：2000-12-05

    申请号：US152746

    申请日：1998-09-14

    申请人： Scott R. Manalis ,  Stephen C. Minne ,  Calvin F. Quate

    发明人： Scott R. Manalis ,  Stephen C. Minne ,  Calvin F. Quate

    IPC分类号： C25F3/00 ,  G01N27/24 ,  G01Q10/00 ,  G01Q30/14 ,  G01Q70/16 ,  G01R31/308 ,  B44C1/22

    CPC分类号： G01N27/24 ,  B82Y35/00 ,  G01Q70/14 ,  G01Q70/16

    摘要： A method for making a silicon stylus protruding through a nitride layer is used to fabricate nitride micro-apertures, silicon styluses supported by nitride cantilever arms and charge sensitive silicon styluses supported by nitride cantilever arms. The method uses an anisotropic dry etch to define the apertures of the nitride micro-apertures and the apexes of the silicon styluses. Nitride apertures made by this method are useful for supporting micro-electronics and micro-optical devices. Surface probing devices with silicon styluses supported by nitride cantilever arms have applications in AFM and STM and are particularly useful in applications that require an electrical connection between the silicon stylus and external circuitry through the cantilever arm.

    摘要翻译： 用于制造穿过氮化物层的硅触针的方法用于制造氮化物微孔，由氮化物悬臂支撑的硅触针和由氮化物悬臂支撑的电荷敏感硅探针。 该方法使用各向异性干蚀刻来限定氮化硅微孔和硅探针的顶点的孔。 通过该方法制造的氮化物孔径对于支持微电子和微型光学器件是有用的。 具有由氮化物悬臂支撑的硅触针的表面探测装置在AFM和STM中具有应用，并且在需要通过悬臂的硅触针和外部电路之间的电连接的应用中特别有用。

    Scanning probe potentiometer
    5.
    发明授权
    Scanning probe potentiometer 失效
    扫描探头电位器

    公开(公告)号：US6002131A

    公开(公告)日：1999-12-14

    申请号：US47887

    申请日：1998-03-25

    申请人： Scott R. Manalis ,  Stephen C. Minne ,  Calvin F. Quate

    发明人： Scott R. Manalis ,  Stephen C. Minne ,  Calvin F. Quate

    IPC分类号： C25F3/00 ,  G01N27/24 ,  G01Q10/00 ,  G01Q30/14 ,  G01Q70/16 ,  G01R31/308 ,  G01R29/12

    CPC分类号： G01Q60/60 ,  G01N27/24 ,  B82Y35/00 ,  Y10S977/854

    摘要： A system for scanning and measuring a surface charge of a sample immersed in a conductive medium, such as an aqueous electrolytic solution or a gel, or positioned on a conducting plate. The system has a semiconductor with a probing surface clad in a charge-sensitive layer. The probing surface moves over the sample during scanning while a bias voltage V.sub.BIAS is applied to create a depletion layer in the semiconductor and to induce the system to alter a measurable electrical property. The electrical property is monitored with the aid of a measuring device and the measurement is correlated to the sample's surface charge. In a preferred embodiment the semiconductor is a part of a cantilever structure of the type having a probing tip and the probing surface is located on the apex of the probing tip thereby enabling examination of the topology and surface charge of the sample concurrently.

    摘要翻译： 一种用于扫描和测量浸渍在诸如电解质水溶液或凝胶的导电介质中的样品的表面电荷或定位在导电板上的系统。 该系统具有包含在电荷敏感层中的探测表面的半导体。 探测表面在扫描期间移动到样品上方，同时施加偏置电压VBIAS以在半导体中产生耗尽层并诱导系统改变可测量的电性能。 借助于测量装置监测电气特性，测量与样品的表面电荷相关。 在优选实施例中，半导体是具有探测尖端的类型的悬臂结构的一部分，并且探测表面位于探测尖端的顶点上，从而能够同时检查样品的拓扑和表面电荷。

    Direct DNA sequencing with a transcription protein and a nanometer scale electrometer
    9.
    发明授权
    Direct DNA sequencing with a transcription protein and a nanometer scale electrometer 失效
    用转录蛋白和纳米级静电计进行直接DNA测序

    公开(公告)号：US06770472B2

    公开(公告)日：2004-08-03

    申请号：US09993338

    申请日：2001-11-13

    申请人： Scott R. Manalis ,  Stephen C. Minne ,  Calvin F. Quate

    发明人： Scott R. Manalis ,  Stephen C. Minne ,  Calvin F. Quate

    IPC分类号： C12M134

    CPC分类号： C12Q1/6869 ,  C12Q2565/607 ,  C12Q2521/543 ,  C12Q2521/119

    摘要： The present invention provides an apparatus and method for nucleotide or DNA sequencing by monitoring the molecular charge configuration as the DNA moves through a protein that is capable of transcribing the DNA. The apparatus and method provides a nanoscale electrometer that immobilizes the protein. The protein receives the DNA and transcribes the DNA. The nanoscale electrometer is a sensitive device that is capable of sensing and measuring the electronic charge that is released during the transcription process. The apparatus and method of the present invention further provides monitoring means that are attached to the nanoscale electrometer to monitor the electronic charge configuration as the DNA moves through the protein. Once the electronic charge configuration is established, a correlation is computed, using computing means, between the electronic charge configuration and a nucleotide signature of the DNA.

    摘要翻译： 本发明提供了一种用于核苷酸或DNA测序的装置和方法，该装置和方法通过在DNA通过能够转录DNA的蛋白质移动时监测分子电荷构型。 该装置和方法提供固定蛋白质的纳米级静电计。 蛋白质接受DNA并转录DNA。 纳米级静电计是能够感测和测量在转录过程中释放的电子电荷的敏感器件。 本发明的装置和方法还提供了监测装置，其连接到纳米级静电计，以在DNA通过蛋白质移动时监测电子电荷构型。 一旦建立了电子充电配置，就使用计算装置在电子电荷配置和DNA的核苷酸特征之间计算相关性。

    Bimorph spirals for uncooled photothermal spectroscopy
    10.
    发明授权
    Bimorph spirals for uncooled photothermal spectroscopy 失效
    双相双螺旋线用于未冷却的光热光谱

    公开(公告)号：US06307202B1

    公开(公告)日：2001-10-23

    申请号：US09332540

    申请日：1999-06-14

    申请人： Scott R. Manalis ,  Stephen C. Minne ,  Calvin F. Quate

    发明人： Scott R. Manalis ,  Stephen C. Minne ,  Calvin F. Quate

    IPC分类号： G01J510

    CPC分类号： G01J5/40

    摘要： A bimorph spiral which exhibits a shape-altering response to thermal radiation and is dimensioned to have a focussing effect on light, such as a visible light, by acting as a quasi-Fresnel element. The focussing effect varies as the shape of the bimorph spiral changes due to absorption of thermal radiation. An array of such bimorph spirals can be used for efficient, high-resolution and rapid uncooled photothermal spectroscopy.

    摘要翻译： 具有对热辐射形状改变的响应的双压电晶片螺旋，并且通过充当准菲涅尔元件的尺寸设计成具有对光（例如可见光）的聚焦效应。 聚焦效应随着双压电晶片的形状由于热辐射的吸收而变化。 这种双压电晶片阵列可用于高效，高分辨率和快速非冷却光热光谱。