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公开(公告)号：US09165740B2
公开(公告)日：2015-10-20
申请号：US14450884
申请日：2014-08-04
发明人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson
IPC分类号： H01J49/10 , H01J49/04 , H01J49/26 , F23D11/32 , H01J27/02 , G01R31/28 , H01J49/16 , C12Q1/68 , G01N23/00
CPC分类号： H01J49/165 , C12Q1/6872 , G01N23/00 , G01R31/2812 , G01R31/2848 , G01R31/2853 , H01J27/02 , H01J49/0422 , H01J49/0431 , H01J49/0468
摘要： The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.
摘要翻译： 本发明一般涉及样品离子化，并且提供电离探针组件，系统，计算机程序产品和用于此目的的方法。
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公开(公告)号：US09752184B2
公开(公告)日：2017-09-05
申请号：US14456806
申请日：2014-08-11
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill K. White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
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公开(公告)号：US09752173B2
公开(公告)日：2017-09-05
申请号：US14754262
申请日：2015-06-29
CPC分类号： C12P19/34 , C07K14/4703 , C07K14/5406 , C12Q1/686 , C12Q2521/131 , C12Q2525/161 , C12Q2527/125 , C12Q2565/627
摘要： The present invention realtes to systems and methods for amplifying nucleic acid. In particular, systems and methods are provided for inhibiting polymerase based terminal transferase activity within a polynucleotide amplification setting (e.g., polymerase chain reaction). In addition, systems and methods are provided for generating amplified products generated with polynucleotide amplification techniques having reduced 3′ non-templated nucleotide addition.
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公开(公告)号：US09725771B2
公开(公告)日：2017-08-08
申请号：US14473603
申请日：2014-08-29
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Raymond Ranken , Thomas A. Hall
CPC分类号： C12Q1/689 , C12Q1/6872 , C12Q1/70 , C12Q1/701 , C12Q2600/16 , G01N1/30 , G01N21/64 , G01N23/00 , G06F19/20
摘要： The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
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公开(公告)号：US09097711B2
公开(公告)日：2015-08-04
申请号：US14102206
申请日：2013-12-10
IPC分类号： G01N27/26 , C12M1/00 , C12Q1/00 , C12Q1/68 , C12M1/34 , G01N27/00 , G01N21/00 , G01N33/543 , G01N27/327 , B01L3/00 , G01N35/00
CPC分类号： G01N33/5302 , B01L3/502715 , G01N27/26 , G01N27/3273 , G01N33/54306 , G01N2035/00158
摘要： Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to methods for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to methods employing an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.
摘要翻译： 本文提供了涉及测试生物样品的技术，特别地但并非排他地涉及用于以一次性一次性格式对样品进行多个同时实时测定的方法。 例如，该技术涉及采用例如用于点护理诊断的装置的方法，包括在事故现场，急诊室，手术中，重症监护室以及非医疗中使用 应用程序。
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公开(公告)号：US09970061B2
公开(公告)日：2018-05-15
申请号：US14369618
申请日：2012-12-27
发明人： David J. Ecker , Steven A. Hofstadler , Rangarajan Sampath , Lawrence B. Blyn , Thomas A. Hall , Mark W. Eshoo
CPC分类号： C12Q1/689 , C12Q1/6853 , C12Q1/686 , C12Q2600/158
摘要： The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.
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7.发明申请公开(公告)号：US20150024398A1
公开(公告)日：2015-01-22
申请号：US14237251
申请日：2012-08-03
申请人： Nina M. Hofstadler
CPC分类号： C12Q1/686 , C12Q1/6872 , C12Q1/6876 , C12Q1/689 , C12Q1/6895 , C12Q1/701 , C12Q2600/156 , C12Q2521/531 , C12Q2525/185 , C12Q2565/627
摘要： The present invention relates generally to methods of determining base compositions for PCR products (e.g., RT PCR products, (rt) RT-PCR products, etc.). In particular, the present invention provides base-composition determination of PCR products containing up to five different nucleobases (e.g., A, C, G, T, U) and/or significant levels of non-templated adenylation.
摘要翻译： 本发明一般涉及确定PCR产物的碱性组合物的方法（例如，RT PCR产物，（rt）RT-PCR产物等）。 特别地，本发明提供含有多达五个不同核碱基（例如A，C，G，T，U）和/或显着水平的非模板腺苷酸化的PCR产物的碱基组成测定。
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8.发明申请公开(公告)号：US20140227704A1
公开(公告)日：2014-08-14
申请号：US14047414
申请日：2013-10-07
申请人： Nina M. Hofstadler
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6872 , C12Q1/6827 , C12Q1/6844 , C12Q1/6858 , C12Q1/6881 , C12Q2600/156 , C12Q2600/16 , C12Q2565/627 , C12Q2537/143 , C12Q2531/113 , C12Q2545/10
摘要： There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass measurement of resulting amplification products by mass spectrometry, and determination of the base compositions of the amplification products.
摘要翻译： 需要具有特异性和快速性的核酸分析，并且其中不需要核酸测序。 本发明除了提供核酸扩增核酸扩增方法之外，还通过质谱法对所得扩增产物进行分子量测定，以及确定扩增产物的碱基组成来解决这一需要。
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公开(公告)号：US10662485B2
公开(公告)日：2020-05-26
申请号：US15952912
申请日：2018-04-13
发明人： David J. Ecker , Steven A. Hofstadler , Rangarajan Sampath , Lawrence B. Blyn , Thomas A. Hall , Mark W. Eshoo
IPC分类号： C07H21/04 , C12Q1/68 , C12Q1/689 , C12Q1/6853 , C12Q1/686
摘要： The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.
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公开(公告)号：US20170044630A1
公开(公告)日：2017-02-16
申请号：US15237261
申请日：2016-08-15
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Raymond Ranken , Thomas A. Hall
CPC分类号： C12Q1/689 , C12Q1/6872 , C12Q1/70 , C12Q1/701 , C12Q2600/16 , G01N1/30 , G01N21/64 , G01N23/00 , G16B25/00
摘要： The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
摘要翻译： 本发明提供了以下方法：鉴定来自人和动物的生物样品中的病原体，解决从人和动物获得的样品中存在的多种病原体，确定关于这种病原体或病原体的详细遗传信息，以及快速检测和鉴定生物代谢 来自环境，临床或其他样品。
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