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30 条记录 (耗时 0.027 秒)

    Stabilized polyhydroxybutadiene compounds
    3.
    发明授权
    Stabilized polyhydroxybutadiene compounds 失效
    稳定的聚羟基丁二烯化合物

    公开(公告)号：US4593128A

    公开(公告)日：1986-06-03

    申请号：US648844

    申请日：1984-09-07

    申请人： Harry R. Hinney ,  John R. Murphy

    发明人： Harry R. Hinney ,  John R. Murphy

    IPC分类号： C08G18/69 ,  C08K5/49 ,  C08K5/50 ,  C08L7/00 ,  C08L9/00 ,  C08L21/00 ,  C07C29/64

    CPC分类号： C08K5/50 ,  C08G18/69

    摘要： Polyhydroxybutadiene compounds are storage stabilized against reactivity changes by incorporating therein an effective amount of a di or triphenyl phosphine compound of the formula ##STR1## wherein each x is hydrogen, a halogen or an alkyl or alkoxy group having from 1 to 10 carbon atoms and y is an alkyl group having from 1 to 10 carbon atoms or an aryl group which may be substituted with a halogen or an alkyl or alkoxy group having from 1 to 10 carbon atoms.

    摘要翻译： 聚羟基丁二烯化合物通过在其中加入有效量的式（II）的二价或三苯基膦化合物，其中每个x是氢，卤素或具有1至10个碳原子的烷基或烷氧基和y 是具有1至10个碳原子的烷基或可以被卤素或具有1至10个碳原子的烷基或烷氧基取代的芳基。

    Hydraulic motor with air distributor-operated valves
    5.
    发明授权
    Hydraulic motor with air distributor-operated valves 失效
    液压马达与空气分配器操作阀

    公开(公告)号：US4110981A

    公开(公告)日：1978-09-05

    申请号：US825462

    申请日：1977-08-17

    申请人： John R. Murphy

    发明人： John R. Murphy

    IPC分类号： B60K3/02 ,  F03C1/02 ,  F16H43/00 ,  F15B11/20

    CPC分类号： F16H43/00 ,  B60K3/02 ,  F03C1/02

    摘要： An oil-operated motor driven from an air-pressurized oil supply tank. The motor has sets of opposing cylinders having oil admission valves and containing drive pistons connected to a crankshaft. The cylinders are connected to the pressurized supply tank through the admission valves and respective ones of a pair of compressed air-controlled pilot valves. The pilot valves are controlled by relay valves alternately opened by a rotating cam driven by the crankshaft. The pilot valves control the delivery of pressurized oil to cylinders arranged to be alternately supplied with pressurized oil, with their pistons acting to drive the crankshaft in a common direction by alternate power pulsations. A common compressed air supply is employed to pressurize the oil reservoir and to operate the pilot valves. The exhaust oil from the motor is returned to the oil reservoir by a hydraulic pump driven by the main oil-operated motor.

    Viral/bacterial toxin polypeptides and methods of using same
    6.
    发明授权
    Viral/bacterial toxin polypeptides and methods of using same 有权
    病毒/细菌毒素多肽及其使用方法

    公开(公告)号：US08841253B2

    公开(公告)日：2014-09-23

    申请号：US12065066

    申请日：2006-08-30

    申请人： John R. Murphy ,  Ryan Ratts

    发明人： John R. Murphy ,  Ryan Ratts

    IPC分类号： A61K38/08

    CPC分类号： G01N33/5076 ,  A61K38/08 ,  C07K14/34 ,  C07K14/55 ,  C07K2319/55 ,  G01N33/5011 ,  G01N33/5035 ,  G01N2510/00

    摘要： The invention features methods for identifying compounds that inhibit cell death, and methods for identifying compounds that promote cell death, by blocking or accelerating, respectively, the translocation of the catalytic domain of toxins or transcription factors through the endosomal membrane into the cytosol of a cell. Also featured are methods for inhibiting cell death that include the administration of polypeptides that include a toxin consensus sequence recognized by one or more components of the cytosolic translocation factor complex.

    摘要翻译： 本发明的特征在于鉴定抑制细胞死亡的化合物的方法，以及用于鉴定促进细胞死亡的化合物的方法，分别通过阻断或加速毒素或转录因子的催化结构域通过内体膜进入细胞的细胞溶质 。 还特征在于抑制细胞死亡的方法，其包括施用包含由细胞溶质易位因子复合物的一种或多种组分识别的毒素共有序列的多肽。

    Novel Compositions and Methods for Promoting, Inhibiting and Detecting Protein Entry Into Cells
    7.
    发明申请
    Novel Compositions and Methods for Promoting, Inhibiting and Detecting Protein Entry Into Cells 有权
    促进，抑制和检测蛋白质进入细胞的新型组合物和方法

    公开(公告)号：US20080306003A1

    公开(公告)日：2008-12-11

    申请号：US12065066

    申请日：2006-08-30

    申请人： John R. Murphy ,  Ryan Ratts

    发明人： John R. Murphy ,  Ryan Ratts

    IPC分类号： A61K38/08 ,  C07K14/00 ,  C07K7/06 ,  C07K7/08 ,  A61K38/16 ,  C12Q1/02 ,  C12Q1/37

    CPC分类号： G01N33/5076 ,  A61K38/08 ,  C07K14/34 ,  C07K14/55 ,  C07K2319/55 ,  G01N33/5011 ,  G01N33/5035 ,  G01N2510/00

    摘要： The invention features methods for identifying compounds that inhibit cell death, and methods for identifying compounds that promote cell death, by blocking or accelerating, respectively, the translocation of the catalytic domain of toxins or transcription factors through the endosomal membrane into the cytosol of a cell. Also featured are methods for inhibiting cell death that include the administration of polypeptides that include a toxin consensus sequence recognized by one or more components of the cytosolic translocation factor complex.

    摘要翻译： 本发明的特征在于鉴定抑制细胞死亡的化合物的方法，以及用于鉴定促进细胞死亡的化合物的方法，分别通过阻断或加速毒素或转录因子的催化结构域通过内体膜进入细胞的细胞溶质 。 还特征在于抑制细胞死亡的方法，其包括施用包含由细胞溶质易位因子复合物的一种或多种组分识别的毒素共有序列的多肽。

    Hybrid molecules having translocation region and cell-binding region
    8.
    发明授权
    Hybrid molecules having translocation region and cell-binding region 失效
    具有易位区和细胞结合区的杂交分子

    公开(公告)号：US6022950A

    公开(公告)日：2000-02-08

    申请号：US479510

    申请日：1995-06-07

    申请人： John R. Murphy

    发明人： John R. Murphy

    IPC分类号： C07K14/16 ,  C07K14/18 ,  C07K14/245 ,  C07K14/25 ,  C07K14/28 ,  C07K14/34 ,  C07K14/415 ,  C07K14/55 ,  C07K14/575 ,  C12N1/21 ,  C12N9/02 ,  C12N9/24 ,  C12N15/12 ,  C07K14/00 ,  C07K14/485 ,  C07K16/28

    CPC分类号： C07K14/005 ,  C07K14/245 ,  C07K14/25 ,  C07K14/28 ,  C07K14/34 ,  C07K14/415 ,  C07K14/55 ,  C07K14/575 ,  C12N9/0071 ,  C12Y114/16001 ,  C12Y302/0102 ,  C12Y302/01052 ,  C07K2319/00 ,  C07K2319/55 ,  C07K2319/75 ,  C12N2740/16022

    摘要： Disclosed is a hybrid molecule comprising a first part, a second part, and a third part connected by covalent bonds,(a) wherein said first part comprises a portion of the binding domain of a cell-binding polypeptide ligand effective to cause said hybrid protein to bind to a cell of an animal;(b) wherein said second part comprises a portion of a translocation domain of naturally occurring protein which translocates said third part across the cytoplasmic membrane into the cytosol of the cell; and(c) wherein said third part comprises a chemical entity to be introduced into the cell, wherein each of said first part and said third part is non-native with respect to said naturally occurring protein, and further wherein said covalent bond connecting said second part and said third part is a cleavable bond, provided that when said second part comprises a portion of a translocation domain of Pseudomonas exotoxin, said third part is not a polypeptide.

    摘要翻译： 公开了包含通过共价键连接的第一部分，第二部分和第三部分的杂化分子，（a）其中所述第一部分包含有效引起所述杂交蛋白的细胞结合多肽配体的结合结构域的一部分 结合动物细胞; （b）其中所述第二部分包含天然存在的蛋白质的易位结构域的一部分，其将所述第三部分穿过细胞质膜转移到细胞的细胞质中; 和（c）其中所述第三部分包括要引入细胞的化学实体，其中所述第一部分和所述第三部分中的每一个相对于所述天然存在的蛋白质是非天然的，并且其中所述共价键连接所述第二部分 部分和所述第三部分是可切割的键，条件是当所述第二部分包含假单胞菌外毒素的易位结构域的一部分时，所述第三部分不是多肽。