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公开(公告)号：US12194432B2
公开(公告)日：2025-01-14
申请号：US18307991
申请日：2023-04-27
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Christopher Belisle , Hong Chen , Yueping Xu , Jiali Liao , Xuemei He
Abstract: Chromatography resins having mixed mode ligands and methods of using such resins are provided.
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公开(公告)号：US09309282B2
公开(公告)日：2016-04-12
申请号：US13654574
申请日：2012-10-18
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jiali Liao , Lee Olech , Hong Chen , Xuemei He , Russell Frost
CPC classification number: B01J39/26 , C07K1/165 , C07K1/22 , C07K16/065
Abstract: Proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of no more than three atoms between the hydrophobic group and the support matrix.
Abstract translation: 蛋白质通过将配体与阳离子交换和疏水功能连接到大孔载体基质形成的混合模式色谱系统来纯化，配体和载体基质之间的唯一连接是具有不超过三个 疏水基团和载体基质之间的原子。
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公开(公告)号：US11666888B2
公开(公告)日：2023-06-06
申请号：US16967429
申请日：2019-02-05
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Christopher Belisle , Hong Chen , Yueping Xu , Jiali Liao , Xuemei He
CPC classification number: B01J20/262 , B01D15/363 , B01J20/289 , B01J20/3208 , B01J20/3219 , B01J20/3227 , B01J20/3248 , B01J20/3253 , B01J20/3285 , C07K16/065 , B01D15/327 , B01D15/3847
Abstract: Chromatography resins having mixed mode ligands and methods of using such resins are provided.
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公开(公告)号：US10792654B2
公开(公告)日：2020-10-06
申请号：US15063235
申请日：2016-03-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jiali Liao , Lee Olech , Hong Chen , Xuemei He , Russell Frost
Abstract: Proteins are purified by a mixed-mode chromatography system formed by attaching a ligand comprising benzamidoacetic acid to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of no more than three atoms between a phenyl ring and the support matrix.
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公开(公告)号：US20130102761A1
公开(公告)日：2013-04-25
申请号：US13654574
申请日：2012-10-18
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jiali Liao , Lee Olech , Hong Chen , Xuemei He , Russell Frost
IPC: C07K1/22 , C08F271/02 , C07K16/00
CPC classification number: B01J39/26 , C07K1/165 , C07K1/22 , C07K16/065
Abstract: Proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of no more than three atoms between the hydrophobic group and the support matrix.
Abstract translation: 蛋白质通过将配体与阳离子交换和疏水功能连接到大孔载体基质形成的混合模式色谱系统来纯化，配体和载体基质之间的唯一连接是具有不超过三个 疏水基团和载体基质之间的原子。
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Patent Agency Ranking
6.发明授权公开(公告)号：US12263467B2
公开(公告)日：2025-04-01
申请号：US18360870
申请日：2023-07-28
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Christopher Belisle , Jiali Liao , Edwin Lozano
IPC: B01J20/28 , B01D15/38 , B01J20/285 , B01J20/289 , B01J20/30 , C07K1/16
Abstract: The subject invention pertains to proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic 1,3-dioxoisoindolin-2-yl group functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of one, two, three, four, or five atoms between the hydrophobic group and the support matrix.
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公开(公告)号：US10814305B2
公开(公告)日：2020-10-27
申请号：US15714368
申请日：2017-09-25
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Jiali Liao , Christopher Belisle
IPC: B01D15/38 , B01J20/04 , B01J20/24 , B01J20/28 , B01J20/285 , C07K1/16 , C07K1/18 , C07K1/22 , C07K1/36 , C07K14/435 , C07K16/00 , C07K16/06
Abstract: Polymer-filled ceramic apatites and their uses are provided.
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公开(公告)号：US10682640B2
公开(公告)日：2020-06-16
申请号：US15581569
申请日：2017-04-28
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jiali Liao , Russell Frost
IPC: B01J41/20 , C07K1/16 , B01J20/22 , B01D15/30 , B01J20/281 , B01D15/26 , C07K1/14 , B01D15/32 , B01D15/36 , B01D15/38 , B01J20/286 , B01J20/289 , B01J20/32 , B01J41/09 , B01J20/26 , B01J20/28 , B01J20/288 , B01J41/04 , C07K16/00
Abstract: Solid supports and ligands are provided for purification of biomolecules by mixed-mode anion exchange-hydrophobic chromatography. Compositions can have the formula Support-(X)—N(R1, R2)-R3-L-Ar, or a salt thereof, wherein: Support is a chromatographic solid support; X is a spacer or absent; R1 and R2 are each selected from hydrogen and an alkyl comprising 1-6 carbons; R3 is an alkyl comprising 1-6 carbons or a cyclo alkyl comprising 1-6 carbons; L is NR4, O, or S; wherein R4 is hydrogen or an alkyl comprising 1-6 carbons; and Ar is an aryl. Methods are also provided for using solid supports and ligands to purify biomolecules such as monomeric antibodies.
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公开(公告)号：US20150258539A1
公开(公告)日：2015-09-17
申请号：US14657701
申请日：2015-03-13
Inventor： Steven Cramer , James Woo , Hong Chen , Jiali Liao , Russell Frost
Abstract: Mixed mode ligands, as well their use for purifying proteins, are provided.
Abstract translation: 提供了混合模式配体，以及它们用于纯化蛋白质的用途。
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公开(公告)号：US11905335B2
公开(公告)日：2024-02-20
申请号：US17165704
申请日：2021-02-02
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jiali Liao , Tom Berkelman
CPC classification number: C07K19/00 , A61K47/6929 , B01D15/34 , B01D15/3809 , B01D15/3847 , C07K1/16 , C07K16/00
Abstract: Methods and kits for purifying protein-nanoparticle conjugates are provided. In some embodiments, a multimodal medium having a size exclusion mode and a capture mode is used to purify the protein-nanoparticle conjugates.
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