公开(公告)号：US11905335B2

公开(公告)日：2024-02-20

申请号：US17165704

申请日：2021-02-02

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Jiali Liao ,  Tom Berkelman

IPC: C07K19/00 ,  A61K47/69 ,  B01D15/34 ,  B01D15/38 ,  C07K1/16 ,  C07K16/00

CPC classification number: C07K19/00 ,  A61K47/6929 ,  B01D15/34 ,  B01D15/3809 ,  B01D15/3847 ,  C07K1/16 ,  C07K16/00

Abstract: Methods and kits for purifying protein-nanoparticle conjugates are provided. In some embodiments, a multimodal medium having a size exclusion mode and a capture mode is used to purify the protein-nanoparticle conjugates.

公开(公告)号：US10934366B2

公开(公告)日：2021-03-02

申请号：US15714736

申请日：2017-09-25

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： Jiali Liao ,  Tom Berkelman

IPC: C07K16/00 ,  C07K19/00 ,  A61K47/69 ,  B01D15/34 ,  B01D15/38 ,  C07K1/16

Abstract: Methods and kits for purifying protein-nanoparticle conjugates are provided. In some embodiments, a multimodal medium having a size exclusion mode and a capture mode is used to purify the protein-nanoparticle conjugates.

公开(公告)号：US20150377869A1

公开(公告)日：2015-12-31

申请号：US14749022

申请日：2015-06-24

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Tom Berkelman ,  Jiali Liao

IPC: G01N33/533 ,  C07K1/34 ,  G01N33/58 ,  C07K16/00

CPC classification number: G01N33/533 ,  A61K47/6929 ,  C07K1/34 ,  C07K16/00 ,  G01N33/54346

Abstract: Methods of purifying antibody-nanoparticle conjugates with size exclusion chromatography are provided.

Abstract translation: 提供了具有尺寸排阻色谱法纯化抗体 - 纳米颗粒缀合物的方法。

公开(公告)号：US10048270B2

公开(公告)日：2018-08-14

申请号：US15036387

申请日：2014-11-12

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Tom Berkelman

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/68 ,  G01N1/30 ,  G01N33/15 ,  G06T7/33

Abstract: Methods and compositions are provided for validating immunological detection reagents for use in detecting contaminating host cell components in a biological preparation.

公开(公告)号：US20160291033A1

公开(公告)日：2016-10-06

申请号：US15036387

申请日：2014-11-12

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： Tom Berkelman

IPC: G01N33/68 ,  G01N33/15 ,  G06T7/00 ,  G01N1/30

CPC classification number: G01N33/6842 ,  G01N1/30 ,  G01N33/15 ,  G01N33/6803 ,  G01N2001/302 ,  G06T7/337

Abstract: Methods and compositions are provided for validating immunological detection reagents for use in detecting contaminating host cell components in a biological preparation.

Abstract translation: 提供了用于验证用于检测生物制剂中的污染宿主细胞成分的免疫检测试剂的方法和组合物。