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    TURKEY VIRAL HEPATITIS VIRUS AND USES THEREOF
    2.
    发明申请
    TURKEY VIRAL HEPATITIS VIRUS AND USES THEREOF 审中-公开
    土耳其病毒性肝炎病毒及其用途

    公开(公告)号：US20130071421A1

    公开(公告)日：2013-03-21

    申请号：US13499871

    申请日：2010-10-04

    申请人： W. Ian Lipkin ,  Thomas Briese ,  Kirsi Honkavuori ,  H.L. Shivaprasad

    发明人： W. Ian Lipkin ,  Thomas Briese ,  Kirsi Honkavuori ,  H.L. Shivaprasad

    IPC分类号： A61K39/29 ,  G01N33/576 ,  A61K31/7088 ,  C12Q1/70

    CPC分类号： A61K39/29 ,  A61K31/7088 ,  C12Q1/706 ,  C12Q1/707 ,  G01N33/5767

    摘要： Isolated a Turkey Viral Hepatitis picomavirus-like viruses associated with Turkey viral hepatitis, and isolated nucleic acid sequences and polypeptides are disclosed. Antibodies against antigens from Turkey Viral Hepatitis picornavirus-like viruses, iRNAs which target nucleic acid sequences of the Turkey Viral Hepatitis picornavirus-like virus, methods for detecting the presence or absence of Turkey Viral Hepatitis picomavirus-like viruses in an animal, and immunogenic compositions for inducing an immune response against Turkey Viral Hepatitis picomavirus-like viruses in an animal are also disclosed.

    摘要翻译： 分离出一种土耳其与土耳其病毒性肝炎相关的病毒性肝炎皮损病毒样病毒，以及分离的核酸序列和多肽。 针对来自土耳其的抗原的抗体病毒性肝炎微小RNA病毒样病毒，靶向土耳其病毒性小RNA病毒样病毒的核酸序列的iRNA，用于检测动物中存在或不存在土耳其病毒性肝炎皮损病毒样病毒的方法和免疫原性组合物 用于诱导针对土耳其的免疫应答也公开了动物中的病毒性乙型皮炎病毒样病毒。

    PICORNAVIRUS AND USES THEREOF
    3.
    发明申请
    PICORNAVIRUS AND USES THEREOF 审中-公开
    PICORNAVIRUS及其用途

    公开(公告)号：US20090275636A1

    公开(公告)日：2009-11-05

    申请号：US12364301

    申请日：2009-02-02

    申请人： Thomas Briese ,  Gustavo Palacios ,  W. Ian Lipkin ,  Daryl Lamson

    发明人： Thomas Briese ,  Gustavo Palacios ,  W. Ian Lipkin ,  Daryl Lamson

    IPC分类号： A61K31/7105 ,  C12N15/11 ,  C07K14/00 ,  C07K16/00 ,  C12Q1/70

    CPC分类号： C12N7/00 ,  A61K39/00 ,  C07K14/005 ,  C12N2770/32721 ,  C12N2770/32722 ,  G01N2333/085

    摘要： The invention is directed to a a clade of newly isolated and identified picornaviruses associated with respiratory infection, and isolated nucleic acids sequences and peptides thereof. The invention also relates to antibodies against antigens derived from the picornavirus. The invention also relates to iRNAs which target nucleic acid sequences of the picornavirus. The invention is related to methods for detecting the presence or absence of picornavirus in a subject. The invention is also related to immunogenic compositions for inducing an immune response against picornavirus in a subject.

    摘要翻译： 本发明涉及与呼吸道感染相关的新分离和鉴定的小核糖核酸病毒的进化枝，以及分离的核酸序列及其肽。 本发明还涉及针对来源于小核糖核酸病毒的抗原的抗体。 本发明还涉及靶向小核糖核酸病毒核酸序列的iRNA。 本发明涉及用于检测受试者中存在或不存在小核糖核酸病毒的方法。 本发明还涉及用于在受试者中诱导针对小RNA病毒的免疫应答的免疫原性组合物。

    Multiplex systems, methods, and kits for detecting and identifying nucleic acids
    8.
    发明授权
    Multiplex systems, methods, and kits for detecting and identifying nucleic acids 有权
    用于检测和鉴定核酸的多重系统，方法和试剂盒

    公开(公告)号：US08216810B2

    公开(公告)日：2012-07-10

    申请号：US10833791

    申请日：2004-04-27

    申请人： W. Ian Lipkin ,  Thomas Briese ,  Gustavo Palacios ,  Omar Jabado

    发明人： W. Ian Lipkin ,  Thomas Briese ,  Gustavo Palacios ,  Omar Jabado

    IPC分类号： C12P19/34 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C07H21/00

    CPC分类号： C12Q1/6837 ,  C12Q2565/549 ,  C12Q2565/125 ,  C12Q2531/113 ,  C12Q2563/149

    摘要： The present invention provides systems and methods for determining the presence or absence of one or more target nucleic acid sequences in a sample. Also provided are kits comprising these systems, and uses of these systems in such applications as determining the presence or absence of at least one target nucleic acid sequence in a sample, detecting microorganism transcripts and host transcripts, differentiating microorganism transcripts from host transcripts, screening blood products, assaying a food product for contamination, assaying a sample for environmental contamination, detecting genetically-modified organisms, biodefense, forensics, and genetic-comparability studies. The present invention further provides a complex that includes a target nucleic acid sequence, a capture nucleic acid, and a reporter nucleic acid.

    摘要翻译： 本发明提供用于确定样品中一种或多种靶核酸序列的存在或不存在的系统和方法。 还提供了包括这些系统的试剂盒，以及这些系统在确定样品中是否存在至少一种靶核酸序列的应用中的用途，检测微生物转录物和宿主转录物，将微生物转录本与宿主转录物区分开来，筛选血液 产品，测定食品污染，测定样品的环境污染，检测转基因生物，生物防治，取证和遗传比较研究。 本发明还提供了包含靶核酸序列，捕获核酸和报道核酸的复合物。