公开(公告)号：US20090275636A1

公开(公告)日：2009-11-05

申请号：US12364301

申请日：2009-02-02

申请人： Thomas Briese ,  Gustavo Palacios ,  W. Ian Lipkin ,  Daryl Lamson

发明人： Thomas Briese ,  Gustavo Palacios ,  W. Ian Lipkin ,  Daryl Lamson

IPC分类号： A61K31/7105 ,  C12N15/11 ,  C07K14/00 ,  C07K16/00 ,  C12Q1/70

CPC分类号： C12N7/00 ,  A61K39/00 ,  C07K14/005 ,  C12N2770/32721 ,  C12N2770/32722 ,  G01N2333/085

摘要： The invention is directed to a a clade of newly isolated and identified picornaviruses associated with respiratory infection, and isolated nucleic acids sequences and peptides thereof. The invention also relates to antibodies against antigens derived from the picornavirus. The invention also relates to iRNAs which target nucleic acid sequences of the picornavirus. The invention is related to methods for detecting the presence or absence of picornavirus in a subject. The invention is also related to immunogenic compositions for inducing an immune response against picornavirus in a subject.

摘要翻译： 本发明涉及与呼吸道感染相关的新分离和鉴定的小核糖核酸病毒的进化枝，以及分离的核酸序列及其肽。 本发明还涉及针对来源于小核糖核酸病毒的抗原的抗体。 本发明还涉及靶向小核糖核酸病毒核酸序列的iRNA。 本发明涉及用于检测受试者中存在或不存在小核糖核酸病毒的方法。 本发明还涉及用于在受试者中诱导针对小RNA病毒的免疫应答的免疫原性组合物。