公开(公告)号：US20240159751A1

公开(公告)日：2024-05-16

申请号：US18514032

申请日：2023-11-20

申请人： Kyoto University ,  KM Biologics Co., Ltd.

发明人： Koichiro HATA ,  Shinji Uemoto ,  Hirofumi Hirao ,  Toyonari Kubota

IPC分类号： G01N33/573 ,  A61K38/48 ,  G01N33/576

CPC分类号： G01N33/573 ,  A61K38/4886 ,  G01N33/576 ,  G01N2333/96494 ,  G01N2800/08 ,  G01N2800/085

摘要： New use of ADAMTS13 in the clinical filed is provided. The use of ADAMTS13 as a biomarker for monitoring the onset of liver damage, hepatic ischemia/reperfusion injury or the liver function after liver transplantation: a method of testing liver damage, a method of testing hepatic ischemia/reperfusion injury, or a method of testing the liver function after liver transplantation, each of the methods comprising measuring or monitoring the ADAMTS13 activity in a sample from a mammal; an agent for treating diseases selected from the group consisting of liver damage, hepatic ischemia/reperfusion injury and hepatic dysfunction after liver transplantation, which comprises ADAMTS13 or a mutant of ADAMTS13 as an effective ingredient.

公开(公告)号：US11841368B2

公开(公告)日：2023-12-12

申请号：US17054298

申请日：2019-05-16

申请人： UNIVERSITÄT HEIDELBERG

发明人： Florian Lempp ,  Stephan Urban

IPC分类号： C07K14/005 ,  C07K14/08 ,  C07K14/02 ,  C12Q1/70 ,  A61K39/29 ,  G01N33/576

CPC分类号： G01N33/5765 ,  C07K14/005 ,  G01N33/5761

摘要： The present invention relates to a polypeptide and a nucleic acid encoding the polypeptide for use in a method of detecting the presence of hepatitis D virus (HDV) and/or of diagnosing an HDV infection and/or of monitoring the treatment of an HDV infection. The present invention further relates to an in vitro method, an immunographic test device as well as a kit. In particular, the present invention relates to a point of care diagnostic for HDV infections.

公开(公告)号：US11340230B2

公开(公告)日：2022-05-24

申请号：US17071976

申请日：2020-10-15

申请人： Abbott Laboratories

发明人： Anthony S. Muerhoff ,  John C. Prostko ,  Christopher C. Marohnic

IPC分类号： G01N33/576

摘要： The present disclosure provides methods, kits, and compositions for detecting subject anti-HCV antibodies in a sample using NS3 capture peptides. In certain embodiments, at least two NS3 helicase (NS3h) capture peptides and at least two conjugate peptides (e.g., NS3h conjugate peptides) are employed together, which allows for a broad dynamic range of subject antibody detection in a one-step type assay. In other embodiments, methods are provided of detecting NS3-specific subject antibodies without the use of a reducing agent. In some embodiments, NS3-specific subject antibodies are detected with a ‘double shot’ of NS3 conjugate peptide (e.g., conjugate peptide added to a sample both before and after washing).

公开(公告)号：US20220034889A1

公开(公告)日：2022-02-03

申请号：US17298106

申请日：2019-11-26

申请人： Hong Jai Lee

发明人： Hong Jai Lee

IPC分类号： G01N33/576 ,  G01N1/30

摘要： The present invention relates to a method for detecting a virus, and more particularly, to a method for detecting a virus including a lipid bilayer envelope, wherein the method allows a surface antigen, which is a lipid bilayer envelope protein, to be effectively exposed from lipoproteins that mask all or part of the envelope protein, thereby revealing the surface antigen that is masked by the lipoproteins, so that a probe such as an antibody can be used to detect the virus with high sensitivity within a short time.

公开(公告)号：US20210285966A1

公开(公告)日：2021-09-16

申请号：US17213954

申请日：2021-03-26

申请人： Meso Scale Technologies, LLC.

发明人： George Sigal

IPC分类号： G01N33/68 ,  G01N33/576

摘要： The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or regimen. The invention also relates to assay kits used in connection with the diagnostic methods described herein.

公开(公告)号：US20210239701A1

公开(公告)日：2021-08-05

申请号：US17054298

申请日：2019-05-16

申请人： UNIVERSITÄT HEIDELBERG

发明人： FLORIAN LEMPP ,  STEPHAN URBAN

IPC分类号： G01N33/576 ,  C07K14/005

摘要： The present invention relates to a polypeptide and a nucleic acid encoding the polypeptide for use in a method of detecting the presence of hepatitis D vims (HDV) and/or of diagnosing an HDV infection and/or of monitoring the treatment of an HDV infection. The present invention further relates to an in vitro method, an immunographic test device as well as a kit. In particular, the present invention relates to a point of care diagnostic for HDV infections.

公开(公告)号：US20210231665A1

公开(公告)日：2021-07-29

申请号：US17231782

申请日：2021-04-15

申请人： Abbott Laboratories

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis

IPC分类号： G01N33/576 ,  C07K16/10

摘要： The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies. In certain embodiments, the lipid binding domain monoclonal antibody recognizes an epitope in amino acids 141 to 161 of HCV core protein.

公开(公告)号：US20200369727A1

公开(公告)日：2020-11-26

申请号：US16986706

申请日：2020-08-06

申请人： King Abdulaziz University

发明人： Moustafa E. EL-ARABY ,  Abdelsattar Mansour Omar ,  Mahmoud Abdelkhalek El-Faky ,  Sameh Hamdy Abdelmageed Soror ,  Maan Talaat Khayat ,  Hani Zakariah Asfour ,  Faida Hassan Bamane

IPC分类号： C07K7/08 ,  G01N33/576 ,  A61K45/06 ,  A61K38/10 ,  A61P31/14

摘要： Peptide inhibitors of activation of hepatitis C virus (HCV) NS3 protease are disclosed. They are analogs of the activation peptide HCV NS4 of residues 21-33 of SEQ ID NO: 2 and contain non-proteinogenic amino acids. Competitive binding studies showed the peptide analogs bind HCV NS3 protease at the activation site.

公开(公告)号：US20200256868A1

公开(公告)日：2020-08-13

申请号：US16862999

申请日：2020-04-30

申请人： SYSMEX CORPORATION

发明人： Toshiyuki SATO ,  Toshikatsu FUKUJU ,  Shuhei KANEKO ,  Atsushi AOKI ,  Tomohiro OKUZAKI ,  Yasuhiro TAKEUCHI ,  Yutaka KAWAMOTO

IPC分类号： G01N33/543 ,  G01N35/10 ,  G01N35/02 ,  G01N33/576

摘要： An immunoassay apparatus may include: a sample dispenser part that dispenses a sample into a first reaction container; a reagent dispenser part that dispenses, into the first reaction container: a solid-phase reagent containing a solid-phase carrier; a labeled reagent; and a releasing reagent that releases, from the solid-phase carrier, an immune complex including a target substance and a labeled substance; a measurement part that measures a signal based on the labeled substance in the immune complex in a second reaction container; a container supply part that stores a plurality of reaction containers; a transfer part that transfers the first reaction container so that the sample dispenser part and the reagent dispenser part perform a dispensing operation to the first reaction container, and that transfers the second reaction container so that the immune complex dispended from the first reaction container is dispensed into the second container.

公开(公告)号：US20200010898A1

公开(公告)日：2020-01-09

申请号：US16491163

申请日：2018-03-15

申请人： Academia Sinica

发明人： Shie-Liang HSIEH ,  Ya-Lang HUANG ,  Tsung-Yu TSAI

IPC分类号： C12Q1/6883 ,  G01N33/566 ,  G01N33/576 ,  C12Q1/70

摘要： Disclosed herein is a novel use of C-type lectin 18 (CLEC18) in disease prognosis. According to embodiments of the present disclosure, the mRNA or protein level of CLEC18 may serve as an indicator for diagnosing hepatitis B virus (HBV) infection, hepatitis B e antigen (HBeAg) loss and seroconversion, and/or liver fibrosis.