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    Subject anti-HCV antibody detection assays employing NS3 capture peptides
    1.
    发明授权
    Subject anti-HCV antibody detection assays employing NS3 capture peptides 有权

    公开(公告)号：US11340230B2

    公开(公告)日：2022-05-24

    申请号：US17071976

    申请日：2020-10-15

    申请人： Abbott Laboratories

    发明人： Anthony S. Muerhoff ,  John C. Prostko ,  Christopher C. Marohnic

    IPC分类号： G01N33/576

    摘要： The present disclosure provides methods, kits, and compositions for detecting subject anti-HCV antibodies in a sample using NS3 capture peptides. In certain embodiments, at least two NS3 helicase (NS3h) capture peptides and at least two conjugate peptides (e.g., NS3h conjugate peptides) are employed together, which allows for a broad dynamic range of subject antibody detection in a one-step type assay. In other embodiments, methods are provided of detecting NS3-specific subject antibodies without the use of a reducing agent. In some embodiments, NS3-specific subject antibodies are detected with a ‘double shot’ of NS3 conjugate peptide (e.g., conjugate peptide added to a sample both before and after washing).

    SUBJECT ANTI-HCV ANTIBODY DETECTION ASSAYS EMPLOYING NS3 CAPTURE PEPTIDES
    2.
    发明申请
    SUBJECT ANTI-HCV ANTIBODY DETECTION ASSAYS EMPLOYING NS3 CAPTURE PEPTIDES 有权

    公开(公告)号：US20210041442A1

    公开(公告)日：2021-02-11

    申请号：US17071976

    申请日：2020-10-15

    申请人： Abbott Laboratories

    发明人： Anthony S. Muerhoff ,  John C. Prostko ,  Christopher C. Marohnic

    IPC分类号： G01N33/576

    摘要： The present disclosure provides methods, kits, and compositions for detecting subject anti-HCV antibodies in a sample using NS3 capture peptides. In certain embodiments, at least two NS3 helicase (NS3h) capture peptides and at least two conjugate peptides (e.g., NS3h conjugate peptides) are employed together, which allows for a broad dynamic range of subject antibody detection in a one-step type assay. In other embodiments, methods are provided of detecting NS3-specific subject antibodies without the use of a reducing agent. In some embodiments, NS3-specific subject antibodies are detected with a ‘double shot’ of NS3 conjugate peptide (e.g., conjugate peptide added to a sample both before and after washing).

    Subject anti-HCV antibody detection assays employing NS3 capture peptides
    3.
    发明授权
    Subject anti-HCV antibody detection assays employing NS3 capture peptides 有权

    公开(公告)号：US10816551B2

    公开(公告)日：2020-10-27

    申请号：US16122261

    申请日：2018-09-05

    申请人： Abbott Laboratories

    发明人： Anthony S. Muerhoff ,  John C. Prostko ,  Christopher C. Marohnic

    IPC分类号： G01N33/576

    摘要： The present disclosure provides methods, kits, and compositions for detecting subject anti-HCV antibodies in a sample using NS3 capture peptides. In certain embodiments, at least two NS3 helicase (NS3h) capture peptides and at least two conjugate peptides (e.g., NS3h conjugate peptides) are employed together, which allows for a broad dynamic range of subject antibody detection in a one-step type assay. In other embodiments, methods are provided of detecting NS3-specific subject antibodies without the use of a reducing agent. In some embodiments, NS3-specific subject antibodies are detected with a ‘double shot’ of NS3 conjugate peptide (e.g., conjugate peptide added to a sample both before and after washing).

    SUBJECT ANTI-HCV ANTIBODY DETECTION ASSAYS EMPLOYING NS3 CAPTURE PEPTIDES
    5.
    发明申请
    SUBJECT ANTI-HCV ANTIBODY DETECTION ASSAYS EMPLOYING NS3 CAPTURE PEPTIDES 审中-公开

    公开(公告)号：US20190064169A1

    公开(公告)日：2019-02-28

    申请号：US16122261

    申请日：2018-09-05

    申请人： Abbott Laboratories

    发明人： Anthony S. Muerhoff ,  John C. Prostko ,  Christopher C. Marohnic

    IPC分类号： G01N33/576

    CPC分类号： G01N33/5767 ,  G01N2333/186 ,  G01N2333/914 ,  G01N2469/20

    摘要： The present disclosure provides methods, kits, and compositions for detecting subject anti-HCV antibodies in a sample using NS3 capture peptides. In certain embodiments, at least two NS3 helicase (NS3h) capture peptides and at least two conjugate peptides (e.g., NS3h conjugate peptides) are employed together, which allows for a broad dynamic range of subject antibody detection in a one-step type assay. In other embodiments, methods are provided of detecting NS3-specific subject antibodies without the use of a reducing agent. In some embodiments, NS3-specific subject antibodies are detected with a ‘double shot’ of NS3 conjugate peptide (e.g., conjugate peptide added to a sample both before and after washing).