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    Testing method of nucleic acid binding protein based on biochip
    2.
    发明授权
    Testing method of nucleic acid binding protein based on biochip 有权
    基于生物芯片的核酸结合蛋白检测方法

    公开(公告)号：US08680016B2

    公开(公告)日：2014-03-25

    申请号：US11791157

    申请日：2004-11-23

    Applicant: Wei Shao ,  Yongchao Zhao ,  Yimin Sun ,  Jiying Qiao ,  Huajiang Wei ,  Weiping Yang ,  Yuxiang Zhou ,  Jing Cheng

    Inventor： Wei Shao ,  Yongchao Zhao ,  Yimin Sun ,  Jiying Qiao ,  Huajiang Wei ,  Weiping Yang ,  Yuxiang Zhou ,  Jing Cheng

    IPC: C40B20/02

    CPC classification number: G01N33/54366 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q2565/531 ,  C12Q2565/501 ,  C12Q2563/131

    Abstract: A testing method of nucleic acid binding protein based on biochip, comprises the following steps: 1. puts a plurality of groups solution including nucleic acid captured probes into biological sample including a plurality of nucleic acid binding protein to be test, and thus forming nucleic acid captured probe-nucleic acid binding protein complexes; such nucleic acid captured probe includes at least a segment of binding sequence which can bind with aimed nucleic acid binding protein; 2. separates such nucleic acid captured probe-nucleic acid binding protein complexes, then recoveries nucleic acid captured probes; 3. hybridizes the nucleic acid captured probes according to step 2 with a plurality of single strand blotting probes on biochip substrate; the sequence of such blotting probe compensates with such nucleic acid captured probe or one of its strand; 4. detects the result of hybridization.

    Abstract translation: 一种基于生物芯片的核酸结合蛋白的检测方法，包括以下步骤：1.将包含核酸捕获探针的多组溶液放入包括待测试的多种核酸结合蛋白的生物样品中，从而形成核酸 捕获的探针 - 核酸结合蛋白复合物; 此类核酸捕获的探针包括可与靶核酸结合蛋白结合的至少一段结合序列; 2.分离这些核酸捕获的探针 - 核酸结合蛋白复合物，然后回收核酸捕获的探针; 3.将根据步骤2的核酸捕获探针与生物芯片底物上的多个单链印迹探针杂交; 这种印迹探针的序列用这种核酸捕获的探针或其一条链补偿; 4.检测杂交结果。

    Testing Method of Nucleic Acid Binding Protein Based on Biochip
    4.
    发明申请
    Testing Method of Nucleic Acid Binding Protein Based on Biochip 有权
    基于生物芯片的核酸结合蛋白检测方法

    公开(公告)号：US20090018025A1

    公开(公告)日：2009-01-15

    申请号：US11791157

    申请日：2004-11-23

    Applicant: Wei Shao ,  Yongchao Zhao ,  Yimin Sun ,  Jiying Qiao ,  Huajiang Wei ,  Weiping Yang ,  Yuxiang Zhou ,  Jing Cheng

    Inventor： Wei Shao ,  Yongchao Zhao ,  Yimin Sun ,  Jiying Qiao ,  Huajiang Wei ,  Weiping Yang ,  Yuxiang Zhou ,  Jing Cheng

    IPC: C40B20/02

    CPC classification number: G01N33/54366 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q2565/531 ,  C12Q2565/501 ,  C12Q2563/131

    Abstract: A testing method of nucleic acid binding protein based on biochip, comprises the following steps: 1. puts a plurality of groups solution including nucleic acid captured probes into biological sample including a plurality of nucleic acid binding protein to be test, and thus forming nucleic acid captured probe-nucleic acid binding protein complexes; such nucleic acid captured probe includes at least a segment of binding sequence which can bind with aimed nucleic acid binding protein; 2. separates such nucleic acid captured probe-nucleic acid binding protein complexes, then recoveries nucleic acid captured probes; 3. hybridizes the nucleic acid captured probes according to step 2 with a plurality of single strand blotting probes on biochip substrate; the sequence of such blotting probe compensates with such nucleic acid captured probe or one of its strand; 4. detects the result of hybridization.

    Abstract translation: 一种基于生物芯片的核酸结合蛋白的检测方法，包括以下步骤：1.将包含核酸捕获探针的多组溶液放入包括待测试的多种核酸结合蛋白的生物样品中，从而形成核酸 捕获的探针 - 核酸结合蛋白复合物; 此类核酸捕获的探针包括可与靶核酸结合蛋白结合的至少一段结合序列; 2.分离这些核酸捕获的探针 - 核酸结合蛋白复合物，然后回收核酸捕获的探针; 3.将根据步骤2的核酸捕获探针与生物芯片底物上的多个单链印迹探针杂交; 这种印迹探针的序列用这种核酸捕获的探针或其一条链补偿; 4.检测杂交结果。

    Nanometer-sized up-converting phosphor fluoride particles and process of preparation
    6.
    发明授权
    Nanometer-sized up-converting phosphor fluoride particles and process of preparation 有权
    纳米级上转换氟化磷颗粒及其制备方法

    公开(公告)号：US07422703B2

    公开(公告)日：2008-09-09

    申请号：US10511363

    申请日：2003-04-15

    Applicant: Guangshun Yi ,  Baoquan Sun ,  Depu Chen ,  Yuxiang Zhou ,  Jing Cheng ,  Wenjun Yang ,  Yue Ge ,  Lianghong Guo

    Inventor： Guangshun Yi ,  Baoquan Sun ,  Depu Chen ,  Yuxiang Zhou ,  Jing Cheng ,  Wenjun Yang ,  Yue Ge ,  Lianghong Guo

    IPC: C09K11/85

    CPC classification number: C09K11/7772 ,  C09K11/7773 ,  Y10S977/83 ,  Y10S977/834

    Abstract: Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium)=(70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35 nm and 200 nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.

    Abstract translation: 公开了纳米级上转换氟化物荧光体颗粒及其制备方法。 在该方法中，以（钇，镧或钆）的摩尔比形成的稀土金属离子的可溶性盐：镱（铒，钬，铽或ium）=（70-90）：（0） -29）:( 0.001-15）混合稀土金属螯合剂和可溶性氟化物盐形成析出物，然后在升高的温度下退火，生成纳米级的上转换氟化物荧光体颗粒。 粒径在35nm和200nm之间，并且可以通过添加到溶液中的金属螯合剂的量来控制。 纳米级粒子适用于许多生物测定。

    AUTOMATIC POSITIONING AND SENSING MICROELECTRODE ARRAYS
    9.
    发明申请
    AUTOMATIC POSITIONING AND SENSING MICROELECTRODE ARRAYS 有权
    自动定位和感应微电极阵列

    公开(公告)号：US20100270176A1

    公开(公告)日：2010-10-28

    申请号：US12667507

    申请日：2007-07-04

    Applicant: Guangxin Xiang ,  Liangbin Pan ,  Wanli Xing ,  Lihua Huang ,  Zhongyao Yu ,  Jing Zhu ,  Yuxiang Zhou ,  Jing Cheng

    Inventor： Guangxin Xiang ,  Liangbin Pan ,  Wanli Xing ,  Lihua Huang ,  Zhongyao Yu ,  Jing Zhu ,  Yuxiang Zhou ,  Jing Cheng

    IPC: G01N33/50 ,  G01N27/26

    CPC classification number: G01N33/4836 ,  B01J2219/00653 ,  B01J2219/00743 ,  B01L3/502707 ,  B01L2300/0645 ,  B01L2400/0421 ,  B01L2400/0424

    Abstract: A microelectrode sensing device includes a substrate and an array of microelectrode sensors. Each sensor includes a first conductive layer that at least partially conducts electricity. The first conductive layer is formed above the substrate and patterned to include a recording electrode that measures electrical activities of target cells. Each sensor also includes a second conductive layer that at least partially conducts electricity. The second conductive layer is elevated above the first layer and patterned to include multiple positioning electrodes arranged to define a sensing region above the recording electrode. The positioning electrodes are designed to generate an electric field pattern in the sensing region to move and confine the target cells to a sub-region of the sensing region that at least partially overlaps the recording electrode.

    Abstract translation: 微电极感测装置包括基板和微电极传感器阵列。 每个传感器包括至少部分地导电的第一导电层。 第一导电层形成在衬底上并被图案化以包括测量靶细胞的电活动的记录电极。 每个传感器还包括至少部分地传导电的第二导电层。 第二导电层在第一层之上被升高并且被图案化以包括布置成限定记录电极上方的感测区域的多个定位电极。 定位电极被设计成在感测区域中产生电场图案以移动并将目标单元限制在至少部分地与记录电极重叠的感测区域的子区域上。

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