公开(公告)号：US07875466B2

公开(公告)日：2011-01-25

申请号：US10567535

申请日：2003-08-13

Applicant: Huachang Lu ,  Guangshun Yi ,  Depu Chen ,  Lianghong Guo ,  Jing Cheng

Inventor： Huachang Lu ,  Guangshun Yi ,  Depu Chen ,  Lianghong Guo ,  Jing Cheng

IPC: G01N33/553 ,  G01N1/00

CPC classification number: B82Y15/00 ,  G01N33/54326 ,  G01N33/588 ,  Y10T428/2991

Abstract: This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.

Abstract translation: 本发明提供纳米级荧光磁性颗粒及其制备方法。 纳米颗粒具有包含磁性材料和荧光材料的核心颗粒，并且其粒径小于约1微米。 纳米颗粒可以用无机或有机层涂覆并且可以进行表面改性。 纳米颗粒可用于许多生物测定。

公开(公告)号：US09512001B2

公开(公告)日：2016-12-06

申请号：US12970688

申请日：2010-12-16

Applicant: Huachang Lu ,  Guangshun Yi ,  Depu Chen ,  Lianghong Guo ,  Jing Cheng

Inventor： Huachang Lu ,  Guangshun Yi ,  Depu Chen ,  Lianghong Guo ,  Jing Cheng

IPC: G01N33/543 ,  B82Y15/00 ,  G01N33/58

CPC classification number: B82Y15/00 ,  G01N33/54326 ,  G01N33/588 ,  Y10T428/2991

Abstract: This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.

Abstract translation: 本发明提供纳米级荧光磁性颗粒及其制备方法。 纳米颗粒具有包含磁性材料和荧光材料的核心颗粒，并且其粒径小于约1微米。 纳米颗粒可以用无机或有机层涂覆并且可以进行表面改性。 纳米颗粒可用于许多生物测定。

公开(公告)号：US20060003466A1

公开(公告)日：2006-01-05

申请号：US10511363

申请日：2003-04-15

Applicant: Guangshun Yi ,  Baoquan Sun ,  Depu Chen ,  Yuxiang Zhou ,  Jing Cheng ,  Wenjun Yang ,  Yue Ge ,  Lianghong Guo

Inventor： Guangshun Yi ,  Baoquan Sun ,  Depu Chen ,  Yuxiang Zhou ,  Jing Cheng ,  Wenjun Yang ,  Yue Ge ,  Lianghong Guo

IPC: G01N33/553

CPC classification number: C09K11/7772 ,  C09K11/7773 ,  Y10S977/83 ,  Y10S977/834

Abstract: Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium)=(70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35 nm and 200 nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.

Abstract translation: 公开了纳米级上转换氟化物荧光体颗粒及其制备方法。 在该方法中，以（钇，镧或钆）的摩尔比形成的稀土金属离子的可溶性盐：镱（铒，钬，铽或ium）=（70-90）：（0） -29）:( 0.001-15）混合稀土金属螯合剂和可溶性氟化物盐形成析出物，然后在升高的温度下退火，生成纳米级的上转换氟化物荧光体颗粒。 粒径在35nm和200nm之间，并且可以通过添加到溶液中的金属螯合剂的量来控制。 纳米级粒子适用于许多生物测定。

公开(公告)号：US20110177339A1

公开(公告)日：2011-07-21

申请号：US12970688

申请日：2010-12-16

Applicant: Huachang Lu ,  Guangshun Yi ,  Depu Chen ,  Lianghong Guo ,  Jing Cheng

Inventor： Huachang Lu ,  Guangshun Yi ,  Depu Chen ,  Lianghong Guo ,  Jing Cheng

IPC: B32B5/16 ,  B05D7/00 ,  B06B1/20

CPC classification number: B82Y15/00 ,  G01N33/54326 ,  G01N33/588 ,  Y10T428/2991

Abstract: This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.

Abstract translation: 本发明提供纳米级荧光磁性颗粒及其制备方法。 纳米颗粒具有包含磁性材料和荧光材料的核心颗粒，并且其粒径小于约1微米。 纳米颗粒可以用无机或有机层涂覆并且可以进行表面改性。 纳米颗粒可用于许多生物测定。

公开(公告)号：US07422703B2

公开(公告)日：2008-09-09

申请号：US10511363

申请日：2003-04-15

Applicant: Guangshun Yi ,  Baoquan Sun ,  Depu Chen ,  Yuxiang Zhou ,  Jing Cheng ,  Wenjun Yang ,  Yue Ge ,  Lianghong Guo

Inventor： Guangshun Yi ,  Baoquan Sun ,  Depu Chen ,  Yuxiang Zhou ,  Jing Cheng ,  Wenjun Yang ,  Yue Ge ,  Lianghong Guo

IPC: C09K11/85

CPC classification number: C09K11/7772 ,  C09K11/7773 ,  Y10S977/83 ,  Y10S977/834

Abstract: Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium)=(70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35 nm and 200 nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.

Abstract translation: 公开了纳米级上转换氟化物荧光体颗粒及其制备方法。 在该方法中，以（钇，镧或钆）的摩尔比形成的稀土金属离子的可溶性盐：镱（铒，钬，铽或ium）=（70-90）：（0） -29）:( 0.001-15）混合稀土金属螯合剂和可溶性氟化物盐形成析出物，然后在升高的温度下退火，生成纳米级的上转换氟化物荧光体颗粒。 粒径在35nm和200nm之间，并且可以通过添加到溶液中的金属螯合剂的量来控制。 纳米级粒子适用于许多生物测定。

公开(公告)号：US20070059705A1

公开(公告)日：2007-03-15

申请号：US10567535

申请日：2003-08-13

Applicant: Huachang Lu ,  Guangshun Yi ,  Depu Chen ,  Lianghong Guo ,  Jing Cheng

Inventor： Huachang Lu ,  Guangshun Yi ,  Depu Chen ,  Lianghong Guo ,  Jing Cheng

IPC: C12Q1/68 ,  G01N33/555 ,  G01N33/551

CPC classification number: B82Y15/00 ,  G01N33/54326 ,  G01N33/588 ,  Y10T428/2991

Abstract: This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.

Abstract translation: 本发明提供纳米级荧光磁性颗粒及其制备方法。 纳米颗粒具有包含磁性材料和荧光材料的核心颗粒，并且其粒径小于约1微米。 纳米颗粒可以用无机或有机层涂覆并且可以进行表面改性。 纳米颗粒可用于许多生物测定。