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公开(公告)号：US10316559B2
公开(公告)日：2019-06-11
申请号：US13663422
申请日：2012-10-29
摘要： A door hinge assembly is provided. The door hinge assembly includes a first hinge plate, a second hinge plate, one or more bushings, a hinge pin and a hollow sleeve. The first and second hinge plate includes a one or more first and second knuckles aligned axially. At least one of the one or more bushings is positioned in between the first and second knuckle to prevent direct contact of first and second knuckle. The hinge pin is disposed through the first and second knuckles and one or more bushings. The hollow sleeve acts a covering to the hinge pin. The hollow sleeve further prevents contact of the sides of the first knuckle, bushings and second knuckle with the hinge pin. This prevents a direct metal on metal contact and further prevents squeak or other noises occurred during the opening and closing of the door.
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2.发明授权
公开(公告)号：US06086897A
公开(公告)日：2000-07-11
申请号：US465093
申请日：1995-06-05
申请人： Wayne Robert Thomas , Kaw-Yan Chua
发明人： Wayne Robert Thomas , Kaw-Yan Chua
IPC分类号： A61K39/35 , A61K38/00 , A61K39/36 , A61K49/00 , A61P37/08 , C07H21/04 , C07K14/00 , C07K14/435 , C07K14/54 , C12N15/09 , C12N15/12 , C12P21/02 , G01N33/53 , G01N33/569
CPC分类号： C07K14/43531 , C07K14/5403 , A61K38/00
摘要： Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.
摘要翻译： 编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是蛋白质过敏原或包括蛋白质变应原的至少一个表位的肽。 特别地，编码两个主要的D. farinae变应原的Der DNA和Der f II以及编码D.pteronssinus变应原Der P的DNA。另外，由分离的DNA编码的蛋白质或肽，它们用作诊断和 诊断和治疗房屋尘螨过敏原敏感性的治疗试剂和方法。
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公开(公告)号：US6077517A
公开(公告)日：2000-06-20
申请号：US462778
申请日：1995-06-05
申请人： Wayne Robert Thomas , Kaw-Yan Chua
发明人： Wayne Robert Thomas , Kaw-Yan Chua
IPC分类号： C12N15/09 , A61K38/00 , A61K38/11 , A61K39/00 , A61K39/35 , A61K39/395 , A61P37/08 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/725 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/06 , C12P21/08 , C12Q1/02 , G01N33/53 , G01N33/569 , G01N33/68 , C07K1/00
CPC分类号： C07K14/43531 , C07K14/7051 , G01N33/56966 , G01N33/6893 , A61K38/00 , C07K2319/00 , G01N2800/24 , Y10S530/868
摘要： A novel protein allergen Der p VII of Dennatophagoides pteronyssinus is described. A cDNA clone encoding Der p VII was isolated from a .lambda.gt11 library of D. pteronyssinus cDNA. The nucleic acid sequence of der p VII encodes a 198 residue mature processed protein having a predicted molecular weight of 22,177 daltons. Der p VII protein may be used as the active ingredient in therapeutic composition for the treatment of sensitivity to house dust mites. The protein may also be used in methods of diagnosing such sensitivity.
摘要翻译： 描述了Dennatophagoides pteronyssinus的新型蛋白质过敏原Der VII。 从D.pteronyssinus cDNA的λgt11文库中分离编码Der p VII的cDNA克隆。 衍生物VII的核酸序列编码具有预测分子量为22,177道尔顿的198残基成熟加工蛋白质。 Der p VII蛋白可用作治疗组合物中用于治疗房尘螨敏感性的活性成分。 该蛋白质也可用于诊断这种敏感性的方法。
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公开(公告)号：US6071522A
公开(公告)日：2000-06-06
申请号：US460040
申请日：1995-06-02
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/35 , A61P37/00 , A61P37/08 , C07G99/00 , C07H21/04 , C07K14/00 , C07K14/435 , C07K19/00 , C12N1/20 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , G01N33/564
CPC分类号： C07K14/43531 , A61K38/00 , A61K39/00 , Y10S436/826
摘要： Recombinant DNA expression vectors or cloning vehicles capable of expressing a polypeptide displaying the antigenicity of an allergen of house dust mites of the genus Dermatophagoides. A synthetic protein or polypeptide displaying antigenicity of all or a portion of an allergen of house dust mites of the genus Dermatophagoides. Methods of diagnosing and treating such allergies.
摘要翻译： 重组DNA表达载体或能够表达显示Dermatophagoides属的房尘螨变应原的抗原性的多肽的克隆载体。 显示Dermatophagoides属的尘螨全部或部分变应原的抗原性的合成蛋白质或多肽。 诊断和治疗这种过敏症的方法。
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5.发明授权Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom 有权构建生物多样性基因片段文库和从其分离的生物调节剂的方法公开(公告)号：US07803765B2
公开(公告)日：2010-09-28
申请号：US10546333
申请日：2004-02-20
CPC分类号： C07K7/08 , C07K7/06 , C07K14/001 , C12N15/1034 , C40B30/04 , G01N33/569 , G01N33/574 , Y02A50/57 , Y02A50/58
摘要： The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid.
摘要翻译： 本发明提供用于产生表达高度多样化的肽或蛋白质结构域的核酸片段文库的新方法，特别是用于产生其中核酸的核酸片段文库的方法。
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6.发明授权Nucleic acids encoding a house dust mite allergen, Der p VII, and uses therefor 失效编码房屋尘螨过敏原的核酸，Der p VII，并用于此公开(公告)号：US06849427B1
公开(公告)日：2005-02-01
申请号：US08081540
申请日：1993-06-22
申请人： Wayne Robert Thomas , Kaw-Yan Chua
发明人： Wayne Robert Thomas , Kaw-Yan Chua
IPC分类号： C12N15/09 , A61K38/00 , A61K38/11 , A61K39/00 , A61K39/35 , A61K39/395 , A61P37/08 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/725 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/06 , C12P21/08 , C12Q1/02 , G01N33/53 , G01N33/569 , G01N33/68 , C12N1/20
CPC分类号： C07K14/43531 , A61K38/00 , C07K14/7051 , C07K2319/00 , G01N33/56966 , G01N33/6893 , G01N2800/24 , Y10S530/868
摘要： A novel protein allergen Der p VII of Dermatophagoides pteronyssinus is described. A cDNA clone encoding Der p VII was isolated from a λgt11 library of D. pteronyssinus cDNA. The nucleic acid sequence of Der p VII encodes a 198 residue mature processed protein having a predicted molecular weight of 22,177 daltons. Der p VII protein may be used as the active ingredient in therapeutic composition for the treatment of sensitivity to house dust mites. The protein may also be used in methods of diagnosing such sensitivity.
摘要翻译： 描述了Dermatophagoides pteronyssinus的新型蛋白质过敏原Der VII。 从D.pteronyssinus cDNA的lambdagt11文库中分离编码Der p VII的cDNA克隆。 Der p VII的核酸序列编码具有预测分子量为22,177道尔顿的198残基成熟加工蛋白。 Der p VII蛋白可用作治疗组合物中用于治疗房尘螨敏感性的活性成分。 该蛋白质也可用于诊断这种敏感性的方法。
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公开(公告)号：US06689876B1
公开(公告)日：2004-02-10
申请号：US08175071
申请日：1993-12-29
申请人： Wayne Robert Thomas , Kaw-Yan Chua
发明人： Wayne Robert Thomas , Kaw-Yan Chua
IPC分类号： C07H2104
CPC分类号： C07K14/43531 , A61K38/00 , C07K14/5403
摘要： Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronyssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.
摘要翻译： 编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是蛋白质过敏原或包括蛋白质变应原的至少一个表位的肽。 特别地，编码两个主要的D. farinae过敏原的DNA，Der f I和Der f II以及编码D.pteronyssinus变应原的DNA，Der p I.另外，由分离的DNA编码的蛋白质或肽，它们用作诊断和 诊断和治疗房屋尘螨过敏原敏感性的治疗试剂和方法。
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公开(公告)号：US20190292822A1
公开(公告)日：2019-09-26
申请号：US16436966
申请日：2019-06-11
摘要： A door hinge assembly is provided. The door hinge assembly includes a first hinge plate, a second hinge plate, one or more bushings, a hinge pin and a hollow sleeve. The first and second hinge plate includes a one or more first and second knuckles aligned axially. At least one of the one or more bushings is positioned in between the first and second knuckle to prevent direct contact of first and second knuckle. The hinge pin is disposed through the first and second knuckles and one or more bushings. The hollow sleeve acts a covering to the hinge pin. The hollow sleeve further prevents contact of the sides of the first knuckle, bushings and second knuckle with the hinge pin. This prevents a direct metal on metal contact and further prevents squeak or other noises occurred during the opening and closing of the door.
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9.发明授权公开(公告)号：US06994982B1
公开(公告)日：2006-02-07
申请号：US09568229
申请日：2000-05-05
IPC分类号： G01N33/569
CPC分类号： C12N15/1086 , C07K7/06 , C07K7/08 , C07K14/001 , C12N15/10 , C12N15/1027 , C12N15/1034 , C12N15/1058 , C40B30/04 , C40B40/08 , C40B40/10 , C40B50/06 , G01N33/569 , G01N33/574 , G01N33/6845 , Y02A50/57 , Y02A50/58
摘要： The present invention provides a method for identifying a modulator or mediator of a biological activity, which activity includes antigenicity and or immunogenicity, said method comprising the step of: (i) producing a gene fragment expression library derived from defined nucleotide sequence fragments; and (ii) assaying the expression library for at least an amino acid sequence derived from step (i) for a biological activity wherein that activity is different from any activity the amino acid sequence may have in its native environment.
摘要翻译： 本发明提供了鉴定生物活性的调节剂或介体的方法，该活性包括抗原性和/或免疫原性，所述方法包括步骤
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公开(公告)号：US06905845B2
公开(公告)日：2005-06-14
申请号：US10024955
申请日：2001-12-19
申请人： Wayne Robert Thomas , Kaw-Yan Chua
发明人： Wayne Robert Thomas , Kaw-Yan Chua
IPC分类号： C12N15/09 , A61K38/00 , A61K38/11 , A61K39/00 , A61K39/35 , A61K39/395 , A61P37/08 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/725 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/06 , C12P21/08 , C12Q1/02 , G01N33/53 , G01N33/569 , G01N33/68 , C12N15/00
CPC分类号： C07K14/43531 , A61K38/00 , C07K14/7051 , C07K2319/00 , G01N33/56966 , G01N33/6893 , G01N2800/24 , Y10S530/868
摘要： Isolated nucleic acids encoding allergens of the species Dermatophagoides pteronyssinus and Dermatophagoides farinae, Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acid of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleotide acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens.
摘要翻译： 公开了分别编码Dermatophagoides pteronyssinus和Dermatophagoides farinae，Der p VII和Der f VII的变应原的分离的核酸。 描述了编码具有Der p VII活性和约22,171道尔顿的预测分子量的肽的cDNA。 还描述了编码具有Der f VII活性的肽的cDNA。 本发明的核酸可以用作探针，以检测样品中Der p VII或Der f VII核苷酸的存在，或用于重组产生具有Der p VII或Der f VII活性的肽。 具有Der p VII或Der f VII活性的肽可用于适于药物施用的组合物或诊断对尘螨过敏原敏感性的方法。
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