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    Cloning and sequencing of allergens of dermatophagoides
    2.
    发明授权
    Cloning and sequencing of allergens of dermatophagoides 失效
    克隆和测序皮肤病的过敏原

    公开(公告)号：US06689876B1

    公开(公告)日：2004-02-10

    申请号：US08175071

    申请日：1993-12-29

    申请人： Wayne Robert Thomas ,  Kaw-Yan Chua

    发明人： Wayne Robert Thomas ,  Kaw-Yan Chua

    IPC分类号： C07H2104

    CPC分类号： C07K14/43531 ,  A61K38/00 ,  C07K14/5403

    摘要： Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronyssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.

    摘要翻译： 编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是蛋白质过敏原或包括蛋白质变应原的至少一个表位的肽。 特别地，编码两个主要的D. farinae过敏原的DNA，Der f I和Der f II以及编码D.pteronyssinus变应原的DNA，Der p I.另外，由分离的DNA编码的蛋白质或肽，它们用作诊断和 诊断和治疗房屋尘螨过敏原敏感性的治疗试剂和方法。

    Cloning and sequencing of allergens of dermatophagoides house dust mite
    3.
    发明授权
    Cloning and sequencing of allergens of dermatophagoides house dust mite 失效
    皮肤癣菌过敏原的克隆和测序房尘螨

    公开(公告)号：US06423837B1

    公开(公告)日：2002-07-23

    申请号：US09295188

    申请日：1999-04-20

    申请人： Wayne Robert Thomas ,  Kaw-Yan Chua

    发明人： Wayne Robert Thomas ,  Kaw-Yan Chua

    IPC分类号： A61K3935

    CPC分类号： C07K14/5403 ,  A61K38/00 ,  C07K14/43531

    摘要： Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronyssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.

    摘要翻译： 编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是蛋白质过敏原或包括蛋白质变应原的至少一个表位的肽。 特别地，编码两个主要的D. farinae过敏原的DNA，Der f I和Der f II以及编码D.pteronyssinus变应原的DNA，Der p I.另外，由分离的DNA编码的蛋白质或肽，它们用作诊断和 诊断和治疗房屋尘螨过敏原敏感性的治疗试剂和方法。

    Cloning and sequencing of allergens of Dermatophagoides (house dust mite)
    4.
    发明授权
    Cloning and sequencing of allergens of Dermatophagoides (house dust mite) 失效
    Dermatophagoides（房尘螨）过敏原的克隆和测序

    公开(公告)号：US6060057A

    公开(公告)日：2000-05-09

    申请号：US460918

    申请日：1995-06-05

    申请人： Wayne Robert Thomas ,  Kaw-Yan Chua

    发明人： Wayne Robert Thomas ,  Kaw-Yan Chua

    IPC分类号： A61K39/35 ,  A61K38/00 ,  A61K39/36 ,  A61K49/00 ,  A61P37/08 ,  C07H21/04 ,  C07K14/00 ,  C07K14/435 ,  C07K14/54 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  G01N33/53 ,  G01N33/569

    CPC分类号： C07K14/43531 ,  C07K14/5403 ,  A61K38/00

    摘要： Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronyssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.

    摘要翻译： 编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是蛋白质过敏原或包括蛋白质变应原的至少一个表位的肽。 特别地，编码两个主要的D. farinae过敏原的DNA，Der f I和Der f II以及编码D.pteronyssinus变应原的DNA，Der p I.另外，由分离的DNA编码的蛋白质或肽，它们用作诊断和 诊断和治疗房屋尘螨过敏原敏感性的治疗试剂和方法。

    House dust mite allergen, Der f VII, and uses therefor
    6.
    发明授权
    House dust mite allergen, Der f VII, and uses therefor 失效

    公开(公告)号：US06413738B1

    公开(公告)日：2002-07-02

    申请号：US08553336

    申请日：1996-06-10

    申请人： Wayne Robert Thomas ,  Kaw-Yan Chua

    发明人： Wayne Robert Thomas ,  Kaw-Yan Chua

    IPC分类号： C12P2106

    CPC分类号： C07K14/43531 ,  A61K38/00 ,  C07K14/7051 ,  C07K2319/00 ,  G01N33/56966 ,  G01N33/6893 ,  G01N2800/24 ,  Y10S530/868

    摘要： Isolated nucleic acids encoding allergens of the species Dermatophagoides pteronyssinus and Dermatophagoides farinae, Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acids of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleic acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens.

    Cloning and sequencing of allergens of dermatophagoides (house dust mite)
    7.
    发明授权
    Cloning and sequencing of allergens of dermatophagoides (house dust mite) 失效
    皮肤癣菌过敏原（室内尘螨）的克隆和测序

    公开(公告)号：US06086897A

    公开(公告)日：2000-07-11

    申请号：US465093

    申请日：1995-06-05

    申请人： Wayne Robert Thomas ,  Kaw-Yan Chua

    发明人： Wayne Robert Thomas ,  Kaw-Yan Chua

    IPC分类号： A61K39/35 ,  A61K38/00 ,  A61K39/36 ,  A61K49/00 ,  A61P37/08 ,  C07H21/04 ,  C07K14/00 ,  C07K14/435 ,  C07K14/54 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  G01N33/53 ,  G01N33/569

    CPC分类号： C07K14/43531 ,  C07K14/5403 ,  A61K38/00

    摘要： Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.

    摘要翻译： 编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是蛋白质过敏原或包括蛋白质变应原的至少一个表位的肽。 特别地，编码两个主要的D. farinae变应原的Der DNA和Der f II以及编码D.pteronssinus变应原Der P的DNA。另外，由分离的DNA编码的蛋白质或肽，它们用作诊断和 诊断和治疗房屋尘螨过敏原敏感性的治疗试剂和方法。

    NUCLEIC ACIDS ENCODING A HOUSE DUST MITE ALLERGEN, DER P III, AND USES THEREFOR
    9.
    发明申请
    NUCLEIC ACIDS ENCODING A HOUSE DUST MITE ALLERGEN, DER P III, AND USES THEREFOR 有权
    核酸编码一个房屋尘埃冥王星过敏原，第三阶段及其用途

    公开(公告)号：US20110117116A1

    公开(公告)日：2011-05-19

    申请号：US12688744

    申请日：2010-01-15

    申请人： Wayne R. THOMAS ,  Kaw-Yan Chua ,  Bruce L. Rogers ,  Mei-chang Kuo

    发明人： Wayne R. THOMAS ,  Kaw-Yan Chua ,  Bruce L. Rogers ,  Mei-chang Kuo

    IPC分类号： A61K39/35 ,  C12P21/02 ,  G01N33/566 ,  A61P37/08 ,  A61P37/04

    CPC分类号： C07K14/43531 ,  A61K38/00

    摘要： Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.

    摘要翻译： 公开了编码Dermatophagoides pteronyssinus，Der p III的变应原的分离的核酸。 还描述了编码具有Der p III活性和约24,985道尔顿的预测分子量的肽的cDNA。 核酸可以用作探针，以检测样品中Der p III核酸的存在或重组产生具有Der p III活性的肽。 具有Der p III活性的肽可用于适用于药物施用的组合物或诊断对尘螨敏感性的方法。