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    Ex vivo progenitor and stem cell expansion and differentiation for use in the treatment of disease of the nervous system
    4.
    发明授权
    Ex vivo progenitor and stem cell expansion and differentiation for use in the treatment of disease of the nervous system 有权
    离体祖细胞和干细胞扩增和分化用于治疗神经系统疾病

    公开(公告)号：US08927276B2

    公开(公告)日：2015-01-06

    申请号：US12707607

    申请日：2010-02-17

    申请人： Kaia Palm ,  Toomas Neuman

    发明人： Kaia Palm ,  Toomas Neuman

    IPC分类号： C12N5/07 ,  C12N5/10 ,  C12N5/00 ,  A61K35/30 ,  C12N5/0797

    CPC分类号： C12N5/0623 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/148 ,  C12N2501/235 ,  C12N2506/08

    摘要： The present invention relates to a simplified process, which is shorter in time, for propagation of proliferating cells, such as e.g. progenitor or stem cells, by means of a biphasic culturing system having a differentiation supporting component and a proliferation supporting component, and to the use of the stem cell cultures obtained in this way for cell therapy purposes. The present invention invention describes a method, which is highly efficient to prime stem or progenitor cells to differentiation using non-attachment matrices and differentiation supporting component. The cells produced therefrom may be used to treat a variety of neurodegenerative disorders.

    摘要翻译： 本发明涉及对于增殖细胞的繁殖，例如时间短的简化方法。 祖细胞或干细胞，通过具有分化支持组分和增殖支持组分的双相培养系统以及以这种方式获得的干细胞培养物用于细胞治疗目的的用途。 本发明描述了一种方法，其使用非附着基质和分化支持组分将茎干或祖细胞分化为高效。 由此产生的细胞可用于治疗各种神经变性疾病。

    Ex Vivo Progenitor and Stem Cell Expansion and Differentiation for Use in the Treatment of Disease of the Nervous System
    5.
    发明申请
    Ex Vivo Progenitor and Stem Cell Expansion and Differentiation for Use in the Treatment of Disease of the Nervous System 有权
    用于治疗神经系统疾病的体外祖细胞和干细胞扩增和分化

    公开(公告)号：US20110201113A1

    公开(公告)日：2011-08-18

    申请号：US12707607

    申请日：2010-02-17

    申请人： Kaia Palm ,  Toomas Neuman

    发明人： Kaia Palm ,  Toomas Neuman

    IPC分类号： C12N5/02 ,  C12N5/00

    CPC分类号： C12N5/0623 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/148 ,  C12N2501/235 ,  C12N2506/08

    摘要： The present invention relates to a simplified process, which is shorter in time, for propagation of proliferating cells, such as e.g. progenitor or stem cells, by means of a biphasic culturing system having a differentiation supporting component and a proliferation supporting component, and to the use of the stem cell cultures obtained in this way for cell therapy purposes. The present invention invention describes a method, which is highly efficient to prime stem or progenitor cells to differentiation using non-attachment matrices and differentiation supporting component. The cells produced therefrom may be used to treat a variety of neurodegenerative disorders,

    摘要翻译： 本发明涉及对于增殖细胞的繁殖，例如时间短的简化方法。 祖细胞或干细胞，通过具有分化支持组分和增殖支持组分的双相培养系统以及以这种方式获得的干细胞培养物用于细胞治疗目的的用途。 本发明描述了一种方法，其使用非附着基质和分化支持组分将茎干或祖细胞分化为高效。 由此产生的细胞可用于治疗各种神经变性疾病，

    TRANSCRIPTIONAL MODULATION OF EXTRACELLULAR MATRIX (ECM) OF DERMAL FIBROBLASTS
    6.
    发明申请
    TRANSCRIPTIONAL MODULATION OF EXTRACELLULAR MATRIX (ECM) OF DERMAL FIBROBLASTS 审中-公开
    超细纤维细胞基质（ECM）的转录调控

    公开(公告)号：US20080306001A1

    公开(公告)日：2008-12-11

    申请号：US12062155

    申请日：2008-04-03

    申请人： Anzelika Liik ,  Ave Laas ,  Rita Zobel ,  Toomas Neuman

    发明人： Anzelika Liik ,  Ave Laas ,  Rita Zobel ,  Toomas Neuman

    IPC分类号： A61K38/00 ,  C07K14/00 ,  C12N5/06 ,  A61P17/00 ,  C12N9/50

    CPC分类号： C07K14/78 ,  A61K38/00 ,  C07K14/475 ,  C12N9/6491

    摘要： The present invention includes peptides, compositions as well as their use for the prevention or treatment of various age related or pathological conditions of skin or other tissues including skin wrinkles, wounds, different types of fibrosis and methods of reconstructing different tissues such as techniques used in regenerative medicine. The invention further includes peptide mimetics and methods of use including interfering with transcriptional complexes characteristic of fibroblasts of aged skin and stimulating synthesis of structural components of extracellular matrix.

    摘要翻译： 本发明包括肽，组合物及其用于预防或治疗皮肤或其他组织的各种年龄相关或病理状况的用途，包括皮肤皱纹，伤口，不同类型的纤维化以及重建不同组织的方法，例如用于 再生医学。 本发明还包括肽模拟物和使用方法，包括干扰老化皮肤的成纤维细胞特征的转录复合物并刺激细胞外基质的结构成分的合成。

    SCREENING METHODS USED TO IDENTIFY COMPOUNDS THAT MODULATE SKIN STROMAL CELLS (FIBROBLASTS) ABILITY TO MODIFY FUNCTION OF EXTRACELLULAR MATRIX
    7.
    发明申请
    SCREENING METHODS USED TO IDENTIFY COMPOUNDS THAT MODULATE SKIN STROMAL CELLS (FIBROBLASTS) ABILITY TO MODIFY FUNCTION OF EXTRACELLULAR MATRIX 审中-公开
    用于鉴定化妆品的筛选方法，调节皮肤细胞（纤维素）修饰细胞外基质功能的能力

    公开(公告)号：US20080206770A1

    公开(公告)日：2008-08-28

    申请号：US12018041

    申请日：2008-01-22

    申请人： Rita Zobel ,  Anzelika Liik ,  Helle Sadam ,  Toomas Neuman

    发明人： Rita Zobel ,  Anzelika Liik ,  Helle Sadam ,  Toomas Neuman

    IPC分类号： C12Q1/68 ,  C12Q1/37 ,  C12Q1/02 ,  C12Q1/26

    CPC分类号： G01N33/5044 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158

    摘要： The cellular response to cosmetic products has been characterized on the molecular level through the use of gene and protein expression technologies. Nucleic acid and protein molecules, the expression of which are induced or repressed in response to exposure to cosmetics, are identified according to a temporal pattern of altered expression post exposure. Methods are disclosed that utilized these cosmetics-regulated molecules as markers for effectiveness of cosmetics. Other screening methods of the invention are designed for the identification of compounds that modulate the response of a cell to exposure to cosmetics. The invention also provides compositions useful for drug screening or pharmaceutical purposes.

    摘要翻译： 通过使用基因和蛋白质表达技术，对化妆品的细胞反应的特征在于分子水平。 根据暴露于化妆品后的表达被诱导或抑制的核酸和蛋白质分子根据暴露后的表达改变的时间模式来鉴定。 公开了使用这些化妆品调节分子作为化妆品有效性的标记物的方法。 本发明的其它筛选方法被设计用于鉴定调节细胞暴露于化妆品的反应的化合物。 本发明还提供了可用于药物筛选或药物目的的组合物。

    Method for inducing DNA synthesis in neurons
    8.
    发明授权
    Method for inducing DNA synthesis in neurons 失效
    在神经元中诱导DNA合成的方法

    公开(公告)号：US6087171A

    公开(公告)日：2000-07-11

    申请号：US362495

    申请日：1996-11-18

    申请人： Toomas Neuman ,  Kikuo Suda ,  Howard O. Nornes

    发明人： Toomas Neuman ,  Kikuo Suda ,  Howard O. Nornes

    IPC分类号： C07K14/075 ,  C07K14/47 ,  C07K14/48 ,  C12N9/02 ,  C12N15/85 ,  A61K48/00 ,  C12N15/87 ,  C12N15/88 ,  C12N15/90

    CPC分类号： C07K14/005 ,  C07K14/4738 ,  C07K14/48 ,  C12N15/85 ,  C12N9/0071 ,  C12Y114/13041 ,  C12Y114/16002 ,  C12N2710/10322

    摘要： A method is provided for inducing DNA synthesis in differentiated neurons. According to certain embodiments of the invention, a method for inducing DNA synthesis in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a differentiated neuron, and transfecting a differentiated neuron with the vector. According to certain embodiments of the invention, a method for integrating DNA encoding a desired protein in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a neuron, obtaining DNA encoding a desired protein, and cotransfecting a differentiated neuron with the vector and the DNA encoding the desired protein such that the DNA encoding the desired protein is integrated in the differentiated neuron and the desired protein is produced.

    摘要翻译： PCT No.PCT / US94 / 14614 Sec。 371日期：1996年11月18日 102（e）1996年11月18日PCT PCT 1994年12月19日PCT公布。 公开号WO95 / 16774 日期：1995年6月22日提供了用于在分化的神经元中诱导DNA合成的方法。 根据本发明的某些实施方案，提供了在分化神经元中诱导DNA合成的方法，其包括获得包含编码E2F调节子和/或E1A调节子的核酸的载体，其中所述载体可用于表达所述核酸 在分化神经元中，并用载体转染分化的神经元。 根据本发明的某些实施方案，提供了一种用于整合在分化神经元中编码所需蛋白质的DNA的方法，其包括获得包含编码E2F调节剂和/或E1A调节剂的核酸的载体，其中所述载体可用于表达 神经元中的核酸，获得编码期望蛋白质的DNA，并用载体和编码所需蛋白质的DNA共转染分化的神经元，使得编码期望的蛋白质的DNA整合在分化的神经元和所需的蛋白质中。