公开(公告)号：US20090176724A1

公开(公告)日：2009-07-09

申请号：US11571585

申请日：2005-06-30

申请人： Daiwei Shen ,  Toomas Neuman ,  Kaia Palm

发明人： Daiwei Shen ,  Toomas Neuman ,  Kaia Palm

IPC分类号： A61K31/7052 ,  G01N33/574 ,  C40B30/00 ,  C12Q1/68 ,  C07K14/00 ,  C40B40/10 ,  A61P35/00 ,  C07K16/00 ,  C07H21/00 ,  G01N33/53 ,  C40B30/04

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： The invention is relates to splice variants of basal transcription factors and other transcriptional modulators, the use of expression analyses of the same as a diagnostic and prognostic tool, and the targeting of such splice variants for therapeutic purposes, particularly in relation to the treatment of cancer.

摘要翻译： 本发明涉及基因转录因子和其他转录调节剂的剪接变体，使用与诊断和预后工具相同的表达分析，以及用于治疗目的的这种剪接变体的靶向，特别是与治疗癌症有关 。

公开(公告)号：US08927276B2

公开(公告)日：2015-01-06

申请号：US12707607

申请日：2010-02-17

申请人： Kaia Palm ,  Toomas Neuman

发明人： Kaia Palm ,  Toomas Neuman

IPC分类号： C12N5/07 ,  C12N5/10 ,  C12N5/00 ,  A61K35/30 ,  C12N5/0797

CPC分类号： C12N5/0623 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/148 ,  C12N2501/235 ,  C12N2506/08

摘要： The present invention relates to a simplified process, which is shorter in time, for propagation of proliferating cells, such as e.g. progenitor or stem cells, by means of a biphasic culturing system having a differentiation supporting component and a proliferation supporting component, and to the use of the stem cell cultures obtained in this way for cell therapy purposes. The present invention invention describes a method, which is highly efficient to prime stem or progenitor cells to differentiation using non-attachment matrices and differentiation supporting component. The cells produced therefrom may be used to treat a variety of neurodegenerative disorders.

摘要翻译： 本发明涉及对于增殖细胞的繁殖，例如时间短的简化方法。 祖细胞或干细胞，通过具有分化支持组分和增殖支持组分的双相培养系统以及以这种方式获得的干细胞培养物用于细胞治疗目的的用途。 本发明描述了一种方法，其使用非附着基质和分化支持组分将茎干或祖细胞分化为高效。 由此产生的细胞可用于治疗各种神经变性疾病。

公开(公告)号：US20110201113A1

公开(公告)日：2011-08-18

申请号：US12707607

申请日：2010-02-17

申请人： Kaia Palm ,  Toomas Neuman

发明人： Kaia Palm ,  Toomas Neuman

IPC分类号： C12N5/02 ,  C12N5/00

CPC分类号： C12N5/0623 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/148 ,  C12N2501/235 ,  C12N2506/08

摘要： The present invention relates to a simplified process, which is shorter in time, for propagation of proliferating cells, such as e.g. progenitor or stem cells, by means of a biphasic culturing system having a differentiation supporting component and a proliferation supporting component, and to the use of the stem cell cultures obtained in this way for cell therapy purposes. The present invention invention describes a method, which is highly efficient to prime stem or progenitor cells to differentiation using non-attachment matrices and differentiation supporting component. The cells produced therefrom may be used to treat a variety of neurodegenerative disorders,

摘要翻译： 本发明涉及对于增殖细胞的繁殖，例如时间短的简化方法。 祖细胞或干细胞，通过具有分化支持组分和增殖支持组分的双相培养系统以及以这种方式获得的干细胞培养物用于细胞治疗目的的用途。 本发明描述了一种方法，其使用非附着基质和分化支持组分将茎干或祖细胞分化为高效。 由此产生的细胞可用于治疗各种神经变性疾病，

公开(公告)号：US20070161023A1

公开(公告)日：2007-07-12

申请号：US11606786

申请日：2006-11-30

申请人： Kaia Palm

发明人： Kaia Palm

IPC分类号： C12Q1/68 ,  G01N33/574 ,  C12M3/00

CPC分类号： G01N33/574 ,  C12Q1/6837 ,  C12Q1/6886 ,  C12Q2600/156

摘要： A method of diagnosing cancer comprising the identification of neoplastic molecular markers is disclosed. Tumor-related or neoplastic molecular markers are identified from samples taken from a subject and the molecular profile of those markers is determined. Based upon the neoplastic molecular marker profile of the subject, the tumor sub-type is ascertained and an appropriate treatment protocols initiated.

摘要翻译： 公开了一种诊断癌症的方法，包括鉴定肿瘤分子标志物。 从取自受试者的样品中鉴定肿瘤相关或肿瘤分子标记，并确定那些标记物的分子谱。 基于受试者的肿瘤分子标志物谱，确定肿瘤亚型并开始适当的治疗方案。

公开(公告)号：US06962985B2

公开(公告)日：2005-11-08

申请号：US09808387

申请日：2001-03-14

申请人： Kaia Palm ,  Tonis Timmusk

发明人： Kaia Palm ,  Tonis Timmusk

IPC分类号： A61K38/00 ,  C07K14/71 ,  C07K14/82 ,  C07H21/02

CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K14/82

摘要： The disclosure relates to isolated polynucleotides and purified polypeptides of the Neu family of proteins, which have been shown to demonstrate transcriptional regulatory activity. For example, the purified polynucleotide can encode a Neu polypeptide, wherein the Neu polypeptide comprises at least one neuralized homology repeat domain and a C3HC4 RING-zinc finger domain is disclosed. A purified Neu polypeptide, wherein the Neu polypeptide comprises at least one neuralized homology repeat domain and a C3HC4 RING-zinc finger domain is disclosed. Antibodies capable of specifically binding to the disclosed Neu polypeptides are disclosed. Vectors expressing the disclosed Neu protein coding regions and host cells containing the vectors are disclosed. Methods of making the Neu proteins disclosed are also provided, as are method of identifying binding partners that interact with a Neu protein family member.

摘要翻译： 本公开涉及已经显示表现出转录调节活性的Neu家族蛋白质的分离的多核苷酸和纯化多肽。 例如，纯化的多核苷酸可以编码Neu多肽，其中Neu多肽包含至少一个神经化同源重复结构域和C3HC4 RING-锌指结构域。 纯化的Neu多肽，其中所述Neu多肽包含至少一个神经化同源重复结构域和C3HC4 RING-锌指结构域。 公开了能够特异性结合所公开的Neu多肽的抗体。 公开了表达所公开的Neu蛋白编码区的载体和含有载体的宿主细胞。 还提供制备所公开的Neu蛋白的方法，以及鉴定与Neu蛋白家族成员相互作用的结合配偶体的方法。

公开(公告)号：US07812124B2

公开(公告)日：2010-10-12

申请号：US11606786

申请日：2006-11-30

申请人： Kaia Palm

发明人： Kaia Palm

IPC分类号： C07K14/00

CPC分类号： G01N33/574 ,  C12Q1/6837 ,  C12Q1/6886 ,  C12Q2600/156

摘要： A method of diagnosing cancer comprising the identification of neoplastic molecular markers is disclosed. Tumor-related or neoplastic molecular markers are identified from samples taken from a subject and the molecular profile of those markers is determined. Based upon the neoplastic molecular marker profile of the subject, the tumor sub-type is ascertained and an appropriate treatment protocols initiated.

摘要翻译： 公开了一种诊断癌症的方法，包括鉴定肿瘤分子标志物。 从取自受试者的样品中鉴定肿瘤相关或肿瘤分子标记，并确定那些标记物的分子谱。 基于受试者的肿瘤分子标志物谱，确定肿瘤亚型并开始适当的治疗方案。

公开(公告)号：US20060160103A1

公开(公告)日：2006-07-20

申请号：US11125970

申请日：2005-05-09

申请人： Kaia Palm ,  Tonis Timmusk

发明人： Kaia Palm ,  Tonis Timmusk

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/475

CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K14/82

摘要： The disclosure relates to isolated polynucleotides and purified polypeptides of the Neu family of proteins, which have been shown to demonstrate transcriptional regulatory activity. For example, the purified polynucleotide can encode a Neu polypeptide, wherein the Neu polypeptide comprises at least one neuralized homology repeat domain and a C3HC4 RING-zinc finger domain is disclosed. A purified Neu polypeptide, wherein the Neu polypeptide comprises at least one neuralized homology repeat domain and a C3HC4 RING-zinc finger domain is disclosed. Antibodies capable of specifically binding to the disclosed Neu polypeptides are disclosed. Vectors expressing the disclosed Neu protein coding regions and host cells containing the vectors are disclosed. Methods of making the Neu proteins disclosed are also provided, as are method of identifying binding partners that interact with a Neu protein family member.

摘要翻译： 本公开涉及已经显示表现出转录调节活性的Neu家族蛋白质的分离的多核苷酸和纯化多肽。 例如，纯化的多核苷酸可以编码Neu多肽，其中Neu多肽包含至少一个神经化同源重复结构域和C3HC4 RING-锌指结构域。 纯化的Neu多肽，其中所述Neu多肽包含至少一个神经化同源重复结构域和C3HC4 RING-锌指结构域。 公开了能够特异性结合所公开的Neu多肽的抗体。 公开了表达所公开的Neu蛋白编码区的载体和含有载体的宿主细胞。 还提供制备所公开的Neu蛋白的方法，以及鉴定与Neu蛋白家族成员相互作用的结合配偶体的方法。