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    Method of Inducing Cellular Growth and Materials for Use Therewith
    2.
    发明申请
    Method of Inducing Cellular Growth and Materials for Use Therewith 审中-公开
    诱导细胞生长的方法及其使用的材料

    公开(公告)号：US20120283618A1

    公开(公告)日：2012-11-08

    申请号：US13512321

    申请日：2010-11-26

    申请人： Stephen Anthony Livesey ,  Kathy Traianedes

    发明人： Stephen Anthony Livesey ,  Kathy Traianedes

    IPC分类号： A61M37/00 ,  C12N5/00

    CPC分类号： A61K35/28 ,  A01K67/0271 ,  A01K2207/12

    摘要： The present invention relates generally to a method of producing a population of cells and materials for use therewith. More particularly, the present invention is directed to a method of generating the growth of a population of blood-derived cells and materials for use therewith. The method of the present invention facilitates cell growth by virtue of the migration of blood-derived cells from the vasculature of a vascularised receptacle to the acellular tissue support matrix of said receptacle. These findings have now facilitated the design of means for reliably and efficiently deriving cellular populations from blood-derived cells, such as the generation of bone marrow cells including haemopoietic stem cells and mesenchymal stem cells, for use in a wide variety of clinical and research settings. The method of the present invention is particularly useful for the therapeutic or prophylactic treatment of a range of conditions via the administration of the cells generated in accordance with the method of the present invention.

    摘要翻译： 本发明一般涉及生产与其一起使用的细胞群和材料的方法。 更具体地说，本发明涉及一种产生血源细胞群体及其使用材料生长的方法。 本发明的方法由于血液源细胞从血管化插管的脉管系统迁移到所述容器的无细胞组织支撑基质而促进细胞生长。 这些发现现在有助于设计用于可靠和有效地从血液来源的细胞衍生细胞群的手段，例如产生包括造血干细胞和间充质干细胞在内的骨髓细胞，用于各种临床和研究环境 。 本发明的方法特别可用于通过施用根据本发明方法产生的细胞来治疗或预防一系列病症。

    METHOD OF EX VIVO CELLULAR GROWTH
    4.
    发明申请
    METHOD OF EX VIVO CELLULAR GROWTH 审中-公开

    公开(公告)号：US20180256643A1

    公开(公告)日：2018-09-13

    申请号：US15910999

    申请日：2018-03-02

    申请人： Kathy Traianedes ,  Stephen Anthony Livesey

    发明人： Kathy Traianedes ,  Stephen Anthony Livesey

    IPC分类号： A61K35/14 ,  A61K35/28 ,  A61L27/36 ,  A61L27/38 ,  A61L27/50

    CPC分类号： A61K35/14 ,  A61K35/28 ,  A61L27/3633 ,  A61L27/3834 ,  A61L27/507

    摘要： The present invention relates generally to an ex vivo method of producing a population of cells and materials for use therewith. More particularly, the present invention is directed to an ex vivo method of generating the growth of a population of blood-derived cells and materials for use therewith. The method of the present invention facilitates cell growth by virtue of the migration of blood-derived cells from the vasculature of a vascularised receptacle to the acellular tissue support matrix of said receptacle. These findings have now facilitated the design of means for reliably and efficiently deriving cellular populations from blood-derived cells, such as the generation of bone marrow cells including haemopoietic stem cells and mesenchymal stem cells, for use in a wide variety of clinical and research settings. The method of the present invention is particularly useful for the therapeutic or prophylactic treatment of a range of conditions via the administration of the cells generated in accordance with the method of the present invention.

    METHOD OF EX VIVO CELLULAR GROWTH
    7.
    发明申请
    METHOD OF EX VIVO CELLULAR GROWTH 审中-公开
    细胞生长的方法

    公开(公告)号：US20140186310A1

    公开(公告)日：2014-07-03

    申请号：US14122598

    申请日：2012-05-25

    申请人： Kathy Traianedes ,  Anthony Stephen Livesey

    发明人： Kathy Traianedes ,  Anthony Stephen Livesey

    IPC分类号： A61K35/14

    CPC分类号： A61K35/14 ,  A61K35/28 ,  A61L27/3633 ,  A61L27/3834 ,  A61L27/507

    摘要： The present invention relates generally to an ex vivo method of producing a population of cells and materials for use therewith. More particularly, the present invention is directed to an ex vivo method of generating the growth of a population of blood-derived cells and materials for use therewith. The method of the present invention facilitates cell growth by virtue of the migration of blood-derived cells from the vasculature of a vascularised receptacle to the acellular tissue support matrix of said receptacle. These findings have now facilitated the design of means for reliably and efficiently deriving cellular populations from blood-derived cells, such as the generation of bone marrow cells including haemopoietic stem cells and mesenchymal stem cells, for use in a wide variety of clinical and research settings. The method of the present invention is particularly useful for the therapeutic or prophylactic treatment of a range of conditions via the administration of the cells generated in accordance with the method of the present invention.

    摘要翻译： 本发明一般涉及一种生产与其一起使用的细胞群和材料的离体方法。 更具体地说，本发明涉及一种离子生成方法，用于产生血源细胞群和其使用的材料的生长。 本发明的方法由于血液源细胞从血管化插管的脉管系统迁移到所述容器的无细胞组织支撑基质而促进细胞生长。 这些发现现在有助于设计用于可靠和有效地从血液来源的细胞衍生细胞群体的手段，例如产生包括造血干细胞和间充质干细胞在内的骨髓细胞，用于各种临床和研究环境 。 本发明的方法特别可用于通过施用根据本发明方法产生的细胞来治疗或预防一系列病症。

    Bone graft comprising a demineralized bone matrix and a stabilizing agent
    9.
    发明授权
    Bone graft comprising a demineralized bone matrix and a stabilizing agent 有权
    骨移植物包含脱矿骨基质和稳定剂

    公开(公告)号：US07959941B2

    公开(公告)日：2011-06-14

    申请号：US11622955

    申请日：2007-01-12

    申请人： David Knaack ,  Kathy Traianedes ,  Michele Diegman ,  Nanette Forsyth ,  John Winterbottom

    发明人： David Knaack ,  Kathy Traianedes ,  Michele Diegman ,  Nanette Forsyth ,  John Winterbottom

    IPC分类号： A61F2/28

    CPC分类号： A61F2/28 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30677 ,  A61L27/227 ,  A61L27/3608 ,  A61L27/3633 ,  A61L27/365 ,  A61L27/505 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2300/434 ,  A61L2300/602 ,  A61L2300/802 ,  A61L2430/02 ,  B33Y80/00

    摘要： An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-.beta., BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteodinductive matrix compositions.

    摘要翻译： 提供了与稳定剂混合的改进的脱矿质骨基质（DBM）或其它基质组合物，其作为（1）扩散阻挡层，（2）酶抑制剂，（3）竞争性底物，或（4） 掩蔽部分。 扩散屏障作为屏障，以保护DBM中发现的骨诱导因子不被植入部位的蛋白水解酶和糖酵解酶降解。 稳定剂可以是任何可生物降解的材料，例如淀粉，改性淀粉，纤维素，葡聚糖，聚合物，蛋白质和胶原蛋白。 当稳定剂在体内降解或溶解时，骨诱导因子如TGF-β，BMP和IGF被活化或暴露，并且活化因子用于将细胞从血管内空间募集到损伤部位并导致 分化成骨形成细胞。 本发明还提供了制备，测试和使用本发明改进的骨吸收性基质组合物的方法。