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公开(公告)号：US08415477B2
公开(公告)日：2013-04-09
申请号：US13149392
申请日：2011-05-31
Applicant: Gayle Buller , Jixiang Liu , Stephen Yue , Jolene Bradford
Inventor： Gayle Buller , Jixiang Liu , Stephen Yue , Jolene Bradford
IPC: C07D413/04 , C07D417/04
CPC classification number: C09B23/0075 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , G01N21/6486 , G01N33/52 , G01N33/582 , G01N2021/6441
Abstract: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
Abstract translation: 本发明提供了在约400nm处最佳激发并具有至少约80nm的斯托克斯位移的染料化合物。 这些染料可用于检测样品中的分析物和染料缀合物的制备。
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公开(公告)号：US20070077549A1
公开(公告)日：2007-04-05
申请号：US11535458
申请日：2006-09-26
Applicant: Gayle Buller , Jixiang Liu , Stephen Yue , Jolene Bradford
Inventor： Gayle Buller , Jixiang Liu , Stephen Yue , Jolene Bradford
IPC: C12Q1/00 , C07D413/02 , C07F9/58 , C07F9/82 , C07F7/02
CPC classification number: C09B23/0075 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , G01N21/6486 , G01N33/52 , G01N33/582 , G01N2021/6441
Abstract: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
Abstract translation: 本发明提供了在约400nm处最佳激发并具有至少约80nm的斯托克斯位移的染料化合物。 这些染料可用于检测样品中的分析物和染料缀合物的制备。
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公开(公告)号：US20140147860A1
公开(公告)日：2014-05-29
申请号：US14129777
申请日：2012-06-27
Applicant: Gregory Kaduchak , Michael Ward , Jolene Bradford , Bradley Dubbels , Barbara Seredick , Rickie Kerndt , Kristi Haataja , April Anderson , Penny Melquist , Christopher Langsdorf , Justin Hicks , Kathleen Kihn
Inventor： Gregory Kaduchak , Michael Ward , Jolene Bradford , Bradley Dubbels , Barbara Seredick , Rickie Kerndt , Kristi Haataja , April Anderson , Penny Melquist , Christopher Langsdorf , Justin Hicks , Kathleen Kihn
IPC: G01N33/569
CPC classification number: G01N33/56966 , G01N15/1404 , G01N21/6408 , G01N21/6486 , G01N2015/142
Abstract: Various embodiments disclosed herein comprise acoustic cytometry based methods, kits, computer software methods and systems to analyze a variety of bioparticles. In one embodiment, a method for analyzing bioparticles comprises: acoustically focusing one or more bioparticles through an interrogation zone; optically exciting the one or more bioparticles in the interrogation zone with an excitation source; detecting an optical signal from the bioparticles; and analyzing the optical signal to characterize at least one quality or quantity parameter of the bioparticles. Properties of biomolecules that may be analyzed include but are not limited to cell proliferation analysis, live/dead cell discrimination, cell cycle analysis, basic phenotyping, immunophenotyping, rare-event detection, apoptosis, phagocytosis, pinocytosis, detection of phosphoproteins, detection of one or more cellular markers, detection of one or more intracellular marker, detection of cancer cells, detection of pathological markers on a cell, microbial cell analysis and/or picophytoplankton analysis.
Abstract translation: 本文公开的各种实施方案包括基于声学细胞计算的方法，试剂盒，计算机软件方法和用于分析各种生物颗粒的系统。 在一个实施方案中，用于分析生物颗粒的方法包括：通过询问区将一种或多种生物颗粒声学聚焦; 用激发源光学激发询问区中的一个或多个生物颗粒; 从生物颗粒检测光信号; 以及分析所述光学信号以表征所述生物颗粒的至少一个质量或数量参数。 可以分析的生物分子的性质包括但不限于细胞增殖分析，活/死细胞鉴别，细胞周期分析，基本表型，免疫分型，罕见事件检测，细胞凋亡，吞噬作用，胞饮作用，磷蛋白检测，检测一种 或更多的细胞标志物，一种或多种细胞内标志物的检测，癌细胞的检测，细胞上的病理标记的检测，微生物细胞分析和/或浮游生物分析。
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公开(公告)号：US08158801B2
公开(公告)日：2012-04-17
申请号：US11535458
申请日：2006-09-26
Applicant: Gayle Buller , Jixiang Liu , Stephen T. Yue , Jolene Bradford
Inventor： Gayle Buller , Jixiang Liu , Stephen T. Yue , Jolene Bradford
IPC: C07D413/04 , G01N33/52
CPC classification number: C09B23/0075 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , G01N21/6486 , G01N33/52 , G01N33/582 , G01N2021/6441
Abstract: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
Abstract translation: 本发明提供了在约400nm处最佳激发并具有至少约80nm的斯托克斯位移的染料化合物。 这些染料可用于检测样品中的分析物和染料缀合物的制备。
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公开(公告)号：US20120004397A1
公开(公告)日：2012-01-05
申请号：US13149392
申请日：2011-05-31
Applicant: Gayle Buller , Jixiang Liu , Stephen T. Yue , Jolene Bradford
Inventor： Gayle Buller , Jixiang Liu , Stephen T. Yue , Jolene Bradford
IPC: C07K16/18 , C07K16/28 , C07D417/04 , C07K14/36 , C07D413/04 , C07D413/14
CPC classification number: C09B23/0075 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , G01N21/6486 , G01N33/52 , G01N33/582 , G01N2021/6441
Abstract: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
Abstract translation: 本发明提供了在约400nm处最佳激发并具有至少约80nm的斯托克斯位移的染料化合物。 这些染料可用于检测样品中的分析物和染料缀合物的制备。
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Patent Agency Ranking
公开(公告)号：US07521577B2
公开(公告)日：2009-04-21
申请号：US11622900
申请日：2007-01-12
Applicant: Kyle R. Gee , Jolene Bradford , Vladimir V. Martin
Inventor： Kyle R. Gee , Jolene Bradford , Vladimir V. Martin
IPC: C07C229/00 , C07C321/00 , C07C205/00
CPC classification number: C07D413/04 , C07D209/14 , C07D335/12 , C09B11/28
Abstract: The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of heavy metal ions in a sample. This metal chelating moiety is a —N,N,O-triacetic acid analog of BAPTA and has the following formula
Abstract translation: 本发明提供金属螯合剂和促进样品中重金属离子结合，检测，监测和定量的方法。 该金属螯合部分是BAPTA的-N，N，O-三乙酸类似物，具有下式
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7.发明授权公开(公告)号：US08653261B2
公开(公告)日：2014-02-18
申请号：US13126150
申请日：2009-10-26
Applicant: Stephen Yue , Jixiang Liu , Jolene Bradford
Inventor： Stephen Yue , Jixiang Liu , Jolene Bradford
IPC: C07D265/38
CPC classification number: C07D265/38
Abstract: Actinomysin-based near IR emitting compounds and methods of their use as nucleic acid stains are provided. The actinomysin-based near IR emitting compounds have the structure: wherein R is H or NH2; R1, R2, R3, and R4 are independently a moiety comprising 1-30 atoms selected from H, O, C, and N, wherein the atoms are in a linear, branched, or cyclic configuration; R3 and/or R4 comprise a quaternary nitrogen atom; and R5 is H, F, or Cl.
Abstract translation: 提供了基于放射性肌动蛋白的近红外发射化合物及其用作核酸污渍的方法。 基于放电肌注蛋白的近红外发射化合物具有以下结构：其中R是H或NH 2; R1，R2，R3和R4独立地是包含1-30个选自H，O，C和N的原子的部分，其中原子是直链，支链或环状构型; R3和/或R4包含季氮原子; R5为H，F或Cl。
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公开(公告)号：US20120028249A1
公开(公告)日：2012-02-02
申请号：US13126234
申请日：2009-10-20
Applicant: Stephen Yue , Shih-Jung Huang , Jolene Bradford
Inventor： Stephen Yue , Shih-Jung Huang , Jolene Bradford
IPC: C12Q1/68 , C07H21/04 , C07D233/61 , C07D403/12 , C07D401/12 , C07D295/13 , C07C255/43 , C07D295/192 , C07D205/04 , C07D207/09
CPC classification number: G01N33/52 , C07C225/36 , C07C237/10 , C07C2603/24 , C07D205/04 , C07D213/36 , C07D233/61 , C07D249/04 , C07D295/13 , C07D295/192 , C07H21/04 , C09B1/5165 , C12Q1/6816 , C12Q1/6841 , G01N21/6428 , G01N2021/6441
Abstract: Disclosed are near IR emitting fluorescent compounds; methods of making and kits containing the described compounds; and their use in fluorescence-based detection of biological materials.
Abstract translation: 近红外发射荧光化合物; 制备方法和含有所述化合物的试剂盒; 以及它们在荧光检测生物材料中的应用。
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公开(公告)号：US20100167333A1
公开(公告)日：2010-07-01
申请号：US12636687
申请日：2009-12-11
Applicant: Kyle R. Gee , Jolene Bradford , Vladimir V. Martin
Inventor： Kyle R. Gee , Jolene Bradford , Vladimir V. Martin
IPC: C12Q1/02 , G01N1/30 , G01N33/20 , C07K2/00 , C07K14/76 , C07K14/435 , C07K16/00 , C07K14/42 , A61K38/18 , C07H21/04 , C08B37/02 , C07D413/04 , C07D209/20 , C07D311/90
CPC classification number: C07D413/04 , C07D209/14 , C07D335/12 , C09B11/28
Abstract: The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of heavy metal ions in a sample. This metal chelating moiety is a —N,N,O-triacetic acid analog of BAPTA and has the following formula
Abstract translation: 本发明提供金属螯合剂和促进样品中重金属离子结合，检测，监测和定量的方法。 该金属螯合部分是BAPTA的-N，N，O-三乙酸类似物，具有下式
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公开(公告)号：US20070161112A1
公开(公告)日：2007-07-12
申请号：US11622900
申请日：2007-01-12
Applicant: Kyle Gee , Jolene Bradford , Vladimir Martin
Inventor： Kyle Gee , Jolene Bradford , Vladimir Martin
IPC: G01N33/20 , C07D311/88 , C07D263/08 , C07D209/04 , C07D413/04
CPC classification number: C07D413/04 , C07D209/14 , C07D335/12 , C09B11/28
Abstract: The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of heavy metal ions in a sample. This metal chelating moiety is a —N,N,O-triacetic acid analog of BAPTA and has the following formula
Abstract translation: 本发明提供金属螯合剂和促进样品中重金属离子结合，检测，监测和定量的方法。 该金属螯合部分是BAPTA的-N，N，O-三乙酸类似物，具有下式
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