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42 条记录 (耗时 0.016 秒)

    Anthraquinone and its derivatives
    2.
    发明授权
    Anthraquinone and its derivatives 有权
    蒽醌及其衍生物

    公开(公告)号：US07605280B2

    公开(公告)日：2009-10-20

    申请号：US11367328

    申请日：2006-03-06

    申请人： Paul James Smith ,  Laurence Hylton Patterson

    发明人： Paul James Smith ,  Laurence Hylton Patterson

    IPC分类号： C09B1/16 ,  C12Q1/00 ,  C12Q1/68 ,  A01N33/24

    CPC分类号： G01N33/52 ,  C07C225/36 ,  C09B1/5155

    摘要： There is disclosed a compound of formula (I) wherein each of X1 and X2 are independently NH-A-NR1R2, and wherein A is A C2-8 alkylene and R1 and R2 are independently selected from hydrogen, C1-4 alkyl, C2-4 hydroxy-alkyl and C2-4 aminoalkyl, or R1 and R2 together form a C2-6 alkylene group which with the nitrogen atom to which R1 and R2 are attached forms a heterocyclic ring, or an N-oxide derivative thereof, and wherein the compound (I) or its N-oxide derivative is optionally in the form of an acid salt derived from an organic or inorganic acid. Also disclosed is a method of its production and its uses, including its use in analyzing a cell or biological material and detecting the emitted fluorescence signal.

    摘要翻译： 公开了式（I）的化合物，其中X1和X2各自独立地为NH-A-NR1R2，其中A为A C2-8亚烷基，R1和R2独立地选自氢，C1-4烷基，C2- 4个羟基 - 烷基和C 2-4氨基烷基，或者R 1和R 2一起形成与R 1和R 2所连接的氮原子一起形成杂环的C 2-6亚烷基或其N-氧化物衍生物，其中 化合物（I）或其N-氧化物衍生物任选为衍生自有机或无机酸的酸盐形式。 还公开了其生产方法及其用途，包括其用于分析细胞或生物材料并检测发出的荧光信号。

    Anthraquinone and its derivatives
    4.
    发明授权
    Anthraquinone and its derivatives 有权
    蒽醌及其衍生物

    公开(公告)号：US07060427B2

    公开(公告)日：2006-06-13

    申请号：US10215945

    申请日：2002-08-12

    申请人： Paul James Smith ,  Laurence Hylton Patterson

    发明人： Paul James Smith ,  Laurence Hylton Patterson

    IPC分类号： C12Q1/00 ,  C09B1/16

    CPC分类号： G01N33/52 ,  C07C225/36 ,  C09B1/5155

    摘要： There is disclosed a compound of formula (I) wherein each of X1 and X2 are independently NH—A—NR1R2, and wherein A is A C2-8 alkylene and R1 and R2 are independently selected from hydrogen, C1-4 alkyl, C2-4 hydroxy-alkyl and C2-4 aminoalkyl, or R1 and R2 together form a C2-6 alkylene group which with the nitrogen atom to which R1 and R2 are attached forms a heterocyclic ring, or an N-oxide derivative thereof, and wherein the compound (I) or its N-oxide derivative is optionally in the form of an acid salt derived from an organic or inorganic acid. Also disclosed is a method of its production and its uses, including its use in analyzing a cell or biological material and detecting the emitted fluorescence signal.

    摘要翻译： 公开了式（I）的化合物，其中X 1和X 2各自独立地为NH-A-NR 1 R SUP > 2，并且其中A是AC 2〜8个亚烷基，R 1和R 2独立地选自氢，C C 1-4烷基，C 2-4 2-4羟基烷基和C 2-4 2-4氨基烷基，或R 1〜 和R 2一起形成C 2〜6亚烷基，其与R 1和R 2的氮原子一起形成， SUP]连接形成杂环或其N-氧化物衍生物，其中化合物（I）或其N-氧化物衍生物任选为衍生自有机或无机酸的酸盐形式。 还公开了其生产方法及其用途，包括其用于分析细胞或生物材料并检测发出的荧光信号。

    Anthraquinone quencher dyes, their methods of preparation and use
    5.
    发明申请
    Anthraquinone quencher dyes, their methods of preparation and use 有权
    蒽醌猝灭剂染料，其制备和使用方法

    公开(公告)号：US20040110308A1

    公开(公告)日：2004-06-10

    申请号：US10666998

    申请日：2003-09-19

    申请人： Integrated DNA Technologies, Inc.

    发明人： Andrei Laikhter ,  Mark Aaron Behlke ,  Yawfui Yong ,  Scott Rose ,  Lingyan Huang

    IPC分类号： C09B001/473 ,  G01N033/543

    CPC分类号： C07H21/00 ,  C07C225/36 ,  C07F9/091 ,  C07F9/2408 ,  C09B1/325 ,  C12Q1/6818

    摘要： The invention provides novel anthraquinone compositions that are useful as broad-spectrum quenchers of fluorescence and provides methods for making and using them. The anthraquinone quenchers can be conjugated to a variety of biologically relevant compounds, including lipids, nucleic acids, polypeptides, and more specifically antigens, steroids, vitamins, drugs, haptens, metabolites, toxins, environmental pollutants, amino acids, peptides, proteins, nucleotides, oligonucleotides, polynucleotides, carbohydrates, and their analogs. The invention also provides kits comprising, in one or more containers, at least one anthraquinone quencher dye composition of the present invention, and instructions for using that composition.

    摘要翻译： 本发明提供了新颖的蒽醌组合物，其可用作荧光的广谱猝灭剂，并提供制备和使用它们的方法。 蒽醌猝灭剂可以与各种生物相关化合物缀合，包括脂质，核酸，多肽，更具体地，抗原，类固醇，维生素，药物，半抗原，代谢物，毒素，环境污染物，氨基酸，肽，蛋白质，核苷酸 ，寡核苷酸，多核苷酸，碳水化合物及其类似物。 本发明还提供在一个或多个容器中包含至少一种本发明的蒽醌猝灭剂染料组合物的试剂盒，以及使用该组合物的说明书。

    Di-alpha amino anthraquinone compositions
    8.
    发明授权
    Di-alpha amino anthraquinone compositions 有权
    二-α氨基蒽醌组合物

    公开(公告)号：US08114979B2

    公开(公告)日：2012-02-14

    申请号：US12853755

    申请日：2010-08-10

    申请人： Andrei Laikhter ,  Mark Aaron Behlke ,  Yawfui Yong ,  Scott Rose ,  Lingyan Huang

    发明人： Andrei Laikhter ,  Mark Aaron Behlke ,  Yawfui Yong ,  Scott Rose ,  Lingyan Huang

    IPC分类号： C07H21/04 ,  C07C45/27

    CPC分类号： C07H21/00 ,  C07C225/36 ,  C07F9/091 ,  C07F9/2408 ,  C09B1/325 ,  C12Q1/6818

    摘要： The invention provides novel anthraquinone compositions that are useful as broad-spectrum quenchers of fluorescence and provides methods for making and using them. The anthraquinone quenchers can be conjugated to a variety of biologically relevant compounds, including lipids, nucleic acids, polypeptides, and more specifically antigens, steroids, vitamins, drugs, haptens, metabolites, toxins, environmental pollutants, amino acids, peptides, proteins, nucleotides, oligonucleotides, polynucleotides, carbohydrates, and their analogs. The invention also provides kits comprising, in one or more containers, at least one anthraquinone quencher dye composition of the present invention, and instructions for using that composition.

    摘要翻译： 本发明提供了新颖的蒽醌组合物，其可用作荧光的广谱猝灭剂，并提供制备和使用它们的方法。 蒽醌猝灭剂可以与各种生物相关化合物缀合，包括脂质，核酸，多肽，更具体地，抗原，类固醇，维生素，药物，半抗原，代谢物，毒素，环境污染物，氨基酸，肽，蛋白质，核苷酸 ，寡核苷酸，多核苷酸，碳水化合物及其类似物。 本发明还提供在一个或多个容器中包含至少一种本发明的蒽醌猝灭剂染料组合物的试剂盒，以及使用该组合物的说明书。

    Methods of detecting fluorescence with anthraquinone quencher dyes
    9.
    发明授权
    Methods of detecting fluorescence with anthraquinone quencher dyes 有权
    用蒽醌猝灭剂染料检测荧光的方法

    公开(公告)号：US07803536B2

    公开(公告)日：2010-09-28

    申请号：US10666998

    申请日：2003-09-19

    申请人： Mark Aaron Behlke ,  Lingyan Huang ,  Andrei Laikhter ,  Yawfui Yong ,  Scott Rose

    发明人： Mark Aaron Behlke ,  Lingyan Huang ,  Andrei Laikhter ,  Yawfui Yong ,  Scott Rose

    IPC分类号： C12Q1/68 ,  C07C45/27

    CPC分类号： C07H21/00 ,  C07C225/36 ,  C07F9/091 ,  C07F9/2408 ,  C09B1/325 ,  C12Q1/6818

    摘要： The invention provides novel anthraquinone compositions that are useful as broad-spectrum quenchers of fluorescence and provides methods for making and using them. The anthraquinone quenchers can be conjugated to a variety of biologically relevant compounds, including lipids, nucleic acids, polypeptides, and more specifically antigens, steroids, vitamins, drugs, haptens, metabolites, toxins, environmental pollutants, amino acids, peptides, proteins, nucleotides, oligonucleotides, polynucleotides, carbohydrates, and their analogs. The invention also provides kits comprising, in one or more containers, at least one anthraquinone quencher dye composition of the present invention, and instructions for using that composition.

    摘要翻译： 本发明提供了新颖的蒽醌组合物，其可用作荧光的广谱猝灭剂，并提供制备和使用它们的方法。 蒽醌猝灭剂可以与各种生物相关化合物缀合，包括脂质，核酸，多肽，更具体地，抗原，类固醇，维生素，药物，半抗原，代谢物，毒素，环境污染物，氨基酸，肽，蛋白质，核苷酸 ，寡核苷酸，多核苷酸，碳水化合物及其类似物。 本发明还提供在一个或多个容器中包含至少一种本发明的蒽醌猝灭剂染料组合物的试剂盒，以及使用该组合物的说明书。