公开(公告)号：US10385009B2

公开(公告)日：2019-08-20

申请号：US14420184

申请日：2013-08-07

申请人： Biostatus Limited

发明人： Stefan Ogrodzinski ,  Paul Smith ,  Stephanie McKeown ,  Laurence Patterson ,  Rachel Jane Errington

IPC分类号： C07C225/36 ,  A61K31/136 ,  C07B59/00 ,  C07C291/04 ,  A61K45/06 ,  G01N31/22 ,  A61K31/277

摘要： An anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an agent capable of reducing the level of oxygenation of a tumor, are also provided. Additionally, an option for combination with chemotherapeutic and radiotherapeutic modalities to enhance overall tumor cell kill is provided. Methods for the detection of cellular hypoxia, both in vivo and in vitro, are additionally provided.

公开(公告)号：US20150307441A1

公开(公告)日：2015-10-29

申请号：US14420184

申请日：2013-08-07

申请人： Biostatus Limited

发明人： Stefan Ogrodzinski ,  Paul Smith ,  Stephanie McKeown ,  Laurence Patterson ,  Rachel Jane Errington

IPC分类号： C07C225/36 ,  G01N31/22 ,  A61K31/277 ,  A61K31/136 ,  A61K45/06

CPC分类号： C07C225/36 ,  A61K31/136 ,  A61K31/277 ,  A61K45/06 ,  C07B59/001 ,  C07B2200/05 ,  C07C291/04 ,  C07C2603/24 ,  G01N31/225

摘要： An anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an agent capable of reducing the level of oxygenation of a tumour, are also provided. Additionally, an option for combination with chemotherapeutic and radiotherapeutic modalities to enhance overall tumour cell kill is provided. Methods for the detection of cellular hypoxia, both in vivo and in vitro, are additionally provided.

摘要翻译： 提供了式I的蒽醌化合物（例如式II至X的化合物）及其制备方法。 还提供了用于治疗癌症的药物组合物，任选地与能够降低肿瘤氧合水平的药剂组合。 另外，提供了与化学治疗和放射治疗方式组合以增强整体肿瘤细胞杀伤的选择。 另外提供了在体内和体外检测细胞缺氧的方法。

公开(公告)号：US20190249011A1

公开(公告)日：2019-08-15

申请号：US16312652

申请日：2017-06-09

申请人： BIOSTATUS LIMITED

发明人： Paul James Smith ,  Rachel Jane Errington ,  Laurence Hylton Patterson ,  Klaus Pors ,  Laura Cosentino

IPC分类号： C09B1/26 ,  C09B1/51 ,  C12Q1/6841 ,  G01N33/50 ,  G01N1/30

CPC分类号： C09B1/262 ,  C07C225/34 ,  C07C225/36 ,  C07C2603/24 ,  C09B1/51 ,  C12Q1/6841 ,  G01N1/30 ,  G01N33/5008 ,  G01N2001/302

摘要： The present invention provides di-substituted acetalanthraquinone-based compounds of the Formulae (l)-(IV) that are useful for cellular staining and for light-based detection of biological material, e.g. fluorescence-based detection of biological material. These compounds may be used in hydrolysed or non-hydrolysed form. Also provided is a fluorescent complex that comprises a nucleic acid and an acetalanthraquinone-based compound of the invention; and a method of staining a biological sample comprising cells or other biological material containing nucleic acid, which method comprises contacting the biological sample with an acetalanthraquinone-based compound of the invention. In the Formulae (l)-(IV), A and B are each independently of formula —RaCH2CH(ORb)2; or one of A and B is of formula —RaCH2CH(ORb)2 and the other one is of formula: —NRb2.

公开(公告)号：US11447638B2

公开(公告)日：2022-09-20

申请号：US16312652

申请日：2017-06-09

申请人： BIOSTATUS LIMITED

发明人： Paul James Smith ,  Rachel Jane Errington ,  Laurence Hylton Patterson ,  Klaus Pors ,  Laura Cosentino

IPC分类号： C09B1/26 ,  C12Q1/6841 ,  G01N1/30 ,  G01N33/50 ,  C09B1/51 ,  C07C225/36 ,  C07C225/34

摘要： The present invention provides di-substituted acetalanthraquinone-based compounds of the Formulae (l)-(IV) that are useful for cellular staining and for light-based detection of biological material, e.g. fluorescence-based detection of biological material. These compounds may be used in hydrolysed or non-hydrolysed form. Also provided is a fluorescent complex that comprises a nucleic acid and an acetalanthraquinone-based compound of the invention; and a method of staining a biological sample comprising cells or other biological material containing nucleic acid, which method comprises contacting the biological sample with an acetalanthraquinone-based compound of the invention. In the Formulae (l)-(IV), A and B are each independently of formula —RaCH2CH(ORb)2; or one of A and B is of formula —RaCH2CH(ORb)2 and the other one is of formula: —NRb2.