公开(公告)号：US20240124390A1

公开(公告)日：2024-04-18

申请号：US18154520

申请日：2023-01-13

申请人： ZHEJIANG YUEJIA PHARMACEUTICALS CO., LTD

发明人： Jing ZHANG

IPC分类号： C07C229/38 ,  A61P29/00 ,  C07C291/04 ,  C07D319/08

CPC分类号： C07C229/38 ,  A61P29/00 ,  C07C291/04 ,  C07D319/08

摘要： Disclosed are benzoate derivatives. Provided is a compound having a formula selected from the group consisting of following structures. The compound can be used for quality control over a 2-(diethylamino)ethyl 2-acetoxybenzoate hydrochloride product, and also for inflammation diminishment.

公开(公告)号：US11780800B1

公开(公告)日：2023-10-10

申请号：US18185180

申请日：2023-03-16

申请人： SpringWorks Therapeutics Inc.

发明人： Kristin Patterson ,  Piero L Ruggiero

IPC分类号： C07C211/55 ,  A61K31/166 ,  C07C291/04

CPC分类号： C07C211/55 ,  A61K31/166 ,  C07C291/04

摘要： The present disclosure relates to fluorinated phenylamino compounds, their pharmaceutical compositions, and methods for treating one or more tumors or cancers selected from the group consisting of plexiform neurofibromas (PN), plexiform neurofibromas associated with neurofibromatosis type 1 (NF1-PN), cutaneous neurofibromas (cNF), pancreatic ductal adenocarcinoma (PDAC), high grade glioma (HGG), low grade ovarian cancer, tuberous sclerosis (TSC), Langerhans cell histiocytosis (LCH), brain cancer, and a cancer that has metastasized to a patient's brain, comprising administering to a patient in need thereof, those pharmaceutical compositions.

公开(公告)号：US10961180B2

公开(公告)日：2021-03-30

申请号：US16243232

申请日：2019-01-09

申请人： Eastman Chemical Company

发明人： Stephanie Kay Clendennen ,  Vasudev R. Bhonde ,  Damon Ray Billodeaux ,  Matthew Allen Boone ,  Kim Dumoleijn ,  Stijn Simonne Paul Van de Vyver ,  Kristof Moonen ,  Neil Warren Boaz

IPC分类号： C09K8/584 ,  C07C207/02 ,  C07C201/00 ,  C11D1/75 ,  C11D1/83 ,  C11D1/835 ,  C11D1/94 ,  C10L1/18 ,  C11D3/39 ,  C11D11/00 ,  C11D3/43 ,  C09D7/63 ,  C11D3/395 ,  A01N41/08 ,  C07C311/32 ,  C07C211/08 ,  C09K8/524 ,  A01N37/44 ,  C07C291/04 ,  C07C45/74 ,  C07C215/10 ,  C07C45/62 ,  A61K8/41 ,  A61K8/44 ,  A61K8/46 ,  A61Q5/02 ,  A61Q19/10 ,  C07C211/04 ,  C07C229/12 ,  C07C309/14 ,  C07H5/06 ,  C11D1/90 ,  A01N33/12 ,  B01J31/02 ,  C07C45/72 ,  C07C209/22 ,  C07C211/63 ,  C07C211/64

摘要： The invention provides branched trialkylamine oxides with improved properties. The trialkylamine oxides of the invention produced from branched trialkylamines, in one embodiment, can be made using certain branched C10-12 enals and aldehydes. The invention also provides an trialkylamine oxide having the formula: wherein R5, R6 and R7 are independently at least one of C3H7, C2H5, CH3, or H, or mixtures thereof; and wherein R5 and R6 are not H at the same time. In one embodiment, the trialkylamine oxides of the invention can be useful in making various products, for example, as surfactants.

公开(公告)号：US20160214933A1

公开(公告)日：2016-07-28

申请号：US15005162

申请日：2016-01-25

申请人： Thomas P. Daly

发明人： Thomas P. Daly

IPC分类号： C07C329/02 ,  C07C291/04 ,  C07C217/08

CPC分类号： C07C329/14 ,  B01F17/0042 ,  B03D1/00 ,  B03D1/008 ,  B03D2201/02 ,  B03D2203/02 ,  C07C215/40 ,  C07C217/08 ,  C09K15/22 ,  C11D1/42

摘要： A family of amine mining collectors that uses alkoxylates allows for the easy adjustment of solubility and molecular weight useful because anionic and cationic mineral collectors require such varying degrees of solubility and molecular weight. The family of the present invention allows for the optimization of both parameters and an increase in collector efficiency.

摘要翻译： 使用烷氧基化物的一族胺开采收集器允许容易地调节溶解度和分子量，因为阴离子和阳离子矿物收集器需要这种不同程度的溶解度和分子量。 本发明的家族允许两个参数的优化和收集器效率的提高。

公开(公告)号：US20120196874A1

公开(公告)日：2012-08-02

申请号：US13360109

申请日：2012-01-27

申请人： David WATT ,  Chunming Liu ,  Vitaliy M. Sviripa ,  Wen Zhang

发明人： David WATT ,  Chunming Liu ,  Vitaliy M. Sviripa ,  Wen Zhang

IPC分类号： A61K31/05 ,  C07C43/23 ,  A61K31/09 ,  C07C291/04 ,  A61K31/136 ,  C07C211/52 ,  C07D495/04 ,  A61K31/4188 ,  C07D295/073 ,  A61K31/495 ,  C07D233/64 ,  A61K31/4164 ,  A61P35/00 ,  G01N33/53 ,  G01N33/566 ,  C12Q1/68 ,  C07C39/21

CPC分类号： A61K31/03 ,  A61K31/44 ,  C07C39/21 ,  C07C43/23 ,  C07C211/48 ,  C07C211/52 ,  C07C291/04 ,  C07D233/64 ,  C07D295/073 ,  C07D495/04 ,  C09B23/148 ,  G01N33/57484 ,  G01N33/582 ,  G01N2800/52

摘要： Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.

摘要翻译： 公开了可用于治疗各种癌症的芪类似物和药物组合物，包括但不限于结肠直肠癌（CRC）和乳腺癌。 卤化1,2-二苯乙烯类似物包括二苯乙烯环上的氮杂芳基和/或氨基。

公开(公告)号：US20110118451A1

公开(公告)日：2011-05-19

申请号：US13006335

申请日：2011-01-13

申请人： Zhenwei Miao ,  Junjie Liu ,  Thea Norman ,  Russell Driver

发明人： Zhenwei Miao ,  Junjie Liu ,  Thea Norman ,  Russell Driver

IPC分类号： C07K14/00 ,  C07C233/18 ,  C07C291/04 ,  C07C271/16 ,  C07C275/64 ,  C07D209/48

CPC分类号： C07C225/10 ,  A61K31/198 ,  A61K38/17 ,  A61K47/08 ,  A61K47/10 ,  A61K47/34 ,  A61K47/60 ,  C07C229/36 ,  C07C237/32 ,  C07C251/28 ,  C07C251/54 ,  C07C251/60 ,  C07C251/86 ,  C07C323/63 ,  C07C2601/08 ,  C07D209/38 ,  C07D209/46 ,  C07D307/83 ,  C07D307/88 ,  C07D307/89 ,  C07D317/22 ,  C07D317/26 ,  C07D317/28 ,  C07D317/30 ,  C07D333/72 ,  C07K14/61 ,  C12P21/02 ,  G01N33/5008 ,  G01N33/68 ,  G01N33/6848 ,  G01N2500/00 ,  Y02A50/473 ,  Y02P20/55

摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

公开(公告)号：US07935846B2

公开(公告)日：2011-05-03

申请号：US12520739

申请日：2007-10-17

申请人： Tetsuaki Fukushima ,  Hideki Taniguchi ,  Michio Terasaka

发明人： Tetsuaki Fukushima ,  Hideki Taniguchi ,  Michio Terasaka

IPC分类号： C07C209/78 ,  C07C291/04

CPC分类号： C07C209/50 ,  B01J21/10 ,  B01J23/002 ,  B01J23/78 ,  B01J23/80 ,  B01J23/8926 ,  B01J23/8946 ,  B01J29/06 ,  B01J29/072 ,  B01J29/143 ,  B01J37/03 ,  B01J2523/00 ,  C07C211/08 ,  B01J2523/17 ,  B01J2523/22 ,  B01J2523/23 ,  B01J2523/25 ,  B01J2523/824 ,  B01J2523/27

摘要： The present invention provides a process for producing high-purity aliphatic tertiary amines containing a less amount of by-products by using a chromium-free catalyst with a good productivity in an economically advantageous manner. The present invention relates to a process for producing a tertiary amine by reducing an amide compound in the presence of a catalyst containing copper and magnesium at a molar ratio of magnesium to copper (magnesium/copper) of from 0.01 to 20.

摘要翻译： 本发明提供一种以经济上有利的方式通过使用无铬催化剂以高生产率生产含少量副产物的高纯度脂族叔胺的方法。 本发明涉及一种通过在含有铜与镁（镁/铜）摩尔比为0.01〜20的铜和镁的催化剂存在下还原酰胺化合物来制备叔胺的方法。

公开(公告)号：US07754923B2

公开(公告)日：2010-07-13

申请号：US12224607

申请日：2007-03-08

申请人： Masaharu Jono ,  Michio Terasaka ,  Hideki Taniguchi ,  Tetusaki Fukushima

发明人： Masaharu Jono ,  Michio Terasaka ,  Hideki Taniguchi ,  Tetusaki Fukushima

IPC分类号： C07C209/78 ,  C07C291/04

CPC分类号： C07C209/50 ,  B01J23/78 ,  B01J29/072 ,  B01J29/076 ,  B01J29/76 ,  B01J29/78 ,  B01J37/031 ,  B01J2229/18 ,  C07C211/08

摘要： The present invention provides a process for producing high-purity aliphatic tertiary amines containing a less amount of by-products by subjecting aliphatic acid amides to hydrogenation reduction under moderate conditions, as well as a process for producing amine derivatives from the aliphatic tertiary amines, with a good productivity in an economically advantageous manner. The present invention relates to a process for producing an aliphatic tertiary amine by subjecting a specific aliphatic amide to hydrogenation reduction in the presence of a catalyst containing copper and at least one element selected from the group consisting of elements belonging to Groups 2, 3 and 7 of the Periodic Table; the catalyst; and a process for producing amine oxide by reacting the tertiary amide obtained by the above production process with hydrogen peroxide.

摘要翻译： 本发明提供一种生产含有少量副产物的高纯度脂肪族叔胺的方法，该方法是在中等条件下使脂肪族酰胺进行氢化还原，以及由脂族叔胺制备胺衍生物的方法， 在经济上有利的方式具有良好的生产率。 本发明涉及通过在含有铜的催化剂和选自属于第2,3和7族的元素的至少一种元素的存在下使特定的脂族酰胺进行氢化还原来制备脂肪族叔胺的方法 的周期表; 催化剂; 以及通过使通过上述制备方法获得的叔酰胺与过氧化氢反应来制备氧化胺的方法。

公开(公告)号：US20090054688A1

公开(公告)日：2009-02-26

申请号：US12224607

申请日：2007-03-08

申请人： Masaharu Jono ,  Michio Terasaka ,  Hideki Taniguchi ,  Tetusaki Fukushima

发明人： Masaharu Jono ,  Michio Terasaka ,  Hideki Taniguchi ,  Tetusaki Fukushima

IPC分类号： C07C291/04 ,  C07C209/26

CPC分类号： C07C209/50 ,  B01J23/78 ,  B01J29/072 ,  B01J29/076 ,  B01J29/76 ,  B01J29/78 ,  B01J37/031 ,  B01J2229/18 ,  C07C211/08

摘要： The present invention provides a process for producing high-purity aliphatic tertiary amines containing a less amount of by-products by subjecting aliphatic acid amides to hydrogenation reduction under moderate conditions, as well as a process for producing amine derivatives from the aliphatic tertiary amines, with a good productivity in an economically advantageous manner. The present invention relates to a process for producing an aliphatic tertiary amine by subjecting a specific aliphatic amide to hydrogenation reduction in the presence of a catalyst containing copper and at least one element selected from the group consisting of elements belonging to Groups 2, 3 and 7 of the Periodic Table; the catalyst; and a process for producing amine oxide by reacting the tertiary amide obtained by the above production process with hydrogen peroxide.

摘要翻译： 本发明提供一种生产含有少量副产物的高纯度脂肪族叔胺的方法，该方法是在中等条件下使脂肪族酰胺进行氢化还原，以及由脂族叔胺制备胺衍生物的方法， 在经济上有利的方式具有良好的生产率。 本发明涉及通过在含有铜的催化剂和选自属于第2,3和7族的元素的至少一种元素的存在下使特定的脂族酰胺进行氢化还原来制备脂肪族叔胺的方法 的周期表; 催化剂; 以及通过使通过上述制备方法获得的叔酰胺与过氧化氢反应来制备氧化胺的方法。

公开(公告)号：US07276537B2

公开(公告)日：2007-10-02

申请号：US11433545

申请日：2006-05-15

申请人： William Alexander Denny ,  Laurence Hylton Patterson ,  Gavin William Halbert ,  Steven John Ford

发明人： William Alexander Denny ,  Laurence Hylton Patterson ,  Gavin William Halbert ,  Steven John Ford

IPC分类号： C07C291/04 ,  A61K47/02 ,  A61K47/12 ,  A61P35/00

CPC分类号： C07C225/36 ,  A61K9/0019 ,  A61K47/02 ,  A61K47/12 ,  C07C291/04 ,  C07C2603/24

摘要： A compound of formula (I): in which A is a C alkylene group with a chain length between NH and N(O)R′R″ of at least 2 carbon atoms and R′ and R″ are each separately selected from C1-4 alkyl groups and C2-4 hydroxyalkyl and C2-4 dihydroxyalkyl groups, or R′ and R″ together are a C2-6 alkylene group, is formulated so that upon dissolution in aqueous solution the pH of the solution is in the range of 5 to 9. The compound may be in the form of salt with a physiologically acceptable acid having a pKa in the range of −3.0 (minus 3.0) to 9.0

摘要翻译： 式（I）化合物：其中A是具有NH和至少2个碳原子的N（O）R'R“之间的链长的C亚烷基，R'和R”分别选自 C 1-4烷基和C 2-4 2-4羟基烷基和C 2-4 2-4羟基烷基，或者R'和R“一起是 配制C 2-6亚烷基，使得当溶解在水溶液中时，溶液的pH在5至9的范围内。该化合物可以是与生理学上的盐的形式 具有-3.0（减3.0）至9.0范围内的pK 的可接受的酸