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1.发明授权Generation of combinatorial patterns by deliberate tilting of a polymer-pen array 有权通过聚合物笔阵列的有意倾斜来产生组合图案公开(公告)号：US08753813B2
公开(公告)日：2014-06-17
申请号：US13513618
申请日：2010-12-02
Applicant: Chad A. Mirkin , Adam B. Braunschweig , Jinan Chai , Dan J. Eichelsdoerfer , Louise R. Giam , Xing Liao , Lu Shin Wong
Inventor： Chad A. Mirkin , Adam B. Braunschweig , Jinan Chai , Dan J. Eichelsdoerfer , Louise R. Giam , Xing Liao , Lu Shin Wong
CPC classification number: G03F7/0002 , B01J2219/00387 , B82Y10/00 , B82Y40/00
Abstract: The disclosure relates to a method of forming a pattern having pattern elements with a plurality of sizes on a substrate surface with a tilted pen array that includes choosing a tilt geometry for a pen array with respect to a substrate, inducing the tilt geometry between the pen array and the substrate surface, and forming a pattern having pattern elements on the substrate surface with the titled pen array, whereby the size of the formed pattern elements varies across the substrate surface along the tilted axis or axes. For example, the tilt geometry is in reference to the substrate surface and comprises a first angle with respect to a first axis of the substrate and a second angle with respect to a second axis of the substrate, the second axis being perpendicular to the first axis, and at least one of the first and second angles being non-zero.
Abstract translation: 本公开涉及一种在衬底表面上形成具有多个尺寸的图案元件的图案的方法，该倾斜笔阵列包括相对于衬底选择笔阵列的倾斜几何形状，从而引起笔之间的倾斜几何形状 阵列和衬底表面，并且用标称笔阵列在衬底表面上形成具有图形元素的图案，由此形成的图案元素的尺寸沿着倾斜的轴线或轴线跨越衬底表面变化。 例如，倾斜几何形状参考衬底表面并且包括相对于衬底的第一轴线的第一角度和相对于衬底的第二轴线的第二角度，第二轴线垂直于第一轴线 并且第一和第二角度中的至少一个是非零。
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公开(公告)号：US20100143666A1
公开(公告)日：2010-06-10
申请号：US12623286
申请日：2009-11-20
Applicant: Chad A. Mirkin , Adam B. Braunschweig , Andrew J. Senesi
Inventor： Chad A. Mirkin , Adam B. Braunschweig , Andrew J. Senesi
CPC classification number: B01J19/0046 , B01J2219/00382 , B01J2219/00436 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00605 , B01J2219/00617 , B01J2219/00626 , B01J2219/00632 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00736 , B01J2219/0075 , C23C18/1658 , C23C18/44 , Y10T428/24802
Abstract: A method of forming a target pattern using a redox activated surface is disclosed. The method includes patterning a redox agent on a template layer formed on a substrate, the template layer having a first oxidation state, wherein upon contact with the redox agent, the contacted portion of the template layer changes to a second oxidation state different than the first oxidation state, and a template pattern is formed from the portion of the template layer having either the first oxidation state or the second oxidation state, and exposing the substrate having the template pattern to a target material, wherein the target material selectively binds to the template pattern to form a target pattern.
Abstract translation: 公开了使用氧化还原活化表面形成靶图案的方法。 该方法包括在形成在基底上的模板层上图案化氧化还原剂，模板层具有第一氧化态，其中，当与氧化还原剂接触时，模板层的接触部分变为不同于第一氧化态的第二氧化态 氧化态，并且模板图案由具有第一氧化态或第二氧化态的模板层的部分形成，并且将具有模板图案的衬底暴露于靶材料，其中靶材料选择性地结合模板 模式形成目标模式。
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公开(公告)号：US20100071098A1
公开(公告)日：2010-03-18
申请号：US12465616
申请日：2009-05-13
Applicant: Chad A. Mirkin , Chang Liu , Yuhuang Wang , Adam B. Braunschweig , Xing Liao , Louise R. Giam , Byung Y. Lee , Shifeng Li , Joseph S. Fragala , Albert K. Henning
Inventor： Chad A. Mirkin , Chang Liu , Yuhuang Wang , Adam B. Braunschweig , Xing Liao , Louise R. Giam , Byung Y. Lee , Shifeng Li , Joseph S. Fragala , Albert K. Henning
IPC: G01Q60/00
Abstract: A dual tip probe for scanning probe epitaxy is disclosed. The dual tip probe includes first and second tips disposed on a cantilever arm. The first and second tips can be a reader tip and a synthesis tip, respectively. The dual tip probe further includes a rib disposed on the cantilever arm between the first and second tips. The dual tip probe can also include a strain gauge disposed along the length of the cantilever arm.
Abstract translation: 公开了一种用于扫描探针外延的双尖端探针。 双尖头探针包括设置在悬臂上的第一和第二尖端。 第一和第二提示可以分别是读取器尖端和合成尖端。 双尖头探针还包括设置在第一和第二尖端之间的悬臂上的肋条。 双尖头探针还可以包括沿着悬臂的长度设置的应变仪。
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公开(公告)号：US08961853B2
公开(公告)日：2015-02-24
申请号：US13375361
申请日：2010-06-04
Applicant: Chad A. Mirkin , Wooyoung Shim , Adam B. Braunschweig , Xing Liao , Jinan Chai , Jong Kuk Lim , Gengfeng Zheng , Zijian Zheng
Inventor： Chad A. Mirkin , Wooyoung Shim , Adam B. Braunschweig , Xing Liao , Jinan Chai , Jong Kuk Lim , Gengfeng Zheng , Zijian Zheng
CPC classification number: G03F7/0002 , B81B2203/0361 , B81B2207/056 , B81C1/00111 , B81C1/0046 , B81C2201/0154 , B81C2201/0185 , B82Y10/00 , B82Y40/00 , Y10S977/732
Abstract: Disclosed are methods of lithography using a tip array having a plurality of pens attached to a backing layer, where the tips can comprise a metal, metalloid, and/or semi-conducting material, and the backing layer can comprise an elastomeric polymer. The tip array can be used to perform a lithography process in which the tips are coated with an ink (e.g., a patterning composition) that is deposited onto a substrate upon contact of the tip with the substrate surface. The tips can be easily leveled onto a substrate and the leveling can be monitored optically by a change in light reflection of the backing layer and/or near the vicinity of the tips upon contact of the tip to the substrate surface.
Abstract translation: 公开了使用具有连接到背衬层的多个笔的尖端阵列的光刻方法，其中尖端可以包括金属，准金属和/或半导电材料，并且背衬层可以包括弹性体聚合物。 尖端阵列可用于执行光刻工艺，其中尖端涂覆有当尖端与衬底表面接触时沉积到衬底上的油墨（例如，图案化组合物）。 尖端可以容易地平整到基底上，并且可以通过背衬层的光反射的变化和/或在尖端与基底表面接触时靠近尖端附近来光学地监测流平。
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公开(公告)号：US20100115672A1
公开(公告)日：2010-05-06
申请号：US12465615
申请日：2009-05-13
Applicant: Chad A. Mirkin , Chang Liu , Yuhuang Wang , Adam B. Braunschweig , Xing Liao , Louise R. Giam , Byung Y. Lee , Shifeng Li
Inventor： Chad A. Mirkin , Chang Liu , Yuhuang Wang , Adam B. Braunschweig , Xing Liao , Louise R. Giam , Byung Y. Lee , Shifeng Li
IPC: G01Q60/24
Abstract: A dual tip probe for scanning probe epitaxy and a method of forming the dual tip probe are disclosed. The dual tip probe includes first and second tips disposed on a cantilever arm. The first and second tips can be a reader tip and a synthesis tip, respectively. The first tip can remain in contact with a substrate during writing and provide in situ characterization of the substrate and or structures written, while the second tip can perform in non-contact mode to write and synthesis nanostructures. This feature can allow the dual tip probe to detect errors in a printed pattern using the first tip and correct the errors using the second tip.
Abstract translation: 公开了一种用于扫描探针外延的双尖端探针和形成双尖端探针的方法。 双尖头探针包括设置在悬臂上的第一和第二尖端。 第一和第二提示可以分别是读取器尖端和合成尖端。 第一尖端可以在书写期间保持与基底接触，并且提供衬底和/或结构的原位表征，而第二尖端可以以非接触模式执行以写入和合成纳米结构。 该功能可以允许双尖端探针使用第一个尖端检测印刷图案中的错误，并使用第二个尖端校正错误。
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Patent Agency Ranking
公开(公告)号：US09296688B2
公开(公告)日：2016-03-29
申请号：US14403686
申请日：2013-05-28
Applicant: Adam B. Braunschweig , Stephen Rieth , Matthew Miner
Inventor： Adam B. Braunschweig , Stephen Rieth , Matthew Miner
IPC: C07D207/335 , C07D403/14 , G01N24/12 , A61K31/4025 , G01N33/53
CPC classification number: C07D207/335 , A61K31/4025 , C07D403/14 , G01N24/12 , G01N33/5308 , G01N2400/00
Abstract: The present invention is directed to a new class of synthetic carbohydrate receptor compounds comprising Formula I as described herein: (I). Other aspects of the present invention relate to pharmaceutical compositions and pharmaceutical delivery vehicles comprising the compound of Formula (I) The present invention is also directed to methods of treatment and diagnosis that involve the administration of a compound of Formula (I).
Abstract translation: 本发明涉及一类新的合成的碳水化合物受体化合物，其包含本文所述的式I：（I）。 本发明的其它方面涉及包含式（I）化合物的药物组合物和药物递送载体。本发明还涉及涉及给予式（I）化合物的治疗和诊断方法。
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7.发明申请Generation of Combinatorial Patterns by Deliberate Tilting of a Polymer-Pen Array 有权通过有意图倾斜聚合物笔阵列来产生组合模式公开(公告)号：US20130040856A1
公开(公告)日：2013-02-14
申请号：US13513618
申请日：2010-12-02
Applicant: Chad A. Mirkin , Adam B. Braunschweig , Jinan Chai , Dan J. Eichelsdoerfer , Louise R. Giam , Xing Liao , Lu Shin Wong
Inventor： Chad A. Mirkin , Adam B. Braunschweig , Jinan Chai , Dan J. Eichelsdoerfer , Louise R. Giam , Xing Liao , Lu Shin Wong
CPC classification number: G03F7/0002 , B01J2219/00387 , B82Y10/00 , B82Y40/00
Abstract: The disclosure relates to a method of forming a pattern having pattern elements with a plurality of sizes on a substrate surface with a tilted pen array that includes choosing a tilt geometry for a pen array with respect to a substrate, inducing the tilt geometry between the pen array and the substrate surface, and forming a pattern having pattern elements on the substrate surface with the titled pen array, whereby the size of the formed pattern elements varies across the substrate surface along the tilted axis or axes. For example, the tilt geometry is in reference to the substrate surface and comprises a first angle with respect to a first axis of the substrate and a second angle with respect to a second axis of the substrate, the second axis being perpendicular to the first axis, and at least one of the first and second angles being non-zero.
Abstract translation: 本公开涉及一种在衬底表面上形成具有多个尺寸的图案元件的图案的方法，该倾斜笔阵列包括相对于衬底选择笔阵列的倾斜几何形状，从而引起笔之间的倾斜几何形状 阵列和衬底表面，并且用标称笔阵列在衬底表面上形成具有图形元素的图案，由此形成的图案元素的尺寸沿着倾斜的轴线或轴线跨越衬底表面变化。 例如，倾斜几何形状参考衬底表面并且包括相对于衬底的第一轴线的第一角度和相对于衬底的第二轴线的第二角度，第二轴线垂直于第一轴线 并且第一和第二角度中的至少一个是非零。
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公开(公告)号：US20170252976A1
公开(公告)日：2017-09-07
申请号：US15447067
申请日：2017-03-01
Applicant: Adam B. Braunschweig , Yiwen JI , Xiaoming LIU , Yeting ZHENG
Inventor： Adam B. Braunschweig , Yiwen JI , Xiaoming LIU , Yeting ZHENG
CPC classification number: B33Y50/02 , B29C64/106 , B29C64/209 , B33Y10/00 , B33Y30/00
Abstract: A method and apparatus for 4-dimensional printing are disclosed. The apparatus includes a polymer pen array translatable in three axes, a light source for illuminating the polymer pen array, a reactive surface disposed opposite the polymer pen array, and a flow-through microfluidic cell having a reactive chamber in fluid communication with influx and outflux conduits. Solutions containing reagents are introduced into the reactive chamber, the polymer pen array is inserted into the reactive chamber, and is then illuminated with the light source so as to initiate polymerization between the reagents and the reactive surface.
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公开(公告)号：US20150141480A1
公开(公告)日：2015-05-21
申请号：US14403686
申请日：2013-05-28
Applicant: Adam B. Braunschweig , Stephen Rieth , Matthew Miner
Inventor： Adam B. Braunschweig , Stephen Rieth , Matthew Miner
IPC: C07D207/335 , G01N33/53
CPC classification number: C07D207/335 , A61K31/4025 , C07D403/14 , G01N24/12 , G01N33/5308 , G01N2400/00
Abstract: The present invention is directed to a new class of synthetic carbohydrate receptor compounds comprising Formula I as described herein: (I). Other aspects of the present invention relate to pharmaceutical compositions and pharmaceutical delivery vehicles comprising the compound of Formula (I) The present invention is also directed to methods of treatment and diagnosis that involve the administration of a compound of Formula (I).
Abstract translation: 本发明涉及一类新的合成的碳水化合物受体化合物，其包含本文所述的式I：（I）。 本发明的其它方面涉及包含式（I）化合物的药物组合物和药物递送载体。本发明还涉及涉及施用式（I）化合物的治疗和诊断方法。
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公开(公告)号：US20140287959A1
公开(公告)日：2014-09-25
申请号：US14129233
申请日：2012-04-03
Applicant: Adam B. Braunschweig , Jiajun He , Shudan Bian , Kevin B. Schesing
Inventor： Adam B. Braunschweig , Jiajun He , Shudan Bian , Kevin B. Schesing
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00612 , B01J2219/00626 , B01J2219/00632 , B01J2219/0065 , B01J2219/00659 , B82Y15/00
Abstract: Polymer Pen Lithography is used to induce bioorthogonal reactions between treated surfaces and functionalized inks create a soft matter layer. Fluorescent and redox-active inks were used to demonstrate that the molecules were immobilized covalently and achieves precise control over ligand orientation and density within each feature. Finally, the utility was demonstrated by creating functional arrays of biologically active probes.
Abstract translation: 聚合物笔平版印刷术用于诱导处理过的表面之间的生物正交反应，功能化油墨产生软质层。 使用荧光和氧化还原活性油墨来证明分子被共价固定，并且在每个特征内实现配体取向和密度的精确控制。 最后，通过创建生物活性探针的功能阵列证明了实用性。
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