公开(公告)号：US20230241608A1

公开(公告)日：2023-08-03

申请号：US18130635

申请日：2023-04-04

申请人： Truvian Sciences, Inc.

发明人： Ian Kleinemolen ,  Dena Marrinucci ,  Kameel Michael Abi-Samra

IPC分类号： B01L3/00 ,  G01N33/49 ,  G01N33/50 ,  A61M1/34 ,  A61M1/36

CPC分类号： B01L3/50273 ,  G01N33/491 ,  G01N33/5002 ,  A61M1/3496 ,  A61M1/3693 ,  B01L3/502 ,  B01L3/502746 ,  A61M1/3472 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0409

摘要： A device for separating blood plasma from whole blood includes a first reservoir and a second reservoir. The first reservoir is configured to receive a sample of whole blood including red blood cells and includes a collection region and a constricted region. The second reservoir is fluidically connected to the constricted region of the first reservoir, such that, responsive to centrifugal force applied to the device, the sample of whole blood disposed within the first reservoir separates into a first fraction and a second fraction. The first fraction is located in the collection region and includes blood plasma from which substantially all red blood cells have been removed. The second fraction is located in the second reservoir and includes blood plasma and red blood cells that have been removed from the first fraction by the centrifugal force. The constricted region inhibits the second fraction from entering the collection region.

公开(公告)号：US11703441B2

公开(公告)日：2023-07-18

申请号：US16145824

申请日：2018-09-28

申请人： KAWASAKI GAKUEN Educational Foundation ,  THE UNIVERSITY OF TOKYO ,  SYSMEX CORPORATION

发明人： Hiromi Kataoka ,  Yutaka Yatomi ,  Akiko Masuda ,  Hironori Shimosaka ,  Hajimu Kawakami

IPC分类号： G01N15/10 ,  G01N15/14 ,  G01N33/49 ,  G16H50/20 ,  G16H50/30 ,  G01N15/00

CPC分类号： G01N15/1031 ,  G01N15/14 ,  G16H50/20 ,  G16H50/30 ,  G01N15/1459 ,  G01N33/49 ,  G01N2015/0073 ,  G01N2015/1006 ,  G01N2015/1062 ,  G01N2015/1486

摘要： Disclosed is a method for assisting prediction of onset of cerebral infarction, based on the number of red blood cells contained in a blood sample collected from a subject, comprising the steps of:
calculating an exponent value for the prediction from a first measured value indicating red blood cell count measured by electrical resistance measurement method and a second measured value indicating red blood cell count measured by optical measurement method,

comparing the exponent value with a reference range, and

suggesting that the subject develops cerebral infarction when the exponent value is outside the reference range.

公开(公告)号：US20230221244A1

公开(公告)日：2023-07-13

申请号：US18000938

申请日：2021-06-09

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Jeffrey R. Jasperse

IPC分类号： G01N21/31 ,  G01N1/40 ,  G01N33/49

CPC分类号： G01N21/31 ,  G01N1/4077 ,  G01N33/491

摘要： Analyzers and methods of use are disclosed, including a blood analyzer comprising a light source to transmit an optical signal; a detector to generate data indicative of optical signal intensity; a transparent sample vessel between the light source and the detector; a dispensing device to pass a first portion of the blood sample comprising whole blood or lysed blood into the vessel at a first instance of time, and to pass a plasma portion of the blood sample into the vessel at a second instance of time; a controller to cause a processor to obtain first and second data generated by the detector, the first data indicative of the optical signal passing through the first portion of the blood sample and the second data indicative of the optical signal passing through the plasma, to determine a total absorbance spectrum in which the first data is adjusted by the second data.

公开(公告)号：US11698331B1

公开(公告)日：2023-07-11

申请号：US17124230

申请日：2020-12-16

申请人： Scanit Technologies, Inc.

发明人： Pedro Manautou ,  Joel Kent ,  An-Chun Tien

IPC分类号： G01N15/06 ,  G01N15/14 ,  G01N33/49 ,  G01N35/00 ,  G01N1/22 ,  G01N15/02 ,  G06V20/69 ,  G01N1/24 ,  G01N15/00

CPC分类号： G01N15/0612 ,  G01N1/2273 ,  G01N15/0227 ,  G01N15/1434 ,  G01N15/1463 ,  G01N15/1475 ,  G01N33/4925 ,  G01N35/00871 ,  G06V20/693 ,  G01N2001/2276 ,  G01N2001/245 ,  G01N2015/0065 ,  G01N2015/1465 ,  G01N2015/1486 ,  G01N2015/1493 ,  G01N2015/1497 ,  G01N2035/009 ,  G01N2035/00881

摘要： An airborne biological particle monitoring device collects particles floating in air. The monitoring device includes a processor, a camera sensor, and a set of approximately monochromatic illumination sources that correspond to a set of spectral curves. The camera sensor captures images of the particles providing a spectral analysis of the particles. The processor analyzes the images to identify the collected particles.

公开(公告)号：US20230213497A1

公开(公告)日：2023-07-06

申请号：US17995682

申请日：2021-04-07

申请人： SEKISUI MEDICAL CO., LTD.

发明人： Toshiki KAWABE

IPC分类号： G01N33/49

CPC分类号： G01N33/4905

摘要： Provided is a method for accurately measuring coagulation time of blood specimens showing various coagulation reactions. The method for measuring blood coagulation time includes acquiring coagulation reaction P(i) of a subject specimen and reaction velocity V(i); calculating a calculation start point Te by using the ratio of the V(i) to maximum reaction velocity as an index; and calculating time Tc giving P(Tc)=P(Te)×N % (0

公开(公告)号：US20230211340A1

公开(公告)日：2023-07-06

申请号：US18118279

申请日：2023-03-07

申请人： FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES

发明人： E Du ,  Darryl Dieujuste ,  Jia Liu ,  Yuhao Qiang

IPC分类号： B01L3/00 ,  G01N15/10 ,  G01N33/49

CPC分类号： B01L3/502715 ,  B01L3/502761 ,  G01N15/1031 ,  G01N33/4915 ,  G01N2015/1006 ,  B01L2300/0645 ,  B01L2300/06 ,  B01L2300/0809 ,  B01L2300/16 ,  B01L2300/025 ,  G01N2015/0073

摘要： An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.

公开(公告)号：US11692996B2

公开(公告)日：2023-07-04

申请号：US17839080

申请日：2022-06-13

申请人： Trustees of Boston University ,  Northwestern University

发明人： Ji-Xin Cheng ,  Junjie Li ,  Yuying Tan ,  Daniela Matei ,  Guangyuan Zhao

IPC分类号： G01J3/44 ,  G01N33/49 ,  G01N27/416 ,  G01Q60/60 ,  G16H20/10 ,  G16H50/30 ,  G01N33/487 ,  G01N27/30 ,  G01N21/65

CPC分类号： G01N33/492 ,  G01N27/30 ,  G01N27/416 ,  G01N33/48735 ,  G01Q60/60 ,  G16H20/10 ,  G16H50/30 ,  G01N21/65 ,  G01N2800/52

摘要： Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.

公开(公告)号：US20230203189A1

公开(公告)日：2023-06-29

申请号：US18168930

申请日：2023-02-14

申请人： MORPHOSYS AG

发明人： Stefan Härtle

IPC分类号： C07K16/30 ,  C07K16/42 ,  G01N33/574 ,  A61P35/00 ,  C07K14/76 ,  G01N33/49 ,  G01N33/561

CPC分类号： C07K16/30 ,  C07K16/42 ,  G01N33/57426 ,  A61P35/00 ,  C07K14/76 ,  G01N33/49 ,  G01N33/561 ,  C07K2317/565 ,  C07K2317/56 ,  C07K2319/31 ,  G01N2800/52

摘要： Applicant discloses an anti-idiotypic antibody to MOR202, which when fused to human albumin, shifted the antibody in IFE thus mitigating any potential interference of MOR202 with the M-protein clinical assessment.

公开(公告)号：US20230194398A1

公开(公告)日：2023-06-22

申请号：US18160985

申请日：2023-01-27

申请人： NOUL CO., LTD.

发明人： Dong Young Lee ,  Chan Yang Lim ,  Kyung Hwan Kim ,  Young Min Shin ,  Hyun Jeong YANG

IPC分类号： G01N1/31 ,  G01N1/30 ,  C12Q1/6844 ,  C12Q1/6848 ,  G01N33/50 ,  G01N21/77 ,  G01N33/558 ,  B01L3/00 ,  G01N15/06 ,  G01N33/52 ,  G01N33/574 ,  G01N15/14 ,  G01N33/49 ,  G01N33/60 ,  C12Q1/686 ,  C07K16/30 ,  C12Q1/70 ,  G01N33/483 ,  G06T7/00 ,  G01N33/53 ,  G01N33/533

CPC分类号： G01N1/312 ,  G01N1/30 ,  C12Q1/6844 ,  C12Q1/6848 ,  G01N33/5082 ,  G01N21/77 ,  G01N33/558 ,  B01L3/00 ,  G01N15/06 ,  G01N33/52 ,  G01N33/574 ,  G01N15/14 ,  G01N33/49 ,  G01N33/60 ,  C12Q1/686 ,  C07K16/3061 ,  G01N1/31 ,  C12Q1/701 ,  G01N33/4833 ,  G06T7/0014 ,  G01N33/5304 ,  G01N33/533 ,  G06T7/0012 ,  G01N2015/0693 ,  G01N2021/7786 ,  B01L7/52

摘要： The present disclosure relates to a blood staining patch, a method and device for a blood test using the same, and more particularly, to a patch configured to contain a staining reagent for staining blood and a method and device for economically testing blood using the same. A blood testing method according to an aspect of the present disclosure, which is a blood testing method in which a patch, which includes a mesh structure forming micro-cavities and is configured to contain a staining reagent for staining staining targets present in blood in the micro-cavities, is used to perform a blood test through staining of the staining target, includes placing blood in a reaction region, and providing the staining reagent to the reaction region using the patch configured to contain the staining reagent.

公开(公告)号：US20230183376A1

公开(公告)日：2023-06-15

申请号：US17923997

申请日：2021-05-21

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Tetsuhiro Soeda ,  Jinki Hadano

IPC分类号： C07K16/42 ,  C12N15/63 ,  G01N33/49

CPC分类号： C07K16/4241 ,  C12N15/63 ,  G01N33/4905

摘要： Production was attempted for antibodies that neutralize the activity of a bispecific antibody having F.VIII function-substituting activity, for use in a method for measuring the reactivity of F.VIII in the presence of a bispecific antibody having F.VIII function-substituting activity. As a result, it was discovered that by using the produced antibodies, F.VIII activity in the plasma of a hemophilia A patient can be evaluated accurately by performing APTT-based one-stage clotting assay on a wide range of bispecific antibodies having F.VIII function-substituting activity. It was also discovered that F.VIII inhibitor titer in the plasma of a hemophilia A patient carrying F.VIII inhibitor can be evaluated accurately by APTT-based Bethesda assay.