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公开(公告)号：US12083515B2
公开(公告)日：2024-09-10
申请号：US18118277
申请日：2023-03-07
发明人： E Du , Darryl Dieujuste , Jia Liu , Yuhao Qiang
IPC分类号： B01L3/00 , G01N15/10 , G01N15/1031 , G01N15/14 , G01N15/1429 , G01N33/49 , G01N15/01
CPC分类号： B01L3/502715 , B01L3/502761 , G01N15/1031 , G01N33/4915 , B01L2300/025 , B01L2300/06 , B01L2300/0645 , B01L2300/0809 , B01L2300/16 , G01N2015/012 , G01N2015/1006 , G01N15/1425 , G01N15/1431 , G01N15/1484
摘要： An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.
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2.发明公开公开(公告)号：US20230211339A1
公开(公告)日：2023-07-06
申请号：US18118277
申请日：2023-03-07
发明人： E Du , Darryl Dieujuste , Jia Liu , Yuhao Qiang
CPC分类号： B01L3/502715 , B01L3/502761 , G01N15/1031 , G01N33/4915 , B01L2300/06 , B01L2300/16 , B01L2300/025 , B01L2300/0645 , B01L2300/0809 , G01N2015/0073 , G01N2015/1006
摘要： An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.
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公开(公告)号：US12083516B2
公开(公告)日：2024-09-10
申请号：US18118279
申请日：2023-03-07
发明人： E Du , Darryl Dieujuste , Jia Liu , Yuhao Qiang
IPC分类号： B01L3/00 , G01N15/10 , G01N15/1031 , G01N15/14 , G01N15/1429 , G01N33/49 , G01N15/01
CPC分类号： B01L3/502715 , B01L3/502761 , G01N15/1031 , G01N33/4915 , B01L2300/025 , B01L2300/06 , B01L2300/0645 , B01L2300/0809 , B01L2300/16 , G01N2015/012 , G01N2015/1006 , G01N15/1425 , G01N15/1431 , G01N15/1484
摘要： An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.
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公开(公告)号：US11618019B2
公开(公告)日：2023-04-04
申请号：US16585897
申请日：2019-09-27
发明人： E Du , Darryl Dieujuste , Jia Liu , Yuhao Qiang
摘要： An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.
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5.发明申请公开(公告)号：US20200171494A1
公开(公告)日：2020-06-04
申请号：US16585897
申请日：2019-09-27
发明人： E Du , Darryl Dieujuste , Jia Liu , Yuhao Qiang
摘要： An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.
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6.发明公开公开(公告)号：US20230211340A1
公开(公告)日：2023-07-06
申请号：US18118279
申请日：2023-03-07
发明人： E Du , Darryl Dieujuste , Jia Liu , Yuhao Qiang
CPC分类号： B01L3/502715 , B01L3/502761 , G01N15/1031 , G01N33/4915 , G01N2015/1006 , B01L2300/0645 , B01L2300/06 , B01L2300/0809 , B01L2300/16 , B01L2300/025 , G01N2015/0073
摘要： An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.
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