公开(公告)号：US20190030301A1

公开(公告)日：2019-01-31

申请号：US16145421

申请日：2018-09-28

申请人： BOSTON SCIENTIFIC SCIMED, INC.

发明人： Aaron Khieu ,  John Jianhua Chen ,  Ying Xiong ,  Joe Khammoungkhoune ,  Daniel James Horn ,  John Blix

IPC分类号： A61M25/10 ,  A61L29/14 ,  C08L77/00 ,  C08L23/06 ,  C08L75/04 ,  A61L29/04 ,  B32B5/02

CPC分类号： A61M25/10 ,  A61L29/049 ,  A61L29/14 ,  A61L29/143 ,  A61M25/1002 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1075 ,  A61M2025/1084 ,  A61M2025/1088 ,  A61M2205/0216 ,  B32B5/02 ,  C08L23/06 ,  C08L75/04 ,  C08L77/00 ,  Y10T428/1334 ,  Y10T428/1352 ,  Y10T428/1362 ,  Y10T428/1366 ,  Y10T428/1372 ,  Y10T428/1386

摘要： Composite fiber reinforced balloons for medical devices are prepared by applying a web of fibers to the exterior of a preformed underlayer balloon, encasing the web with a matrix material to form an assembly, and inserting the assembly into a preformed outer layer balloon to form the composite balloon.

公开(公告)号：US10166137B2

公开(公告)日：2019-01-01

申请号：US14005814

申请日：2012-03-16

申请人： Tinh Nguyen-Demary ,  Mingliang Lawrence Tsai

发明人： Tinh Nguyen-Demary ,  Mingliang Lawrence Tsai

IPC分类号： A61F5/441 ,  A61L29/02 ,  A61L29/14 ,  A61F5/445 ,  A61L29/04 ,  A61L28/00 ,  A61L29/08 ,  A61L29/12

摘要： A fecal catheter or ostomy pouch made of an odor barrier material including a thermoplastic elastomer, odor barrier modifier and an antiblocking agent.

公开(公告)号：US10124088B2

公开(公告)日：2018-11-13

申请号：US14860128

申请日：2015-09-21

申请人： SurModics, Inc.

发明人： Ralph A. Chappa ,  Nathan A. Lockwood ,  Joseph Schmidt McGonigle

IPC分类号： A61L29/14 ,  A61L29/08 ,  A61L29/04 ,  C08J3/20 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14

摘要： Embodiments of the invention include medical device elements formed from polymers with lubricious properties. In an embodiment, a method of forming a medical device element is included. The method can include mixing a first polymeric component and a second polymeric component to form a polymer mixture. The method can further include forming the polymer mixture into the medical device element. The method can also include treating the polymer mixture with at least one of an acid or a base. In an embodiment, a medical device is included. The medical device can include a lubricious element, the lubricious element comprising a mixture of a first polymeric component and a second polymeric component. The second polymeric component can include a polymer that is treated with at least one of an acid or a base after formation of the element. Other embodiments are also included herein.

公开(公告)号：US10118334B2

公开(公告)日：2018-11-06

申请号：US15210069

申请日：2016-07-14

申请人： Custom Wire Technologies, Inc.

发明人： Robert Boldig ,  Michael Boldig ,  James Boldig ,  Zachary Judy

IPC分类号： B32B37/00 ,  B29C63/24 ,  B29C47/00 ,  A61L29/04 ,  A61M25/00 ,  B29C41/00 ,  B29C69/02 ,  B29C41/08 ,  B29C41/20 ,  B29C63/00 ,  B29C47/02 ,  B29K675/00 ,  B29L23/00 ,  B29K21/00 ,  B29L31/00

摘要： An apparatus for and method of manufacturing an improved wire-reinforced plastic tubing for medical and other applications is disclosed. A plurality of spaced-apart wire segments may be wound onto successive portions of a long segment of plastic tubing which portions are supported for rotation to wind coil wire thereon by rotating the plastic tubing while a supply of coil wire is wound onto the plastic tubing. When multiple winding segments have been wound on the long segment of plastic tubing, the segments may be separated into individual wire-reinforced tubing products each having one or more wire windings thereupon.

公开(公告)号：US20180296731A1

公开(公告)日：2018-10-18

申请号：US15489109

申请日：2017-04-17

申请人： Becton, Dickinson and Company

发明人： Lisa Lim ,  Theresa Hermel-Davidock ,  Marc W. Weimer ,  Jonathan Karl Burkholz

IPC分类号： A61L29/04 ,  A61L29/18 ,  A61L29/02 ,  A61M25/00

摘要： Catheter tubing comprises: an elongate body comprising a base thermoplastic polyurethane; and a compounded thermoplastic polyurethane co-extruded with the base thermoplastic polyurethane to provide a section of catheter tubing discrete from the elongate body, the compounded thermoplastic polyurethane comprising a thermoplastic polyurethane and a radiopaque material, wherein the catheter tubing comprises a first elastic modulus under first conditions prior to entry into a patient; and wherein when exposed to second conditions comprising two or more in vivo stimuli for a duration of time the catheter tubing comprises a second elastic modulus that is not more than fifty percent of the first modulus.

公开(公告)号：US20180242587A1

公开(公告)日：2018-08-30

申请号：US15964219

申请日：2018-04-27

申请人： WilMarc Holdings, LLC

发明人： William A. Coulson ,  Marcia Coulson

IPC分类号： A01N59/16 ,  A01N25/10 ,  A61M39/08 ,  A61L29/16 ,  A61L29/12 ,  A01N25/34 ,  A47G21/18 ,  A61J7/00 ,  A61J15/00 ,  A61L29/04 ,  A61L29/06 ,  A01N25/08

CPC分类号： A01N59/16 ,  A01N25/10 ,  A01N25/34 ,  A47G21/18 ,  A47G21/183 ,  A61J7/0038 ,  A61J15/0026 ,  A61L29/041 ,  A61L29/06 ,  A61L29/126 ,  A61L29/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61M39/08 ,  A61M2205/0205 ,  A61M2207/00 ,  A01N25/08

摘要： A polymeric tubular conduit including a polymeric tubular conduit wall having an outer tubular layer coaxially overlaying an inner tubular layer which defines a continuous tubular passage along a polymeric tubular conduit length of the polymeric tubular conduit; whereby the outer tubular layer, the inner tubular layer, or combinations thereof, include an amount of antimicrobial agent. The amount of antimicrobial agent can be sufficient to kill or inhibit growth of microorganisms in contact with a corresponding polymeric tubular conduit wall external surface, polymeric tubular conduit wall internal surface, or combinations thereof, of the polymeric tubular conduit wall.

公开(公告)号：US10059752B2

公开(公告)日：2018-08-28

申请号：US14506383

申请日：2014-10-03

申请人： Alison McDermott ,  Marialuisa Mangoni

发明人： Alison McDermott ,  Marialuisa Mangoni

IPC分类号： A61K38/17 ,  A61K45/06 ,  A61K9/00 ,  C07K14/46 ,  A61L27/22 ,  A61L27/34 ,  A61L27/54 ,  A61L29/04 ,  A61L29/08 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16

CPC分类号： C07K14/463 ,  A61K9/0051 ,  A61K38/1703 ,  A61K45/06 ,  A61L27/22 ,  A61L27/34 ,  A61L27/54 ,  A61L29/048 ,  A61L29/085 ,  A61L29/16 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/483 ,  A61K2300/00

摘要： The present invention provides synthetic antibacterial peptides comprising a sequence at least 80% identical to a sequence shown in SEQ ID NO: 2 or the diastereomer thereof with a sequence shown in SEQ ID NO: 3 or pharmaceutical compositions thereof. Also provided are methods for reducing the severity of microbe-induced inflammation and for stimulating wound healing via the synthetic antibacterial peptides. Further provided is a device having a surface with a coating comprising the synthetic antibacterial peptides.

公开(公告)号：US10052388B2

公开(公告)日：2018-08-21

申请号：US15483686

申请日：2017-04-10

申请人： UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION

发明人： Warren O. Haggard ,  Scott P. Noel ,  Joel D. Bumgardner

IPC分类号： A61K47/36 ,  A61K9/70 ,  A61K31/7036 ,  A61L29/14 ,  A61L29/16 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16 ,  C08B37/08 ,  C08J5/18 ,  A61L29/04 ,  A61K38/14

CPC分类号： A61K47/36 ,  A61K9/0024 ,  A61K9/7007 ,  A61K31/00 ,  A61K31/7036 ,  A61K38/14 ,  A61L15/28 ,  A61L15/44 ,  A61L27/20 ,  A61L27/58 ,  A61L29/043 ,  A61L29/146 ,  A61L29/148 ,  A61L29/16 ,  A61L31/042 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/232 ,  A61L2300/25 ,  A61L2300/406 ,  C08B37/003 ,  C08J5/18 ,  C08J2305/08 ,  C08L5/08 ,  A61K2300/00

摘要： The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).

公开(公告)号：US20180228942A1

公开(公告)日：2018-08-16

申请号：US15751517

申请日：2016-08-11

申请人： PTT HOLDING APS

发明人： Peter Theilade THOMSEN ,  Martin ALM

IPC分类号： A61L29/04 ,  A61M25/00 ,  A61M25/10 ,  A61B5/01 ,  A61B5/145 ,  A61F6/14 ,  A61D7/00 ,  A61B5/00 ,  A61L29/14 ,  A61L29/16 ,  A61L29/00 ,  A61K9/00 ,  A61K9/48 ,  C02F1/68

CPC分类号： A61L29/049 ,  A61B5/01 ,  A61B5/14539 ,  A61B5/6852 ,  A61D7/00 ,  A61F6/08 ,  A61F6/14 ,  A61F6/142 ,  A61K9/0036 ,  A61K9/127 ,  A61K9/4866 ,  A61L29/005 ,  A61L29/126 ,  A61L29/145 ,  A61L29/16 ,  A61M25/0017 ,  A61M25/1002 ,  A61M31/002 ,  A61M2025/1004 ,  A61M2025/105 ,  A61M2205/0216 ,  A61N5/062 ,  A61N2005/0652 ,  A61N2005/0659 ,  A61N2005/067 ,  C02F1/685 ,  C08L75/04 ,  Y02W10/37 ,  C08L33/10 ,  C08L83/04 ,  C08L33/00

摘要： The invention relates to a delivery device suitable for delivering a chemical substance, e.g. a medical device such as a catheter, a microcapsule, an implantable capsule or a P-ring, or a delivery device for use in the construction industries e.g. in the form of microcapsules comprising antifouling agent for marine paint. The delivery device comprises a closed cavity, the cavity is defined by an innermost wall surface, wherein at least a section of the inner wall surface constitutes an inner surface of a delivery membrane wherein the delivery membrane comprises an interpenetrating polymer network substrate comprising a host polymer and a guest polymer, where the guest polymer is interpenetrating the host polymer to form substantially continuous pathways within said host polymer.

公开(公告)号：US20180207322A1

公开(公告)日：2018-07-26

申请号：US15903965

申请日：2018-02-23

申请人： St. Jude Medical, Atrial Fibrillation Division, Inc.

发明人： Xiaoping Guo ,  Richard E. Stehr

IPC分类号： A61L29/04 ,  A61M25/00

CPC分类号： A61L29/049 ,  A61M25/00 ,  A61M25/0021 ,  A61M2025/0048 ,  A61M2025/006 ,  A61M2025/0062 ,  C08L83/04

摘要： The invention comprises self-lubricating polymer compositions that are especially useful in medical devices and valves and gaskets of medical devices. In a preferred embodiment, the polymer compositions comprise a thermosetting or thermoplastic silicone elastomer in combination with a lubricity enhancing polyfluoropolyether fluid or hydrocarbon-based synthetic oil. In other preferred embodiments, the polymer compositions contain only biocompatible components. The improved anti-friction properties of the self-lubricating polymers can be demonstrated over a course of insertion and withdrawal cycles, where conventional polymers have changing and mostly increasing force required for each insertion and withdrawal, while the polymer compositions of the invention remain stable.