公开(公告)号：US11938165B2

公开(公告)日：2024-03-26

申请号：US17405491

申请日：2021-08-18

Applicant: Omrix Biopharmaceuticals Ltd. ,  Ethicon, Inc

Inventor： Tamar Auerbach-Nevo ,  Ashley Deanglis ,  Israel Nur

IPC: A61K38/01 ,  A61K9/12 ,  A61K38/36 ,  A61K38/48 ,  A61L24/00 ,  A61L24/10 ,  A61L26/00

CPC classification number: A61K38/018 ,  A61K9/122 ,  A61K38/014 ,  A61K38/363 ,  A61K38/4833 ,  A61L24/0036 ,  A61L24/10 ,  A61L26/0028 ,  A61L26/0085 ,  C12Y304/21005 ,  A61L2400/04

Abstract: Provided are pharmaceutical foam compositions comprising a peptone, a peptide hydrolysate or an enzymatically-hydrolyzed protein prepared by enzymatic hydrolysis of a full-length protein; methods of preparation and uses thereof.

公开(公告)号：US20180311404A1

公开(公告)日：2018-11-01

申请号：US15771260

申请日：2015-10-27

Applicant: Hélio Nogueira da SILVA JUNIOR

Inventor： Hélio Nogueira da SILVA JUNIOR

IPC: A61L24/10 ,  A61M1/36

CPC classification number: A61L24/10 ,  A61M1/36

Abstract: A device for preparing a biological wound dressing made of autologous fibrin. The device includes a cylindrical container with a bottom which is inclined from the side slopes towards a central channel with a slope that leads the liquid sealant remaining from pressing the fibrin clot through the sieve towards the outlet and from there to the multiduct collection system.

公开(公告)号：US20180250343A1

公开(公告)日：2018-09-06

申请号：US15450566

申请日：2017-03-06

Applicant: University of Utah Research Foundation

Inventor： Jo-Anna Reems ,  Jan Pierce

IPC: A61K35/50 ,  A61K38/17 ,  A61K31/728 ,  A61K9/19 ,  A61K45/06 ,  A61K35/28 ,  A61L27/36 ,  A61L27/26 ,  A61L27/20 ,  A61L27/22 ,  A61L27/54 ,  A61L24/04 ,  A61L24/08 ,  A61L24/10 ,  A61L24/00 ,  A61K38/18 ,  A61K9/00 ,  B01D21/26

CPC classification number: A61K35/50 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/728 ,  A61K35/28 ,  A61K38/1709 ,  A61K38/1808 ,  A61K45/06 ,  A61L24/0005 ,  A61L24/0015 ,  A61L24/043 ,  A61L24/08 ,  A61L24/10 ,  A61L27/20 ,  A61L27/22 ,  A61L27/26 ,  A61L27/3604 ,  A61L27/365 ,  A61L27/54 ,  A61L2400/06 ,  A61L2430/02 ,  B01D21/26 ,  A61K2300/00 ,  C08L5/08 ,  C08L89/00

Abstract: A therapeutic composition can include an amount of amniotic fluid having a therapeutically effective amount of at least one protein, hyaluronic acid, or both. The therapeutic composition can be substantially free of lanugo, vernix, and cells harvested with the amniotic fluid.

公开(公告)号：US20180071358A1

公开(公告)日：2018-03-15

申请号：US15700655

申请日：2017-09-11

Applicant: Omrix Biopharmaceuticals Ltd. ,  Ethicon, Inc

Inventor： Tamar Auerbach-Nevo ,  Ashley DEANGLIS ,  Israel Nur

IPC: A61K38/01 ,  A61K9/12 ,  A61K38/36 ,  A61K38/48

CPC classification number: A61K38/018 ,  A61K9/122 ,  A61K38/014 ,  A61K38/363 ,  A61K38/4833 ,  A61L24/0036 ,  A61L24/10 ,  A61L26/0028 ,  A61L26/0085 ,  A61L2400/04 ,  C12Y304/21005

Abstract: Provided are pharmaceutical foam compositions comprising a peptone, a peptide hydrolysate or an enzymatically-hydrolyzed protein prepared by enzymatic hydrolysis of a full-length protein; methods of preparation and uses thereof.

公开(公告)号：US09913876B2

公开(公告)日：2018-03-13

申请号：US15098028

申请日：2016-04-13

Applicant: Haemostatix Limited

Inventor： Greg Walker

IPC: A61K38/07 ,  A61L24/06 ,  A61L24/10 ,  A61K9/00 ,  A61L24/00

CPC classification number: A61K38/07 ,  A61K9/0014 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/06 ,  A61L24/10 ,  A61L24/106 ,  A61L2400/04

Abstract: A biogel, and kits, agents, and methods for formation of the biogel are described. The biogel can be used for a variety of applications, including haemostasis, wound sealing, tissue engineering or localized drug delivery.

公开(公告)号：US09867899B2

公开(公告)日：2018-01-16

申请号：US15131583

申请日：2016-04-18

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Russell J. Stewart

IPC: A61L24/02 ,  A61L24/04 ,  A61L24/06 ,  A61L24/10 ,  D07B3/00 ,  A61L24/00 ,  A61L27/26 ,  A61L27/54 ,  C08F8/00 ,  C08F8/06

CPC classification number: A61L24/046 ,  A61L24/0015 ,  A61L24/02 ,  A61L24/043 ,  A61L24/06 ,  A61L24/10 ,  A61L27/26 ,  A61L27/54 ,  A61L2300/62 ,  A61L2430/16 ,  C08F8/00 ,  C08F8/06 ,  C08L89/00

Abstract: Described herein is the synthesis of reinforced adhesive complex coacervates and their use thereof. The reinforced adhesive complex coacervates are composed of (a) at least one polycation, (b) at least one polyanion, and (c) a reinforcing component. The adhesive complex coacervates described herein can be subsequently cured to produce strong, cohesive adhesives. The reinforced adhesive complex coacervates have several desirable features when compared to conventional adhesives. The reinforced adhesive complex coacervates are effective in wet or underwater applications. The reinforced adhesive complex coacervates described herein, being phase separated from water, can be applied underwater without dissolving or dispersing into the water. The reinforced adhesive complex coacervates have numerous biological applications as bioadhesives and bioactive delivery devices. In particular, the reinforced adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, wet tissues in physiological conditions.

公开(公告)号：US09833615B2

公开(公告)日：2017-12-05

申请号：US14705756

申请日：2015-06-04

Applicant: Boston Scientific Scimed, Inc.

Inventor： Peter J. Pereira ,  David Ernest Wechter ,  John M. Barker ,  Jonathan Zoll ,  Mark W. Boden

IPC: A61N1/00 ,  A61N1/05 ,  A61L24/00 ,  A61B17/00 ,  A61L24/10

CPC classification number: A61N1/0558 ,  A61B2017/00513 ,  A61L24/00 ,  A61L24/10

Abstract: Embodiments of the present disclosure include medical apparatus, and related methods thereof. The apparatus may include a longitudinally extending lead, at least one electrode, an anchor component, and a control module. The lead may include a distal end and a proximal end. The at least one electrode may be coupled to the lead, wherein the at least one electrode may be disposed on the distal end of the lead. The anchor component may be disposed in the lead proximate of the at least one electrode. The anchor component may include solder. The control module may be operably coupled to the proximal end of the lead and may be configured to deliver energy to the at least one electrode.

公开(公告)号：US20170216485A1

公开(公告)日：2017-08-03

申请号：US15326420

申请日：2015-07-16

Applicant: Nanyang Technological University

Inventor： Dongan Wang ,  Changjiang Fan

IPC: A61L24/10 ,  A61L24/00 ,  A61L24/02

CPC classification number: A61L24/104 ,  A61L24/0031 ,  A61L24/02 ,  A61L24/043 ,  A61L24/10 ,  C08L89/00

Abstract: A biological tissue adhesive composition is provided. The biological tissue adhesive composition comprises one or more macromolecules grafted with at least one catechol moiety and comprising at least one cross-linkable functional group, a first cross-linker for cross-linking the at least one catechol moiety, wherein the first cross-linker comprises or consists or 10 a multivalent metal ion, and a second cross-linker for covalently cross-linking the at least one cross-linkable functional group, wherein the one or more macromolecules are cross-linked by (a) complex formation between the at least one catechol moiety and the multivalent metal ion, and (b) covalent bonding of the at least one cross-linkable functional group with the second cross-linker. Fabrication method and working principle of a biological tissue adhesive 15 composition are also provided.

公开(公告)号：US09669132B1

公开(公告)日：2017-06-06

申请号：US15404566

申请日：2017-01-12

Applicant: Cook Medical Technologies LLC

Inventor： Alan George Brownlee ,  Christopher Malcolm Elvin

IPC: A61K31/74 ,  A61K9/00 ,  A01N25/34 ,  A61B17/08 ,  A61F13/00 ,  A61L24/10 ,  C09J189/00

CPC classification number: A61L24/106 ,  A61L24/0015 ,  A61L24/02 ,  A61L24/10 ,  A61L2400/04 ,  C08J3/24 ,  C08J2389/00 ,  C09J189/00

Abstract: A method of joining and/or sealing tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photoactivate the photoactivatable metal-ligand complex; thereby initiating a cross-linking reaction of the matrix protein to seal said tissue portion or join said tissue portion to an adjacent tissue portion.

公开(公告)号：US20160030631A1

公开(公告)日：2016-02-04

申请号：US14774500

申请日：2014-03-13

Applicant: THE UNIVERSITY OF TOLEDO

Inventor： Anand K. Agarwal ,  Vijay K. Goel ,  Dong-Shik Kim ,  Sarit B. Bhaduri ,  Boren Lin

IPC: A61L27/12 ,  A61K45/06 ,  A61K9/00 ,  A61L27/54 ,  A61L27/38 ,  A61L27/26 ,  A61L24/10 ,  A61L24/08 ,  A61L24/02 ,  A61L24/00 ,  A61K38/08 ,  A61K33/42 ,  A61K35/32 ,  A61K38/05 ,  A61K35/545 ,  C12N5/077 ,  A61K31/05

CPC classification number: A61L27/12 ,  A61K9/0024 ,  A61K31/05 ,  A61K33/42 ,  A61K35/32 ,  A61K35/545 ,  A61K38/05 ,  A61K38/08 ,  A61K38/12 ,  A61K38/1793 ,  A61K45/06 ,  A61L24/0005 ,  A61L24/0015 ,  A61L24/0063 ,  A61L24/02 ,  A61L24/08 ,  A61L24/10 ,  A61L24/108 ,  A61L27/227 ,  A61L27/26 ,  A61L27/3821 ,  A61L27/3847 ,  A61L27/3895 ,  A61L27/425 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/432 ,  A61L2300/62 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/02 ,  C12N5/0654 ,  C12N2506/03 ,  A61K2300/00

Abstract: Bone filler compositions, methods of making and using the same, and methods of treating osteoporosis and cancer-induced bone defects, are described.

Abstract translation: 描述了骨填充剂组合物，制备和使用骨填充剂组合物的方法，以及治疗骨质疏松症和癌症诱导的骨缺损的方法。