公开(公告)号：US5723588A

公开(公告)日：1998-03-03

申请号：US89862

申请日：1993-07-09

申请人： David A. Donofrio ,  Erwin R. Stedronsky

发明人： David A. Donofrio ,  Erwin R. Stedronsky

IPC分类号： A61L17/00 ,  A61L29/04 ,  C07K14/00 ,  C07K14/435 ,  C07K14/78 ,  C07K17/08 ,  C12N1/06 ,  C12N5/00 ,  C12N15/11 ,  C12N15/62 ,  C12N15/66 ,  C12N15/70 ,  C12N15/75 ,  C07K17/04

CPC分类号： C12N5/0068 ,  A61L17/00 ,  A61L29/049 ,  C07K14/00 ,  C07K14/43586 ,  C07K14/78 ,  C07K17/08 ,  C12N1/06 ,  C12N15/11 ,  C12N15/62 ,  C12N15/66 ,  C12N15/70 ,  C12N15/75 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/33 ,  C07K2319/61 ,  C12N2533/30 ,  C12N2533/52 ,  Y10S530/815 ,  Y10S530/817

摘要： Thermoplastics interdispersed with a variety of functional thermostable polypeptides, including proteins, and methods of making such thermoplastics are provided. The disclosure demonstrates that certain polypeptides can retain functional activity through exposure to plastic thermomolding. The polypeptides are exposed to the heating and molding/extrusion/casting process and are hence present on the formed plastic surface and at a depth below the plastic surface. The polypeptides contained in the disclosed compositions retain functional properties or binding specificities through the heating and molding/extrusion/casting processes. Preferred thermostable polypeptides used in the disclosed compositions include silk-like protein polymers, particularly ProNectin.RTM.F. The disclosed methods and compositions find use in many applications where plastics containing functional thermostable polypeptides are desired, in particular, cell cultureware.

摘要翻译： 提供了分散有各种功能性热稳定多肽（包括蛋白质）的热塑性塑料，以及制备这种热塑性塑料的方法。 本公开内容表明某些多肽可以通过暴露于塑料热塑性成型来保留功能活性。 多肽暴露于加热和模制/挤出/浇铸过程中，因此存在于形成的塑料表面上并且在塑料表面下方的深度处。 包含在所公开的组合物中的多肽通过加热和模制/挤出/浇铸方法保持功能性质或结合特异性。 所公开的组合物中使用的优选的热稳定性多肽包括丝状蛋白质聚合物，特别是ProNectin TM F.所公开的方法和组合物可用于需要含有功能性热稳定性多肽的塑料，特别是细胞培养器具的许多应用中。

公开(公告)号：US20240245399A1

公开(公告)日：2024-07-25

申请号：US18397177

申请日：2023-12-27

申请人： Northwestern University

发明人： Gregory A. Dumanian

IPC分类号： A61B17/06 ,  A61B17/00 ,  A61B17/04 ,  A61L17/00 ,  A61L17/04 ,  A61L17/12 ,  A61L17/14

CPC分类号： A61B17/06166 ,  A61B17/06 ,  A61L17/00 ,  A61L17/04 ,  A61L17/12 ,  A61L17/145 ,  A61B2017/00526 ,  A61B2017/0412 ,  A61B2017/0417 ,  A61B2017/0461 ,  A61B2017/0464 ,  A61B2017/06009 ,  A61B2017/0608 ,  A61B2017/061 ,  A61B2017/06185 ,  Y10T29/49826

摘要： A medical device includes a surgical needle, an elongated suture, and an intervening segment. The elongated suture has a first end proximate to the needle and a second end located away from the needle. The elongated suture also includes a plurality of fibers defining a mesh wall between the first and second ends. A plurality of pores extend through the mesh wall, at least some which are in the macroporous size range of greater than 200 microns for facilitating tissue integration when introduced into a body. The intervening segment is disposed between and connected to either or both ends of the elongated suture and the needle. The intervening segment includes one or more fibers of the plurality of fibers and has a cross-sectional dimension smaller than a cross-sectional dimension of the mesh wall such that the intervening segment facilitates indirect attachment of the elongated macroporous mesh suture to the needle.

公开(公告)号：US09839719B2

公开(公告)日：2017-12-12

申请号：US11920507

申请日：2006-05-22

申请人： Hans Hitz ,  Rolf Schäfer ,  Christoph Schäfer

发明人： Hans Hitz ,  Rolf Schäfer ,  Christoph Schäfer

IPC分类号： A61L29/00 ,  A61L27/16

CPC分类号： C08F220/48 ,  A61K9/0048 ,  A61K47/32 ,  A61L15/24 ,  A61L17/00 ,  A61L27/16 ,  C08F220/06 ,  C08F220/28 ,  C08F2220/281 ,  G02B1/043 ,  C08L33/08 ,  C08L33/26

摘要： The invention relates to highly biocompatible or biophilic un-cross-linked or cross-linked polymers comprising one or more side-chain active acrylic amino acids of formula I wherein: X is —NH(CH2)4—, —O—C6H4—CH2—, —OCH2—, —O—CH(CH3)—, —S—CH2—, —O-proline, and R is H or CH3; and wherein the polymer further includes a free radical initiator and, optionally, a cross-linking agent having a plurality of polymerizable ethylenically unsaturated groups. The invention further concerns various highly biocompatible, cross-linked co-polymers comprising one or more monomers of formula I, and one or more other polymerizable monomers. Uses of such polymers and co-polymers for the production of contact lenses, intraocular lenses, implants, wound healing slabs, additives for food and cosmetics, conductive plastics, spinnable fibers, and the like are disclosed.

公开(公告)号：US20170189553A1

公开(公告)日：2017-07-06

申请号：US15320292

申请日：2015-06-25

申请人： CANARY MEDICAL INC.

发明人： William L. Hunter

IPC分类号： A61K49/00 ,  A61L29/14 ,  A61L17/00 ,  H04Q9/00 ,  A61L31/14 ,  A61K47/30 ,  G01N33/44 ,  H04B5/00 ,  A61L29/04 ,  A61L31/04

CPC分类号： A61K49/00 ,  A61K47/30 ,  A61L17/00 ,  A61L29/04 ,  A61L29/14 ,  A61L31/04 ,  A61L31/14 ,  G01D11/245 ,  G01L19/0092 ,  G01N33/442 ,  G16H10/60 ,  H04B5/0068 ,  H04Q9/00 ,  H04Q2209/40 ,  H04Q2209/82

摘要： A polymer comprising a medical polymer and one or more sensors positioned within or upon said medical polymer. The sensor may be selected from the group consisting of fluid pressure sensors, contact sensors, position sensors, pulse pressure sensors, liquid volume sensors, liquid flow sensors, chemistry sensors, metabolic sensors, accelerometers, mechanical stress sensors and temperature sensors. The medical polymer may be a biodegradable polymer or a non-biodegradable polymer.

公开(公告)号：US20170014542A1

公开(公告)日：2017-01-19

申请号：US15280240

申请日：2016-09-29

申请人： The Curators of the University of Missouri

发明人： Steven B. Jung ,  Delbert E. Day

IPC分类号： A61L15/18 ,  A61F13/00 ,  A61F13/06 ,  A61L15/64 ,  A61L15/44

CPC分类号： A61L15/18 ,  A61F13/00008 ,  A61F13/00034 ,  A61F13/069 ,  A61F2013/00157 ,  A61F2013/00221 ,  A61F2013/00519 ,  A61F2013/00829 ,  A61F2013/00936 ,  A61K9/0014 ,  A61K9/06 ,  A61K33/16 ,  A61K33/22 ,  A61K33/26 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K33/38 ,  A61L15/42 ,  A61L15/425 ,  A61L15/44 ,  A61L15/64 ,  A61L17/00 ,  A61L26/0004 ,  A61L26/0009 ,  A61L26/0085 ,  A61L2300/10 ,  A61L2300/102 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2400/12

摘要： Glass-based particles of a biocompatible material which comprises 40 to about 80 wt % borate (B2O3) intermixed into a carrier which is an ointment, cream, or surgical glue.

摘要翻译： 生物相容性材料的玻璃基颗粒，其包含40至约80重量％的硼酸盐（B 2 O 3），其混合到作为软膏，乳膏或手术胶的载体中。

公开(公告)号：US20160106423A1

公开(公告)日：2016-04-21

申请号：US14976864

申请日：2015-12-21

申请人： NORTHWESTERN UNIVERSITY

发明人： Gregory Dumanian ,  Anandev Gurjala

IPC分类号： A61B17/06

CPC分类号： A61B17/06166 ,  A61B17/06 ,  A61B2017/00526 ,  A61B2017/0412 ,  A61B2017/0417 ,  A61B2017/0461 ,  A61B2017/0464 ,  A61B2017/0608 ,  A61B2017/061 ,  A61B2017/06185 ,  A61L17/00 ,  Y10T29/49826

摘要： A medical device includes a surgical needle attached to a hollow tubular suture. The suture is constructed of macroporous hollow tubular wall that facilitates and allows tissue integration into the suture core subsequent to introduction to the body, thereby preventing suture pull-through and improving biocompatibility.

摘要翻译： 医疗装置包括附接到中空管状缝合线的外科用针。 该缝合线由大孔中空的管状壁构成，其在导入身体之后促进并允许组织融合到缝合芯中，从而防止缝合线穿透并提高生物相容性。

公开(公告)号：US20160015472A1

公开(公告)日：2016-01-21

申请号：US14776768

申请日：2014-03-14

申请人： Aaron Matthew NOBLE ,  John Patrick TIERNAN ,  Lawrence Scott ARONSON

发明人： John Patrick Tiernan ,  Lawrence Scott Aronson

IPC分类号： A61B19/00 ,  A61B17/28 ,  A61B17/06 ,  A61B17/3211 ,  A61F13/44 ,  A61F13/36

CPC分类号： A61B17/3211 ,  A61B17/06166 ,  A61B17/28 ,  A61B34/20 ,  A61B90/92 ,  A61B2017/00287 ,  A61B2017/00526 ,  A61B2090/3941 ,  A61B2090/3958 ,  A61B2090/397 ,  A61B2090/3995 ,  A61F13/36 ,  A61F13/44 ,  A61F2013/530233 ,  A61L15/54 ,  A61L17/00 ,  D04H1/413 ,  D04H1/732 ,  D04H1/736

摘要： The present disclosure relates to a medical material or surgical sponge including an integral construction having a plurality of micro-particle taggants that are UV or radio wave detectable. The sponge includes a fibrous, nonwoven fabric containing entangled fibers arranged in an interconnecting patterned relationship in a plane of the fabric, and at least one UV or radio wave detectable element positioned interiorly of the fibrous nonwoven fabric in the plane. The fibers of the nonwoven fabric may be inter twined about the micro-particle taggants.

摘要翻译： 本公开涉及一种医疗材料或手术海绵，其包括具有UV或无线电波检测的多个微粒标签的整体结构。 海绵包括在织物的平面中以互连图案化关系布置的缠结纤维的纤维状非织造织物和位于该平面中的纤维无纺布内部的至少一个UV或无线电波可检测元件。 无纺织物的纤维可以围绕微粒子标签缠结。

公开(公告)号：US20150366653A1

公开(公告)日：2015-12-24

申请号：US14770323

申请日：2013-02-26

申请人： NICEM LTD.

发明人： Yasuharu NOISHIKI

IPC分类号： A61F2/07 ,  A61F2/24 ,  A61B17/06

CPC分类号： A61F2/07 ,  A61B17/06166 ,  A61F2/24 ,  A61F2002/065 ,  A61F2002/075 ,  A61F2002/826 ,  A61L17/00 ,  Y10T156/10

摘要： A suture to be used in producing a medical instrument provided with a sutured site such as a stent graft, an artificial blood vessel or an artificial heart valve, namely, a suture for sewing a medical instrument. The suture comprises two components, i.e., a high melting-point component and a low-melting point component, the difference between the melting points of components being 30° C. or more and the low-melting point component is exposed on the suture surface entirely along the length direction. The suture is, for example, a multifilament yarn comprising a combination of a high melting-point filament (3) with a low-melting point filament (4) shown in FIG. 2 or a composite filament comprising the high melting-point component and the low-melting point component, or a yarn wherein the high melting-point component is coated with the low-melting point component. When a medical material formed of a fabric or a film is sutured or knotted with the suture and then the suture site is heated at such a temperature allowing not the high-melting point component but the low-melting point component alone to melt, the sutured site is fused and fixed. Thus, a knot or a seam, which sustains the fiber shape and strength and never becomes loose, can be formed.

摘要翻译： 用于制造具有缝合部位的医疗器械的缝合线，例如支架移植物，人造血管或人造心脏瓣膜，即用于缝合医疗器械的缝合线。 缝合线包括高熔点成分和低熔点成分两部分，成分的熔点之间的差为30℃以上，低熔点成分在缝合面上露出 完全沿长度方向。 缝合线例如是包含高熔点丝（3）与图1所示的低熔点丝（4）的组合的复丝纱。 2或包含高熔点组分和低熔点组分的复合长丝，或其中高熔点组分涂覆有低熔点组分的纱线。 当由织物或膜形成的医疗材料用缝合线缝合或打结时，然后在不允许高熔点成分而不是单独的低熔点组分熔化的温度下加热缝合部位，缝合 场地融合固定。 因此，可以形成维持纤维形状和强度并且不会变松的结或接缝。

公开(公告)号：US20150327988A1

公开(公告)日：2015-11-19

申请号：US14721957

申请日：2015-05-26

申请人： Refine, LLC

发明人： Gordon Bishop ,  Randy Lashinski

IPC分类号： A61F2/12 ,  A61B17/00 ,  A61F2/00

CPC分类号： A61L17/00 ,  A61B17/00234 ,  A61B17/06166 ,  A61B2017/00411 ,  A61B2017/00557 ,  A61B2017/00792 ,  A61B2017/00796 ,  A61B2017/00867 ,  A61B2017/00893 ,  A61B2017/06176 ,  A61B2017/0618 ,  A61B2090/3908 ,  A61F2/0059 ,  A61F2/0063 ,  A61F2/12 ,  A61L17/06 ,  A61L17/145 ,  A61M29/00

摘要： Embodiments of apparatus and methods for tissue lifting, or for correcting a ptosis condition caused by tissue stretching, are described. In some embodiments a tissue is supported by a support member. In some embodiments, tension is applied to a support member through at least one suspension member. The described embodiments provide examples of methods and apparatus effective for use in lifting or otherwise applying tension to various tissues, including tissues of the breast, buttock, thigh, arm, abdomen, neck and face.

摘要翻译： 描述了用于组织提升或用于校正由组织拉伸引起的下垂状况的装置和方法的实施例。 在一些实施例中，组织由支撑构件支撑。 在一些实施例中，通过至少一个悬挂构件将张力施加到支撑构件。 所描述的实施例提供了有效用于提升或以其他方式施加张力的方法和装置的实例，所述各种组织包括乳房，臀部，大腿，手臂，腹部，颈部和脸部的组织。

公开(公告)号：US09174924B2

公开(公告)日：2015-11-03

申请号：US14724779

申请日：2015-05-28

申请人： Bezwada Biomedical, LLC

发明人： Rao S Bezwada

IPC分类号： C07C69/74 ,  C07C69/708 ,  A61L31/10 ,  A61L17/14 ,  A61L27/18 ,  A61L17/00 ,  A61L24/06 ,  C08G63/16 ,  C08G63/91

CPC分类号： C07C265/12 ,  A47F5/0006 ,  A61L17/00 ,  A61L17/105 ,  A61L17/12 ,  A61L17/145 ,  A61L24/06 ,  A61L27/18 ,  A61L27/34 ,  A61L27/52 ,  A61L27/58 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  B65D25/22 ,  C07C69/34 ,  C07C69/67 ,  C07C69/708 ,  C07C205/37 ,  C07C205/43 ,  C07C205/57 ,  C07C217/84 ,  C07C219/34 ,  C07C225/22 ,  C07C229/18 ,  C07C229/60 ,  C07C235/16 ,  C08G63/16 ,  C08G63/916 ,  Y02W90/13 ,  Y10T24/44291 ,  Y10T24/51 ,  Y10T428/139 ,  Y10T442/10 ,  C08L67/04

摘要： The present invention relates to the discovery of new class of linear and multiarmed hydrolysable linkers and cross linkers for use in the synthesis of biodegradable polymers such as, polyesters, polyurethanes, polyamides, polyureas and degradable epoxy amine resin. The linear and multiarmed hydrolysable linkers of the present invention include symmetrical and/or unsymmetrical ether carboxylic acids, amines, amide diols, amine polyols and isocyanates.