公开(公告)号：US09927429B2

公开(公告)日：2018-03-27

申请号：US14411496

申请日：2013-07-08

Applicant: Randox Laboratories Ltd.

Inventor： Maria Zellner ,  Ellen Umlauf

IPC: G01N33/53 ,  G01N33/566 ,  C07K16/00 ,  G01N33/68

CPC classification number: G01N33/5308 ,  G01N33/6896 ,  G01N2333/4712 ,  G01N2800/2814 ,  G01N2800/2821

Abstract: The present invention provides an in vitro method to aid the diagnosis of Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI), comprising determining the level of expression of one or more tropomyosin isoform(s) corresponding to P09493-3 and/or P09493-1 in a patient's sample. A kit comprising probes that bind to tropomyosin isoforms P09493-3 and P09493-1 is also provided.

公开(公告)号：US09892229B2

公开(公告)日：2018-02-13

申请号：US14435991

申请日：2013-10-16

Applicant: RANDOX LABORATORIES LTD.

Inventor： Mark William Ruddock ,  Cherith N. Reid ,  Kate E. Williamson ,  Frank Emmert-Streib ,  John V. Lamont ,  Peter Fitzgerald

IPC: G01N33/48 ,  G06F19/18 ,  G01N33/574 ,  G06F19/24 ,  G06F19/00 ,  G06G7/58

CPC classification number: G06F19/18 ,  G01N33/57407 ,  G01N33/57484 ,  G01N2333/4737 ,  G01N2333/4742 ,  G01N2333/475 ,  G01N2333/485 ,  G01N2333/523 ,  G01N2333/525 ,  G01N2333/5406 ,  G01N2333/5412 ,  G01N2333/5421 ,  G01N2333/545 ,  G01N2333/55 ,  G01N2333/70578 ,  G01N2333/70596 ,  G01N2333/7151 ,  G01N2333/7452 ,  G01N2333/928 ,  G01N2333/96433 ,  G01N2333/96494 ,  G01N2333/988 ,  G01N2400/00 ,  G06F19/00 ,  G06F19/24 ,  G16H50/30

Abstract: The invention provides a method of defining the likelihood of a subject having bladder cancer, comprising the steps of: (A) assessing the subject's likelihood of having bladder cancer by: i. identifying at least one sub-population group appropriate to the subject; ii. determining the level of one or more biomarkers selected according to the sub-population group in a sample obtained from the subject; iii. inputting each of the biomarker values into an algorithm to produce an output value; and iv. correlating the output value with the likelihood of the subject having bladder cancer, wherein the sub-population group is selected according to smoking habits, gender, presence/absence of stone disease, history of benign prostate enlargement (BPE) or prescription of anti-hypertensive, anti-platelet and/or anti-ulcer medication, and (B) determining the subject's stratified risk level of serious disease by: v. determining the level of one or more biomarkers specific for one or more risk classifiers defined using Random Forest Classifiers (RFC), logistic regression or another appropriate systems biology or statistical approach in a sample obtained from the subject, vi. inputting each of the biomarker values into an algorithm or algorithms to produce an output value; and vii. correlating the output value with a stratified risk level of underlying serious disease, wherein the likelihood of having bladder cancer is combined with the stratified risk level of having serious disease, wherein the risk of having bladder cancer and/or serious disease is categorized as: high-risk bladder cancer requiring immediate cystoscopy; low-risk bladder cancer requiring urgent cystoscopy; high-risk control requiring close evaluation and further investigation; or low-risk control requiring primary care monitoring.

公开(公告)号：US09302831B2

公开(公告)日：2016-04-05

申请号：US13812691

申请日：2011-07-26

Applicant: Gareth Wilson ,  Carl Wrigglesworth ,  Peter Fitzgerald ,  John Lamont ,  Ivan McConnell

Inventor： Gareth Wilson ,  Carl Wrigglesworth ,  Peter Fitzgerald ,  John Lamont ,  Ivan McConnell

IPC: A61B10/00 ,  B65D51/24 ,  B01L3/00 ,  B65D51/00 ,  G01N35/10 ,  G01N35/04

CPC classification number: B65D51/243 ,  B01L3/523 ,  B01L2300/044 ,  B65D51/002 ,  G01N35/1002 ,  G01N2035/0401

Abstract: A valve for a reagent bottle is provided, the valve including a resilient membrane configured to extend across an opening in the reagent bottle, the resilient membrane having at least one slit extending therethrough. Also disclosed is a dispensing apparatus for dispensing a reagent from a reagent bottle, the dispensing apparatus comprising: a probe assembly having a probe adapted for insertion into the reagent bottle through the valve and an extraction mechanism for drawing reagent out of the reagent bottle through the probe. A valve opening assembly is provided, which is adapted to open the valve of the reagent bottle such that the probe can pass through the valve without contacting the valve.

Abstract translation: 提供了一种用于试剂瓶的阀，所述阀包括构造成延伸穿过所述试剂瓶中的开口的弹性膜，所述弹性膜具有延伸穿过其中的至少一个狭缝。 还公开了一种用于从试剂瓶分配试剂的分配装置，该分配装置包括：探针组件，其具有适于通过阀插入试剂瓶的探针和用于将试剂从试剂瓶中抽出的提取机构 探测。 提供了一种阀开启组件，其适于打开试剂瓶的阀，使得探针可以通过阀而不接触阀。

公开(公告)号：US20140072987A1

公开(公告)日：2014-03-13

申请号：US14025623

申请日：2013-09-12

Applicant: RANDOX LABORATORIES LTD.

Inventor： Mark W. Ruddock ,  Cherith N. Reid ,  Kathleen Williamson ,  John V. Lamont ,  Stephen P. Fitzgerald

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/57407 ,  G01N2800/52 ,  G01N2800/60

Abstract: The disclosure relates to methods of detecting bladder cancer including assaying a patient sample for the levels of certain combinations of biomarkers. The disclosure also relates to methods for determining the efficacy of a drug for the treatment of bladder cancer.

Abstract translation: 本公开涉及检测膀胱癌的方法，包括测定患者样品中生物标志物的某些组合的水平。 本公开还涉及用于确定药物治疗膀胱癌的功效的方法。

公开(公告)号：US20130224878A1

公开(公告)日：2013-08-29

申请号：US13812767

申请日：2011-07-26

Applicant: Gareth Wilson ,  Michael Hooks ,  Peter Fitzgerald ,  John Lamont ,  Ivan McConnell

Inventor： Gareth Wilson ,  Michael Hooks ,  Peter Fitzgerald ,  John Lamont ,  Ivan McConnell

IPC: B65B69/00 ,  G01N1/28 ,  G01N33/50

CPC classification number: B01L9/52 ,  B01L3/5085 ,  B01L9/527 ,  B01L2200/025 ,  B01L2300/044 ,  B01L2300/0609 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0822 ,  B65B69/00 ,  B65D71/50 ,  G01N1/28 ,  G01N33/50 ,  Y10T436/2575

Abstract: A biochip well is disclosed, including a vessel containing a well therewithin, the vessel forming at least base and side walls of the well and defining at least one aperture giving access to the well, and further including retaining means for holding a biochip at a predetermined position within the well, the well including a laterally offset region into which the biochip does not protrude when held at the predetermined position by the retaining means. Also disclosed are sealed well assemblies and apparatus and methods for opening sealed wells.

Abstract translation: 公开了一种生物芯片井，包括容纳其中的井的容器，所述容器至少形成井的底壁和侧壁，并且限定了至少一个允许进入井的孔，并且还包括用于将生物芯片保持在预定的 井内的位置，井包括横向偏移区域，当通过保持装置保持在预定位置时，生物芯片不会突出。 还公开了密封井组件以及用于打开密封井的装置和方法。

公开(公告)号：US20130121878A1

公开(公告)日：2013-05-16

申请号：US13812691

申请日：2011-07-26

Applicant: Gareth Wilson ,  Carl Wrigglesworth ,  Peter Fitzgerald ,  John Lamont ,  Ivan Mcconnell

Inventor： Gareth Wilson ,  Carl Wrigglesworth ,  Peter Fitzgerald ,  John Lamont ,  Ivan Mcconnell

IPC: B65D51/24

CPC classification number: B65D51/243 ,  B01L3/523 ,  B01L2300/044 ,  B65D51/002 ,  G01N35/1002 ,  G01N2035/0401

Abstract: A valve for a reagent bottle is provided, the valve including a resilient membrane configured to extend across an opening in the reagent bottle, the resilient membrane having at least one slit extending therethrough. Also disclosed is a dispensing apparatus for dispensing a reagent from a reagent bottle, the dispensing apparatus comprising: a probe assembly having a probe adapted for insertion into the reagent bottle through the valve and an extraction mechanism for drawing reagent out of the reagent bottle through the probe. A valve opening assembly is provided, which is adapted to open the valve of the reagent bottle such that the probe can pass through the valve without contacting the valve.

Abstract translation: 提供了一种用于试剂瓶的阀，所述阀包括构造成延伸穿过所述试剂瓶中的开口的弹性膜，所述弹性膜具有延伸穿过其中的至少一个狭缝。 还公开了一种用于从试剂瓶分配试剂的分配装置，该分配装置包括：探针组件，其具有适于通过阀插入试剂瓶的探针和用于将试剂从试剂瓶中抽出的提取机构， 探测。 提供了一种阀开启组件，其适于打开试剂瓶的阀，使得探针可以通过阀而不接触阀。

公开(公告)号：US20120208294A1

公开(公告)日：2012-08-16

申请号：US13384278

申请日：2010-07-16

Applicant: Elouard Benchikh ,  Stephen Peter Fitzgerald ,  Philip Andrew Lowry ,  Ivan Robert Mcconnell

Inventor： Elouard Benchikh ,  Stephen Peter Fitzgerald ,  Philip Andrew Lowry ,  Ivan Robert Mcconnell

IPC: G01N33/53 ,  C07K14/77 ,  C07K14/765 ,  C07K14/47 ,  C07K16/18

CPC classification number: C07D487/04 ,  C07K16/44 ,  G01N33/948 ,  G01N2430/00

Abstract: The invention relates to novel immunogens, antibodies, methods and kits for use in immunoassays to detect and quantify zaleplon, metabolites of zaleplon and indiplon. These are the first described immunoassays for these compounds and have greater sensitivity than alternative analytical techniques.

Abstract translation: 本发明涉及用于免疫测定中的新型免疫原，抗体，方法和试剂盒，以检测和量化扎来普隆，扎来普隆和独特的代谢物。 这些是对这些化合物的首次描述的免疫测定，并且具有比替代分析技术更大的灵敏度。

公开(公告)号：US20090053824A1

公开(公告)日：2009-02-26

申请号：US12087653

申请日：2007-01-25

Applicant: Aiden John Walsh ,  Stephen Peter Fitzgerald

Inventor： Aiden John Walsh ,  Stephen Peter Fitzgerald

IPC: G01N1/34 ,  B01L9/00 ,  B01L3/02 ,  B01J19/00 ,  G01N1/38

CPC classification number: G01N35/00029 ,  G01N35/0099 ,  G01N2035/00158 ,  G01N2035/00524 ,  G01N2035/00564 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Assay device processing apparatus includes a rotatably mounted assay device vessel support; and a drive for rotating the support. The support is rotatable about a substantially horizontal first axis so that, upon rotation, an assay device vessel attached to the support can be inverted.

Abstract translation: 测定装置处理装置包括可旋转地安装的测定装置容器支架; 以及用于旋转支撑件的驱动器。 支撑件可围绕基本上水平的第一轴线旋转，使得在旋转时，附接到支撑件的测定装置容器可以反转。

公开(公告)号：US20080206780A1

公开(公告)日：2008-08-28

申请号：US11662827

申请日：2005-09-19

Applicant: Peter Fitzgerald ,  John Lamont ,  Marshall Dunlop ,  Shirley Schon

Inventor： Peter Fitzgerald ,  John Lamont ,  Marshall Dunlop ,  Shirley Schon

IPC: G01N33/53 ,  C07K16/18 ,  C40B40/10 ,  C07K1/00 ,  C07H21/00

CPC classification number: C12N15/1093 ,  C07K16/005 ,  C07K16/18 ,  C07K2317/622

Abstract: The invention relates to a composition comprising a plurality of antibody fragments, each comprising a framework region having a murine VH14 heavy chain and a murine VK2 light chain, or homologues thereof, each antibody fragment further comprising at least one different CDR.

Abstract translation: 本发明涉及包含多个抗体片段的组合物，每个抗体片段包含具有鼠VH14重链和鼠VK2轻链的框架区或其同源物，每个抗体片段还包含至少一个不同的CDR。

公开(公告)号：US07109310B2

公开(公告)日：2006-09-19

申请号：US10295700

申请日：2002-11-15

Applicant: Robert Ivan McConnell ,  Elouard Benchikh ,  Stephen Peter Fitzgerald ,  John Victor Lamont

Inventor： Robert Ivan McConnell ,  Elouard Benchikh ,  Stephen Peter Fitzgerald ,  John Victor Lamont

IPC: C07K16/44 ,  C12N9/96 ,  G01N33/533 ,  G01N33/534 ,  G01N33/535

CPC classification number: G01N33/9486 ,  C07D211/58 ,  G01N33/531 ,  G01N2430/00

Abstract: The invention provides an immunogen comprising a hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least one structural epitope of metabolites of fentanyl and of metabolites of fentanyl analogs.