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    Dried tetramethoxysilane sol-gel containing a leachable reagent
    3.
    发明授权
    Dried tetramethoxysilane sol-gel containing a leachable reagent 失效
    含有可浸出试剂的干燥四甲氧基硅烷溶胶 - 凝胶

    公开(公告)号：US06232090B1

    公开(公告)日：2001-05-15

    申请号：US09192280

    申请日：1998-11-16

    Applicant: Stephen Peter Fitzgerald ,  John Victor Lamont ,  Robert Ivan McConnell

    Inventor： Stephen Peter Fitzgerald ,  John Victor Lamont ,  Robert Ivan McConnell

    IPC: C12Q100

    CPC classification number: G01N33/535 ,  G01N33/5436 ,  G01N33/552

    Abstract: First and second reactants that give a signal when mixed in the presence of an analyte in a liquid sample, are separately contained in sol-gels that release the reactants in the presence of the liquid. For example, when the first and second reactants respectively comprise an oxidant and a reductant, and the reaction provides a detectable signal, the system can be used to detect the presence of contaminants in a water sample. The sol-gel may be obtained by reaction of water with, per part by volume thereof, at least 2 parts of a metal alkoxide, and drying the resultant gel.

    Abstract translation: 在液体样品中的分析物存在下混合时产生信号的第一和第二反应物分别包含在溶液中，在溶液存在下释放反应物。 例如，当第一和第二反应物分别包含氧化剂和还原剂并且反应提供可检测的信号时，该系统可用于检测水样品中污染物的存在。 可以通过水与其每体积体积的至少2份金属醇盐反应并干燥所得凝胶来获得溶胶 - 凝胶。

    Method and apparatus for monitoring the properties of a biological or chemical sample
    4.
    发明授权
    Method and apparatus for monitoring the properties of a biological or chemical sample 有权
    用于监测生物或化学样品性质的方法和装置

    公开(公告)号：US07811824B2

    公开(公告)日：2010-10-12

    申请号：US11392808

    申请日：2006-03-30

    Applicant: John Victor Lamont ,  Robert Ivan McConnell ,  Stephen Peter Fitzgerald

    Inventor： John Victor Lamont ,  Robert Ivan McConnell ,  Stephen Peter Fitzgerald

    IPC: G01N33/48 ,  G01N33/483

    CPC classification number: G06Q50/22 ,  G06F19/20 ,  G06F19/28 ,  Y10T436/115831 ,  Y10T436/12

    Abstract: A method of monitoring the properties of a biological or chemical sample. The method includes carrying out a plurality of different tests on the sample to generate corresponding test data; optionally carrying out a preliminary processing of the test data to generate partially processed data; storing the test data and/or partially processed data; causing a processing system to analyze a user-defined selection of the test data or partially processed data to generate result data relating to one or more properties of the sample; and subsequent to the previous step, receiving a second user defined selection of the test data or partially processed data, different from the first selection, and causing the processing system to analyze the second user-defined selection of the test data or partially processed data to generate second result data relating to one or more properties of the sample different from the properties corresponding to the first user-defined selection.

    Abstract translation: 监测生物或化学样品性质的方法。 该方法包括对样本进行多个不同的测试以产生相应的测试数据; 可选地执行测试数据的初步处理以产生部分处理的数据; 存储测试数据和/或部分处理的数据; 使处理系统分析用户定义的测试数据选择或部分处理的数据，以生成与样本的一个或多个属性有关的结果数据; 并且在所述前一步骤之后，接收与所述第一选择不同的所述测试数据或部分处理的数据的第二用户定义的选择，并且使所述处理系统分析所述测试数据或部分处理的数据的所述第二用户定义的选择， 产生与不同于与第一用户定义的选择相对应的属性的样本的一个或多个属性相关的第二结果数据。

    Assay device incubator
    5.
    发明授权
    Assay device incubator 有权
    测定装置孵化器

    公开(公告)号：US06881572B2

    公开(公告)日：2005-04-19

    申请号：US10406224

    申请日：2003-04-04

    Applicant: Stephen Peter Fitzgerald ,  John Victor Lamont ,  Robert Ivan McConnell

    Inventor： Stephen Peter Fitzgerald ,  John Victor Lamont ,  Robert Ivan McConnell

    IPC: B01F11/00 ,  B01L7/00 ,  C12M1/00 ,  G01N35/00 ,  G01N35/02 ,  C12M1/02

    CPC classification number: G01N35/028 ,  B01F11/0022 ,  B01L7/00 ,  G01N2035/00356 ,  G01N2035/00524 ,  Y10S435/809

    Abstract: An assay device incubator comprises a housing (46) defining a region within which at least one assay device is located in use, the housing defining laterally opposed sidewalls (48, 50) of at least one bay (33) in which an assay device can be located. The housing (46) includes one or more guides (49, 51) for supporting the assay device and enabling the assay device to undergo to and fro movement therealong. A vibration system (40, 60) is coupled to the at least one tray in use for vibrating the tray to and fro along the or each guide. A heating system (70) heats the region within the housing.

    Abstract translation: 测定装置培养箱包括限定其中至少一个测定装置位于使用中的区域的壳体（46），所述壳体限定至少一个隔间（33）的横向相对的侧壁（48,50），其中测定装置可以 位于。 壳体（46）包括用于支撑测定装置的一个或多个引导件（49,51），并且使测定装置能够沿着其移动。 振动系统（40,60）在使用中联接到所述至少一个托盘，用于沿着或每个引导件来回振动托盘。 加热系统（70）加热壳体内的区域。

    Calibrating microarrays
    6.
    发明授权
    Calibrating microarrays 有权
    校准微阵列

    公开(公告)号：US07846713B2

    公开(公告)日：2010-12-07

    申请号：US10491811

    申请日：2002-10-10

    Applicant: John Victor Lamont ,  Robert Ivan McConnell ,  Stephen Peter Fitzgerald ,  Maria Luz Rodriguez

    Inventor： John Victor Lamont ,  Robert Ivan McConnell ,  Stephen Peter Fitzgerald ,  Maria Luz Rodriguez

    IPC: C12M1/00

    CPC classification number: G01N33/54386 ,  G01N33/54306 ,  Y10S436/807 ,  Y10S436/809

    Abstract: An assay for measuring the amount of a first analyte in a sample, comprises the steps of: (i) contacting the sample with a device that comprises one or more first reaction sites which comprise a first ligand having affinity for the first analyte, and a series of second reaction sites each comprising different known concentrations of an immobilized second analyte; (ii) removing any unbound first analyte; (iii) contacting the device with a second ligand that is detectably labelled and which has affinity for the first analyte, and a third ligand that is detectably labelled and which has affinity for the second analyte; (iv) removing any unbound second and third ligands; and (v) measuring the amount of second and third ligands, wherein measurement of the third ligand is used to establish a calibration curve, used to determine the amount of first analyte present in sample.

    Abstract translation: 用于测量样品中第一分析物的量的测定包括以下步骤：（i）使样品与包含一个或多个包含对第一分析物具有亲和力的第一配体的第一反应位点的装置接触，以及 一系列第二反应位点各自包含不同已知浓度的固定化第二分析物; （ii）去除任何未结合的第一分析物; （iii）使该装置与可检测标记并对第一分析物具有亲和力的第二配体和可检测地标记并对第二分析物具有亲和力的第三配体; （iv）除去任何未结合的第二和第三配体; 和（v）测量第二和第三配体的量，其中第三配体的测量用于建立校准曲线，用于确定样品中存在的第一分析物的量。

    Breast Cancer Markers
    7.
    发明申请
    Breast Cancer Markers 审中-公开
    乳腺癌标志物

    公开(公告)号：US20090192107A1

    公开(公告)日：2009-07-30

    申请号：US12226012

    申请日：2007-04-10

    Applicant: Martin Andrew Crockard ,  John Victor Lamont ,  Stephen Peter Fitzgerald

    Inventor： Martin Andrew Crockard ,  John Victor Lamont ,  Stephen Peter Fitzgerald

    IPC: A61K31/7088 ,  C12Q1/68 ,  C07H21/00 ,  C07K7/06 ,  C07K16/00 ,  A61P35/00

    CPC classification number: C12Q1/6886 ,  C07K14/4702 ,  C12Q2600/158

    Abstract: A method for the detection of the presence of or the risk of cancer in a patient, comprising, with reference to a normal control, the step of: (i) detecting the expression level of a gene characterised by any of the nucleotide sequences identified herein as SEQ ID No. 1 to SEQ ID No. 10, in a sample isolated from a patient, wherein an increased expression level of the gene characterised by any of SEQ ID Nos. 1 to 6 and 10, or a decreased expression level of the gene characterised by any of SEQ ID Nos. 7 to 9, indicates the presence of or the risk of cancer in the patient from whom the sample was isolated.

    Abstract translation: 一种检测患者癌症存在或癌症风险的方法，包括参照正常对照的步骤：（i）检测以本文所鉴定的任何核苷酸序列为特征的基因的表达水平 作为SEQ ID No.1〜SEQ ID No.10所示的样品，分离自患者的样品，其中以SEQ ID NO：1至6和10中任一个为特征的基因的表达水平提高，或者表达水平降低 以SEQ ID NO：7至9中任一项为特征的基因表示在分离样品的患者中存在癌症的风险或癌症的风险。

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