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520 条记录 (耗时 0.037 秒)

    HIV-producing cell line and uses thereof
    52.
    发明申请
    HIV-producing cell line and uses thereof 审中-公开
    产生HIV的细胞系及其用途

    公开(公告)号：US20030109023A1

    公开(公告)日：2003-06-12

    申请号：US10275417

    申请日：2002-11-04

    发明人： Hiroshi Miyake ,  Yuji Iizawa ,  Masanori Baba

    IPC分类号： C12Q001/70 ,  C12N007/00 ,  C12N005/08 ,  C12N015/867

    CPC分类号： G01N33/56988 ,  C12N7/00 ,  C12N2503/02 ,  C12N2510/02 ,  C12N2740/16011 ,  C12N2740/16051 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/505 ,  G01N2333/16 ,  G01N2333/705

    摘要： The object of the present invention is to provide a T cell line capable of continuously producing human immunodeficiency virus (HIV) using CC chemokine receptor 5 (CCR5); and being in a state of continuously producing human immunodeficiency virus (HIV) or in a state wherein human immunodeficiency virus (HIV) is latently infecting, and a method for isolating and producing the T cell line. The present invention related to T cell line capable continuously producing human immunodeficiency virus (HIV) using cc chemokine receptor 5 (CCR5) and being in a state of continuously producing human immunodeficiency virus (HIV) is latently infecting, a method for screenings by use of the T cell line of (1) HIV resistant to an agent having an anti-HIV activity, (2) an agent having an anti-HIV activity, (3) an agent inhibiting the transition of HIV from the latent period into the proliferation period, and (4) an agent capable of eliminating HIV from T cell line; and a pharmaceutical composition comprising the agent obtained by the above screenings of (2) to (4). A T cell line of the present invention having a continuous productivity of human immunodeficiency virus (HIV) usnig CC Chemokine receptor 5 (CCR5) is useful in screening for agents or salts thereof for the treatment or prevention of diseases such as AIDS caused by HIV.

    摘要翻译： 本发明的目的是提供能够使用CC趋化因子受体5（CCR5）连续生产人类免疫缺陷病毒（HIV）的T细胞系。 并且处于连续产生人体免疫缺陷病毒（HIV）或者人类免疫缺陷病毒（HIV）潜伏感染的状态中的状态，以及分离和产生T细胞系的方法。 涉及使用cc趋化因子受体5（CCR5）连续生产人类免疫缺陷病毒（HIV）并处于连续生产人体免疫缺陷病毒（HIV）的状态的T细胞系的本发明是潜在的感染，一种使用 （1）HIV抗体的T细胞系具有抗HIV活性的药剂，（2）具有抗HIV活性的药剂，（3）抑制HIV从潜伏期向增殖期转变的药剂 ，和（4）能够从T细胞系中除去HIV的药剂; 以及包含通过上述（2）至（4）的筛选获得的试剂的药物组合物。 具有人类免疫缺陷病毒（HIV）us CCI趋化因子受体5（CCR5）的连续生产力的本发明的T细胞系可用于筛选其用于治疗或预防HIV引起的AIDS等疾病的药剂或其盐。

    Test system for studying a biological fluid
    55.
    发明申请
    Test system for studying a biological fluid 审中-公开
    用于研究生物液体的测试系统

    公开(公告)号：US20030088192A1

    公开(公告)日：2003-05-08

    申请号：US10287529

    申请日：2002-11-05

    发明人： Thomas Lengsfeld

    IPC分类号： A61B005/00

    CPC分类号： G01N33/54366 ,  G01N2333/16 ,  G01N2333/52

    摘要： A test system for studying a biological fluid which comprises a tube- or pipe-like hollow body which is intended for receiving or passing through a biological fluid and on whose inside a support is attached on which binding molecules for one or more different antigens, antibodies, pathogens, toxins and/or exogenous or endogenous proteins to be detected in the biological fluid are arranged in fields separated from one another is described.

    摘要翻译： 一种用于研究生物流体的测试系统，其包括管状或管状中空体，其旨在用于接收或通过生物流体，并且其内部附着有支持物的结合分子用于一种或多种不同抗原，抗体 ，在生物流体中要检测的病原体，毒素和/或外源或内源蛋白质被排列在彼此分离的区域中。

    Methods and compositions for the priming of specific cytotoxic T-lymphocyte response
    60.
    发明授权
    Methods and compositions for the priming of specific cytotoxic T-lymphocyte response 失效
    用于引发特异性细胞毒性T淋巴细胞反应的方法和组合物

    公开(公告)号：US06210873B1

    公开(公告)日：2001-04-03

    申请号：US07800932

    申请日：1991-12-02

    申请人： Jagannadha K. Sastry ,  Ralph B. Arlinghaus ,  Chris D. Platsoucas

    发明人： Jagannadha K. Sastry ,  Ralph B. Arlinghaus ,  Chris D. Platsoucas

    IPC分类号： C12Q170

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2740/16122 ,  G01N33/505 ,  G01N2333/16 ,  Y10S435/974

    摘要： The present invention discloses a novel method for the rapid screening of candidate cytotoxic T lymphocyte- (CTL-) inducing compounds, such as peptides, by the in vivo priming of CTLs with synthetic peptides. The use of compounds so identified for the development of CTL vaccines for the treatment of various infectious disorders, including the treatment of viral diseases such as AIDS, herpes, influenza, and feline or bovine leukemia, is also disclosed, as is the use of this methodology for the preparation of specifically primed CTLs.

    摘要翻译： 本发明公开了通过用合成肽体内引发CTLs来快速筛选候选细胞毒性T淋巴细胞（CTL）诱导化合物如肽的新方法。 还公开了如此鉴定用于开发用于治疗各种感染性疾病，包括治疗病毒性疾病如AIDS，疱疹，流感和猫科动物或牛白血病的CTL疫苗的化合物的使用，正如使用这种 制备特异性引发CTL的方法。